Research ArticlePerspectives in Pharmacology
Nonclassical Pharmacology of the Dopamine Transporter: Atypical Inhibitors, Allosteric Modulators, and Partial Substrates
Kyle C. Schmitt, Richard B. Rothman and Maarten E. A. Reith
Journal of Pharmacology and Experimental Therapeutics July 2013, 346 (1) 2-10; DOI: https://doi.org/10.1124/jpet.111.191056
Kyle C. Schmitt
Department of Neurosurgery (K.C.S.) and Departments of Pharmacology and Psychiatry (M.E.A.R.), New York University School of Medicine, New York, New York; and Medicinal Chemistry Section of the Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland (R.B.R.)
Richard B. Rothman
Department of Neurosurgery (K.C.S.) and Departments of Pharmacology and Psychiatry (M.E.A.R.), New York University School of Medicine, New York, New York; and Medicinal Chemistry Section of the Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland (R.B.R.)
Maarten E. A. Reith
Department of Neurosurgery (K.C.S.) and Departments of Pharmacology and Psychiatry (M.E.A.R.), New York University School of Medicine, New York, New York; and Medicinal Chemistry Section of the Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland (R.B.R.)
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Research ArticlePerspectives in Pharmacology
Pleiotropic Characteristics of DAT Ligands
Kyle C. Schmitt, Richard B. Rothman and Maarten E. A. Reith
Journal of Pharmacology and Experimental Therapeutics July 1, 2013, 346 (1) 2-10; DOI: https://doi.org/10.1124/jpet.111.191056
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- Article
- Abstract
- Introduction
- The Conformational Cycle of the NSS Protein Family
- Partial Substrates and Allosteric Modulators: Differential Effects on Uptake Versus Efflux
- Atypical Uptake Inhibitors: Conformation-Specific Binding Mechanisms
- Conclusions: Molecular Mechanisms of Action for Atypical DAT Ligands
- Authorship Contributions
- Footnotes
- Abbreviations
- References
- Figures & Data
- Info & Metrics
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