Journal of Pharmacology and Experimental Therapeutics: 347 (2)

November 01, 2013; Volume 347,Issue 2

Highlighted Papers

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Effects of a Delta-Opioid Receptor Ligand on Nociceptive Threshold
Journal of Pharmacology and Experimental Therapeutics November 2013, 347 (2) 250; DOI: https://doi.org/10.1124/jpet.113.1113HI
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Isoform Selectivity of Adenylyl Cyclase Inhibitors
Journal of Pharmacology and Experimental Therapeutics November 2013, 347 (2) 250; DOI: https://doi.org/10.1124/jpet.113.1113HIa
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High-Throughput Screening Paradigm Identifying an Adenylyl Cyclase 2 Inhibitor
Journal of Pharmacology and Experimental Therapeutics November 2013, 347 (2) 250; DOI: https://doi.org/10.1124/jpet.113.1113HIb
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Analysis of the Influence of β₃-Adrenoceptors on the Rat Micturition Cycle
Journal of Pharmacology and Experimental Therapeutics November 2013, 347 (2) 250; DOI: https://doi.org/10.1124/jpet.113.1113HIc

Perspectives in Pharmacology

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Experimental Treatments for Cocaine Toxicity: A Difficult Transition to the Bedside
Nicholas J. Connors and Robert S. Hoffman

Journal of Pharmacology and Experimental Therapeutics November 2013, 347 (2) 251-257; DOI: https://doi.org/10.1124/jpet.113.206383

Behavioral Pharmacology

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Effects of Intrathecal SNC80, a Delta Receptor Ligand, on Nociceptive Threshold and Dorsal Horn Substance P Release
Milad Kouchek, Toshifumi Takasusuki, Tetsuji Terashima, Tony L. Yaksh and Qinghao Xu

Journal of Pharmacology and Experimental Therapeutics November 2013, 347 (2) 258-264; DOI: https://doi.org/10.1124/jpet.113.206573

Cellular and Molecular

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Isoform Selectivity of Adenylyl Cyclase Inhibitors: Characterization of Known and Novel Compounds
Cameron S. Brand, Harrison J. Hocker, Alemayehu A. Gorfe, Claudio N. Cavasotto and Carmen W. Dessauer

Journal of Pharmacology and Experimental Therapeutics November 2013, 347 (2) 265-275; DOI: https://doi.org/10.1124/jpet.113.208157
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Development of a High-Throughput Screening Paradigm for the Discovery of Small-Molecule Modulators of Adenylyl Cyclase: Identification of an Adenylyl Cyclase 2 Inhibitor
Jason M. Conley, Cameron S. Brand, Amy S. Bogard, Evan P. S. Pratt, Ruqiang Xu, Gregory H. Hockerman, Rennolds S. Ostrom, Carmen W. Dessauer and Val J. Watts

Journal of Pharmacology and Experimental Therapeutics November 2013, 347 (2) 276-287; DOI: https://doi.org/10.1124/jpet.113.207449
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MCP-1-Induced Protein Promotes Endothelial-Like and Angiogenic Properties in Human Bone Marrow Monocytic Cells
Jianli Niu, Kangkai Wang, Olga Zhelyabovska, Yasser Saad and Pappachan E. Kolattukudy

Journal of Pharmacology and Experimental Therapeutics November 2013, 347 (2) 288-297; DOI: https://doi.org/10.1124/jpet.113.207316
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Delineation of the GPRC6A Receptor Signaling Pathways Using a Mammalian Cell Line Stably Expressing the Receptor
Stine Engesgaard Jacobsen, Lenea Nørskov-Lauritsen, Alex Rojas Bie Thomsen, Sanela Smajilovic, Petrine Wellendorph, Niklas H. P. Larsson, Anders Lehmann, Vikram Kjøller Bhatia and Hans Bräuner-Osborne

Journal of Pharmacology and Experimental Therapeutics November 2013, 347 (2) 298-309; DOI: https://doi.org/10.1124/jpet.113.206276
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Effects of Eugenol on T-type Ca²⁺ Channel Isoforms
Haengsoo Seo, Hai Ying Li, Edward Perez-Reyes and Jung-Ha Lee

Journal of Pharmacology and Experimental Therapeutics November 2013, 347 (2) 310-317; DOI: https://doi.org/10.1124/jpet.113.207936

Chemotherapy, Antibiotics, and Gene Therapy

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Tobramycin Disposition in the Rat Lung Following Airway Administration
Min Li and Peter R. Byron

Journal of Pharmacology and Experimental Therapeutics November 2013, 347 (2) 318-324; DOI: https://doi.org/10.1124/jpet.113.207415

Drug Discovery and Translational Medicine

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Biaryl Amides and Hydrazones as Therapeutics for Prion Disease in Transgenic Mice
Duo Lu, Kurt Giles, Zhe Li, Satish Rao, Elena Dolghih, Joel R. Gever, Michal Geva, Manuel L. Elepano, Abby Oehler, Clifford Bryant, Adam R. Renslo, Matthew P. Jacobson, Stephen J. DeArmond, B. Michael Silber and Stanley B. Prusiner

Journal of Pharmacology and Experimental Therapeutics November 2013, 347 (2) 325-338; DOI: https://doi.org/10.1124/jpet.113.205799
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Platelet Endothelial Cell Adhesion Molecule Targeted Oxidant-Resistant Mutant Thrombomodulin Fusion Protein with Enhanced Potency In Vitro and In Vivo
Ronald Carnemolla, Colin F. Greineder, Ann-Marie Chacko, Kruti Rajan Patel, Bi-Sen Ding, Sergei Zaitsev, Charles T. Esmon and Vladimir R. Muzykantov

Journal of Pharmacology and Experimental Therapeutics November 2013, 347 (2) 339-345; DOI: https://doi.org/10.1124/jpet.113.205104
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Pharmacologic Suppression of Inflammation by a Diphenyldifluoroketone, EF24, in a Rat Model of Fixed-Volume Hemorrhage Improves Survival
Vivek R. Yadav, Kaustuv Sahoo, Pamela R. Roberts and Vibhudutta Awasthi

Journal of Pharmacology and Experimental Therapeutics November 2013, 347 (2) 346-356; DOI: https://doi.org/10.1124/jpet.113.208009

Gastrointestinal, Hepatic, Pulmonary, and Renal

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Rolipram Improves Renal Perfusion and Function during Sepsis in the Mouse
Joseph H. Holthoff, Zhen Wang, Naeem K. Patil, Neriman Gokden and Philip R. Mayeux

Journal of Pharmacology and Experimental Therapeutics November 2013, 347 (2) 357-364; DOI: https://doi.org/10.1124/jpet.113.208520

Inflammation, Immunopharmacology, and Asthma

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PXS-4681A, a Potent and Selective Mechanism-Based Inhibitor of SSAO/VAP-1 with Anti-Inflammatory Effects In Vivo
Jonathan S. Foot, Tin T. Yow, Heidi Schilter, Alberto Buson, Mandar Deodhar, Alison D. Findlay, Lily Guo, Ian A. McDonald, Craig I. Turner, Wenbin Zhou and Wolfgang Jarolimek

Journal of Pharmacology and Experimental Therapeutics November 2013, 347 (2) 365-374; DOI: https://doi.org/10.1124/jpet.113.207613

Metabolism, Transport, and Pharmacogenomics

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A Correlation between Cytotoxicity and Reductase-Mediated Metabolism in Cell Lines Treated with Doxorubicin and Daunorubicin
Onkar S. Bains, András Szeitz, Joanna M. Lubieniecka, Gina E. Cragg, Thomas A. Grigliatti, K. Wayne Riggs and Ronald E. Reid

Journal of Pharmacology and Experimental Therapeutics November 2013, 347 (2) 375-387; DOI: https://doi.org/10.1124/jpet.113.206805
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Cellular Influx, Efflux, and Anabolism of 3-Carboranyl Thymidine Analogs: Potential Boron Delivery Agents for Neutron Capture Therapy
Elena Sjuvarsson, Vijaya L. Damaraju, Delores Mowles, Michael B. Sawyer, Rohit Tiwari, Hitesh K. Agarwal, Ahmed Khalil, Sherifa Hasabelnaby, Ayman Goudah, Robin J. Nakkula, Rolf F. Barth, Carol E. Cass, Staffan Eriksson and Werner Tjarks

Journal of Pharmacology and Experimental Therapeutics November 2013, 347 (2) 388-397; DOI: https://doi.org/10.1124/jpet.113.207464

Neuropharmacology

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Menthol Inhibits 5-HT₃ Receptor–Mediated Currents
Abrar Ashoor, Jacob C. Nordman, Daniel Veltri, Keun-Hang Susan Yang, Yaroslav Shuba, Lina Al Kury, Bassem Sadek, Frank C. Howarth, Amarda Shehu, Nadine Kabbani and Murat Oz

Journal of Pharmacology and Experimental Therapeutics November 2013, 347 (2) 398-409; DOI: https://doi.org/10.1124/jpet.113.203976
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Reduction of Cocaine Self-Administration and D3 Receptor-Mediated Behavior by Two Novel Dopamine D3 Receptor-Selective Partial Agonists, OS-3-106 and WW-III-55
Timothy H. C. Cheung, Amy L. Loriaux, Suzanne M. Weber, Kayla N. Chandler, Jeffrey D. Lenz, Romina F. Schaan, Robert H. Mach, Robert R. Luedtke and Janet L. Neisewander

Journal of Pharmacology and Experimental Therapeutics November 2013, 347 (2) 410-423; DOI: https://doi.org/10.1124/jpet.112.202911
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Differential Modulation of Brain Nicotinic Acetylcholine Receptor Function by Cytisine, Varenicline, and Two Novel Bispidine Compounds: Emergent Properties of a Hybrid Molecule
Can Peng, Clare Stokes, Yann S. Mineur, Marina R. Picciotto, Chengju Tian, Christoph Eibl, Isabelle Tomassoli, Daniela Guendisch and Roger L. Papke

Journal of Pharmacology and Experimental Therapeutics November 2013, 347 (2) 424-437; DOI: https://doi.org/10.1124/jpet.113.206904
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N-Aryl Piperazine Metabotropic Glutamate Receptor 5 Positive Allosteric Modulators Possess Efficacy in Preclinical Models of NMDA Hypofunction and Cognitive Enhancement
K.J. Gregory, E.J. Herman, A.J. Ramsey, A.S. Hammond, N.E. Byun, S.R. Stauffer, J.T. Manka, S. Jadhav, T.M. Bridges, C.D. Weaver, C.M. Niswender, T. Steckler, W.H. Drinkenburg, A. Ahnaou, H. Lavreysen, G.J. Macdonald, J.M. Bartolomé, C. Mackie, B.J. Hrupka, M.G. Caron, T.L. Daigle, C.W. Lindsley, P.J. Conn and C.K. Jones

Journal of Pharmacology and Experimental Therapeutics November 2013, 347 (2) 438-457; DOI: https://doi.org/10.1124/jpet.113.206623
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Stimulation of Sigma Receptors with Afobazole Blocks Activation of Microglia and Reduces Toxicity Caused by Amyloid-β_25–35
Adam A. Behensky, Ilya E. Yasny, Alexander M. Shuster, Sergei B. Seredenin, Andrey V. Petrov and Javier Cuevas

Journal of Pharmacology and Experimental Therapeutics November 2013, 347 (2) 458-467; DOI: https://doi.org/10.1124/jpet.113.208348
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Afobazole Activation of σ-1 Receptors Modulates Neuronal Responses to Amyloid-β_25–35
Adam A. Behensky, Ilya E. Yasny, Alexander M. Shuster, Sergei B. Seredenin, Andrey V. Petrov and Javier Cuevas

Journal of Pharmacology and Experimental Therapeutics November 2013, 347 (2) 468-477; DOI: https://doi.org/10.1124/jpet.113.208330
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In Vivo Quantification of Calcitonin Gene-Related Peptide Receptor Occupancy by Telcagepant in Rhesus Monkey and Human Brain Using the Positron Emission Tomography Tracer [¹¹C]MK-4232
Eric D. Hostetler, Aniket D. Joshi, Sandra Sanabria-Bohórquez, Hong Fan, Zhizhen Zeng, Mona Purcell, Liza Gantert, Kerry Riffel, Mangay Williams, Stacey O’Malley, Patricia Miller, Harold G. Selnick, Steven N. Gallicchio, Ian M. Bell, Christopher A. Salvatore, Stefanie A. Kane, Chi-Chung Li, Richard J. Hargreaves, Tjibbe de Groot, Guy Bormans, Anne Van Hecken, Inge Derdelinckx, Jan de Hoon, Tom Reynders, Ruben Declercq, Inge De Lepeleire, W. P. Kennedy, Rebecca Blanchard, Eugene E. Marcantonio, Cyrille Sur, Jacquelynn J. Cook, Koen Van Laere and Jeffrey L. Evelhoch

Journal of Pharmacology and Experimental Therapeutics November 2013, 347 (2) 478-486; DOI: https://doi.org/10.1124/jpet.113.206458
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Modulation of the Antidepressant-Like Effects of Sustained Administration of Carisbamate and Lamotrigine on Monoaminergic Systems: Electrophysiological Studies in the Rat Brain
Stacey Shim, Mostafa El Mansari and Pierre Blier

Journal of Pharmacology and Experimental Therapeutics November 2013, 347 (2) 487-496; DOI: https://doi.org/10.1124/jpet.113.203315
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In Vivo Activity of Norhydrocodone: An Active Metabolite of Hydrocodone
Dipesh M. Navani and Byron C. Yoburn

Journal of Pharmacology and Experimental Therapeutics November 2013, 347 (2) 497-505; DOI: https://doi.org/10.1124/jpet.113.207548
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A Functional Analysis of the Influence of β₃-adrenoceptors on the Rat Micturition Cycle
Prajni Sadananda, Marcus J. Drake, Julian F. R. Paton and Anthony E. Pickering

Journal of Pharmacology and Experimental Therapeutics November 2013, 347 (2) 506-515; DOI: https://doi.org/10.1124/jpet.113.207340
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Pharmacological Inhibition of Pleckstrin Homology Domain Leucine-Rich Repeat Protein Phosphatase Is Neuroprotective: Differential Effects on Astrocytes
Travis C. Jackson, Jonathan D. Verrier, Tomas Drabek, Keri Janesko-Feldman, Delbert G. Gillespie, Thomas Uray, Cameron Dezfulian, Robert S. Clark, Hülya Bayir, Edwin K. Jackson and Patrick M. Kochanek

Journal of Pharmacology and Experimental Therapeutics November 2013, 347 (2) 516-528; DOI: https://doi.org/10.1124/jpet.113.206888

Toxicology

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Bimodal Concentration-Response of Nicotine Involves the Nicotinic Acetylcholine Receptor, Transient Receptor Potential Vanilloid Type 1, and Transient Receptor Potential Ankyrin 1 Channels in Mouse Trachea and Sensory Neurons
Tatjana I. Kichko, Jochen Lennerz, Mirjam Eberhardt, Ramona M. Babes, Winfried Neuhuber, Gerd Kobal and Peter W. Reeh

Journal of Pharmacology and Experimental Therapeutics November 2013, 347 (2) 529-539; DOI: https://doi.org/10.1124/jpet.113.205971

Erratum

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Correction to “The Novel Anti-Cancer Agent JNJ-26854165 Induces Cell Death through Inhibition of Cholesterol Transport and Degradation of ABCA1”
Journal of Pharmacology and Experimental Therapeutics November 2013, 347 (2) 540; DOI: https://doi.org/10.1124/jpet.113.11er13

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Table of Contents

Highlighted Papers

Perspectives in Pharmacology

Behavioral Pharmacology

Cellular and Molecular

Chemotherapy, Antibiotics, and Gene Therapy

Drug Discovery and Translational Medicine

Gastrointestinal, Hepatic, Pulmonary, and Renal

Inflammation, Immunopharmacology, and Asthma

Metabolism, Transport, and Pharmacogenomics

Neuropharmacology

Toxicology

Erratum

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