Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET

User menu

  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Journal of Pharmacology and Experimental Therapeutics
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET
  • My alerts
  • Log in
  • My Cart
Journal of Pharmacology and Experimental Therapeutics

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Visit jpet on Facebook
  • Follow jpet on Twitter
  • Follow jpet on LinkedIn
Research ArticleCardiovascular

Catharanthine Dilates Small Mesenteric Arteries and Decreases Heart Rate and Cardiac Contractility by Inhibition of Voltage-Operated Calcium Channels on Vascular Smooth Muscle Cells and Cardiomyocytes

Ashok Jadhav, Wenbin Liang, Peter C. Papageorgiou, Ahmed Shoker, Selliah C. Kanthan, John Balsevich, Andrew S. Levy, Scott Heximer, Peter H. Backx and Venkat Gopalakrishnan
Journal of Pharmacology and Experimental Therapeutics June 2013, 345 (3) 383-392; DOI: https://doi.org/10.1124/jpet.112.199661
Ashok Jadhav
Departments of Pharmacology (A.J., V.G.), Medicine (A.S.), and Surgery (S.C.K.), College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada; Departments of Physiology and Medicine, Heart & Stroke/Richard Lewar Centre of Excellence, University of Toronto, Toronto, Ontario, Canada (W.L., P.C.P., A.S.L., S.H., P.H.B.); Department of Medicine, Division of Cardiology, University Health Network and Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada (P.C.P., P.H.B.); and Plant Biotechnology Institute, National Research Council of Canada, Saskatoon, Saskatchewan, Canada (J.B.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Wenbin Liang
Departments of Pharmacology (A.J., V.G.), Medicine (A.S.), and Surgery (S.C.K.), College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada; Departments of Physiology and Medicine, Heart & Stroke/Richard Lewar Centre of Excellence, University of Toronto, Toronto, Ontario, Canada (W.L., P.C.P., A.S.L., S.H., P.H.B.); Department of Medicine, Division of Cardiology, University Health Network and Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada (P.C.P., P.H.B.); and Plant Biotechnology Institute, National Research Council of Canada, Saskatoon, Saskatchewan, Canada (J.B.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Peter C. Papageorgiou
Departments of Pharmacology (A.J., V.G.), Medicine (A.S.), and Surgery (S.C.K.), College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada; Departments of Physiology and Medicine, Heart & Stroke/Richard Lewar Centre of Excellence, University of Toronto, Toronto, Ontario, Canada (W.L., P.C.P., A.S.L., S.H., P.H.B.); Department of Medicine, Division of Cardiology, University Health Network and Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada (P.C.P., P.H.B.); and Plant Biotechnology Institute, National Research Council of Canada, Saskatoon, Saskatchewan, Canada (J.B.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ahmed Shoker
Departments of Pharmacology (A.J., V.G.), Medicine (A.S.), and Surgery (S.C.K.), College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada; Departments of Physiology and Medicine, Heart & Stroke/Richard Lewar Centre of Excellence, University of Toronto, Toronto, Ontario, Canada (W.L., P.C.P., A.S.L., S.H., P.H.B.); Department of Medicine, Division of Cardiology, University Health Network and Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada (P.C.P., P.H.B.); and Plant Biotechnology Institute, National Research Council of Canada, Saskatoon, Saskatchewan, Canada (J.B.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Selliah C. Kanthan
Departments of Pharmacology (A.J., V.G.), Medicine (A.S.), and Surgery (S.C.K.), College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada; Departments of Physiology and Medicine, Heart & Stroke/Richard Lewar Centre of Excellence, University of Toronto, Toronto, Ontario, Canada (W.L., P.C.P., A.S.L., S.H., P.H.B.); Department of Medicine, Division of Cardiology, University Health Network and Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada (P.C.P., P.H.B.); and Plant Biotechnology Institute, National Research Council of Canada, Saskatoon, Saskatchewan, Canada (J.B.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
John Balsevich
Departments of Pharmacology (A.J., V.G.), Medicine (A.S.), and Surgery (S.C.K.), College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada; Departments of Physiology and Medicine, Heart & Stroke/Richard Lewar Centre of Excellence, University of Toronto, Toronto, Ontario, Canada (W.L., P.C.P., A.S.L., S.H., P.H.B.); Department of Medicine, Division of Cardiology, University Health Network and Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada (P.C.P., P.H.B.); and Plant Biotechnology Institute, National Research Council of Canada, Saskatoon, Saskatchewan, Canada (J.B.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Andrew S. Levy
Departments of Pharmacology (A.J., V.G.), Medicine (A.S.), and Surgery (S.C.K.), College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada; Departments of Physiology and Medicine, Heart & Stroke/Richard Lewar Centre of Excellence, University of Toronto, Toronto, Ontario, Canada (W.L., P.C.P., A.S.L., S.H., P.H.B.); Department of Medicine, Division of Cardiology, University Health Network and Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada (P.C.P., P.H.B.); and Plant Biotechnology Institute, National Research Council of Canada, Saskatoon, Saskatchewan, Canada (J.B.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Scott Heximer
Departments of Pharmacology (A.J., V.G.), Medicine (A.S.), and Surgery (S.C.K.), College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada; Departments of Physiology and Medicine, Heart & Stroke/Richard Lewar Centre of Excellence, University of Toronto, Toronto, Ontario, Canada (W.L., P.C.P., A.S.L., S.H., P.H.B.); Department of Medicine, Division of Cardiology, University Health Network and Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada (P.C.P., P.H.B.); and Plant Biotechnology Institute, National Research Council of Canada, Saskatoon, Saskatchewan, Canada (J.B.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Peter H. Backx
Departments of Pharmacology (A.J., V.G.), Medicine (A.S.), and Surgery (S.C.K.), College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada; Departments of Physiology and Medicine, Heart & Stroke/Richard Lewar Centre of Excellence, University of Toronto, Toronto, Ontario, Canada (W.L., P.C.P., A.S.L., S.H., P.H.B.); Department of Medicine, Division of Cardiology, University Health Network and Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada (P.C.P., P.H.B.); and Plant Biotechnology Institute, National Research Council of Canada, Saskatoon, Saskatchewan, Canada (J.B.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Venkat Gopalakrishnan
Departments of Pharmacology (A.J., V.G.), Medicine (A.S.), and Surgery (S.C.K.), College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada; Departments of Physiology and Medicine, Heart & Stroke/Richard Lewar Centre of Excellence, University of Toronto, Toronto, Ontario, Canada (W.L., P.C.P., A.S.L., S.H., P.H.B.); Department of Medicine, Division of Cardiology, University Health Network and Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada (P.C.P., P.H.B.); and Plant Biotechnology Institute, National Research Council of Canada, Saskatoon, Saskatchewan, Canada (J.B.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF
Loading
Submit a Response to This Article
Compose eLetter

More information about text formats

Plain text

  • No HTML tags allowed.
  • Web page addresses and e-mail addresses turn into links automatically.
  • Lines and paragraphs break automatically.
Author Information
First or given name, e.g. 'Peter'.
Your last, or family, name, e.g. 'MacMoody'.
Your email address, e.g. higgs-boson@gmail.com
Your role and/or occupation, e.g. 'Orthopedic Surgeon'.
Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.
Statement of Competing Interests

Vertical Tabs

Jump to comment:

No eLetters have been published for this article.
PreviousNext
Back to top

In this issue

Journal of Pharmacology and Experimental Therapeutics: 345 (3)
Journal of Pharmacology and Experimental Therapeutics
Vol. 345, Issue 3
1 Jun 2013
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
  • Editorial Board (PDF)
  • Front Matter (PDF)
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Journal of Pharmacology and Experimental Therapeutics article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Catharanthine Dilates Small Mesenteric Arteries and Decreases Heart Rate and Cardiac Contractility by Inhibition of Voltage-Operated Calcium Channels on Vascular Smooth Muscle Cells and Cardiomyocytes
(Your Name) has forwarded a page to you from Journal of Pharmacology and Experimental Therapeutics
(Your Name) thought you would be interested in this article in Journal of Pharmacology and Experimental Therapeutics.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Research ArticleCardiovascular

Catharanthine Blocks Voltage-Operated Ca2+ Channels

Ashok Jadhav, Wenbin Liang, Peter C. Papageorgiou, Ahmed Shoker, Selliah C. Kanthan, John Balsevich, Andrew S. Levy, Scott Heximer, Peter H. Backx and Venkat Gopalakrishnan
Journal of Pharmacology and Experimental Therapeutics June 1, 2013, 345 (3) 383-392; DOI: https://doi.org/10.1124/jpet.112.199661

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Research ArticleCardiovascular

Catharanthine Blocks Voltage-Operated Ca2+ Channels

Ashok Jadhav, Wenbin Liang, Peter C. Papageorgiou, Ahmed Shoker, Selliah C. Kanthan, John Balsevich, Andrew S. Levy, Scott Heximer, Peter H. Backx and Venkat Gopalakrishnan
Journal of Pharmacology and Experimental Therapeutics June 1, 2013, 345 (3) 383-392; DOI: https://doi.org/10.1124/jpet.112.199661
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Introduction
    • Materials and Methods
    • Results
    • Discussion
    • Authorship Contributions
    • Footnotes
    • Abbreviations
    • References
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF

Related Articles

Cited By...

More in this TOC Section

  • Effect of Acetate and on HR, BP, and Cardiac Contractility
  • Amphetaminelike Effects of α-Ethylphenethylamine Analogs
  • Metoprolol Impairs Cerebral Vasodilator Responses
Show more Cardiovascular

Similar Articles

  • Home
  • Alerts
Facebook   Twitter   LinkedIn   RSS

Navigate

  • Current Issue
  • Fast Forward by date
  • Fast Forward by section
  • Latest Articles
  • Archive
  • Search for Articles
  • Feedback
  • ASPET

More Information

  • About JPET
  • Editorial Board
  • Instructions to Authors
  • Submit a Manuscript
  • Customized Alerts
  • RSS Feeds
  • Subscriptions
  • Permissions
  • Terms & Conditions of Use

ASPET's Other Journals

  • Drug Metabolism and Disposition
  • Molecular Pharmacology
  • Pharmacological Reviews
  • Pharmacology Research & Perspectives
ISSN 1521-0103 (Online)

Copyright © 2021 by the American Society for Pharmacology and Experimental Therapeutics