Journal of Pharmacology and Experimental Therapeutics: 345 (2)

May 01, 2013; Volume 345,Issue 2

Highlighted Papers

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CB₁ Receptor Signaling: A Key Interaction between Extracellular-3 Loop and Transmembrane Helix 2
Journal of Pharmacology and Experimental Therapeutics May 2013, 345 (2) 169; DOI: https://doi.org/10.1124/jpet.112.0513HI
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Experimental Models of Disseminated Scedosporiosis with Cerebral Involvement
Journal of Pharmacology and Experimental Therapeutics May 2013, 345 (2) 169; DOI: https://doi.org/10.1124/jpet.112.0513HIa
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Mechanism of LX4211 Induced Increases Serum GLP-1 and PYY Levels
Journal of Pharmacology and Experimental Therapeutics May 2013, 345 (2) 169; DOI: https://doi.org/10.1124/jpet.112.0513HIb
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UGT 1A Polymorphism rs8330 Is Associated with Liver Acetaminophen Glucuronidation
Journal of Pharmacology and Experimental Therapeutics May 2013, 345 (2) 169; DOI: https://doi.org/10.1124/jpet.112.0513HIc

Cardiovascular

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Attenuation by Statins of Membrane Raft-Redox Signaling in Coronary Arterial Endothelium
Yu-Miao Wei, Xiang Li, Jing Xiong, Justine M. Abais, Min Xia, Krishna M. Boini, Yang Zhang and Pin-Lan Li

Journal of Pharmacology and Experimental Therapeutics May 2013, 345 (2) 170-179; DOI: https://doi.org/10.1124/jpet.112.201442

Cellular and Molecular

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Chromatin Remodeling by Rosuvastatin Normalizes TSC2^-/meth Cell Phenotype through the Expression of Tuberin
Elena Lesma, Silvia Ancona, Emanuela Orpianesi, Vera Grande, Anna Maria Di Giulio and Alfredo Gorio

Journal of Pharmacology and Experimental Therapeutics May 2013, 345 (2) 180-188; DOI: https://doi.org/10.1124/jpet.113.203141
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Novel Insights into CB₁ Cannabinoid Receptor Signaling: A Key Interaction Identified between the Extracellular-3 Loop and Transmembrane Helix 2
Jahan Marcu, Derek M. Shore, Ankur Kapur, Megan Trznadel, Alexandros Makriyannis, Patricia H. Reggio and Mary E. Abood

Journal of Pharmacology and Experimental Therapeutics May 2013, 345 (2) 189-197; DOI: https://doi.org/10.1124/jpet.112.201046

Chemotherapy, Antibiotics, and Gene Therapy

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Experimental Models of Disseminated Scedosporiosis with Cerebral Involvement
Bénédicte Lelièvre, Pierre Legras, Charlotte Godon, Florence Franconi, Jean-Paul Saint-André, Jean-Philippe Bouchara and Bertrand Diquet

Journal of Pharmacology and Experimental Therapeutics May 2013, 345 (2) 198-205; DOI: https://doi.org/10.1124/jpet.112.201541

Drug Discovery and Translational Medicine

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Silibinin Synergizes with Histone Deacetylase and DNA Methyltransferase Inhibitors in Upregulating E-cadherin Expression Together with Inhibition of Migration and Invasion of Human Non-small Cell Lung Cancer Cells
Samiha Mateen, Komal Raina, Chapla Agarwal, Daniel Chan and Rajesh Agarwal

Journal of Pharmacology and Experimental Therapeutics May 2013, 345 (2) 206-214; DOI: https://doi.org/10.1124/jpet.113.203471
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Synergistic GABA-Enhancing Therapy against Seizures in a Mouse Model of Dravet Syndrome
John C. Oakley, Alvin R. Cho, Christine S. Cheah, Todd Scheuer and William A. Catterall

Journal of Pharmacology and Experimental Therapeutics May 2013, 345 (2) 215-224; DOI: https://doi.org/10.1124/jpet.113.203331
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Generation and Characterization of Fully Human Monoclonal Antibodies Against Human Orai1 for Autoimmune Disease
Fen-Fen Lin, Robin Elliott, Anne Colombero, Kevin Gaida, Laura Kelley, Angelica Moksa, Shu-Yin Ho, Ekaterina Bykova, Min Wong, Palaniswami Rathanaswami, Sylvia Hu, John K. Sullivan, Hung Q. Nguyen and Helen J. McBride

Journal of Pharmacology and Experimental Therapeutics May 2013, 345 (2) 225-238; DOI: https://doi.org/10.1124/jpet.112.202788

Endocrine and Diabetes

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The Heme Oxygenase System Selectively Enhances the Anti-Inflammatory Macrophage-M2 Phenotype, Reduces Pericardial Adiposity, and Ameliorated Cardiac Injury in Diabetic Cardiomyopathy in Zucker Diabetic Fatty Rats
Ashok Jadhav, Shuchita Tiwari, Paul Lee and Joseph Fomusi Ndisang

Journal of Pharmacology and Experimental Therapeutics May 2013, 345 (2) 239-249; DOI: https://doi.org/10.1124/jpet.112.200808
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LX4211 Increases Serum Glucagon-Like Peptide 1 and Peptide YY Levels by Reducing Sodium/Glucose Cotransporter 1 (SGLT1)–Mediated Absorption of Intestinal Glucose
David R. Powell, Melinda Smith, Jennifer Greer, Angela Harris, Sharon Zhao, Christopher DaCosta, Faika Mseeh, Melanie K. Shadoan, Arthur Sands, Brian Zambrowicz and Zhi-Ming Ding

Journal of Pharmacology and Experimental Therapeutics May 2013, 345 (2) 250-259; DOI: https://doi.org/10.1124/jpet.113.203364

Gastrointestinal, Hepatic, Pulmonary, and Renal

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Pharmacological Characterization of GSK573719 (Umeclidinium): A Novel, Long-Acting, Inhaled Antagonist of the Muscarinic Cholinergic Receptors for Treatment of Pulmonary Diseases
Michael Salmon, Mark A. Luttmann, James J. Foley, Peter T. Buckley, Dulcie B. Schmidt, Miriam Burman, Edward F. Webb, Christopher J. DeHaas, Charles J. Kotzer, Victoria J. Barrett, Robert J. Slack, Henry M. Sarau, Michael R. Palovich, Dramane I. Lainé, Douglas W. P. Hay and William L. Rumsey

Journal of Pharmacology and Experimental Therapeutics May 2013, 345 (2) 260-270; DOI: https://doi.org/10.1124/jpet.112.202051
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Long-Acting Human Serum Albumin-Thioredoxin Fusion Protein Suppresses Bleomycin-Induced Pulmonary Fibrosis Progression
Ryota Tanaka, Hiroshi Watanabe, Azusa Kodama, Victor Tuan Giam Chuang, Yu Ishima, Keisuke Hamasaki, Ken-ichiro Tanaka, Tohru Mizushima, Masaki Otagiri and Toru Maruyama

Journal of Pharmacology and Experimental Therapeutics May 2013, 345 (2) 271-283; DOI: https://doi.org/10.1124/jpet.112.201814

Inflammation, Immunopharmacology, and Asthma

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A Novel Nontoxic Inhibitor of the Activation of NADPH Oxidase Reduces Reactive Oxygen Species Production in Mouse Lung
Intae Lee, Chandra Dodia, Shampa Chatterjee, John Zagorski, Clementina Mesaros, Ian A. Blair, Sheldon I. Feinstein, Mahendra Jain and Aron B. Fisher

Journal of Pharmacology and Experimental Therapeutics May 2013, 345 (2) 284-296; DOI: https://doi.org/10.1124/jpet.112.201079

Metabolism, Transport, and Pharmacogenomics

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The UDP-Glucuronosyltransferase (UGT) 1A Polymorphism c.2042C>G (rs8330) Is Associated with Increased Human Liver Acetaminophen Glucuronidation, Increased UGT1A Exon 5a/5b Splice Variant mRNA Ratio, and Decreased Risk of Unintentional Acetaminophen-Induced Acute Liver Failure
Michael H. Court, Marina Freytsis, Xueding Wang, Inga Peter, Chantal Guillemette, Suwagmani Hazarika, Su X. Duan, David J. Greenblatt, William M. Lee and the Acute Liver Failure Study Group

Journal of Pharmacology and Experimental Therapeutics May 2013, 345 (2) 297-307; DOI: https://doi.org/10.1124/jpet.112.202010
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Metabolism of Beclomethasone Dipropionate by Cytochrome P450 3A Enzymes
Jessica K. Roberts, Chad D. Moore, Robert M. Ward, Garold S. Yost and Christopher A. Reilly

Journal of Pharmacology and Experimental Therapeutics May 2013, 345 (2) 308-316; DOI: https://doi.org/10.1124/jpet.112.202556

Neuropharmacology

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Ethanol Activation of Protein Kinase A Regulates GABA_A α1 Receptor Function and Trafficking in Cultured Cerebral Cortical Neurons
Stephen L. Carlson, Sandeep Kumar, David F. Werner, Christopher E. Comerford and A. Leslie Morrow

Journal of Pharmacology and Experimental Therapeutics May 2013, 345 (2) 317-325; DOI: https://doi.org/10.1124/jpet.112.201954

Errata

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Correction to “R406, an Orally Available Spleen Tyrosine Kinase Inhibitor Blocks Fc Receptor Signaling and Reduces Immune Complex-Mediated Inflammation”
Journal of Pharmacology and Experimental Therapeutics May 2013, 345 (2) 326; DOI: https://doi.org/10.1124/jpet.112.05er13
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Correction to “Using Chimeric Mice with Humanized Livers to Predict Human Drug Metabolism and a Drug-Drug Interaction”
Journal of Pharmacology and Experimental Therapeutics May 2013, 345 (2) 327; DOI: https://doi.org/10.1124/jpet.112.05er13a
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Correction to “ADX71743, a Potent and Selective Negative Allosteric Modulator of Metabotropic Glutamate Receptor 7: In Vitro and In Vivo Characterization”
Journal of Pharmacology and Experimental Therapeutics May 2013, 345 (2) 328; DOI: https://doi.org/10.1124/jpet.112.05er13b
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Correction to “Mending Leaky Blood Vessels: The Angiopoietin-Tie2 Pathway in Sepsis”
Journal of Pharmacology and Experimental Therapeutics May 2013, 345 (2) 329; DOI: https://doi.org/10.1124/jpet.112.05er13c

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Table of Contents

Highlighted Papers

Cardiovascular

Cellular and Molecular

Chemotherapy, Antibiotics, and Gene Therapy

Drug Discovery and Translational Medicine

Endocrine and Diabetes

Gastrointestinal, Hepatic, Pulmonary, and Renal

Inflammation, Immunopharmacology, and Asthma

Metabolism, Transport, and Pharmacogenomics

Neuropharmacology

Errata

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