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Research ArticleInflammation, Immunopharmacology, and Asthma

Positional Isomers of Aspirin Are Equally Potent in Inhibiting Colon Cancer Cell Growth: Differences in Mode of Cyclooxygenase Inhibition

Ravinder Kodela, Mitali Chattopadhyay, Satindra Goswami, Zong Yuan Gan, Praveen P. N. Rao, Kamran V. Nia, Carlos A. Velázquez-Martínez and Khosrow Kashfi
Journal of Pharmacology and Experimental Therapeutics April 2013, 345 (1) 85-94; DOI: https://doi.org/10.1124/jpet.112.201970
Ravinder Kodela
Department of Physiology, Pharmacology, and Neuroscience, Sophie Davis School of Biomedical Education, City University of New York Medical School, New York, New York (R.K., M.C., S.G., Z.Y.G., K.V.N., K.K.); School of Pharmacy Health Science Campus, University of Waterloo, Waterloo, Ontario, Canada (P.P.N.R.); and Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada (C.A.V.-M.)
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Mitali Chattopadhyay
Department of Physiology, Pharmacology, and Neuroscience, Sophie Davis School of Biomedical Education, City University of New York Medical School, New York, New York (R.K., M.C., S.G., Z.Y.G., K.V.N., K.K.); School of Pharmacy Health Science Campus, University of Waterloo, Waterloo, Ontario, Canada (P.P.N.R.); and Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada (C.A.V.-M.)
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Satindra Goswami
Department of Physiology, Pharmacology, and Neuroscience, Sophie Davis School of Biomedical Education, City University of New York Medical School, New York, New York (R.K., M.C., S.G., Z.Y.G., K.V.N., K.K.); School of Pharmacy Health Science Campus, University of Waterloo, Waterloo, Ontario, Canada (P.P.N.R.); and Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada (C.A.V.-M.)
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Zong Yuan Gan
Department of Physiology, Pharmacology, and Neuroscience, Sophie Davis School of Biomedical Education, City University of New York Medical School, New York, New York (R.K., M.C., S.G., Z.Y.G., K.V.N., K.K.); School of Pharmacy Health Science Campus, University of Waterloo, Waterloo, Ontario, Canada (P.P.N.R.); and Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada (C.A.V.-M.)
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Praveen P. N. Rao
Department of Physiology, Pharmacology, and Neuroscience, Sophie Davis School of Biomedical Education, City University of New York Medical School, New York, New York (R.K., M.C., S.G., Z.Y.G., K.V.N., K.K.); School of Pharmacy Health Science Campus, University of Waterloo, Waterloo, Ontario, Canada (P.P.N.R.); and Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada (C.A.V.-M.)
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Kamran V. Nia
Department of Physiology, Pharmacology, and Neuroscience, Sophie Davis School of Biomedical Education, City University of New York Medical School, New York, New York (R.K., M.C., S.G., Z.Y.G., K.V.N., K.K.); School of Pharmacy Health Science Campus, University of Waterloo, Waterloo, Ontario, Canada (P.P.N.R.); and Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada (C.A.V.-M.)
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Carlos A. Velázquez-Martínez
Department of Physiology, Pharmacology, and Neuroscience, Sophie Davis School of Biomedical Education, City University of New York Medical School, New York, New York (R.K., M.C., S.G., Z.Y.G., K.V.N., K.K.); School of Pharmacy Health Science Campus, University of Waterloo, Waterloo, Ontario, Canada (P.P.N.R.); and Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada (C.A.V.-M.)
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Khosrow Kashfi
Department of Physiology, Pharmacology, and Neuroscience, Sophie Davis School of Biomedical Education, City University of New York Medical School, New York, New York (R.K., M.C., S.G., Z.Y.G., K.V.N., K.K.); School of Pharmacy Health Science Campus, University of Waterloo, Waterloo, Ontario, Canada (P.P.N.R.); and Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada (C.A.V.-M.)
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Article Information

vol. 345 no. 1 85-94
DOI 
https://doi.org/10.1124/jpet.112.201970
PubMed 
23349335

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received November 19, 2012
  • Accepted January 8, 2013
  • Published online March 19, 2013.

Article Versions

  • Earlier version (January 24, 2013 - 13:00).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2013 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Ravinder Kodela,
  2. Mitali Chattopadhyay,
  3. Satindra Goswami,
  4. Zong Yuan Gan,
  5. Praveen P. N. Rao,
  6. Kamran V. Nia,
  7. Carlos A. Velázquez-Martínez, and
  8. Khosrow Kashfi
  1. Department of Physiology, Pharmacology, and Neuroscience, Sophie Davis School of Biomedical Education, City University of New York Medical School, New York, New York (R.K., M.C., S.G., Z.Y.G., K.V.N., K.K.); School of Pharmacy Health Science Campus, University of Waterloo, Waterloo, Ontario, Canada (P.P.N.R.); and Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada (C.A.V.-M.)
  1. Address correspondence to:
    Dr. Khosrow Kashfi, Department of Physiology, Pharmacology, and Neuroscience, City University of New York Medical School, 138th Street and Convent Avenue, New York, NY 10031. E-mail: kashfi{at}med.cuny.edu
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Journal of Pharmacology and Experimental Therapeutics: 345 (1)
Journal of Pharmacology and Experimental Therapeutics
Vol. 345, Issue 1
1 Apr 2013
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Research ArticleInflammation, Immunopharmacology, and Asthma

Differential Modes of COX Inhibition by Isomers of Aspirin

Ravinder Kodela, Mitali Chattopadhyay, Satindra Goswami, Zong Yuan Gan, Praveen P. N. Rao, Kamran V. Nia, Carlos A. Velázquez-Martínez and Khosrow Kashfi
Journal of Pharmacology and Experimental Therapeutics April 1, 2013, 345 (1) 85-94; DOI: https://doi.org/10.1124/jpet.112.201970

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Research ArticleInflammation, Immunopharmacology, and Asthma

Differential Modes of COX Inhibition by Isomers of Aspirin

Ravinder Kodela, Mitali Chattopadhyay, Satindra Goswami, Zong Yuan Gan, Praveen P. N. Rao, Kamran V. Nia, Carlos A. Velázquez-Martínez and Khosrow Kashfi
Journal of Pharmacology and Experimental Therapeutics April 1, 2013, 345 (1) 85-94; DOI: https://doi.org/10.1124/jpet.112.201970
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