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Research ArticleDrug Discovery and Translational Medicine

Pharmacology of AMG 416 (Velcalcetide), a Novel Peptide Agonist of the Calcium-Sensing Receptor, for the Treatment of Secondary Hyperparathyroidism in Hemodialysis Patients

Sarah Walter, Amos Baruch, Jin Dong, James E. Tomlinson, Shawn T. Alexander, Julie Janes, Tom Hunter, Qun Yin, Derek Maclean, Gregory Bell, Dirk B. Mendel, Randolph M. Johnson and Felix Karim
Journal of Pharmacology and Experimental Therapeutics August 2013, 346 (2) 229-240; DOI: https://doi.org/10.1124/jpet.113.204834
Sarah Walter
Amgen, Inc., South San Francisco, California (S.W., A.B., J.D., J.E.T., S.T.A., J.J., T.H., Q.Y., D.B.M., G.B., D.M., R.M.J., F.K.); and Department of Medicine, University of California, San Francisco, California (G.B.)
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Amos Baruch
Amgen, Inc., South San Francisco, California (S.W., A.B., J.D., J.E.T., S.T.A., J.J., T.H., Q.Y., D.B.M., G.B., D.M., R.M.J., F.K.); and Department of Medicine, University of California, San Francisco, California (G.B.)
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Jin Dong
Amgen, Inc., South San Francisco, California (S.W., A.B., J.D., J.E.T., S.T.A., J.J., T.H., Q.Y., D.B.M., G.B., D.M., R.M.J., F.K.); and Department of Medicine, University of California, San Francisco, California (G.B.)
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James E. Tomlinson
Amgen, Inc., South San Francisco, California (S.W., A.B., J.D., J.E.T., S.T.A., J.J., T.H., Q.Y., D.B.M., G.B., D.M., R.M.J., F.K.); and Department of Medicine, University of California, San Francisco, California (G.B.)
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Shawn T. Alexander
Amgen, Inc., South San Francisco, California (S.W., A.B., J.D., J.E.T., S.T.A., J.J., T.H., Q.Y., D.B.M., G.B., D.M., R.M.J., F.K.); and Department of Medicine, University of California, San Francisco, California (G.B.)
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Julie Janes
Amgen, Inc., South San Francisco, California (S.W., A.B., J.D., J.E.T., S.T.A., J.J., T.H., Q.Y., D.B.M., G.B., D.M., R.M.J., F.K.); and Department of Medicine, University of California, San Francisco, California (G.B.)
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Tom Hunter
Amgen, Inc., South San Francisco, California (S.W., A.B., J.D., J.E.T., S.T.A., J.J., T.H., Q.Y., D.B.M., G.B., D.M., R.M.J., F.K.); and Department of Medicine, University of California, San Francisco, California (G.B.)
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Qun Yin
Amgen, Inc., South San Francisco, California (S.W., A.B., J.D., J.E.T., S.T.A., J.J., T.H., Q.Y., D.B.M., G.B., D.M., R.M.J., F.K.); and Department of Medicine, University of California, San Francisco, California (G.B.)
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Derek Maclean
Amgen, Inc., South San Francisco, California (S.W., A.B., J.D., J.E.T., S.T.A., J.J., T.H., Q.Y., D.B.M., G.B., D.M., R.M.J., F.K.); and Department of Medicine, University of California, San Francisco, California (G.B.)
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Gregory Bell
Amgen, Inc., South San Francisco, California (S.W., A.B., J.D., J.E.T., S.T.A., J.J., T.H., Q.Y., D.B.M., G.B., D.M., R.M.J., F.K.); and Department of Medicine, University of California, San Francisco, California (G.B.)
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Dirk B. Mendel
Amgen, Inc., South San Francisco, California (S.W., A.B., J.D., J.E.T., S.T.A., J.J., T.H., Q.Y., D.B.M., G.B., D.M., R.M.J., F.K.); and Department of Medicine, University of California, San Francisco, California (G.B.)
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Randolph M. Johnson
Amgen, Inc., South San Francisco, California (S.W., A.B., J.D., J.E.T., S.T.A., J.J., T.H., Q.Y., D.B.M., G.B., D.M., R.M.J., F.K.); and Department of Medicine, University of California, San Francisco, California (G.B.)
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Felix Karim
Amgen, Inc., South San Francisco, California (S.W., A.B., J.D., J.E.T., S.T.A., J.J., T.H., Q.Y., D.B.M., G.B., D.M., R.M.J., F.K.); and Department of Medicine, University of California, San Francisco, California (G.B.)
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Article Information

vol. 346 no. 2 229-240
DOI 
https://doi.org/10.1124/jpet.113.204834
PubMed 
23674604

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received March 15, 2013
  • Accepted May 14, 2013
  • Published online July 17, 2013.

Article Versions

  • Earlier version (May 14, 2013 - 11:47).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2013 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Sarah Walter,
  2. Amos Baruch,
  3. Jin Dong,
  4. James E. Tomlinson,
  5. Shawn T. Alexander,
  6. Julie Janes,
  7. Tom Hunter,
  8. Qun Yin,
  9. Derek Maclean,
  10. Gregory Bell,
  11. Dirk B. Mendel,
  12. Randolph M. Johnson, and
  13. Felix Karim
  1. Amgen, Inc., South San Francisco, California (S.W., A.B., J.D., J.E.T., S.T.A., J.J., T.H., Q.Y., D.B.M., G.B., D.M., R.M.J., F.K.); and Department of Medicine, University of California, San Francisco, California (G.B.)
  1. Address correspondence to
    : James E. Tomlinson, Amgen, Inc. ASF1-1, 1120 Veterans Blvd., South San Francisco, CA 94080. E-mail: jitomlin{at}amgen.com
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Journal of Pharmacology and Experimental Therapeutics: 346 (2)
Journal of Pharmacology and Experimental Therapeutics
Vol. 346, Issue 2
1 Aug 2013
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Research ArticleDrug Discovery and Translational Medicine

AMG 416 (Velcalcetide) Activates the Calcium Sensing Receptor

Sarah Walter, Amos Baruch, Jin Dong, James E. Tomlinson, Shawn T. Alexander, Julie Janes, Tom Hunter, Qun Yin, Derek Maclean, Gregory Bell, Dirk B. Mendel, Randolph M. Johnson and Felix Karim
Journal of Pharmacology and Experimental Therapeutics August 1, 2013, 346 (2) 229-240; DOI: https://doi.org/10.1124/jpet.113.204834

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Research ArticleDrug Discovery and Translational Medicine

AMG 416 (Velcalcetide) Activates the Calcium Sensing Receptor

Sarah Walter, Amos Baruch, Jin Dong, James E. Tomlinson, Shawn T. Alexander, Julie Janes, Tom Hunter, Qun Yin, Derek Maclean, Gregory Bell, Dirk B. Mendel, Randolph M. Johnson and Felix Karim
Journal of Pharmacology and Experimental Therapeutics August 1, 2013, 346 (2) 229-240; DOI: https://doi.org/10.1124/jpet.113.204834
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