Journal of Pharmacology and Experimental Therapeutics: 345 (1)

April 01, 2013; Volume 345,Issue 1

Highlighted Papers

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Paclitaxel Ameliorates Lipopolysaccharide-Induced Kidney Injury by Binding Myeloid Differentiation Protein-2
Journal of Pharmacology and Experimental Therapeutics April 2013, 345 (1) 1; DOI: https://doi.org/10.1124/jpet.112.0413HI
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Quantifying the Attenuation of the Ketamine Pharmacological Magnetic Resonance Imaging Response in Humans
Journal of Pharmacology and Experimental Therapeutics April 2013, 345 (1) 1; DOI: https://doi.org/10.1124/jpet.112.0413HIa
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A Novel Macrolide Solithromycin Exerts Superior Anti-inflammatory Effect
Journal of Pharmacology and Experimental Therapeutics April 2013, 345 (1) 1; DOI: https://doi.org/10.1124/jpet.112.0413HIb
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Refining the UGT1A Haplotype Associated with Irinotecan-Induced Hematological Toxicity in Patients with Colorectal Cancer
Journal of Pharmacology and Experimental Therapeutics April 2013, 345 (1) 1; DOI: https://doi.org/10.1124/jpet.112.0413HIc

Perspectives in Pharmacology

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Mending Leaky Blood Vessels: The Angiopoietin-Tie2 Pathway in Sepsis
Sascha David, Philipp Kümpers, Paul van Slyke and Samir M. Parikh

Journal of Pharmacology and Experimental Therapeutics April 2013, 345 (1) 2-6; DOI: https://doi.org/10.1124/jpet.112.201061

Cardiovascular

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Peroxynitrite Mediates Testosterone-Induced Vasodilation of Microvascular Resistance Vessels
Yashoda Puttabyatappa, John N. Stallone, Adviye Ergul, Azza B. El-Remessy, Sanjiv Kumar, Stephen Black, Maribeth Johnson, Mary P. Owen and Richard E. White

Journal of Pharmacology and Experimental Therapeutics April 2013, 345 (1) 7-14; DOI: https://doi.org/10.1124/jpet.112.201947
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Pharmacologic Protein Kinase Cα Inhibition Uncouples Human Platelet-Stimulated Angiogenesis from Collagen-Induced Aggregation
Cesar Moncada de la Rosa, Aneta Radziwon-Balicka, Haitham El-Sikhry, John Seubert, Peter P. Ruvolo, Marek W. Radomski and Paul Jurasz

Journal of Pharmacology and Experimental Therapeutics April 2013, 345 (1) 15-24; DOI: https://doi.org/10.1124/jpet.112.200881
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Prolyl-Hydroxylase Inhibition Preserves Endothelial Cell Function in a Rat Model of Vascular Ischemia Reperfusion Injury
Enikő Barnucz, Gábor Veres, Péter Hegedűs, Stephanie Klein, Raphael Zöller, Tamás Radovits, Sevil Korkmaz, Ferenc Horkay, Béla Merkely, Matthias Karck and Gábor Szabó

Journal of Pharmacology and Experimental Therapeutics April 2013, 345 (1) 25-31; DOI: https://doi.org/10.1124/jpet.112.200790
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Impaired Function of Prejunctional Adenosine A₁ Receptors Expressed by Perivascular Sympathetic Nerves in DOCA-Salt Hypertensive Rats
Sutheera Sangsiri, Hua Dong, Gregory M. Swain, James J. Galligan and Hui Xu

Journal of Pharmacology and Experimental Therapeutics April 2013, 345 (1) 32-40; DOI: https://doi.org/10.1124/jpet.112.199612

Drug Discovery and Translational Medicine

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Parallel Buprenorphine phMRI Responses in Conscious Rodents and Healthy Human Subjects
Lino Becerra, Jaymin Upadhyay, Pei-Ching Chang, James Bishop, Julie Anderson, Richard Baumgartner, Adam J. Schwarz, Alexandre Coimbra, Diana Wallin, Lauren Nutile, Edward George, Gary Maier, Soujanya Sunkaraneni, Smriti Iyengar, Jeffrey L. Evelhoch, David Bleakman, Richard Hargreaves and David Borsook

Journal of Pharmacology and Experimental Therapeutics April 2013, 345 (1) 41-51; DOI: https://doi.org/10.1124/jpet.112.201145
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In Vitro–In Vivo Correlation of the Inhibition Potency of Sodium-Glucose Cotransporter Inhibitors in Rat: A Pharmacokinetic and Pharmacodynamic Modeling Approach
Koji Yamaguchi, Motohiro Kato, Masayuki Suzuki, Hitoshi Hagita, Maiko Takada, Miho Ayabe, Yoshinori Aso, Masaki Ishigai and Sachiya Ikeda

Journal of Pharmacology and Experimental Therapeutics April 2013, 345 (1) 52-61; DOI: https://doi.org/10.1124/jpet.113.203125

Endocrine and Diabetes

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Adiponectin Enhances Calcium Dependency of Mouse Bladder Contraction Mediated by Protein Kinase Cα Expression
Koji Nobe, Akiko Fujii, Kiyomi Saito, Takaharu Negoro, Yoshio Ogawa, Yasuko Nakano, Terumasa Hashimoto and Kazuo Honda

Journal of Pharmacology and Experimental Therapeutics April 2013, 345 (1) 62-68; DOI: https://doi.org/10.1124/jpet.112.202028

Gastrointestinal, Hepatic, Pulmonary, and Renal

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Paclitaxel Ameliorates Lipopolysaccharide-Induced Kidney Injury by Binding Myeloid Differentiation Protein-2 to Block Toll-Like Receptor 4–Mediated Nuclear Factor-κB Activation and Cytokine Production
Dongshan Zhang, Yijian Li, Yu Liu, Xudong Xiang and Zheng Dong

Journal of Pharmacology and Experimental Therapeutics April 2013, 345 (1) 69-75; DOI: https://doi.org/10.1124/jpet.112.202481

Inflammation, Immunopharmacology, and Asthma

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A Novel Macrolide Solithromycin Exerts Superior Anti-inflammatory Effect via NF-κB Inhibition
Yoshiki Kobayashi, Hiroo Wada, Christos Rossios, Dai Takagi, Manabu Higaki, Shin'ichiro Mikura, Hajime Goto, Peter J. Barnes and Kazuhiro Ito

Journal of Pharmacology and Experimental Therapeutics April 2013, 345 (1) 76-84; DOI: https://doi.org/10.1124/jpet.112.200733
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Positional Isomers of Aspirin Are Equally Potent in Inhibiting Colon Cancer Cell Growth: Differences in Mode of Cyclooxygenase Inhibition
Ravinder Kodela, Mitali Chattopadhyay, Satindra Goswami, Zong Yuan Gan, Praveen P. N. Rao, Kamran V. Nia, Carlos A. Velázquez-Martínez and Khosrow Kashfi

Journal of Pharmacology and Experimental Therapeutics April 2013, 345 (1) 85-94; DOI: https://doi.org/10.1124/jpet.112.201970

Metabolism, Transport, and Pharmacogenomics

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Refining the UGT1A Haplotype Associated with Irinotecan-Induced Hematological Toxicity in Metastatic Colorectal Cancer Patients Treated with 5-Fluorouracil/Irinotecan-Based Regimens
Éric Lévesque, Anne-Sophie Bélanger, Mario Harvey, Félix Couture, Derek Jonker, Federico Innocenti, Erica Cecchin, Giuseppe Toffoli and Chantal Guillemette

Journal of Pharmacology and Experimental Therapeutics April 2013, 345 (1) 95-101; DOI: https://doi.org/10.1124/jpet.112.202242
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Effects of Monocarboxylate Transporter Inhibition on the Oral Toxicokinetics/Toxicodynamics of γ-Hydroxybutyrate and γ-Butyrolactone
Bridget L. Morse and Marilyn E. Morris

Journal of Pharmacology and Experimental Therapeutics April 2013, 345 (1) 102-110; DOI: https://doi.org/10.1124/jpet.112.202796
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Saturable Active Efflux by P-Glycoprotein and Breast Cancer Resistance Protein at the Blood-Brain Barrier Leads to Nonlinear Distribution of Elacridar to the Central Nervous System
Ramola Sane, Sagar Agarwal, Rajendar K. Mittapalli and William F. Elmquist

Journal of Pharmacology and Experimental Therapeutics April 2013, 345 (1) 111-124; DOI: https://doi.org/10.1124/jpet.112.199786

Neuropharmacology

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Neuroprotective Efficacy and Pharmacokinetic Behavior of Novel Anti-Inflammatory Para-Phenyl Substituted Diindolylmethanes in a Mouse Model of Parkinson’s Disease
Briana R. De Miranda, James A. Miller, Ryan J. Hansen, Paul J. Lunghofer, Stephen Safe, Daniel L. Gustafson, Dorothy Colagiovanni and Ronald B. Tjalkens

Journal of Pharmacology and Experimental Therapeutics April 2013, 345 (1) 125-138; DOI: https://doi.org/10.1124/jpet.112.201558
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Group I mGluRs Evoke K-ATP Current by Intracellular Ca²⁺ Mobilization in Rat Subthalamus Neurons
Ke-Zhong Shen and Steven W. Johnson

Journal of Pharmacology and Experimental Therapeutics April 2013, 345 (1) 139-150; DOI: https://doi.org/10.1124/jpet.112.201566
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Quantifying the Attenuation of the Ketamine Pharmacological Magnetic Resonance Imaging Response in Humans: A Validation Using Antipsychotic and Glutamatergic Agents
O. M. Doyle, S. De Simoni, A. J. Schwarz, C. Brittain, O. G. O’Daly, S. C. R. Williams and M. A. Mehta

Journal of Pharmacology and Experimental Therapeutics April 2013, 345 (1) 151-160; DOI: https://doi.org/10.1124/jpet.112.201665
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Upregulation of Nuclear Factor of Activated T-Cells by Nerve Injury Contributes to Development of Neuropathic Pain
You-Qing Cai, Shao-Rui Chen and Hui-Lin Pan

Journal of Pharmacology and Experimental Therapeutics April 2013, 345 (1) 161-168; DOI: https://doi.org/10.1124/jpet.112.202192

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Table of Contents

Highlighted Papers

Perspectives in Pharmacology

Cardiovascular

Drug Discovery and Translational Medicine

Endocrine and Diabetes

Gastrointestinal, Hepatic, Pulmonary, and Renal

Inflammation, Immunopharmacology, and Asthma

Metabolism, Transport, and Pharmacogenomics

Neuropharmacology

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