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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

October 01, 2013; Volume 347,Issue 1

Highlighted Papers

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    NSC23766, an Inhibitor of Rac1, Also Acts as a Muscarinic Antagonist
    Journal of Pharmacology and Experimental Therapeutics October 2013, 347 (1) 1; DOI: https://doi.org/10.1124/jpet.113.1013HI
  • You have access
    Enhancement of Ca2+ Influx and Ciliary Beating due to K+ Channel Opening
    Journal of Pharmacology and Experimental Therapeutics October 2013, 347 (1) 1; DOI: https://doi.org/10.1124/jpet.113.1013HIa
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    GITRL Triggering Increases VCAM-1 and ICAM-1 and Promotes Leukocyte Adhesion
    Journal of Pharmacology and Experimental Therapeutics October 2013, 347 (1) 1; DOI: https://doi.org/10.1124/jpet.113.1013HIb
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    Hepatocyte Nuclear Factor 1 Regulates the Expression of OCT1
    Journal of Pharmacology and Experimental Therapeutics October 2013, 347 (1) 1; DOI: https://doi.org/10.1124/jpet.113.1013HIc

Perspectives in Pharmacology

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    Translation of Central Nervous System Occupancy from Animal Models: Application of Pharmacokinetic/Pharmacodynamic Modeling
    Murad Melhem
    Journal of Pharmacology and Experimental Therapeutics October 2013, 347 (1) 2-6; DOI: https://doi.org/10.1124/jpet.112.199794

Behavioral Pharmacology

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    Building a Better Analgesic: Multifunctional Compounds that Address Injury-Induced Pathology to Enhance Analgesic Efficacy while Eliminating Unwanted Side Effects
    T. M. Largent-Milnes, S. W. Brookshire, D. P. Skinner, K. E. Hanlon, D. Giuvelis, T. Yamamoto, P. Davis, C. R. Campos, P. Nair, S. Deekonda, E. J. Bilsky, F. Porreca, V. J. Hruby and T. W. Vanderah
    Journal of Pharmacology and Experimental Therapeutics October 2013, 347 (1) 7-19; DOI: https://doi.org/10.1124/jpet.113.205245
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    Stimulants as Specific Inducers of Dopamine-Independent σ Agonist Self-Administration in Rats
    Takato Hiranita, Paul L. Soto, Gianluigi Tanda, Theresa A. Kopajtic and Jonathan L. Katz
    Journal of Pharmacology and Experimental Therapeutics October 2013, 347 (1) 20-29; DOI: https://doi.org/10.1124/jpet.113.207522

Cardiovascular

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    Preservation of Endothelium-Dependent Relaxation in Atherosclerotic Mice with Endothelium-Restricted Endothelin-1 Overexpression
    Muhammad Oneeb Rehman Mian, Noureddine Idris-Khodja, Melissa W. Li, Avshalom Leibowitz, Pierre Paradis, Yohann Rautureau and Ernesto L. Schiffrin
    Journal of Pharmacology and Experimental Therapeutics October 2013, 347 (1) 30-37; DOI: https://doi.org/10.1124/jpet.113.206532

Cellular and Molecular

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    Is GPR17 a P2Y/Leukotriene Receptor? Examination of Uracil Nucleotides, Nucleotide Sugars, and Cysteinyl Leukotrienes as Agonists of GPR17
    Ai-Dong Qi, T. Kendall Harden and Robert A. Nicholas
    Journal of Pharmacology and Experimental Therapeutics October 2013, 347 (1) 38-46; DOI: https://doi.org/10.1124/jpet.113.207647
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    Intracellular Transactivation of Epidermal Growth Factor Receptor by α1A-Adrenoceptor Is Mediated by Phosphatidylinositol 3-Kinase Independently of Activation of Extracellular Signal Regulated Kinases 1/2 and Serine-Threonine Kinases in Chinese Hamster Ovary Cells
    Nadir Ulu, Robert H. Henning, Sahika Guner, Teuta Zoto, Basak Duman-Dalkilic, Marry Duin and Hakan Gurdal
    Journal of Pharmacology and Experimental Therapeutics October 2013, 347 (1) 47-56; DOI: https://doi.org/10.1124/jpet.113.206243

Drug Discovery and Translational Medicine

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    Pharmacological Profile of 2-Bromoterguride at Human Dopamine D2, Porcine Serotonin 5-Hydroxytryptamine 2A, and α2C-Adrenergic Receptors, and Its Antipsychotic-Like Effects in Rats
    F. Jantschak, J. Brosda, R. T. Franke, H. Fink, D. Möller, H. Hübner, P. Gmeiner and H. H. Pertz
    Journal of Pharmacology and Experimental Therapeutics October 2013, 347 (1) 57-68; DOI: https://doi.org/10.1124/jpet.113.205997
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    NSC23766, a Widely Used Inhibitor of Rac1 Activation, Additionally Acts as a Competitive Antagonist at Muscarinic Acetylcholine Receptors
    Magdolna Levay, Kurt Allen Krobert, Karola Wittig, Niels Voigt, Marcel Bermudez, Gerhard Wolber, Dobromir Dobrev, Finn Olav Levy and Thomas Wieland
    Journal of Pharmacology and Experimental Therapeutics October 2013, 347 (1) 69-79; DOI: https://doi.org/10.1124/jpet.113.207266

Gastrointestinal, Hepatic, Pulmonary, and Renal

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    Rolipram Attenuates Bile Duct Ligation–Induced Liver Injury in Rats: A Potential Pathogenic Role of PDE4
    Leila Gobejishvili, Shirish Barve, Katja Breitkopf-Heinlein, Yan Li, JingWen Zhang, Diana V. Avila, Steven Dooley and Craig J. McClain
    Journal of Pharmacology and Experimental Therapeutics October 2013, 347 (1) 80-90; DOI: https://doi.org/10.1124/jpet.113.204933
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    Mechanisms That Underlie μ-Opioid Receptor Agonist–Induced Constipation: Differential Involvement of μ-Opioid Receptor Sites and Responsible Regions
    Tomohisa Mori, Yumiko Shibasaki, Kenjiro Matsumoto, Masahiro Shibasaki, Minami Hasegawa, Erika Wang, Daiki Masukawa, Kazumi Yoshizawa, Syunji Horie and Tsutomu Suzuki
    Journal of Pharmacology and Experimental Therapeutics October 2013, 347 (1) 91-99; DOI: https://doi.org/10.1124/jpet.113.204313
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    Comparative Pharmacology of Bombesin Receptor Subtype-3, Nonpeptide Agonist MK-5046, a Universal Peptide Agonist, and Peptide Antagonist Bantag-1 for Human Bombesin Receptors
    Paola Moreno, Samuel A. Mantey, Bernardo Nuche-Berenguer, Marc L. Reitman, Nieves González, David H. Coy and Robert T. Jensen
    Journal of Pharmacology and Experimental Therapeutics October 2013, 347 (1) 100-116; DOI: https://doi.org/10.1124/jpet.113.206896
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    Sepiapterin Ameliorates Chemically Induced Murine Colitis and Azoxymethane-Induced Colon Cancer
    Robert J. G. Cardnell, Christopher S. Rabender, Gracious R. Ross, Chunqing Guo, Eric L. Howlett, Asim Alam, Xiang-Yang Wang, Hamid I. Akbarali and Ross B. Mikkelsen
    Journal of Pharmacology and Experimental Therapeutics October 2013, 347 (1) 117-125; DOI: https://doi.org/10.1124/jpet.113.203828
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    Olanzapine Activates Hepatic Mammalian Target of Rapamycin: New Mechanistic Insight into Metabolic Dysregulation with Atypical Antipsychotic Drugs
    Robin H. Schmidt, Jenny D. Jokinen, Veronica L. Massey, K. Cameron Falkner, Xue Shi, Xinmin Yin, Xiang Zhang, Juliane I. Beier and Gavin E. Arteel
    Journal of Pharmacology and Experimental Therapeutics October 2013, 347 (1) 126-135; DOI: https://doi.org/10.1124/jpet.113.207621
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    Differential Regulation of Hepatic Organic Cation Transporter 1, Organic Anion-Transporting Polypeptide 1a4, Bile-Salt Export Pump, and Multidrug Resistance-Associated Protein 2 Transporter Expression in Lymphocyte-Deficient Mice Associates with Interleukin-6 Production
    Connor E. Bodeman, Anika L. Dzierlenga, Catherine M. Tally, Ryan M. Mulligan, April D. Lake, Nathan J. Cherrington and Susan C. McKarns
    Journal of Pharmacology and Experimental Therapeutics October 2013, 347 (1) 136-144; DOI: https://doi.org/10.1124/jpet.113.205369
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    Enhancement of Ca2+ Influx and Ciliary Beating by Membrane Hyperpolarization due to ATP-Sensitive K+ Channel Opening in Mouse Airway Epithelial Cells
    Teruya Ohba, Eiji Sawada, Yoshiaki Suzuki, Hisao Yamamura, Susumu Ohya, Hiroyuki Tsuda and Yuji Imaizumi
    Journal of Pharmacology and Experimental Therapeutics October 2013, 347 (1) 145-153; DOI: https://doi.org/10.1124/jpet.113.205138

Inflammation, Immunopharmacology, and Asthma

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    Low-Dose Methotrexate Results in the Selective Accumulation of Aminoimidazole Carboxamide Ribotide in an Erythroblastoid Cell Line
    Ryan S. Funk, Leon van Haandel, Mara L. Becker and J. Steven Leeder
    Journal of Pharmacology and Experimental Therapeutics October 2013, 347 (1) 154-163; DOI: https://doi.org/10.1124/jpet.113.206672
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    Glucocorticoid-Induced Tumor Necrosis Factor Receptor Family-Related Ligand Triggering Upregulates Vascular Cell Adhesion Molecule-1 and Intercellular Adhesion Molecule-1 and Promotes Leukocyte Adhesion
    Pedro Miguel Lacal, Maria Grazia Petrillo, Federica Ruffini, Alessia Muzi, Rodolfo Bianchini, Simona Ronchetti, Graziella Migliorati, Carlo Riccardi, Grazia Graziani and Giuseppe Nocentini
    Journal of Pharmacology and Experimental Therapeutics October 2013, 347 (1) 164-172; DOI: https://doi.org/10.1124/jpet.113.207605
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    Neutrophil Chemotaxis Caused by Chronic Obstructive Pulmonary Disease Alveolar Macrophages: The Role of CXCL8 and the Receptors CXCR1/CXCR2
    Manminder Kaur and Dave Singh
    Journal of Pharmacology and Experimental Therapeutics October 2013, 347 (1) 173-180; DOI: https://doi.org/10.1124/jpet.112.201855

Metabolism, Transport, and Pharmacogenomics

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    Hepatocyte Nuclear Factor 1 Regulates the Expression of the Organic Cation Transporter 1 via Binding to an Evolutionary Conserved Region in Intron 1 of the OCT1 Gene
    Valerie P. O’Brien, Kristin Bokelmann, Jacqueline Ramírez, Karoline Jobst, Mark J. Ratain, Jürgen Brockmöller and Mladen V. Tzvetkov
    Journal of Pharmacology and Experimental Therapeutics October 2013, 347 (1) 181-192; DOI: https://doi.org/10.1124/jpet.113.206359
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    Evaluation of Oatp and Mrp2 Activities in Hepatobiliary Excretion Using Newly Developed Positron Emission Tomography Tracer [11C]Dehydropravastatin in Rats
    Tomotaka Shingaki, Tadayuki Takashima, Ryosuke Ijuin, Xuan Zhang, Tomohiro Onoue, Yumiko Katayama, Takashi Okauchi, Emi Hayashinaka, Yilong Cui, Yasuhiro Wada, Masaaki Suzuki, Kazuya Maeda, Hiroyuki Kusuhara, Yuichi Sugiyama and Yasuyoshi Watanabe
    Journal of Pharmacology and Experimental Therapeutics October 2013, 347 (1) 193-202; DOI: https://doi.org/10.1124/jpet.113.206425

Neuropharmacology

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    Effects of Prophylactic and Therapeutic Teriflunomide in Transcranial Magnetic Stimulation–Induced Motor-Evoked Potentials in the Dark Agouti Rat Model of Experimental Autoimmune Encephalomyelitis
    Deborah Iglesias-Bregna, Susan Hanak, Zhongqi Ji, Margaret Petty, Li Liu, Donghui Zhang and Kathleen McMonagle-Strucko
    Journal of Pharmacology and Experimental Therapeutics October 2013, 347 (1) 203-211; DOI: https://doi.org/10.1124/jpet.113.205146
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    Positive Allosteric Modulation of AMPA Receptors from Efficacy to Toxicity: The Interspecies Exposure-Response Continuum of the Novel Potentiator PF-4778574
    Christopher L. Shaffer, Raymond S. Hurst, Renato J. Scialis, Sarah M. Osgood, Dianne K. Bryce, William E. Hoffmann, John T. Lazzaro, Ashley N. Hanks, Susan Lotarski, Mark L. Weber, JianHua Liu, Frank S. Menniti, Christopher J. Schmidt and Mihály Hajós
    Journal of Pharmacology and Experimental Therapeutics October 2013, 347 (1) 212-224; DOI: https://doi.org/10.1124/jpet.113.204735
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    Nicotinic Receptor Agonists Reduce l-DOPA–Induced Dyskinesias in a Monkey Model of Parkinson's Disease
    Danhui Zhang, Archana Mallela, David Sohn, F. Ivy Carroll, Merouane Bencherif, Sharon Letchworth and Maryka Quik
    Journal of Pharmacology and Experimental Therapeutics October 2013, 347 (1) 225-234; DOI: https://doi.org/10.1124/jpet.113.207639
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    SB-205384 Is a Positive Allosteric Modulator of Recombinant GABAA Receptors Containing Rat α3, α5, or α6 Subunit Subtypes Coexpressed with β3 and γ2 Subunits
    Laura S. Heidelberg, James W. Warren and Janet L. Fisher
    Journal of Pharmacology and Experimental Therapeutics October 2013, 347 (1) 235-241; DOI: https://doi.org/10.1124/jpet.113.207324

Toxicology

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    Involvement of Wee1 in the Circadian Rhythm–Dependent Intestinal Damage Induced by Docetaxel
    Yuri Obi-Ioka, Kentaro Ushijima, Mikio Kusama, Eiko Ishikawa-Kobayashi and Akio Fujimura
    Journal of Pharmacology and Experimental Therapeutics October 2013, 347 (1) 242-248; DOI: https://doi.org/10.1124/jpet.113.203299

Erratum

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    Correction to “A New Pyrroline Compound Selective for I1-Imidazoline Receptors Improves Metabolic Syndrome in Rats”
    Journal of Pharmacology and Experimental Therapeutics October 2013, 347 (1) 249; DOI: https://doi.org/10.1124/jpet.113.10er13
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Journal of Pharmacology and Experimental Therapeutics: 347 (1)
Journal of Pharmacology and Experimental Therapeutics
Vol. 347, Issue 1
1 Oct 2013
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  • Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.
  • Functional Selectivity and Classical Concepts of Quantitative Pharmacology
  • Abl Protein-Tyrosine Kinase Inhibitor STI571 Inhibits In Vitro Signal Transduction Mediated by c-Kit and Platelet-Derived Growth Factor Receptors
  • The Prediction of Human Pharmacokinetic Parameters from Preclinical and In Vitro Metabolism Data
  • A METHOD FOR DETERMINING LOSS OF PAIN SENSATION
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