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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

August 01, 2013; Volume 346,Issue 2

Highlighted Papers

  • You have access
    Organ Sites of Endothelin A Receptor Antagonist Fluid Retention
    Journal of Pharmacology and Experimental Therapeutics August 2013, 346 (2) 162; DOI: https://doi.org/10.1124/jpet.113.0813HI
  • You have access
    The Grasshopper: A Novel Model for Assessing Vertebrate Brain Uptake
    Journal of Pharmacology and Experimental Therapeutics August 2013, 346 (2) 162; DOI: https://doi.org/10.1124/jpet.113.0813HIa
  • You have access
    Inhibition of Btk with CC-292 Provides Early Pharmacodynamics Assessment of Activity in Mice and Humans
    Journal of Pharmacology and Experimental Therapeutics August 2013, 346 (2) 162; DOI: https://doi.org/10.1124/jpet.113.0813HIb
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    The Role of Neurotensin in Methamphetamine Self-Administration Extinction
    Journal of Pharmacology and Experimental Therapeutics August 2013, 346 (2) 162; DOI: https://doi.org/10.1124/jpet.113.0813HIc

Perspectives in Pharmacology

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    Endothelin-1–Induced Endoplasmic Reticulum Stress in Disease
    Arjun Jain
    Journal of Pharmacology and Experimental Therapeutics August 2013, 346 (2) 163-172; DOI: https://doi.org/10.1124/jpet.113.205567

Behavioral Pharmacology

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    Response of Neurotensin Basal Ganglia Systems during Extinction of Methamphetamine Self-Administration in Rat
    Glen R. Hanson, Amanda J. Hoonakker, Christina M. Robson, Lisa M. McFadden, Paul S. Frankel and Mario E. Alburges
    Journal of Pharmacology and Experimental Therapeutics August 2013, 346 (2) 173-181; DOI: https://doi.org/10.1124/jpet.113.205310

Cardiovascular

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    Myocardial, Smooth Muscle, Nephron, and Collecting Duct Gene Targeting Reveals the Organ Sites of Endothelin A Receptor Antagonist Fluid Retention
    Deborah Stuart, Mark Chapman, Sara Rees, Stephanie Woodward and Donald E. Kohan
    Journal of Pharmacology and Experimental Therapeutics August 2013, 346 (2) 182-189; DOI: https://doi.org/10.1124/jpet.113.205286
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    In Vivo Cardiovascular Pharmacology of 2′,3′-cAMP, 2′-AMP, and 3′-AMP in the Rat
    Edwin K. Jackson and Zaichuan Mi
    Journal of Pharmacology and Experimental Therapeutics August 2013, 346 (2) 190-200; DOI: https://doi.org/10.1124/jpet.113.205757

Cellular and Molecular

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    Survivin Inhibitor YM-155 Sensitizes Tumor Necrosis Factor– Related Apoptosis-Inducing Ligand-Resistant Glioma Cells to Apoptosis through Mcl-1 Downregulation and by Engaging the Mitochondrial Death Pathway
    Daniel R. Premkumar, Esther P. Jane, Kimberly A. Foster and Ian F. Pollack
    Journal of Pharmacology and Experimental Therapeutics August 2013, 346 (2) 201-210; DOI: https://doi.org/10.1124/jpet.113.204743

Drug Discovery and Translational Medicine

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    The Grasshopper: A Novel Model for Assessing Vertebrate Brain Uptake
    Olga Andersson, Steen Honoré Hansen, Karin Hellman, Line Rørbæk Olsen, Gunnar Andersson, Lassina Badolo, Niels Svenstrup and Peter Aadal Nielsen
    Journal of Pharmacology and Experimental Therapeutics August 2013, 346 (2) 211-218; DOI: https://doi.org/10.1124/jpet.113.205476
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    Inhibition of Btk with CC-292 Provides Early Pharmacodynamic Assessment of Activity in Mice and Humans
    Erica K. Evans, Richland Tester, Sharon Aslanian, Russell Karp, Michael Sheets, Matthew T. Labenski, Steven R. Witowski, Heather Lounsbury, Prasoon Chaturvedi, Hormoz Mazdiyasni, Zhendong Zhu, Mariana Nacht, Martin I. Freed, Russell C. Petter, Alex Dubrovskiy, Juswinder Singh and William F. Westlin
    Journal of Pharmacology and Experimental Therapeutics August 2013, 346 (2) 219-228; DOI: https://doi.org/10.1124/jpet.113.203489
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    Pharmacology of AMG 416 (Velcalcetide), a Novel Peptide Agonist of the Calcium-Sensing Receptor, for the Treatment of Secondary Hyperparathyroidism in Hemodialysis Patients
    Sarah Walter, Amos Baruch, Jin Dong, James E. Tomlinson, Shawn T. Alexander, Julie Janes, Tom Hunter, Qun Yin, Derek Maclean, Gregory Bell, Dirk B. Mendel, Randolph M. Johnson and Felix Karim
    Journal of Pharmacology and Experimental Therapeutics August 2013, 346 (2) 229-240; DOI: https://doi.org/10.1124/jpet.113.204834
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    In Vivo Pharmacological Characterization of TD-4208, a Novel Lung-Selective Inhaled Muscarinic Antagonist with Sustained Bronchoprotective Effect in Experimental Animal Models
    M. T. Pulido-Rios, A. McNamara, G. P. Obedencio, Y. Ji, S. Jaw-Tsai, W. J. Martin and S. S. Hegde
    Journal of Pharmacology and Experimental Therapeutics August 2013, 346 (2) 241-250; DOI: https://doi.org/10.1124/jpet.113.203554
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    Monitoring Tumor Response to Linifanib Therapy with SPECT/CT Using the Integrin αvβ3–Targeted Radiotracer 99mTc-3P-RGD2
    Shundong Ji, Yang Zhou, Martin J. Voorbach, Guoqiang Shao, Yumin Zhang, Gerard B. Fox, Daniel H. Albert, Yanping Luo, Shuang Liu and Sarah R. Mudd
    Journal of Pharmacology and Experimental Therapeutics August 2013, 346 (2) 251-258; DOI: https://doi.org/10.1124/jpet.112.202622
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    Protective Properties of 2-Acetylcyclopentanone in a Mouse Model of Acetaminophen Hepatotoxicity
    Lihai Zhang, Terrence Gavin, Brian C. Geohagen, Qiang Liu, Katherine J. Downey and Richard M. LoPachin
    Journal of Pharmacology and Experimental Therapeutics August 2013, 346 (2) 259-269; DOI: https://doi.org/10.1124/jpet.113.205435

Endocrine and Diabetes

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    Development of a Novel Long-Acting Antidiabetic FGF21 Mimetic by Targeted Conjugation to a Scaffold Antibody
    Jie Huang, Tetsuya Ishino, Gang Chen, Paul Rolzin, Trina F. Osothprarop, Kelsey Retting, Lingna Li, Ping Jin, Marla J. Matin, Bernard Huyghe, Saswata Talukdar, Curt W. Bradshaw, Moorthy Palanki, Bernard N. Violand, Gary Woodnutt, Rodney W. Lappe, Kathleen Ogilvie and Nancy Levin
    Journal of Pharmacology and Experimental Therapeutics August 2013, 346 (2) 270-280; DOI: https://doi.org/10.1124/jpet.113.204420

Gastrointestinal, Hepatic, Pulmonary, and Renal

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    PA21, a New Iron-Based Noncalcium Phosphate Binder, Prevents Vascular Calcification in Chronic Renal Failure Rats
    Olivier Phan, Marc Maillard, Christine Peregaux, David Mordasini, Jean-Christophe Stehle, Felix Funk and Michel Burnier
    Journal of Pharmacology and Experimental Therapeutics August 2013, 346 (2) 281-289; DOI: https://doi.org/10.1124/jpet.113.204792

Inflammation, Immunopharmacology, and Asthma

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    Endothelin Receptor Antagonists Attenuate the Inflammatory Response of Human Pulmonary Vascular Smooth Muscle Cells to Bacterial Endotoxin
    Jürgen Knobloch, Maria Feldmann, Chiara Wahl, David Jungck, Jürgen Behr, Erich Stoelben and Andrea Koch
    Journal of Pharmacology and Experimental Therapeutics August 2013, 346 (2) 290-299; DOI: https://doi.org/10.1124/jpet.112.202358

Metabolism, Transport, and Pharmacogenomics

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    Substrate-Dependent Ligand Inhibition of the Human Organic Cation Transporter OCT2
    Mathew Belzer, Mark Morales, Bhumasamudram Jagadish, Eugene A. Mash and Stephen H. Wright
    Journal of Pharmacology and Experimental Therapeutics August 2013, 346 (2) 300-310; DOI: https://doi.org/10.1124/jpet.113.203257

Neuropharmacology

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    Monoamine Transporter Occupancy of a Novel Triple Reuptake Inhibitor in Baboons and Humans Using Positron Emission Tomography
    Robert A. Comley, Cristian A. Salinas, Mark Slifstein, Marcella Petrone, Carmine Marzano, Idriss Bennacef, Paul Shotbolt, Jasper Van der Aart, Marta Neve, Laura Iavarone, Roberto Gomeni, Marc Laruelle, Frank A. Gray, Roger N. Gunn and Eugenii A. Rabiner
    Journal of Pharmacology and Experimental Therapeutics August 2013, 346 (2) 311-317; DOI: https://doi.org/10.1124/jpet.112.202895
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    Selective and Potent Agonists and Antagonists for Investigating the Role of Mouse Oxytocin Receptors
    Marta Busnelli, Elisabetta Bulgheroni, Maurice Manning, Gunnar Kleinau and Bice Chini
    Journal of Pharmacology and Experimental Therapeutics August 2013, 346 (2) 318-327; DOI: https://doi.org/10.1124/jpet.113.202994
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    HAMI 3379, a CysLT2 Receptor Antagonist, Attenuates Ischemia-Like Neuronal Injury by Inhibiting Microglial Activation
    Xia-Yan Zhang, Xiao-Rong Wang, Dong-Min Xu, Shu-Ying Yu, Qiao-Juan Shi, Li-Hui Zhang, Lu Chen, San-Hua Fang, Yun-Bi Lu, Wei-Ping Zhang and Er-Qing Wei
    Journal of Pharmacology and Experimental Therapeutics August 2013, 346 (2) 328-341; DOI: https://doi.org/10.1124/jpet.113.203604
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In this issue

Journal of Pharmacology and Experimental Therapeutics: 346 (2)
Journal of Pharmacology and Experimental Therapeutics
Vol. 346, Issue 2
1 Aug 2013
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
  • Editorial Board (PDF)
  • Front Matter (PDF)
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Jump to

  • Highlighted Papers
  • Perspectives in Pharmacology
  • Behavioral Pharmacology
  • Cardiovascular
  • Cellular and Molecular
  • Drug Discovery and Translational Medicine
  • Endocrine and Diabetes
  • Gastrointestinal, Hepatic, Pulmonary, and Renal
  • Inflammation, Immunopharmacology, and Asthma
  • Metabolism, Transport, and Pharmacogenomics
  • Neuropharmacology
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  • Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.
  • Functional Selectivity and Classical Concepts of Quantitative Pharmacology
  • Abl Protein-Tyrosine Kinase Inhibitor STI571 Inhibits In Vitro Signal Transduction Mediated by c-Kit and Platelet-Derived Growth Factor Receptors
  • The Prediction of Human Pharmacokinetic Parameters from Preclinical and In Vitro Metabolism Data
  • A METHOD FOR DETERMINING LOSS OF PAIN SENSATION
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