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Research ArticleDrug Discovery and Translational Medicine

In Vitro–In Vivo Correlation of the Inhibition Potency of Sodium-Glucose Cotransporter Inhibitors in Rat: A Pharmacokinetic and Pharmacodynamic Modeling Approach

Koji Yamaguchi, Motohiro Kato, Masayuki Suzuki, Hitoshi Hagita, Maiko Takada, Miho Ayabe, Yoshinori Aso, Masaki Ishigai and Sachiya Ikeda
Journal of Pharmacology and Experimental Therapeutics April 2013, 345 (1) 52-61; DOI: https://doi.org/10.1124/jpet.113.203125
Koji Yamaguchi
Research Division, Chugai Pharmaceutical Co., Ltd., (K.Y., M.K., M.S., M.T., M.A., Y.A., M.I., S.I.), and Chugai Research Institute for Medical Science, Inc. (H.H.), Gotemba, Shizuoka, Japan
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Motohiro Kato
Research Division, Chugai Pharmaceutical Co., Ltd., (K.Y., M.K., M.S., M.T., M.A., Y.A., M.I., S.I.), and Chugai Research Institute for Medical Science, Inc. (H.H.), Gotemba, Shizuoka, Japan
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Masayuki Suzuki
Research Division, Chugai Pharmaceutical Co., Ltd., (K.Y., M.K., M.S., M.T., M.A., Y.A., M.I., S.I.), and Chugai Research Institute for Medical Science, Inc. (H.H.), Gotemba, Shizuoka, Japan
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Hitoshi Hagita
Research Division, Chugai Pharmaceutical Co., Ltd., (K.Y., M.K., M.S., M.T., M.A., Y.A., M.I., S.I.), and Chugai Research Institute for Medical Science, Inc. (H.H.), Gotemba, Shizuoka, Japan
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Maiko Takada
Research Division, Chugai Pharmaceutical Co., Ltd., (K.Y., M.K., M.S., M.T., M.A., Y.A., M.I., S.I.), and Chugai Research Institute for Medical Science, Inc. (H.H.), Gotemba, Shizuoka, Japan
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Miho Ayabe
Research Division, Chugai Pharmaceutical Co., Ltd., (K.Y., M.K., M.S., M.T., M.A., Y.A., M.I., S.I.), and Chugai Research Institute for Medical Science, Inc. (H.H.), Gotemba, Shizuoka, Japan
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Yoshinori Aso
Research Division, Chugai Pharmaceutical Co., Ltd., (K.Y., M.K., M.S., M.T., M.A., Y.A., M.I., S.I.), and Chugai Research Institute for Medical Science, Inc. (H.H.), Gotemba, Shizuoka, Japan
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Masaki Ishigai
Research Division, Chugai Pharmaceutical Co., Ltd., (K.Y., M.K., M.S., M.T., M.A., Y.A., M.I., S.I.), and Chugai Research Institute for Medical Science, Inc. (H.H.), Gotemba, Shizuoka, Japan
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Sachiya Ikeda
Research Division, Chugai Pharmaceutical Co., Ltd., (K.Y., M.K., M.S., M.T., M.A., Y.A., M.I., S.I.), and Chugai Research Institute for Medical Science, Inc. (H.H.), Gotemba, Shizuoka, Japan
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Article Information

vol. 345 no. 1 52-61
DOI 
https://doi.org/10.1124/jpet.113.203125
PubMed 
23386251

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received January 8, 2013
  • Accepted February 4, 2013
  • Published online March 19, 2013.

Article Versions

  • Earlier version (February 5, 2013 - 07:20).
  • Earlier version (February 6, 2013 - 04:40).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2013 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Koji Yamaguchi,
  2. Motohiro Kato,
  3. Masayuki Suzuki,
  4. Hitoshi Hagita,
  5. Maiko Takada,
  6. Miho Ayabe,
  7. Yoshinori Aso,
  8. Masaki Ishigai, and
  9. Sachiya Ikeda
  1. Research Division, Chugai Pharmaceutical Co., Ltd., (K.Y., M.K., M.S., M.T., M.A., Y.A., M.I., S.I.), and Chugai Research Institute for Medical Science, Inc. (H.H.), Gotemba, Shizuoka, Japan
  1. Address correspondence to:
    Koji Yamaguchi, Research Division, Chugai Pharmaceutical Co., Ltd., 1-135 Komakado, Gotemba, Shizuoka 412-8513, Japan. E-mail: yamaguchikuj{at}chugai-pharm.co.jp
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Journal of Pharmacology and Experimental Therapeutics: 345 (1)
Journal of Pharmacology and Experimental Therapeutics
Vol. 345, Issue 1
1 Apr 2013
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Research ArticleDrug Discovery and Translational Medicine

IVIVC for Inhibition Potency of SGLT Inhibitors

Koji Yamaguchi, Motohiro Kato, Masayuki Suzuki, Hitoshi Hagita, Maiko Takada, Miho Ayabe, Yoshinori Aso, Masaki Ishigai and Sachiya Ikeda
Journal of Pharmacology and Experimental Therapeutics April 1, 2013, 345 (1) 52-61; DOI: https://doi.org/10.1124/jpet.113.203125

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Research ArticleDrug Discovery and Translational Medicine

IVIVC for Inhibition Potency of SGLT Inhibitors

Koji Yamaguchi, Motohiro Kato, Masayuki Suzuki, Hitoshi Hagita, Maiko Takada, Miho Ayabe, Yoshinori Aso, Masaki Ishigai and Sachiya Ikeda
Journal of Pharmacology and Experimental Therapeutics April 1, 2013, 345 (1) 52-61; DOI: https://doi.org/10.1124/jpet.113.203125
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