Journal of Pharmacology and Experimental Therapeutics: 346 (2)

August 01, 2013; Volume 346,Issue 2

Highlighted Papers

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Organ Sites of Endothelin A Receptor Antagonist Fluid Retention
Journal of Pharmacology and Experimental Therapeutics August 2013, 346 (2) 162; DOI: https://doi.org/10.1124/jpet.113.0813HI
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The Grasshopper: A Novel Model for Assessing Vertebrate Brain Uptake
Journal of Pharmacology and Experimental Therapeutics August 2013, 346 (2) 162; DOI: https://doi.org/10.1124/jpet.113.0813HIa
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Inhibition of Btk with CC-292 Provides Early Pharmacodynamics Assessment of Activity in Mice and Humans
Journal of Pharmacology and Experimental Therapeutics August 2013, 346 (2) 162; DOI: https://doi.org/10.1124/jpet.113.0813HIb
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The Role of Neurotensin in Methamphetamine Self-Administration Extinction
Journal of Pharmacology and Experimental Therapeutics August 2013, 346 (2) 162; DOI: https://doi.org/10.1124/jpet.113.0813HIc

Perspectives in Pharmacology

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Endothelin-1–Induced Endoplasmic Reticulum Stress in Disease
Arjun Jain

Journal of Pharmacology and Experimental Therapeutics August 2013, 346 (2) 163-172; DOI: https://doi.org/10.1124/jpet.113.205567

Behavioral Pharmacology

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Response of Neurotensin Basal Ganglia Systems during Extinction of Methamphetamine Self-Administration in Rat
Glen R. Hanson, Amanda J. Hoonakker, Christina M. Robson, Lisa M. McFadden, Paul S. Frankel and Mario E. Alburges

Journal of Pharmacology and Experimental Therapeutics August 2013, 346 (2) 173-181; DOI: https://doi.org/10.1124/jpet.113.205310

Cardiovascular

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Myocardial, Smooth Muscle, Nephron, and Collecting Duct Gene Targeting Reveals the Organ Sites of Endothelin A Receptor Antagonist Fluid Retention
Deborah Stuart, Mark Chapman, Sara Rees, Stephanie Woodward and Donald E. Kohan

Journal of Pharmacology and Experimental Therapeutics August 2013, 346 (2) 182-189; DOI: https://doi.org/10.1124/jpet.113.205286
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In Vivo Cardiovascular Pharmacology of 2′,3′-cAMP, 2′-AMP, and 3′-AMP in the Rat
Edwin K. Jackson and Zaichuan Mi

Journal of Pharmacology and Experimental Therapeutics August 2013, 346 (2) 190-200; DOI: https://doi.org/10.1124/jpet.113.205757

Cellular and Molecular

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Survivin Inhibitor YM-155 Sensitizes Tumor Necrosis Factor– Related Apoptosis-Inducing Ligand-Resistant Glioma Cells to Apoptosis through Mcl-1 Downregulation and by Engaging the Mitochondrial Death Pathway
Daniel R. Premkumar, Esther P. Jane, Kimberly A. Foster and Ian F. Pollack

Journal of Pharmacology and Experimental Therapeutics August 2013, 346 (2) 201-210; DOI: https://doi.org/10.1124/jpet.113.204743

Drug Discovery and Translational Medicine

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The Grasshopper: A Novel Model for Assessing Vertebrate Brain Uptake
Olga Andersson, Steen Honoré Hansen, Karin Hellman, Line Rørbæk Olsen, Gunnar Andersson, Lassina Badolo, Niels Svenstrup and Peter Aadal Nielsen

Journal of Pharmacology and Experimental Therapeutics August 2013, 346 (2) 211-218; DOI: https://doi.org/10.1124/jpet.113.205476
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Inhibition of Btk with CC-292 Provides Early Pharmacodynamic Assessment of Activity in Mice and Humans
Erica K. Evans, Richland Tester, Sharon Aslanian, Russell Karp, Michael Sheets, Matthew T. Labenski, Steven R. Witowski, Heather Lounsbury, Prasoon Chaturvedi, Hormoz Mazdiyasni, Zhendong Zhu, Mariana Nacht, Martin I. Freed, Russell C. Petter, Alex Dubrovskiy, Juswinder Singh and William F. Westlin

Journal of Pharmacology and Experimental Therapeutics August 2013, 346 (2) 219-228; DOI: https://doi.org/10.1124/jpet.113.203489
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Pharmacology of AMG 416 (Velcalcetide), a Novel Peptide Agonist of the Calcium-Sensing Receptor, for the Treatment of Secondary Hyperparathyroidism in Hemodialysis Patients
Sarah Walter, Amos Baruch, Jin Dong, James E. Tomlinson, Shawn T. Alexander, Julie Janes, Tom Hunter, Qun Yin, Derek Maclean, Gregory Bell, Dirk B. Mendel, Randolph M. Johnson and Felix Karim

Journal of Pharmacology and Experimental Therapeutics August 2013, 346 (2) 229-240; DOI: https://doi.org/10.1124/jpet.113.204834
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In Vivo Pharmacological Characterization of TD-4208, a Novel Lung-Selective Inhaled Muscarinic Antagonist with Sustained Bronchoprotective Effect in Experimental Animal Models
M. T. Pulido-Rios, A. McNamara, G. P. Obedencio, Y. Ji, S. Jaw-Tsai, W. J. Martin and S. S. Hegde

Journal of Pharmacology and Experimental Therapeutics August 2013, 346 (2) 241-250; DOI: https://doi.org/10.1124/jpet.113.203554
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Monitoring Tumor Response to Linifanib Therapy with SPECT/CT Using the Integrin α_vβ₃–Targeted Radiotracer ^99mTc-3P-RGD₂
Shundong Ji, Yang Zhou, Martin J. Voorbach, Guoqiang Shao, Yumin Zhang, Gerard B. Fox, Daniel H. Albert, Yanping Luo, Shuang Liu and Sarah R. Mudd

Journal of Pharmacology and Experimental Therapeutics August 2013, 346 (2) 251-258; DOI: https://doi.org/10.1124/jpet.112.202622
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Protective Properties of 2-Acetylcyclopentanone in a Mouse Model of Acetaminophen Hepatotoxicity
Lihai Zhang, Terrence Gavin, Brian C. Geohagen, Qiang Liu, Katherine J. Downey and Richard M. LoPachin

Journal of Pharmacology and Experimental Therapeutics August 2013, 346 (2) 259-269; DOI: https://doi.org/10.1124/jpet.113.205435

Endocrine and Diabetes

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Development of a Novel Long-Acting Antidiabetic FGF21 Mimetic by Targeted Conjugation to a Scaffold Antibody
Jie Huang, Tetsuya Ishino, Gang Chen, Paul Rolzin, Trina F. Osothprarop, Kelsey Retting, Lingna Li, Ping Jin, Marla J. Matin, Bernard Huyghe, Saswata Talukdar, Curt W. Bradshaw, Moorthy Palanki, Bernard N. Violand, Gary Woodnutt, Rodney W. Lappe, Kathleen Ogilvie and Nancy Levin

Journal of Pharmacology and Experimental Therapeutics August 2013, 346 (2) 270-280; DOI: https://doi.org/10.1124/jpet.113.204420

Gastrointestinal, Hepatic, Pulmonary, and Renal

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PA21, a New Iron-Based Noncalcium Phosphate Binder, Prevents Vascular Calcification in Chronic Renal Failure Rats
Olivier Phan, Marc Maillard, Christine Peregaux, David Mordasini, Jean-Christophe Stehle, Felix Funk and Michel Burnier

Journal of Pharmacology and Experimental Therapeutics August 2013, 346 (2) 281-289; DOI: https://doi.org/10.1124/jpet.113.204792

Inflammation, Immunopharmacology, and Asthma

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Endothelin Receptor Antagonists Attenuate the Inflammatory Response of Human Pulmonary Vascular Smooth Muscle Cells to Bacterial Endotoxin
Jürgen Knobloch, Maria Feldmann, Chiara Wahl, David Jungck, Jürgen Behr, Erich Stoelben and Andrea Koch

Journal of Pharmacology and Experimental Therapeutics August 2013, 346 (2) 290-299; DOI: https://doi.org/10.1124/jpet.112.202358

Metabolism, Transport, and Pharmacogenomics

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Substrate-Dependent Ligand Inhibition of the Human Organic Cation Transporter OCT2
Mathew Belzer, Mark Morales, Bhumasamudram Jagadish, Eugene A. Mash and Stephen H. Wright

Journal of Pharmacology and Experimental Therapeutics August 2013, 346 (2) 300-310; DOI: https://doi.org/10.1124/jpet.113.203257

Neuropharmacology

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Monoamine Transporter Occupancy of a Novel Triple Reuptake Inhibitor in Baboons and Humans Using Positron Emission Tomography
Robert A. Comley, Cristian A. Salinas, Mark Slifstein, Marcella Petrone, Carmine Marzano, Idriss Bennacef, Paul Shotbolt, Jasper Van der Aart, Marta Neve, Laura Iavarone, Roberto Gomeni, Marc Laruelle, Frank A. Gray, Roger N. Gunn and Eugenii A. Rabiner

Journal of Pharmacology and Experimental Therapeutics August 2013, 346 (2) 311-317; DOI: https://doi.org/10.1124/jpet.112.202895
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Selective and Potent Agonists and Antagonists for Investigating the Role of Mouse Oxytocin Receptors
Marta Busnelli, Elisabetta Bulgheroni, Maurice Manning, Gunnar Kleinau and Bice Chini

Journal of Pharmacology and Experimental Therapeutics August 2013, 346 (2) 318-327; DOI: https://doi.org/10.1124/jpet.113.202994
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HAMI 3379, a CysLT₂ Receptor Antagonist, Attenuates Ischemia-Like Neuronal Injury by Inhibiting Microglial Activation
Xia-Yan Zhang, Xiao-Rong Wang, Dong-Min Xu, Shu-Ying Yu, Qiao-Juan Shi, Li-Hui Zhang, Lu Chen, San-Hua Fang, Yun-Bi Lu, Wei-Ping Zhang and Er-Qing Wei

Journal of Pharmacology and Experimental Therapeutics August 2013, 346 (2) 328-341; DOI: https://doi.org/10.1124/jpet.113.203604

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Table of Contents

Highlighted Papers

Perspectives in Pharmacology

Behavioral Pharmacology

Cardiovascular

Cellular and Molecular

Drug Discovery and Translational Medicine

Endocrine and Diabetes

Gastrointestinal, Hepatic, Pulmonary, and Renal

Inflammation, Immunopharmacology, and Asthma

Metabolism, Transport, and Pharmacogenomics

Neuropharmacology

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