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Research ArticleNeuropharmacology

Monoamine Transporter Occupancy of a Novel Triple Reuptake Inhibitor in Baboons and Humans Using Positron Emission Tomography

Robert A. Comley, Cristian A. Salinas, Mark Slifstein, Marcella Petrone, Carmine Marzano, Idriss Bennacef, Paul Shotbolt, Jasper Van der Aart, Marta Neve, Laura Iavarone, Roberto Gomeni, Marc Laruelle, Frank A. Gray, Roger N. Gunn and Eugenii A. Rabiner
Journal of Pharmacology and Experimental Therapeutics August 2013, 346 (2) 311-317; DOI: https://doi.org/10.1124/jpet.112.202895
Robert A. Comley
Clinical Imaging Centre (R.A.C., C.A.S., C.M., I.B., P.S., J.V., M.L., R.N.G., E.A.R.) and Clinical Pharmacology and Discovery Medicine (F.G.) GlaxoSmithKline, London, United Kingdom; Columbia University, New York, New York (M.S.); and Clinical Pharmacology Modelling and Simulation, GlaxoSmithKline, Verona, Italy (M.P, M.N., L.I., R.G.)
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Cristian A. Salinas
Clinical Imaging Centre (R.A.C., C.A.S., C.M., I.B., P.S., J.V., M.L., R.N.G., E.A.R.) and Clinical Pharmacology and Discovery Medicine (F.G.) GlaxoSmithKline, London, United Kingdom; Columbia University, New York, New York (M.S.); and Clinical Pharmacology Modelling and Simulation, GlaxoSmithKline, Verona, Italy (M.P, M.N., L.I., R.G.)
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Mark Slifstein
Clinical Imaging Centre (R.A.C., C.A.S., C.M., I.B., P.S., J.V., M.L., R.N.G., E.A.R.) and Clinical Pharmacology and Discovery Medicine (F.G.) GlaxoSmithKline, London, United Kingdom; Columbia University, New York, New York (M.S.); and Clinical Pharmacology Modelling and Simulation, GlaxoSmithKline, Verona, Italy (M.P, M.N., L.I., R.G.)
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Marcella Petrone
Clinical Imaging Centre (R.A.C., C.A.S., C.M., I.B., P.S., J.V., M.L., R.N.G., E.A.R.) and Clinical Pharmacology and Discovery Medicine (F.G.) GlaxoSmithKline, London, United Kingdom; Columbia University, New York, New York (M.S.); and Clinical Pharmacology Modelling and Simulation, GlaxoSmithKline, Verona, Italy (M.P, M.N., L.I., R.G.)
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Carmine Marzano
Clinical Imaging Centre (R.A.C., C.A.S., C.M., I.B., P.S., J.V., M.L., R.N.G., E.A.R.) and Clinical Pharmacology and Discovery Medicine (F.G.) GlaxoSmithKline, London, United Kingdom; Columbia University, New York, New York (M.S.); and Clinical Pharmacology Modelling and Simulation, GlaxoSmithKline, Verona, Italy (M.P, M.N., L.I., R.G.)
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Idriss Bennacef
Clinical Imaging Centre (R.A.C., C.A.S., C.M., I.B., P.S., J.V., M.L., R.N.G., E.A.R.) and Clinical Pharmacology and Discovery Medicine (F.G.) GlaxoSmithKline, London, United Kingdom; Columbia University, New York, New York (M.S.); and Clinical Pharmacology Modelling and Simulation, GlaxoSmithKline, Verona, Italy (M.P, M.N., L.I., R.G.)
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Paul Shotbolt
Clinical Imaging Centre (R.A.C., C.A.S., C.M., I.B., P.S., J.V., M.L., R.N.G., E.A.R.) and Clinical Pharmacology and Discovery Medicine (F.G.) GlaxoSmithKline, London, United Kingdom; Columbia University, New York, New York (M.S.); and Clinical Pharmacology Modelling and Simulation, GlaxoSmithKline, Verona, Italy (M.P, M.N., L.I., R.G.)
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Jasper Van der Aart
Clinical Imaging Centre (R.A.C., C.A.S., C.M., I.B., P.S., J.V., M.L., R.N.G., E.A.R.) and Clinical Pharmacology and Discovery Medicine (F.G.) GlaxoSmithKline, London, United Kingdom; Columbia University, New York, New York (M.S.); and Clinical Pharmacology Modelling and Simulation, GlaxoSmithKline, Verona, Italy (M.P, M.N., L.I., R.G.)
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Marta Neve
Clinical Imaging Centre (R.A.C., C.A.S., C.M., I.B., P.S., J.V., M.L., R.N.G., E.A.R.) and Clinical Pharmacology and Discovery Medicine (F.G.) GlaxoSmithKline, London, United Kingdom; Columbia University, New York, New York (M.S.); and Clinical Pharmacology Modelling and Simulation, GlaxoSmithKline, Verona, Italy (M.P, M.N., L.I., R.G.)
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Laura Iavarone
Clinical Imaging Centre (R.A.C., C.A.S., C.M., I.B., P.S., J.V., M.L., R.N.G., E.A.R.) and Clinical Pharmacology and Discovery Medicine (F.G.) GlaxoSmithKline, London, United Kingdom; Columbia University, New York, New York (M.S.); and Clinical Pharmacology Modelling and Simulation, GlaxoSmithKline, Verona, Italy (M.P, M.N., L.I., R.G.)
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Roberto Gomeni
Clinical Imaging Centre (R.A.C., C.A.S., C.M., I.B., P.S., J.V., M.L., R.N.G., E.A.R.) and Clinical Pharmacology and Discovery Medicine (F.G.) GlaxoSmithKline, London, United Kingdom; Columbia University, New York, New York (M.S.); and Clinical Pharmacology Modelling and Simulation, GlaxoSmithKline, Verona, Italy (M.P, M.N., L.I., R.G.)
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Marc Laruelle
Clinical Imaging Centre (R.A.C., C.A.S., C.M., I.B., P.S., J.V., M.L., R.N.G., E.A.R.) and Clinical Pharmacology and Discovery Medicine (F.G.) GlaxoSmithKline, London, United Kingdom; Columbia University, New York, New York (M.S.); and Clinical Pharmacology Modelling and Simulation, GlaxoSmithKline, Verona, Italy (M.P, M.N., L.I., R.G.)
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Frank A. Gray
Clinical Imaging Centre (R.A.C., C.A.S., C.M., I.B., P.S., J.V., M.L., R.N.G., E.A.R.) and Clinical Pharmacology and Discovery Medicine (F.G.) GlaxoSmithKline, London, United Kingdom; Columbia University, New York, New York (M.S.); and Clinical Pharmacology Modelling and Simulation, GlaxoSmithKline, Verona, Italy (M.P, M.N., L.I., R.G.)
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Roger N. Gunn
Clinical Imaging Centre (R.A.C., C.A.S., C.M., I.B., P.S., J.V., M.L., R.N.G., E.A.R.) and Clinical Pharmacology and Discovery Medicine (F.G.) GlaxoSmithKline, London, United Kingdom; Columbia University, New York, New York (M.S.); and Clinical Pharmacology Modelling and Simulation, GlaxoSmithKline, Verona, Italy (M.P, M.N., L.I., R.G.)
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Eugenii A. Rabiner
Clinical Imaging Centre (R.A.C., C.A.S., C.M., I.B., P.S., J.V., M.L., R.N.G., E.A.R.) and Clinical Pharmacology and Discovery Medicine (F.G.) GlaxoSmithKline, London, United Kingdom; Columbia University, New York, New York (M.S.); and Clinical Pharmacology Modelling and Simulation, GlaxoSmithKline, Verona, Italy (M.P, M.N., L.I., R.G.)
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Article Information

vol. 346 no. 2 311-317
DOI 
https://doi.org/10.1124/jpet.112.202895
PubMed 
23685546

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received January 17, 2013
  • Accepted May 17, 2013
  • Published online July 17, 2013.

Article Versions

  • Earlier version (May 17, 2013 - 11:37).
  • Earlier version (May 21, 2013 - 04:31).
  • Earlier version (May 29, 2013 - 07:18).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2013 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Robert A. Comley1,
  2. Cristian A. Salinas2,
  3. Mark Slifstein,
  4. Marcella Petrone3,
  5. Carmine Marzano,
  6. Idriss Bennacef4,
  7. Paul Shotbolt,
  8. Jasper Van der Aart2,
  9. Marta Neve3,
  10. Laura Iavarone,
  11. Roberto Gomeni5,
  12. Marc Laruelle6,
  13. Frank A. Gray,
  14. Roger N. Gunn2, and
  15. Eugenii A. Rabiner2
  1. Clinical Imaging Centre (R.A.C., C.A.S., C.M., I.B., P.S., J.V., M.L., R.N.G., E.A.R.) and Clinical Pharmacology and Discovery Medicine (F.G.) GlaxoSmithKline, London, United Kingdom; Columbia University, New York, New York (M.S.); and Clinical Pharmacology Modelling and Simulation, GlaxoSmithKline, Verona, Italy (M.P, M.N., L.I., R.G.)
  1. Address correspondence to:
    Dr. Eugenii Rabiner, Imanova Limited, Burlington Danes Building,, Imperial College London, Hammersmith Hospital, Du Cane Road, London, W12 0NN, United Kingdom. E-mail: Ilan.Rabiner{at}imanova.co.uk
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Journal of Pharmacology and Experimental Therapeutics: 346 (2)
Journal of Pharmacology and Experimental Therapeutics
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1 Aug 2013
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Research ArticleNeuropharmacology

Occupancy of a Novel Triple Reuptake Inhibitor Using PET

Robert A. Comley, Cristian A. Salinas, Mark Slifstein, Marcella Petrone, Carmine Marzano, Idriss Bennacef, Paul Shotbolt, Jasper Van der Aart, Marta Neve, Laura Iavarone, Roberto Gomeni, Marc Laruelle, Frank A. Gray, Roger N. Gunn and Eugenii A. Rabiner
Journal of Pharmacology and Experimental Therapeutics August 1, 2013, 346 (2) 311-317; DOI: https://doi.org/10.1124/jpet.112.202895

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Research ArticleNeuropharmacology

Occupancy of a Novel Triple Reuptake Inhibitor Using PET

Robert A. Comley, Cristian A. Salinas, Mark Slifstein, Marcella Petrone, Carmine Marzano, Idriss Bennacef, Paul Shotbolt, Jasper Van der Aart, Marta Neve, Laura Iavarone, Roberto Gomeni, Marc Laruelle, Frank A. Gray, Roger N. Gunn and Eugenii A. Rabiner
Journal of Pharmacology and Experimental Therapeutics August 1, 2013, 346 (2) 311-317; DOI: https://doi.org/10.1124/jpet.112.202895
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