Research ArticleMetabolism, Transport, and Pharmacogenomics
Cynomolgus Monkey as a Potential Model to Assess Drug Interactions Involving Hepatic Organic Anion Transporting Polypeptides: In Vitro, In Vivo, and In Vitro-to-In Vivo Extrapolation
Hong Shen, Zheng Yang, Gabe Mintier, Yong-Hae Han, Cliff Chen, Praveen Balimane, Mohammed Jemal, Weiping Zhao, Renjie Zhang, Sanjith Kallipatti, Sabariya Selvam, Sunil Sukrutharaj, Prasad Krishnamurthy, Punit Marathe and A. David Rodrigues
Journal of Pharmacology and Experimental Therapeutics March 2013, 344 (3) 673-685; DOI: https://doi.org/10.1124/jpet.112.200691
Hong Shen
Departments of Pharmaceutical Candidate Optimization (H.S., Z.Y., Y.-H.H., C.C., P.B., M.J., W.Z., P.M., A.D.R.) and Genomic Technologies (G.M.), Bristol-Myers Squibb Research and Development, Princeton, New Jersey; Department of Molecular Biology, Bristol-Myers Squibb Biocon R&D Center, Bangalore, India (S.K., Sa.S., Su.S., P.K.); and Department of Bioanalytical Service, WuXi AppTec Co., Ltd, Shanghai, China (R.Z.)
Zheng Yang
Departments of Pharmaceutical Candidate Optimization (H.S., Z.Y., Y.-H.H., C.C., P.B., M.J., W.Z., P.M., A.D.R.) and Genomic Technologies (G.M.), Bristol-Myers Squibb Research and Development, Princeton, New Jersey; Department of Molecular Biology, Bristol-Myers Squibb Biocon R&D Center, Bangalore, India (S.K., Sa.S., Su.S., P.K.); and Department of Bioanalytical Service, WuXi AppTec Co., Ltd, Shanghai, China (R.Z.)
Gabe Mintier
Departments of Pharmaceutical Candidate Optimization (H.S., Z.Y., Y.-H.H., C.C., P.B., M.J., W.Z., P.M., A.D.R.) and Genomic Technologies (G.M.), Bristol-Myers Squibb Research and Development, Princeton, New Jersey; Department of Molecular Biology, Bristol-Myers Squibb Biocon R&D Center, Bangalore, India (S.K., Sa.S., Su.S., P.K.); and Department of Bioanalytical Service, WuXi AppTec Co., Ltd, Shanghai, China (R.Z.)
Yong-Hae Han
Departments of Pharmaceutical Candidate Optimization (H.S., Z.Y., Y.-H.H., C.C., P.B., M.J., W.Z., P.M., A.D.R.) and Genomic Technologies (G.M.), Bristol-Myers Squibb Research and Development, Princeton, New Jersey; Department of Molecular Biology, Bristol-Myers Squibb Biocon R&D Center, Bangalore, India (S.K., Sa.S., Su.S., P.K.); and Department of Bioanalytical Service, WuXi AppTec Co., Ltd, Shanghai, China (R.Z.)
Cliff Chen
Departments of Pharmaceutical Candidate Optimization (H.S., Z.Y., Y.-H.H., C.C., P.B., M.J., W.Z., P.M., A.D.R.) and Genomic Technologies (G.M.), Bristol-Myers Squibb Research and Development, Princeton, New Jersey; Department of Molecular Biology, Bristol-Myers Squibb Biocon R&D Center, Bangalore, India (S.K., Sa.S., Su.S., P.K.); and Department of Bioanalytical Service, WuXi AppTec Co., Ltd, Shanghai, China (R.Z.)
Praveen Balimane
Departments of Pharmaceutical Candidate Optimization (H.S., Z.Y., Y.-H.H., C.C., P.B., M.J., W.Z., P.M., A.D.R.) and Genomic Technologies (G.M.), Bristol-Myers Squibb Research and Development, Princeton, New Jersey; Department of Molecular Biology, Bristol-Myers Squibb Biocon R&D Center, Bangalore, India (S.K., Sa.S., Su.S., P.K.); and Department of Bioanalytical Service, WuXi AppTec Co., Ltd, Shanghai, China (R.Z.)
Mohammed Jemal
Departments of Pharmaceutical Candidate Optimization (H.S., Z.Y., Y.-H.H., C.C., P.B., M.J., W.Z., P.M., A.D.R.) and Genomic Technologies (G.M.), Bristol-Myers Squibb Research and Development, Princeton, New Jersey; Department of Molecular Biology, Bristol-Myers Squibb Biocon R&D Center, Bangalore, India (S.K., Sa.S., Su.S., P.K.); and Department of Bioanalytical Service, WuXi AppTec Co., Ltd, Shanghai, China (R.Z.)
Weiping Zhao
Departments of Pharmaceutical Candidate Optimization (H.S., Z.Y., Y.-H.H., C.C., P.B., M.J., W.Z., P.M., A.D.R.) and Genomic Technologies (G.M.), Bristol-Myers Squibb Research and Development, Princeton, New Jersey; Department of Molecular Biology, Bristol-Myers Squibb Biocon R&D Center, Bangalore, India (S.K., Sa.S., Su.S., P.K.); and Department of Bioanalytical Service, WuXi AppTec Co., Ltd, Shanghai, China (R.Z.)
Renjie Zhang
Departments of Pharmaceutical Candidate Optimization (H.S., Z.Y., Y.-H.H., C.C., P.B., M.J., W.Z., P.M., A.D.R.) and Genomic Technologies (G.M.), Bristol-Myers Squibb Research and Development, Princeton, New Jersey; Department of Molecular Biology, Bristol-Myers Squibb Biocon R&D Center, Bangalore, India (S.K., Sa.S., Su.S., P.K.); and Department of Bioanalytical Service, WuXi AppTec Co., Ltd, Shanghai, China (R.Z.)
Sanjith Kallipatti
Departments of Pharmaceutical Candidate Optimization (H.S., Z.Y., Y.-H.H., C.C., P.B., M.J., W.Z., P.M., A.D.R.) and Genomic Technologies (G.M.), Bristol-Myers Squibb Research and Development, Princeton, New Jersey; Department of Molecular Biology, Bristol-Myers Squibb Biocon R&D Center, Bangalore, India (S.K., Sa.S., Su.S., P.K.); and Department of Bioanalytical Service, WuXi AppTec Co., Ltd, Shanghai, China (R.Z.)
Sabariya Selvam
Departments of Pharmaceutical Candidate Optimization (H.S., Z.Y., Y.-H.H., C.C., P.B., M.J., W.Z., P.M., A.D.R.) and Genomic Technologies (G.M.), Bristol-Myers Squibb Research and Development, Princeton, New Jersey; Department of Molecular Biology, Bristol-Myers Squibb Biocon R&D Center, Bangalore, India (S.K., Sa.S., Su.S., P.K.); and Department of Bioanalytical Service, WuXi AppTec Co., Ltd, Shanghai, China (R.Z.)
Sunil Sukrutharaj
Departments of Pharmaceutical Candidate Optimization (H.S., Z.Y., Y.-H.H., C.C., P.B., M.J., W.Z., P.M., A.D.R.) and Genomic Technologies (G.M.), Bristol-Myers Squibb Research and Development, Princeton, New Jersey; Department of Molecular Biology, Bristol-Myers Squibb Biocon R&D Center, Bangalore, India (S.K., Sa.S., Su.S., P.K.); and Department of Bioanalytical Service, WuXi AppTec Co., Ltd, Shanghai, China (R.Z.)
Prasad Krishnamurthy
Departments of Pharmaceutical Candidate Optimization (H.S., Z.Y., Y.-H.H., C.C., P.B., M.J., W.Z., P.M., A.D.R.) and Genomic Technologies (G.M.), Bristol-Myers Squibb Research and Development, Princeton, New Jersey; Department of Molecular Biology, Bristol-Myers Squibb Biocon R&D Center, Bangalore, India (S.K., Sa.S., Su.S., P.K.); and Department of Bioanalytical Service, WuXi AppTec Co., Ltd, Shanghai, China (R.Z.)
Punit Marathe
Departments of Pharmaceutical Candidate Optimization (H.S., Z.Y., Y.-H.H., C.C., P.B., M.J., W.Z., P.M., A.D.R.) and Genomic Technologies (G.M.), Bristol-Myers Squibb Research and Development, Princeton, New Jersey; Department of Molecular Biology, Bristol-Myers Squibb Biocon R&D Center, Bangalore, India (S.K., Sa.S., Su.S., P.K.); and Department of Bioanalytical Service, WuXi AppTec Co., Ltd, Shanghai, China (R.Z.)
A. David Rodrigues
Departments of Pharmaceutical Candidate Optimization (H.S., Z.Y., Y.-H.H., C.C., P.B., M.J., W.Z., P.M., A.D.R.) and Genomic Technologies (G.M.), Bristol-Myers Squibb Research and Development, Princeton, New Jersey; Department of Molecular Biology, Bristol-Myers Squibb Biocon R&D Center, Bangalore, India (S.K., Sa.S., Su.S., P.K.); and Department of Bioanalytical Service, WuXi AppTec Co., Ltd, Shanghai, China (R.Z.)

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Research ArticleMetabolism, Transport, and Pharmacogenomics
Use of Cynomolgus Monkey to Assess DDIs Involving OATPs
Hong Shen, Zheng Yang, Gabe Mintier, Yong-Hae Han, Cliff Chen, Praveen Balimane, Mohammed Jemal, Weiping Zhao, Renjie Zhang, Sanjith Kallipatti, Sabariya Selvam, Sunil Sukrutharaj, Prasad Krishnamurthy, Punit Marathe and A. David Rodrigues
Journal of Pharmacology and Experimental Therapeutics March 1, 2013, 344 (3) 673-685; DOI: https://doi.org/10.1124/jpet.112.200691
Research ArticleMetabolism, Transport, and Pharmacogenomics
Use of Cynomolgus Monkey to Assess DDIs Involving OATPs
Hong Shen, Zheng Yang, Gabe Mintier, Yong-Hae Han, Cliff Chen, Praveen Balimane, Mohammed Jemal, Weiping Zhao, Renjie Zhang, Sanjith Kallipatti, Sabariya Selvam, Sunil Sukrutharaj, Prasad Krishnamurthy, Punit Marathe and A. David Rodrigues
Journal of Pharmacology and Experimental Therapeutics March 1, 2013, 344 (3) 673-685; DOI: https://doi.org/10.1124/jpet.112.200691
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