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Research ArticlePerspectives in Pharmacology

Mending Leaky Blood Vessels: The Angiopoietin-Tie2 Pathway in Sepsis

Sascha David, Philipp Kümpers, Paul van Slyke and Samir M. Parikh
Journal of Pharmacology and Experimental Therapeutics April 2013, 345 (1) 2-6; DOI: https://doi.org/10.1124/jpet.112.201061
Sascha David
Department of Nephrology & Hypertension, Medical School Hannover, Hannover, Germany (S.D.); Department of Medicine D, Division of General Internal Medicine, Nephrology, and Rheumatology, University Hospital Münster, Münster, Germany (P.K.); Biological Sciences Platform, Sunnybrook Research Institute, University of Toronto, Toronto, Ontario, Canada (P.v.S.); Center for Vascular Biology Research, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts (S.M.P.)
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Philipp Kümpers
Department of Nephrology & Hypertension, Medical School Hannover, Hannover, Germany (S.D.); Department of Medicine D, Division of General Internal Medicine, Nephrology, and Rheumatology, University Hospital Münster, Münster, Germany (P.K.); Biological Sciences Platform, Sunnybrook Research Institute, University of Toronto, Toronto, Ontario, Canada (P.v.S.); Center for Vascular Biology Research, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts (S.M.P.)
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Paul van Slyke
Department of Nephrology & Hypertension, Medical School Hannover, Hannover, Germany (S.D.); Department of Medicine D, Division of General Internal Medicine, Nephrology, and Rheumatology, University Hospital Münster, Münster, Germany (P.K.); Biological Sciences Platform, Sunnybrook Research Institute, University of Toronto, Toronto, Ontario, Canada (P.v.S.); Center for Vascular Biology Research, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts (S.M.P.)
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Samir M. Parikh
Department of Nephrology & Hypertension, Medical School Hannover, Hannover, Germany (S.D.); Department of Medicine D, Division of General Internal Medicine, Nephrology, and Rheumatology, University Hospital Münster, Münster, Germany (P.K.); Biological Sciences Platform, Sunnybrook Research Institute, University of Toronto, Toronto, Ontario, Canada (P.v.S.); Center for Vascular Biology Research, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts (S.M.P.)
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This article has corrections. Please see:

  • Correction to “Mending Leaky Blood Vessels: The Angiopoietin-Tie2 Pathway in Sepsis” - May 01, 2013
  • Correction to “Mending Leaky Blood Vessels: The Angiopoietin-Tie2 Pathway in Sepsis” - May 01, 2013

Abstract

Sepsis is a systemic inflammatory response to infection. A common end-feature, these patients regularly suffer from is the so-called multiple organ dysfunction syndrome, an often fatal consequence of organ hypoperfusion, coagulopathy, immune dysregulation, and mitochondrial dysfunction. Microvascular dysfunction critically contributes to the morbidity and mortality of this disease. The angiopoietin (Angpt)/Tie2 system consists of the transmembrane endothelial tyrosine kinase Tie2 and its circulating ligands (Angpt-1, -2, and -3/4). The balance between the canonical agonist Angpt-1 and its competitive inhibitor, Angpt-2, regulates basal endothelial barrier function and the leakage and vascular inflammation that develop in response to pathogens and cytokines. Here we summarize recent work in mice and men to highlight the therapeutic potential in this pathway to prevent or even reverse microvascular dysfunction in this deadly disease.

Footnotes

    • Received October 17, 2012.
    • Accepted January 28, 2013.
  • dx.doi.org/10.1124/jpet.112.201061.

  • Copyright © 2013 by The American Society for Pharmacology and Experimental Therapeutics
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Journal of Pharmacology and Experimental Therapeutics: 345 (1)
Journal of Pharmacology and Experimental Therapeutics
Vol. 345, Issue 1
1 Apr 2013
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Research ArticlePerspectives in Pharmacology

Angiopoietin/Tie2 in Sepsis

Sascha David, Philipp Kümpers, Paul van Slyke and Samir M. Parikh
Journal of Pharmacology and Experimental Therapeutics April 1, 2013, 345 (1) 2-6; DOI: https://doi.org/10.1124/jpet.112.201061

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Research ArticlePerspectives in Pharmacology

Angiopoietin/Tie2 in Sepsis

Sascha David, Philipp Kümpers, Paul van Slyke and Samir M. Parikh
Journal of Pharmacology and Experimental Therapeutics April 1, 2013, 345 (1) 2-6; DOI: https://doi.org/10.1124/jpet.112.201061
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