Journal of Pharmacology and Experimental Therapeutics: 347 (1)

October 01, 2013; Volume 347,Issue 1

Highlighted Papers

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NSC23766, an Inhibitor of Rac1, Also Acts as a Muscarinic Antagonist
Journal of Pharmacology and Experimental Therapeutics October 2013, 347 (1) 1; DOI: https://doi.org/10.1124/jpet.113.1013HI
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Enhancement of Ca²⁺ Influx and Ciliary Beating due to K⁺ Channel Opening
Journal of Pharmacology and Experimental Therapeutics October 2013, 347 (1) 1; DOI: https://doi.org/10.1124/jpet.113.1013HIa
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GITRL Triggering Increases VCAM-1 and ICAM-1 and Promotes Leukocyte Adhesion
Journal of Pharmacology and Experimental Therapeutics October 2013, 347 (1) 1; DOI: https://doi.org/10.1124/jpet.113.1013HIb
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Hepatocyte Nuclear Factor 1 Regulates the Expression of OCT1
Journal of Pharmacology and Experimental Therapeutics October 2013, 347 (1) 1; DOI: https://doi.org/10.1124/jpet.113.1013HIc

Perspectives in Pharmacology

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Translation of Central Nervous System Occupancy from Animal Models: Application of Pharmacokinetic/Pharmacodynamic Modeling
Murad Melhem

Journal of Pharmacology and Experimental Therapeutics October 2013, 347 (1) 2-6; DOI: https://doi.org/10.1124/jpet.112.199794

Behavioral Pharmacology

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Building a Better Analgesic: Multifunctional Compounds that Address Injury-Induced Pathology to Enhance Analgesic Efficacy while Eliminating Unwanted Side Effects
T. M. Largent-Milnes, S. W. Brookshire, D. P. Skinner, K. E. Hanlon, D. Giuvelis, T. Yamamoto, P. Davis, C. R. Campos, P. Nair, S. Deekonda, E. J. Bilsky, F. Porreca, V. J. Hruby and T. W. Vanderah

Journal of Pharmacology and Experimental Therapeutics October 2013, 347 (1) 7-19; DOI: https://doi.org/10.1124/jpet.113.205245
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Stimulants as Specific Inducers of Dopamine-Independent σ Agonist Self-Administration in Rats
Takato Hiranita, Paul L. Soto, Gianluigi Tanda, Theresa A. Kopajtic and Jonathan L. Katz

Journal of Pharmacology and Experimental Therapeutics October 2013, 347 (1) 20-29; DOI: https://doi.org/10.1124/jpet.113.207522

Cardiovascular

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Preservation of Endothelium-Dependent Relaxation in Atherosclerotic Mice with Endothelium-Restricted Endothelin-1 Overexpression
Muhammad Oneeb Rehman Mian, Noureddine Idris-Khodja, Melissa W. Li, Avshalom Leibowitz, Pierre Paradis, Yohann Rautureau and Ernesto L. Schiffrin

Journal of Pharmacology and Experimental Therapeutics October 2013, 347 (1) 30-37; DOI: https://doi.org/10.1124/jpet.113.206532

Cellular and Molecular

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Is GPR17 a P2Y/Leukotriene Receptor? Examination of Uracil Nucleotides, Nucleotide Sugars, and Cysteinyl Leukotrienes as Agonists of GPR17
Ai-Dong Qi, T. Kendall Harden and Robert A. Nicholas

Journal of Pharmacology and Experimental Therapeutics October 2013, 347 (1) 38-46; DOI: https://doi.org/10.1124/jpet.113.207647
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Intracellular Transactivation of Epidermal Growth Factor Receptor by α_1A-Adrenoceptor Is Mediated by Phosphatidylinositol 3-Kinase Independently of Activation of Extracellular Signal Regulated Kinases 1/2 and Serine-Threonine Kinases in Chinese Hamster Ovary Cells
Nadir Ulu, Robert H. Henning, Sahika Guner, Teuta Zoto, Basak Duman-Dalkilic, Marry Duin and Hakan Gurdal

Journal of Pharmacology and Experimental Therapeutics October 2013, 347 (1) 47-56; DOI: https://doi.org/10.1124/jpet.113.206243

Drug Discovery and Translational Medicine

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Pharmacological Profile of 2-Bromoterguride at Human Dopamine D₂, Porcine Serotonin 5-Hydroxytryptamine 2A, and α_2C-Adrenergic Receptors, and Its Antipsychotic-Like Effects in Rats
F. Jantschak, J. Brosda, R. T. Franke, H. Fink, D. Möller, H. Hübner, P. Gmeiner and H. H. Pertz

Journal of Pharmacology and Experimental Therapeutics October 2013, 347 (1) 57-68; DOI: https://doi.org/10.1124/jpet.113.205997
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NSC23766, a Widely Used Inhibitor of Rac1 Activation, Additionally Acts as a Competitive Antagonist at Muscarinic Acetylcholine Receptors
Magdolna Levay, Kurt Allen Krobert, Karola Wittig, Niels Voigt, Marcel Bermudez, Gerhard Wolber, Dobromir Dobrev, Finn Olav Levy and Thomas Wieland

Journal of Pharmacology and Experimental Therapeutics October 2013, 347 (1) 69-79; DOI: https://doi.org/10.1124/jpet.113.207266

Gastrointestinal, Hepatic, Pulmonary, and Renal

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Rolipram Attenuates Bile Duct Ligation–Induced Liver Injury in Rats: A Potential Pathogenic Role of PDE4
Leila Gobejishvili, Shirish Barve, Katja Breitkopf-Heinlein, Yan Li, JingWen Zhang, Diana V. Avila, Steven Dooley and Craig J. McClain

Journal of Pharmacology and Experimental Therapeutics October 2013, 347 (1) 80-90; DOI: https://doi.org/10.1124/jpet.113.204933
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Mechanisms That Underlie μ-Opioid Receptor Agonist–Induced Constipation: Differential Involvement of μ-Opioid Receptor Sites and Responsible Regions
Tomohisa Mori, Yumiko Shibasaki, Kenjiro Matsumoto, Masahiro Shibasaki, Minami Hasegawa, Erika Wang, Daiki Masukawa, Kazumi Yoshizawa, Syunji Horie and Tsutomu Suzuki

Journal of Pharmacology and Experimental Therapeutics October 2013, 347 (1) 91-99; DOI: https://doi.org/10.1124/jpet.113.204313
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Comparative Pharmacology of Bombesin Receptor Subtype-3, Nonpeptide Agonist MK-5046, a Universal Peptide Agonist, and Peptide Antagonist Bantag-1 for Human Bombesin Receptors
Paola Moreno, Samuel A. Mantey, Bernardo Nuche-Berenguer, Marc L. Reitman, Nieves González, David H. Coy and Robert T. Jensen

Journal of Pharmacology and Experimental Therapeutics October 2013, 347 (1) 100-116; DOI: https://doi.org/10.1124/jpet.113.206896
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Sepiapterin Ameliorates Chemically Induced Murine Colitis and Azoxymethane-Induced Colon Cancer
Robert J. G. Cardnell, Christopher S. Rabender, Gracious R. Ross, Chunqing Guo, Eric L. Howlett, Asim Alam, Xiang-Yang Wang, Hamid I. Akbarali and Ross B. Mikkelsen

Journal of Pharmacology and Experimental Therapeutics October 2013, 347 (1) 117-125; DOI: https://doi.org/10.1124/jpet.113.203828
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Olanzapine Activates Hepatic Mammalian Target of Rapamycin: New Mechanistic Insight into Metabolic Dysregulation with Atypical Antipsychotic Drugs
Robin H. Schmidt, Jenny D. Jokinen, Veronica L. Massey, K. Cameron Falkner, Xue Shi, Xinmin Yin, Xiang Zhang, Juliane I. Beier and Gavin E. Arteel

Journal of Pharmacology and Experimental Therapeutics October 2013, 347 (1) 126-135; DOI: https://doi.org/10.1124/jpet.113.207621
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Differential Regulation of Hepatic Organic Cation Transporter 1, Organic Anion-Transporting Polypeptide 1a4, Bile-Salt Export Pump, and Multidrug Resistance-Associated Protein 2 Transporter Expression in Lymphocyte-Deficient Mice Associates with Interleukin-6 Production
Connor E. Bodeman, Anika L. Dzierlenga, Catherine M. Tally, Ryan M. Mulligan, April D. Lake, Nathan J. Cherrington and Susan C. McKarns

Journal of Pharmacology and Experimental Therapeutics October 2013, 347 (1) 136-144; DOI: https://doi.org/10.1124/jpet.113.205369
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Enhancement of Ca²⁺ Influx and Ciliary Beating by Membrane Hyperpolarization due to ATP-Sensitive K⁺ Channel Opening in Mouse Airway Epithelial Cells
Teruya Ohba, Eiji Sawada, Yoshiaki Suzuki, Hisao Yamamura, Susumu Ohya, Hiroyuki Tsuda and Yuji Imaizumi

Journal of Pharmacology and Experimental Therapeutics October 2013, 347 (1) 145-153; DOI: https://doi.org/10.1124/jpet.113.205138

Inflammation, Immunopharmacology, and Asthma

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Low-Dose Methotrexate Results in the Selective Accumulation of Aminoimidazole Carboxamide Ribotide in an Erythroblastoid Cell Line
Ryan S. Funk, Leon van Haandel, Mara L. Becker and J. Steven Leeder

Journal of Pharmacology and Experimental Therapeutics October 2013, 347 (1) 154-163; DOI: https://doi.org/10.1124/jpet.113.206672
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Glucocorticoid-Induced Tumor Necrosis Factor Receptor Family-Related Ligand Triggering Upregulates Vascular Cell Adhesion Molecule-1 and Intercellular Adhesion Molecule-1 and Promotes Leukocyte Adhesion
Pedro Miguel Lacal, Maria Grazia Petrillo, Federica Ruffini, Alessia Muzi, Rodolfo Bianchini, Simona Ronchetti, Graziella Migliorati, Carlo Riccardi, Grazia Graziani and Giuseppe Nocentini

Journal of Pharmacology and Experimental Therapeutics October 2013, 347 (1) 164-172; DOI: https://doi.org/10.1124/jpet.113.207605
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Neutrophil Chemotaxis Caused by Chronic Obstructive Pulmonary Disease Alveolar Macrophages: The Role of CXCL8 and the Receptors CXCR1/CXCR2
Manminder Kaur and Dave Singh

Journal of Pharmacology and Experimental Therapeutics October 2013, 347 (1) 173-180; DOI: https://doi.org/10.1124/jpet.112.201855

Metabolism, Transport, and Pharmacogenomics

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Hepatocyte Nuclear Factor 1 Regulates the Expression of the Organic Cation Transporter 1 via Binding to an Evolutionary Conserved Region in Intron 1 of the OCT1 Gene
Valerie P. O’Brien, Kristin Bokelmann, Jacqueline Ramírez, Karoline Jobst, Mark J. Ratain, Jürgen Brockmöller and Mladen V. Tzvetkov

Journal of Pharmacology and Experimental Therapeutics October 2013, 347 (1) 181-192; DOI: https://doi.org/10.1124/jpet.113.206359
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Evaluation of Oatp and Mrp2 Activities in Hepatobiliary Excretion Using Newly Developed Positron Emission Tomography Tracer [¹¹C]Dehydropravastatin in Rats
Tomotaka Shingaki, Tadayuki Takashima, Ryosuke Ijuin, Xuan Zhang, Tomohiro Onoue, Yumiko Katayama, Takashi Okauchi, Emi Hayashinaka, Yilong Cui, Yasuhiro Wada, Masaaki Suzuki, Kazuya Maeda, Hiroyuki Kusuhara, Yuichi Sugiyama and Yasuyoshi Watanabe

Journal of Pharmacology and Experimental Therapeutics October 2013, 347 (1) 193-202; DOI: https://doi.org/10.1124/jpet.113.206425

Neuropharmacology

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Effects of Prophylactic and Therapeutic Teriflunomide in Transcranial Magnetic Stimulation–Induced Motor-Evoked Potentials in the Dark Agouti Rat Model of Experimental Autoimmune Encephalomyelitis
Deborah Iglesias-Bregna, Susan Hanak, Zhongqi Ji, Margaret Petty, Li Liu, Donghui Zhang and Kathleen McMonagle-Strucko

Journal of Pharmacology and Experimental Therapeutics October 2013, 347 (1) 203-211; DOI: https://doi.org/10.1124/jpet.113.205146
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Positive Allosteric Modulation of AMPA Receptors from Efficacy to Toxicity: The Interspecies Exposure-Response Continuum of the Novel Potentiator PF-4778574
Christopher L. Shaffer, Raymond S. Hurst, Renato J. Scialis, Sarah M. Osgood, Dianne K. Bryce, William E. Hoffmann, John T. Lazzaro, Ashley N. Hanks, Susan Lotarski, Mark L. Weber, JianHua Liu, Frank S. Menniti, Christopher J. Schmidt and Mihály Hajós

Journal of Pharmacology and Experimental Therapeutics October 2013, 347 (1) 212-224; DOI: https://doi.org/10.1124/jpet.113.204735
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Nicotinic Receptor Agonists Reduce l-DOPA–Induced Dyskinesias in a Monkey Model of Parkinson's Disease
Danhui Zhang, Archana Mallela, David Sohn, F. Ivy Carroll, Merouane Bencherif, Sharon Letchworth and Maryka Quik

Journal of Pharmacology and Experimental Therapeutics October 2013, 347 (1) 225-234; DOI: https://doi.org/10.1124/jpet.113.207639
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SB-205384 Is a Positive Allosteric Modulator of Recombinant GABA_A Receptors Containing Rat α3, α5, or α6 Subunit Subtypes Coexpressed with β3 and γ2 Subunits
Laura S. Heidelberg, James W. Warren and Janet L. Fisher

Journal of Pharmacology and Experimental Therapeutics October 2013, 347 (1) 235-241; DOI: https://doi.org/10.1124/jpet.113.207324

Toxicology

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Involvement of Wee1 in the Circadian Rhythm–Dependent Intestinal Damage Induced by Docetaxel
Yuri Obi-Ioka, Kentaro Ushijima, Mikio Kusama, Eiko Ishikawa-Kobayashi and Akio Fujimura

Journal of Pharmacology and Experimental Therapeutics October 2013, 347 (1) 242-248; DOI: https://doi.org/10.1124/jpet.113.203299

Erratum

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Correction to “A New Pyrroline Compound Selective for I₁-Imidazoline Receptors Improves Metabolic Syndrome in Rats”
Journal of Pharmacology and Experimental Therapeutics October 2013, 347 (1) 249; DOI: https://doi.org/10.1124/jpet.113.10er13

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Table of Contents

Highlighted Papers

Perspectives in Pharmacology

Behavioral Pharmacology

Cardiovascular

Cellular and Molecular

Drug Discovery and Translational Medicine

Gastrointestinal, Hepatic, Pulmonary, and Renal

Inflammation, Immunopharmacology, and Asthma

Metabolism, Transport, and Pharmacogenomics

Neuropharmacology

Toxicology

Erratum

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