Research ArticleMetabolism, Transport, and Pharmacogenomics
The UDP-Glucuronosyltransferase (UGT) 1A Polymorphism c.2042C>G (rs8330) Is Associated with Increased Human Liver Acetaminophen Glucuronidation, Increased UGT1A Exon 5a/5b Splice Variant mRNA Ratio, and Decreased Risk of Unintentional Acetaminophen-Induced Acute Liver Failure
Michael H. Court, Marina Freytsis, Xueding Wang, Inga Peter, Chantal Guillemette, Suwagmani Hazarika, Su X. Duan, David J. Greenblatt, William M. Lee and the Acute Liver Failure Study Group
Journal of Pharmacology and Experimental Therapeutics May 2013, 345 (2) 297-307; DOI: https://doi.org/10.1124/jpet.112.202010
Michael H. Court
Comparative and Molecular Pharmacogenomics Laboratory (M.H.C., M.F., X.W., S.H., S.D.), Department of Molecular Physiology and Pharmacology (D.J.G.), Tufts University School of Medicine, Boston, Massachusetts; Program in Genetics, Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, Massachusetts (M.H.C., M.F.); Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, New York (I.P.); Faculty of Pharmacy, Centre Hospitalier Universitaire de Québec, Laval University, Québec, Québec, Canada (C.G.); and the Department of Internal Medicine, University of Texas, Southwestern Medical Center, Dallas, Texas (W.M.L.)
Marina Freytsis
Comparative and Molecular Pharmacogenomics Laboratory (M.H.C., M.F., X.W., S.H., S.D.), Department of Molecular Physiology and Pharmacology (D.J.G.), Tufts University School of Medicine, Boston, Massachusetts; Program in Genetics, Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, Massachusetts (M.H.C., M.F.); Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, New York (I.P.); Faculty of Pharmacy, Centre Hospitalier Universitaire de Québec, Laval University, Québec, Québec, Canada (C.G.); and the Department of Internal Medicine, University of Texas, Southwestern Medical Center, Dallas, Texas (W.M.L.)
Xueding Wang
Comparative and Molecular Pharmacogenomics Laboratory (M.H.C., M.F., X.W., S.H., S.D.), Department of Molecular Physiology and Pharmacology (D.J.G.), Tufts University School of Medicine, Boston, Massachusetts; Program in Genetics, Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, Massachusetts (M.H.C., M.F.); Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, New York (I.P.); Faculty of Pharmacy, Centre Hospitalier Universitaire de Québec, Laval University, Québec, Québec, Canada (C.G.); and the Department of Internal Medicine, University of Texas, Southwestern Medical Center, Dallas, Texas (W.M.L.)
Inga Peter
Comparative and Molecular Pharmacogenomics Laboratory (M.H.C., M.F., X.W., S.H., S.D.), Department of Molecular Physiology and Pharmacology (D.J.G.), Tufts University School of Medicine, Boston, Massachusetts; Program in Genetics, Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, Massachusetts (M.H.C., M.F.); Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, New York (I.P.); Faculty of Pharmacy, Centre Hospitalier Universitaire de Québec, Laval University, Québec, Québec, Canada (C.G.); and the Department of Internal Medicine, University of Texas, Southwestern Medical Center, Dallas, Texas (W.M.L.)
Chantal Guillemette
Comparative and Molecular Pharmacogenomics Laboratory (M.H.C., M.F., X.W., S.H., S.D.), Department of Molecular Physiology and Pharmacology (D.J.G.), Tufts University School of Medicine, Boston, Massachusetts; Program in Genetics, Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, Massachusetts (M.H.C., M.F.); Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, New York (I.P.); Faculty of Pharmacy, Centre Hospitalier Universitaire de Québec, Laval University, Québec, Québec, Canada (C.G.); and the Department of Internal Medicine, University of Texas, Southwestern Medical Center, Dallas, Texas (W.M.L.)
Suwagmani Hazarika
Comparative and Molecular Pharmacogenomics Laboratory (M.H.C., M.F., X.W., S.H., S.D.), Department of Molecular Physiology and Pharmacology (D.J.G.), Tufts University School of Medicine, Boston, Massachusetts; Program in Genetics, Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, Massachusetts (M.H.C., M.F.); Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, New York (I.P.); Faculty of Pharmacy, Centre Hospitalier Universitaire de Québec, Laval University, Québec, Québec, Canada (C.G.); and the Department of Internal Medicine, University of Texas, Southwestern Medical Center, Dallas, Texas (W.M.L.)
Su X. Duan
Comparative and Molecular Pharmacogenomics Laboratory (M.H.C., M.F., X.W., S.H., S.D.), Department of Molecular Physiology and Pharmacology (D.J.G.), Tufts University School of Medicine, Boston, Massachusetts; Program in Genetics, Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, Massachusetts (M.H.C., M.F.); Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, New York (I.P.); Faculty of Pharmacy, Centre Hospitalier Universitaire de Québec, Laval University, Québec, Québec, Canada (C.G.); and the Department of Internal Medicine, University of Texas, Southwestern Medical Center, Dallas, Texas (W.M.L.)
David J. Greenblatt
Comparative and Molecular Pharmacogenomics Laboratory (M.H.C., M.F., X.W., S.H., S.D.), Department of Molecular Physiology and Pharmacology (D.J.G.), Tufts University School of Medicine, Boston, Massachusetts; Program in Genetics, Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, Massachusetts (M.H.C., M.F.); Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, New York (I.P.); Faculty of Pharmacy, Centre Hospitalier Universitaire de Québec, Laval University, Québec, Québec, Canada (C.G.); and the Department of Internal Medicine, University of Texas, Southwestern Medical Center, Dallas, Texas (W.M.L.)
William M. Lee
Comparative and Molecular Pharmacogenomics Laboratory (M.H.C., M.F., X.W., S.H., S.D.), Department of Molecular Physiology and Pharmacology (D.J.G.), Tufts University School of Medicine, Boston, Massachusetts; Program in Genetics, Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, Massachusetts (M.H.C., M.F.); Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, New York (I.P.); Faculty of Pharmacy, Centre Hospitalier Universitaire de Québec, Laval University, Québec, Québec, Canada (C.G.); and the Department of Internal Medicine, University of Texas, Southwestern Medical Center, Dallas, Texas (W.M.L.)
Comparative and Molecular Pharmacogenomics Laboratory (M.H.C., M.F., X.W., S.H., S.D.), Department of Molecular Physiology and Pharmacology (D.J.G.), Tufts University School of Medicine, Boston, Massachusetts; Program in Genetics, Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, Massachusetts (M.H.C., M.F.); Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, New York (I.P.); Faculty of Pharmacy, Centre Hospitalier Universitaire de Québec, Laval University, Québec, Québec, Canada (C.G.); and the Department of Internal Medicine, University of Texas, Southwestern Medical Center, Dallas, Texas (W.M.L.)
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In this issue
Research ArticleMetabolism, Transport, and Pharmacogenomics
Acetaminophen Pharmacogenomics
Michael H. Court, Marina Freytsis, Xueding Wang, Inga Peter, Chantal Guillemette, Suwagmani Hazarika, Su X. Duan, David J. Greenblatt, William M. Lee and the Acute Liver Failure Study Group
Journal of Pharmacology and Experimental Therapeutics May 1, 2013, 345 (2) 297-307; DOI: https://doi.org/10.1124/jpet.112.202010
Research ArticleMetabolism, Transport, and Pharmacogenomics
Acetaminophen Pharmacogenomics
Michael H. Court, Marina Freytsis, Xueding Wang, Inga Peter, Chantal Guillemette, Suwagmani Hazarika, Su X. Duan, David J. Greenblatt, William M. Lee and the Acute Liver Failure Study Group
Journal of Pharmacology and Experimental Therapeutics May 1, 2013, 345 (2) 297-307; DOI: https://doi.org/10.1124/jpet.112.202010
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