Research ArticleDrug Discovery and Translational Medicine
NSC23766, a Widely Used Inhibitor of Rac1 Activation, Additionally Acts as a Competitive Antagonist at Muscarinic Acetylcholine Receptors
Magdolna Levay, Kurt Allen Krobert, Karola Wittig, Niels Voigt, Marcel Bermudez, Gerhard Wolber, Dobromir Dobrev, Finn Olav Levy and Thomas Wieland
Journal of Pharmacology and Experimental Therapeutics October 2013, 347 (1) 69-79; DOI: https://doi.org/10.1124/jpet.113.207266
Magdolna Levay
Institute of Experimental Pharmacology and Toxicology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany (M.L., K.W., T.W.); DZHK (German Center for Cardiovascular Research), Partner Site, Heidelberg-Mannheim, Mannheim, Germany (M.L., D.D., T.W.); Department of Pharmacology, Institute of Clinical Medicine, Faculty of Medicine and K.G. Jebsen Cardiac Research Center and Center for Heart Failure Research, University of Oslo, Oslo, Norway (K.A.K., F.O.V.); Institute of Pharmacology, Faculty of Medicine, University Duisburg-Essen, Essen, Germany, and Division of Experimental Cardiology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany (N.V., D.D.); and Computer-Aided Drug Design, Institute of Pharmacy, Free University of Berlin, Berlin, Germany (M.B., G.W.)
Kurt Allen Krobert
Institute of Experimental Pharmacology and Toxicology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany (M.L., K.W., T.W.); DZHK (German Center for Cardiovascular Research), Partner Site, Heidelberg-Mannheim, Mannheim, Germany (M.L., D.D., T.W.); Department of Pharmacology, Institute of Clinical Medicine, Faculty of Medicine and K.G. Jebsen Cardiac Research Center and Center for Heart Failure Research, University of Oslo, Oslo, Norway (K.A.K., F.O.V.); Institute of Pharmacology, Faculty of Medicine, University Duisburg-Essen, Essen, Germany, and Division of Experimental Cardiology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany (N.V., D.D.); and Computer-Aided Drug Design, Institute of Pharmacy, Free University of Berlin, Berlin, Germany (M.B., G.W.)
Karola Wittig
Institute of Experimental Pharmacology and Toxicology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany (M.L., K.W., T.W.); DZHK (German Center for Cardiovascular Research), Partner Site, Heidelberg-Mannheim, Mannheim, Germany (M.L., D.D., T.W.); Department of Pharmacology, Institute of Clinical Medicine, Faculty of Medicine and K.G. Jebsen Cardiac Research Center and Center for Heart Failure Research, University of Oslo, Oslo, Norway (K.A.K., F.O.V.); Institute of Pharmacology, Faculty of Medicine, University Duisburg-Essen, Essen, Germany, and Division of Experimental Cardiology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany (N.V., D.D.); and Computer-Aided Drug Design, Institute of Pharmacy, Free University of Berlin, Berlin, Germany (M.B., G.W.)
Niels Voigt
Institute of Experimental Pharmacology and Toxicology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany (M.L., K.W., T.W.); DZHK (German Center for Cardiovascular Research), Partner Site, Heidelberg-Mannheim, Mannheim, Germany (M.L., D.D., T.W.); Department of Pharmacology, Institute of Clinical Medicine, Faculty of Medicine and K.G. Jebsen Cardiac Research Center and Center for Heart Failure Research, University of Oslo, Oslo, Norway (K.A.K., F.O.V.); Institute of Pharmacology, Faculty of Medicine, University Duisburg-Essen, Essen, Germany, and Division of Experimental Cardiology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany (N.V., D.D.); and Computer-Aided Drug Design, Institute of Pharmacy, Free University of Berlin, Berlin, Germany (M.B., G.W.)
Marcel Bermudez
Institute of Experimental Pharmacology and Toxicology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany (M.L., K.W., T.W.); DZHK (German Center for Cardiovascular Research), Partner Site, Heidelberg-Mannheim, Mannheim, Germany (M.L., D.D., T.W.); Department of Pharmacology, Institute of Clinical Medicine, Faculty of Medicine and K.G. Jebsen Cardiac Research Center and Center for Heart Failure Research, University of Oslo, Oslo, Norway (K.A.K., F.O.V.); Institute of Pharmacology, Faculty of Medicine, University Duisburg-Essen, Essen, Germany, and Division of Experimental Cardiology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany (N.V., D.D.); and Computer-Aided Drug Design, Institute of Pharmacy, Free University of Berlin, Berlin, Germany (M.B., G.W.)
Gerhard Wolber
Institute of Experimental Pharmacology and Toxicology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany (M.L., K.W., T.W.); DZHK (German Center for Cardiovascular Research), Partner Site, Heidelberg-Mannheim, Mannheim, Germany (M.L., D.D., T.W.); Department of Pharmacology, Institute of Clinical Medicine, Faculty of Medicine and K.G. Jebsen Cardiac Research Center and Center for Heart Failure Research, University of Oslo, Oslo, Norway (K.A.K., F.O.V.); Institute of Pharmacology, Faculty of Medicine, University Duisburg-Essen, Essen, Germany, and Division of Experimental Cardiology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany (N.V., D.D.); and Computer-Aided Drug Design, Institute of Pharmacy, Free University of Berlin, Berlin, Germany (M.B., G.W.)
Dobromir Dobrev
Institute of Experimental Pharmacology and Toxicology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany (M.L., K.W., T.W.); DZHK (German Center for Cardiovascular Research), Partner Site, Heidelberg-Mannheim, Mannheim, Germany (M.L., D.D., T.W.); Department of Pharmacology, Institute of Clinical Medicine, Faculty of Medicine and K.G. Jebsen Cardiac Research Center and Center for Heart Failure Research, University of Oslo, Oslo, Norway (K.A.K., F.O.V.); Institute of Pharmacology, Faculty of Medicine, University Duisburg-Essen, Essen, Germany, and Division of Experimental Cardiology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany (N.V., D.D.); and Computer-Aided Drug Design, Institute of Pharmacy, Free University of Berlin, Berlin, Germany (M.B., G.W.)
Finn Olav Levy
Institute of Experimental Pharmacology and Toxicology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany (M.L., K.W., T.W.); DZHK (German Center for Cardiovascular Research), Partner Site, Heidelberg-Mannheim, Mannheim, Germany (M.L., D.D., T.W.); Department of Pharmacology, Institute of Clinical Medicine, Faculty of Medicine and K.G. Jebsen Cardiac Research Center and Center for Heart Failure Research, University of Oslo, Oslo, Norway (K.A.K., F.O.V.); Institute of Pharmacology, Faculty of Medicine, University Duisburg-Essen, Essen, Germany, and Division of Experimental Cardiology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany (N.V., D.D.); and Computer-Aided Drug Design, Institute of Pharmacy, Free University of Berlin, Berlin, Germany (M.B., G.W.)
Thomas Wieland
Institute of Experimental Pharmacology and Toxicology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany (M.L., K.W., T.W.); DZHK (German Center for Cardiovascular Research), Partner Site, Heidelberg-Mannheim, Mannheim, Germany (M.L., D.D., T.W.); Department of Pharmacology, Institute of Clinical Medicine, Faculty of Medicine and K.G. Jebsen Cardiac Research Center and Center for Heart Failure Research, University of Oslo, Oslo, Norway (K.A.K., F.O.V.); Institute of Pharmacology, Faculty of Medicine, University Duisburg-Essen, Essen, Germany, and Division of Experimental Cardiology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany (N.V., D.D.); and Computer-Aided Drug Design, Institute of Pharmacy, Free University of Berlin, Berlin, Germany (M.B., G.W.)
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In this issue
Research ArticleDrug Discovery and Translational Medicine
Competitive Antagonism of NSC23766 at mAChRs
Magdolna Levay, Kurt Allen Krobert, Karola Wittig, Niels Voigt, Marcel Bermudez, Gerhard Wolber, Dobromir Dobrev, Finn Olav Levy and Thomas Wieland
Journal of Pharmacology and Experimental Therapeutics October 1, 2013, 347 (1) 69-79; DOI: https://doi.org/10.1124/jpet.113.207266
Research ArticleDrug Discovery and Translational Medicine
Competitive Antagonism of NSC23766 at mAChRs
Magdolna Levay, Kurt Allen Krobert, Karola Wittig, Niels Voigt, Marcel Bermudez, Gerhard Wolber, Dobromir Dobrev, Finn Olav Levy and Thomas Wieland
Journal of Pharmacology and Experimental Therapeutics October 1, 2013, 347 (1) 69-79; DOI: https://doi.org/10.1124/jpet.113.207266
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