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Research ArticleDrug Discovery and Translational Medicine

In Vitro–In Vivo Correlation of the Inhibition Potency of Sodium-Glucose Cotransporter Inhibitors in Rat: A Pharmacokinetic and Pharmacodynamic Modeling Approach

Koji Yamaguchi, Motohiro Kato, Masayuki Suzuki, Hitoshi Hagita, Maiko Takada, Miho Ayabe, Yoshinori Aso, Masaki Ishigai and Sachiya Ikeda
Journal of Pharmacology and Experimental Therapeutics April 2013, 345 (1) 52-61; DOI: https://doi.org/10.1124/jpet.113.203125

Article Information

vol. 345 no. 1 52-61
DOI 
https://doi.org/10.1124/jpet.113.203125
PubMed 
23386251
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received January 8, 2013
  • Accepted February 4, 2013
  • Published online March 19, 2013.

Article Versions

Copyright & Usage 
Copyright © 2013 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Koji Yamaguchi,
  2. Motohiro Kato,
  3. Masayuki Suzuki,
  4. Hitoshi Hagita,
  5. Maiko Takada,
  6. Miho Ayabe,
  7. Yoshinori Aso,
  8. Masaki Ishigai, and
  9. Sachiya Ikeda
  1. Research Division, Chugai Pharmaceutical Co., Ltd., (K.Y., M.K., M.S., M.T., M.A., Y.A., M.I., S.I.), and Chugai Research Institute for Medical Science, Inc. (H.H.), Gotemba, Shizuoka, Japan
  1. Address correspondence to:
    Koji Yamaguchi, Research Division, Chugai Pharmaceutical Co., Ltd., 1-135 Komakado, Gotemba, Shizuoka 412-8513, Japan. E-mail: yamaguchikuj{at}chugai-pharm.co.jp
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Research ArticleDrug Discovery and Translational Medicine

IVIVC for Inhibition Potency of SGLT Inhibitors

Koji Yamaguchi, Motohiro Kato, Masayuki Suzuki, Hitoshi Hagita, Maiko Takada, Miho Ayabe, Yoshinori Aso, Masaki Ishigai and Sachiya Ikeda
Journal of Pharmacology and Experimental Therapeutics April 1, 2013, 345 (1) 52-61; DOI: https://doi.org/10.1124/jpet.113.203125
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