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Research ArticleInflammation, Immunopharmacology, and Asthma

A Novel Macrolide Solithromycin Exerts Superior Anti-inflammatory Effect via NF-κB Inhibition

Yoshiki Kobayashi, Hiroo Wada, Christos Rossios, Dai Takagi, Manabu Higaki, Shin'ichiro Mikura, Hajime Goto, Peter J. Barnes and Kazuhiro Ito
Journal of Pharmacology and Experimental Therapeutics April 2013, 345 (1) 76-84; DOI: https://doi.org/10.1124/jpet.112.200733
Yoshiki Kobayashi
Airway Disease Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom (Y.K., C.R., D.T., P.J.B., K.I.); and Department of Respiratory Medicine, Kyorin University, School of Medicine, Tokyo, Japan (H.W., M.H., S.M., H.G.)
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Hiroo Wada
Airway Disease Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom (Y.K., C.R., D.T., P.J.B., K.I.); and Department of Respiratory Medicine, Kyorin University, School of Medicine, Tokyo, Japan (H.W., M.H., S.M., H.G.)
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Christos Rossios
Airway Disease Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom (Y.K., C.R., D.T., P.J.B., K.I.); and Department of Respiratory Medicine, Kyorin University, School of Medicine, Tokyo, Japan (H.W., M.H., S.M., H.G.)
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Dai Takagi
Airway Disease Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom (Y.K., C.R., D.T., P.J.B., K.I.); and Department of Respiratory Medicine, Kyorin University, School of Medicine, Tokyo, Japan (H.W., M.H., S.M., H.G.)
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Manabu Higaki
Airway Disease Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom (Y.K., C.R., D.T., P.J.B., K.I.); and Department of Respiratory Medicine, Kyorin University, School of Medicine, Tokyo, Japan (H.W., M.H., S.M., H.G.)
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Shin'ichiro Mikura
Airway Disease Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom (Y.K., C.R., D.T., P.J.B., K.I.); and Department of Respiratory Medicine, Kyorin University, School of Medicine, Tokyo, Japan (H.W., M.H., S.M., H.G.)
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Hajime Goto
Airway Disease Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom (Y.K., C.R., D.T., P.J.B., K.I.); and Department of Respiratory Medicine, Kyorin University, School of Medicine, Tokyo, Japan (H.W., M.H., S.M., H.G.)
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Peter J. Barnes
Airway Disease Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom (Y.K., C.R., D.T., P.J.B., K.I.); and Department of Respiratory Medicine, Kyorin University, School of Medicine, Tokyo, Japan (H.W., M.H., S.M., H.G.)
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Kazuhiro Ito
Airway Disease Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom (Y.K., C.R., D.T., P.J.B., K.I.); and Department of Respiratory Medicine, Kyorin University, School of Medicine, Tokyo, Japan (H.W., M.H., S.M., H.G.)
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Article Information

vol. 345 no. 1 76-84
DOI 
https://doi.org/10.1124/jpet.112.200733
PubMed 
23359665

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received September 28, 2012
  • Accepted December 20, 2012
  • Published online March 19, 2013.

Article Versions

  • Earlier version (January 28, 2013 - 08:47).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2013 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Yoshiki Kobayashi,
  2. Hiroo Wada,
  3. Christos Rossios,
  4. Dai Takagi,
  5. Manabu Higaki,
  6. Shin'ichiro Mikura,
  7. Hajime Goto,
  8. Peter J. Barnes, and
  9. Kazuhiro Ito
  1. Airway Disease Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom (Y.K., C.R., D.T., P.J.B., K.I.); and Department of Respiratory Medicine, Kyorin University, School of Medicine, Tokyo, Japan (H.W., M.H., S.M., H.G.)
  1. Address correspondence to:
    Kazuhiro Ito, Airway Disease Section, National Heart and Lung Institute, Imperial College London, Guy Scadding Building, Royal Brompton Campus, Dovehouse Street, London SW3 6LY. E-mail: k.ito{at}imperial.ac.uk
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Journal of Pharmacology and Experimental Therapeutics: 345 (1)
Journal of Pharmacology and Experimental Therapeutics
Vol. 345, Issue 1
1 Apr 2013
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Research ArticleInflammation, Immunopharmacology, and Asthma

Anti-inflammatory Effect of Solithromycin

Yoshiki Kobayashi, Hiroo Wada, Christos Rossios, Dai Takagi, Manabu Higaki, Shin'ichiro Mikura, Hajime Goto, Peter J. Barnes and Kazuhiro Ito
Journal of Pharmacology and Experimental Therapeutics April 1, 2013, 345 (1) 76-84; DOI: https://doi.org/10.1124/jpet.112.200733

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Research ArticleInflammation, Immunopharmacology, and Asthma

Anti-inflammatory Effect of Solithromycin

Yoshiki Kobayashi, Hiroo Wada, Christos Rossios, Dai Takagi, Manabu Higaki, Shin'ichiro Mikura, Hajime Goto, Peter J. Barnes and Kazuhiro Ito
Journal of Pharmacology and Experimental Therapeutics April 1, 2013, 345 (1) 76-84; DOI: https://doi.org/10.1124/jpet.112.200733
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