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Research ArticleCardiovascular

Catharanthine Dilates Small Mesenteric Arteries and Decreases Heart Rate and Cardiac Contractility by Inhibition of Voltage-Operated Calcium Channels on Vascular Smooth Muscle Cells and Cardiomyocytes

Ashok Jadhav, Wenbin Liang, Peter C. Papageorgiou, Ahmed Shoker, Selliah C. Kanthan, John Balsevich, Andrew S. Levy, Scott Heximer, Peter H. Backx and Venkat Gopalakrishnan
Journal of Pharmacology and Experimental Therapeutics June 2013, 345 (3) 383-392; DOI: https://doi.org/10.1124/jpet.112.199661
Ashok Jadhav
Departments of Pharmacology (A.J., V.G.), Medicine (A.S.), and Surgery (S.C.K.), College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada; Departments of Physiology and Medicine, Heart & Stroke/Richard Lewar Centre of Excellence, University of Toronto, Toronto, Ontario, Canada (W.L., P.C.P., A.S.L., S.H., P.H.B.); Department of Medicine, Division of Cardiology, University Health Network and Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada (P.C.P., P.H.B.); and Plant Biotechnology Institute, National Research Council of Canada, Saskatoon, Saskatchewan, Canada (J.B.)
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Wenbin Liang
Departments of Pharmacology (A.J., V.G.), Medicine (A.S.), and Surgery (S.C.K.), College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada; Departments of Physiology and Medicine, Heart & Stroke/Richard Lewar Centre of Excellence, University of Toronto, Toronto, Ontario, Canada (W.L., P.C.P., A.S.L., S.H., P.H.B.); Department of Medicine, Division of Cardiology, University Health Network and Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada (P.C.P., P.H.B.); and Plant Biotechnology Institute, National Research Council of Canada, Saskatoon, Saskatchewan, Canada (J.B.)
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Peter C. Papageorgiou
Departments of Pharmacology (A.J., V.G.), Medicine (A.S.), and Surgery (S.C.K.), College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada; Departments of Physiology and Medicine, Heart & Stroke/Richard Lewar Centre of Excellence, University of Toronto, Toronto, Ontario, Canada (W.L., P.C.P., A.S.L., S.H., P.H.B.); Department of Medicine, Division of Cardiology, University Health Network and Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada (P.C.P., P.H.B.); and Plant Biotechnology Institute, National Research Council of Canada, Saskatoon, Saskatchewan, Canada (J.B.)
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Ahmed Shoker
Departments of Pharmacology (A.J., V.G.), Medicine (A.S.), and Surgery (S.C.K.), College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada; Departments of Physiology and Medicine, Heart & Stroke/Richard Lewar Centre of Excellence, University of Toronto, Toronto, Ontario, Canada (W.L., P.C.P., A.S.L., S.H., P.H.B.); Department of Medicine, Division of Cardiology, University Health Network and Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada (P.C.P., P.H.B.); and Plant Biotechnology Institute, National Research Council of Canada, Saskatoon, Saskatchewan, Canada (J.B.)
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Selliah C. Kanthan
Departments of Pharmacology (A.J., V.G.), Medicine (A.S.), and Surgery (S.C.K.), College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada; Departments of Physiology and Medicine, Heart & Stroke/Richard Lewar Centre of Excellence, University of Toronto, Toronto, Ontario, Canada (W.L., P.C.P., A.S.L., S.H., P.H.B.); Department of Medicine, Division of Cardiology, University Health Network and Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada (P.C.P., P.H.B.); and Plant Biotechnology Institute, National Research Council of Canada, Saskatoon, Saskatchewan, Canada (J.B.)
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John Balsevich
Departments of Pharmacology (A.J., V.G.), Medicine (A.S.), and Surgery (S.C.K.), College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada; Departments of Physiology and Medicine, Heart & Stroke/Richard Lewar Centre of Excellence, University of Toronto, Toronto, Ontario, Canada (W.L., P.C.P., A.S.L., S.H., P.H.B.); Department of Medicine, Division of Cardiology, University Health Network and Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada (P.C.P., P.H.B.); and Plant Biotechnology Institute, National Research Council of Canada, Saskatoon, Saskatchewan, Canada (J.B.)
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Andrew S. Levy
Departments of Pharmacology (A.J., V.G.), Medicine (A.S.), and Surgery (S.C.K.), College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada; Departments of Physiology and Medicine, Heart & Stroke/Richard Lewar Centre of Excellence, University of Toronto, Toronto, Ontario, Canada (W.L., P.C.P., A.S.L., S.H., P.H.B.); Department of Medicine, Division of Cardiology, University Health Network and Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada (P.C.P., P.H.B.); and Plant Biotechnology Institute, National Research Council of Canada, Saskatoon, Saskatchewan, Canada (J.B.)
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Scott Heximer
Departments of Pharmacology (A.J., V.G.), Medicine (A.S.), and Surgery (S.C.K.), College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada; Departments of Physiology and Medicine, Heart & Stroke/Richard Lewar Centre of Excellence, University of Toronto, Toronto, Ontario, Canada (W.L., P.C.P., A.S.L., S.H., P.H.B.); Department of Medicine, Division of Cardiology, University Health Network and Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada (P.C.P., P.H.B.); and Plant Biotechnology Institute, National Research Council of Canada, Saskatoon, Saskatchewan, Canada (J.B.)
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Peter H. Backx
Departments of Pharmacology (A.J., V.G.), Medicine (A.S.), and Surgery (S.C.K.), College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada; Departments of Physiology and Medicine, Heart & Stroke/Richard Lewar Centre of Excellence, University of Toronto, Toronto, Ontario, Canada (W.L., P.C.P., A.S.L., S.H., P.H.B.); Department of Medicine, Division of Cardiology, University Health Network and Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada (P.C.P., P.H.B.); and Plant Biotechnology Institute, National Research Council of Canada, Saskatoon, Saskatchewan, Canada (J.B.)
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Venkat Gopalakrishnan
Departments of Pharmacology (A.J., V.G.), Medicine (A.S.), and Surgery (S.C.K.), College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada; Departments of Physiology and Medicine, Heart & Stroke/Richard Lewar Centre of Excellence, University of Toronto, Toronto, Ontario, Canada (W.L., P.C.P., A.S.L., S.H., P.H.B.); Department of Medicine, Division of Cardiology, University Health Network and Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada (P.C.P., P.H.B.); and Plant Biotechnology Institute, National Research Council of Canada, Saskatoon, Saskatchewan, Canada (J.B.)
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Article Information

vol. 345 no. 3 383-392
DOI 
https://doi.org/10.1124/jpet.112.199661
PubMed 
23532933

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received August 31, 2012
  • Accepted January 24, 2013
  • Published online May 16, 2013.

Article Versions

  • Earlier version (March 26, 2013 - 08:08).
  • Earlier version (March 27, 2013 - 09:01).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2013 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Ashok Jadhav,
  2. Wenbin Liang,
  3. Peter C. Papageorgiou,
  4. Ahmed Shoker,
  5. Selliah C. Kanthan,
  6. John Balsevich,
  7. Andrew S. Levy,
  8. Scott Heximer,
  9. Peter H. Backx, and
  10. Venkat Gopalakrishnan
  1. Departments of Pharmacology (A.J., V.G.), Medicine (A.S.), and Surgery (S.C.K.), College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada; Departments of Physiology and Medicine, Heart & Stroke/Richard Lewar Centre of Excellence, University of Toronto, Toronto, Ontario, Canada (W.L., P.C.P., A.S.L., S.H., P.H.B.); Department of Medicine, Division of Cardiology, University Health Network and Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada (P.C.P., P.H.B.); and Plant Biotechnology Institute, National Research Council of Canada, Saskatoon, Saskatchewan, Canada (J.B.)
  1. Address correspondence to:
    Venkat Gopalakrishnan, Department of Pharmacology, University of Saskatchewan, Saskatoon, SK, S7N 5E5, Canada; or Dr. Peter H. Backx, Departments of Physiology and Medicine, Heart & Stroke/Richard Lewar Centre of Excellence, University of Toronto, Toronto, ON, M5S 3E2 Canada. E-mail: venkat.goapl{at}usask.ca or p.backx{at}utoronto.ca
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Journal of Pharmacology and Experimental Therapeutics: 345 (3)
Journal of Pharmacology and Experimental Therapeutics
Vol. 345, Issue 3
1 Jun 2013
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Research ArticleCardiovascular

Catharanthine Blocks Voltage-Operated Ca2+ Channels

Ashok Jadhav, Wenbin Liang, Peter C. Papageorgiou, Ahmed Shoker, Selliah C. Kanthan, John Balsevich, Andrew S. Levy, Scott Heximer, Peter H. Backx and Venkat Gopalakrishnan
Journal of Pharmacology and Experimental Therapeutics June 1, 2013, 345 (3) 383-392; DOI: https://doi.org/10.1124/jpet.112.199661

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Research ArticleCardiovascular

Catharanthine Blocks Voltage-Operated Ca2+ Channels

Ashok Jadhav, Wenbin Liang, Peter C. Papageorgiou, Ahmed Shoker, Selliah C. Kanthan, John Balsevich, Andrew S. Levy, Scott Heximer, Peter H. Backx and Venkat Gopalakrishnan
Journal of Pharmacology and Experimental Therapeutics June 1, 2013, 345 (3) 383-392; DOI: https://doi.org/10.1124/jpet.112.199661
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