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Research ArticleNeuropharmacology

A G Protein-Biased Ligand at the μ-Opioid Receptor Is Potently Analgesic with Reduced Gastrointestinal and Respiratory Dysfunction Compared with Morphine

Scott M. DeWire, Dennis S. Yamashita, David H. Rominger, Guodong Liu, Conrad L. Cowan, Thomas M. Graczyk, Xiao-Tao Chen, Philip M. Pitis, Dimitar Gotchev, Catherine Yuan, Michael Koblish, Michael W. Lark and Jonathan D. Violin
Journal of Pharmacology and Experimental Therapeutics March 2013, 344 (3) 708-717; DOI: https://doi.org/10.1124/jpet.112.201616
Scott M. DeWire
Trevena Inc, King of Prussia, Pennsylvania
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Dennis S. Yamashita
Trevena Inc, King of Prussia, Pennsylvania
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David H. Rominger
Trevena Inc, King of Prussia, Pennsylvania
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Guodong Liu
Trevena Inc, King of Prussia, Pennsylvania
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Conrad L. Cowan
Trevena Inc, King of Prussia, Pennsylvania
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Thomas M. Graczyk
Trevena Inc, King of Prussia, Pennsylvania
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Xiao-Tao Chen
Trevena Inc, King of Prussia, Pennsylvania
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Philip M. Pitis
Trevena Inc, King of Prussia, Pennsylvania
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Dimitar Gotchev
Trevena Inc, King of Prussia, Pennsylvania
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Catherine Yuan
Trevena Inc, King of Prussia, Pennsylvania
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Michael Koblish
Trevena Inc, King of Prussia, Pennsylvania
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Michael W. Lark
Trevena Inc, King of Prussia, Pennsylvania
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Jonathan D. Violin
Trevena Inc, King of Prussia, Pennsylvania
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Article Information

vol. 344 no. 3 708-717
DOI 
https://doi.org/10.1124/jpet.112.201616
PubMed 
23300227

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received November 5, 2012
  • Accepted January 7, 2013
  • Published online February 19, 2013.

Article Versions

  • Earlier version (January 8, 2013 - 12:31).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2013 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Scott M. DeWire,
  2. Dennis S. Yamashita,
  3. David H. Rominger,
  4. Guodong Liu,
  5. Conrad L. Cowan,
  6. Thomas M. Graczyk,
  7. Xiao-Tao Chen,
  8. Philip M. Pitis,
  9. Dimitar Gotchev,
  10. Catherine Yuan,
  11. Michael Koblish,
  12. Michael W. Lark, and
  13. Jonathan D. Violin
  1. Trevena Inc, King of Prussia, Pennsylvania
  1. Address correspondence to:
    Dr. Jonathan Violin, Trevena Inc., 1018 West 8th Ave., Suite A, King of Prussia, PA 19406. E-mail: jviolin{at}trevenainc.com
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Journal of Pharmacology and Experimental Therapeutics: 344 (3)
Journal of Pharmacology and Experimental Therapeutics
Vol. 344, Issue 3
1 Mar 2013
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Research ArticleNeuropharmacology

TRV130: A μ-Opioid Receptor-Biased Ligand

Scott M. DeWire, Dennis S. Yamashita, David H. Rominger, Guodong Liu, Conrad L. Cowan, Thomas M. Graczyk, Xiao-Tao Chen, Philip M. Pitis, Dimitar Gotchev, Catherine Yuan, Michael Koblish, Michael W. Lark and Jonathan D. Violin
Journal of Pharmacology and Experimental Therapeutics March 1, 2013, 344 (3) 708-717; DOI: https://doi.org/10.1124/jpet.112.201616

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Research ArticleNeuropharmacology

TRV130: A μ-Opioid Receptor-Biased Ligand

Scott M. DeWire, Dennis S. Yamashita, David H. Rominger, Guodong Liu, Conrad L. Cowan, Thomas M. Graczyk, Xiao-Tao Chen, Philip M. Pitis, Dimitar Gotchev, Catherine Yuan, Michael Koblish, Michael W. Lark and Jonathan D. Violin
Journal of Pharmacology and Experimental Therapeutics March 1, 2013, 344 (3) 708-717; DOI: https://doi.org/10.1124/jpet.112.201616
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