Table of Contents

Drug Discovery and Translational Medicine

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  The Grasshopper: A Novel Model for Assessing Vertebrate Brain Uptake

  Olga Andersson, Steen Honoré Hansen, Karin Hellman, Line Rørbæk Olsen, Gunnar Andersson, Lassina Badolo, Niels Svenstrup and Peter Aadal Nielsen

  Journal of Pharmacology and Experimental Therapeutics August 2013, 346 (2) 211-218; DOI: https://doi.org/10.1124/jpet.113.205476
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  Inhibition of Btk with CC-292 Provides Early Pharmacodynamic Assessment of Activity in Mice and Humans

  Erica K. Evans, Richland Tester, Sharon Aslanian, Russell Karp, Michael Sheets, Matthew T. Labenski, Steven R. Witowski, Heather Lounsbury, Prasoon Chaturvedi, Hormoz Mazdiyasni, Zhendong Zhu, Mariana Nacht, Martin I. Freed, Russell C. Petter, Alex Dubrovskiy, Juswinder Singh and William F. Westlin

  Journal of Pharmacology and Experimental Therapeutics August 2013, 346 (2) 219-228; DOI: https://doi.org/10.1124/jpet.113.203489
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  Pharmacology of AMG 416 (Velcalcetide), a Novel Peptide Agonist of the Calcium-Sensing Receptor, for the Treatment of Secondary Hyperparathyroidism in Hemodialysis Patients

  Sarah Walter, Amos Baruch, Jin Dong, James E. Tomlinson, Shawn T. Alexander, Julie Janes, Tom Hunter, Qun Yin, Derek Maclean, Gregory Bell, Dirk B. Mendel, Randolph M. Johnson and Felix Karim

  Journal of Pharmacology and Experimental Therapeutics August 2013, 346 (2) 229-240; DOI: https://doi.org/10.1124/jpet.113.204834
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  In Vivo Pharmacological Characterization of TD-4208, a Novel Lung-Selective Inhaled Muscarinic Antagonist with Sustained Bronchoprotective Effect in Experimental Animal Models

  M. T. Pulido-Rios, A. McNamara, G. P. Obedencio, Y. Ji, S. Jaw-Tsai, W. J. Martin and S. S. Hegde

  Journal of Pharmacology and Experimental Therapeutics August 2013, 346 (2) 241-250; DOI: https://doi.org/10.1124/jpet.113.203554
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  Monitoring Tumor Response to Linifanib Therapy with SPECT/CT Using the Integrin α_vβ₃–Targeted Radiotracer ^99mTc-3P-RGD₂

  Shundong Ji, Yang Zhou, Martin J. Voorbach, Guoqiang Shao, Yumin Zhang, Gerard B. Fox, Daniel H. Albert, Yanping Luo, Shuang Liu and Sarah R. Mudd

  Journal of Pharmacology and Experimental Therapeutics August 2013, 346 (2) 251-258; DOI: https://doi.org/10.1124/jpet.112.202622
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  Protective Properties of 2-Acetylcyclopentanone in a Mouse Model of Acetaminophen Hepatotoxicity

  Lihai Zhang, Terrence Gavin, Brian C. Geohagen, Qiang Liu, Katherine J. Downey and Richard M. LoPachin

  Journal of Pharmacology and Experimental Therapeutics August 2013, 346 (2) 259-269; DOI: https://doi.org/10.1124/jpet.113.205435