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Research ArticleMetabolism, Transport, and Pharmacogenomics

Cynomolgus Monkey as a Potential Model to Assess Drug Interactions Involving Hepatic Organic Anion Transporting Polypeptides: In Vitro, In Vivo, and In Vitro-to-In Vivo Extrapolation

Hong Shen, Zheng Yang, Gabe Mintier, Yong-Hae Han, Cliff Chen, Praveen Balimane, Mohammed Jemal, Weiping Zhao, Renjie Zhang, Sanjith Kallipatti, Sabariya Selvam, Sunil Sukrutharaj, Prasad Krishnamurthy, Punit Marathe and A. David Rodrigues
Journal of Pharmacology and Experimental Therapeutics March 2013, 344 (3) 673-685; DOI: https://doi.org/10.1124/jpet.112.200691
Hong Shen
Departments of Pharmaceutical Candidate Optimization (H.S., Z.Y., Y.-H.H., C.C., P.B., M.J., W.Z., P.M., A.D.R.) and Genomic Technologies (G.M.), Bristol-Myers Squibb Research and Development, Princeton, New Jersey; Department of Molecular Biology, Bristol-Myers Squibb Biocon R&D Center, Bangalore, India (S.K., Sa.S., Su.S., P.K.); and Department of Bioanalytical Service, WuXi AppTec Co., Ltd, Shanghai, China (R.Z.)
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Zheng Yang
Departments of Pharmaceutical Candidate Optimization (H.S., Z.Y., Y.-H.H., C.C., P.B., M.J., W.Z., P.M., A.D.R.) and Genomic Technologies (G.M.), Bristol-Myers Squibb Research and Development, Princeton, New Jersey; Department of Molecular Biology, Bristol-Myers Squibb Biocon R&D Center, Bangalore, India (S.K., Sa.S., Su.S., P.K.); and Department of Bioanalytical Service, WuXi AppTec Co., Ltd, Shanghai, China (R.Z.)
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Gabe Mintier
Departments of Pharmaceutical Candidate Optimization (H.S., Z.Y., Y.-H.H., C.C., P.B., M.J., W.Z., P.M., A.D.R.) and Genomic Technologies (G.M.), Bristol-Myers Squibb Research and Development, Princeton, New Jersey; Department of Molecular Biology, Bristol-Myers Squibb Biocon R&D Center, Bangalore, India (S.K., Sa.S., Su.S., P.K.); and Department of Bioanalytical Service, WuXi AppTec Co., Ltd, Shanghai, China (R.Z.)
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Yong-Hae Han
Departments of Pharmaceutical Candidate Optimization (H.S., Z.Y., Y.-H.H., C.C., P.B., M.J., W.Z., P.M., A.D.R.) and Genomic Technologies (G.M.), Bristol-Myers Squibb Research and Development, Princeton, New Jersey; Department of Molecular Biology, Bristol-Myers Squibb Biocon R&D Center, Bangalore, India (S.K., Sa.S., Su.S., P.K.); and Department of Bioanalytical Service, WuXi AppTec Co., Ltd, Shanghai, China (R.Z.)
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Cliff Chen
Departments of Pharmaceutical Candidate Optimization (H.S., Z.Y., Y.-H.H., C.C., P.B., M.J., W.Z., P.M., A.D.R.) and Genomic Technologies (G.M.), Bristol-Myers Squibb Research and Development, Princeton, New Jersey; Department of Molecular Biology, Bristol-Myers Squibb Biocon R&D Center, Bangalore, India (S.K., Sa.S., Su.S., P.K.); and Department of Bioanalytical Service, WuXi AppTec Co., Ltd, Shanghai, China (R.Z.)
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Praveen Balimane
Departments of Pharmaceutical Candidate Optimization (H.S., Z.Y., Y.-H.H., C.C., P.B., M.J., W.Z., P.M., A.D.R.) and Genomic Technologies (G.M.), Bristol-Myers Squibb Research and Development, Princeton, New Jersey; Department of Molecular Biology, Bristol-Myers Squibb Biocon R&D Center, Bangalore, India (S.K., Sa.S., Su.S., P.K.); and Department of Bioanalytical Service, WuXi AppTec Co., Ltd, Shanghai, China (R.Z.)
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Mohammed Jemal
Departments of Pharmaceutical Candidate Optimization (H.S., Z.Y., Y.-H.H., C.C., P.B., M.J., W.Z., P.M., A.D.R.) and Genomic Technologies (G.M.), Bristol-Myers Squibb Research and Development, Princeton, New Jersey; Department of Molecular Biology, Bristol-Myers Squibb Biocon R&D Center, Bangalore, India (S.K., Sa.S., Su.S., P.K.); and Department of Bioanalytical Service, WuXi AppTec Co., Ltd, Shanghai, China (R.Z.)
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Weiping Zhao
Departments of Pharmaceutical Candidate Optimization (H.S., Z.Y., Y.-H.H., C.C., P.B., M.J., W.Z., P.M., A.D.R.) and Genomic Technologies (G.M.), Bristol-Myers Squibb Research and Development, Princeton, New Jersey; Department of Molecular Biology, Bristol-Myers Squibb Biocon R&D Center, Bangalore, India (S.K., Sa.S., Su.S., P.K.); and Department of Bioanalytical Service, WuXi AppTec Co., Ltd, Shanghai, China (R.Z.)
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Renjie Zhang
Departments of Pharmaceutical Candidate Optimization (H.S., Z.Y., Y.-H.H., C.C., P.B., M.J., W.Z., P.M., A.D.R.) and Genomic Technologies (G.M.), Bristol-Myers Squibb Research and Development, Princeton, New Jersey; Department of Molecular Biology, Bristol-Myers Squibb Biocon R&D Center, Bangalore, India (S.K., Sa.S., Su.S., P.K.); and Department of Bioanalytical Service, WuXi AppTec Co., Ltd, Shanghai, China (R.Z.)
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Sanjith Kallipatti
Departments of Pharmaceutical Candidate Optimization (H.S., Z.Y., Y.-H.H., C.C., P.B., M.J., W.Z., P.M., A.D.R.) and Genomic Technologies (G.M.), Bristol-Myers Squibb Research and Development, Princeton, New Jersey; Department of Molecular Biology, Bristol-Myers Squibb Biocon R&D Center, Bangalore, India (S.K., Sa.S., Su.S., P.K.); and Department of Bioanalytical Service, WuXi AppTec Co., Ltd, Shanghai, China (R.Z.)
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Sabariya Selvam
Departments of Pharmaceutical Candidate Optimization (H.S., Z.Y., Y.-H.H., C.C., P.B., M.J., W.Z., P.M., A.D.R.) and Genomic Technologies (G.M.), Bristol-Myers Squibb Research and Development, Princeton, New Jersey; Department of Molecular Biology, Bristol-Myers Squibb Biocon R&D Center, Bangalore, India (S.K., Sa.S., Su.S., P.K.); and Department of Bioanalytical Service, WuXi AppTec Co., Ltd, Shanghai, China (R.Z.)
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Sunil Sukrutharaj
Departments of Pharmaceutical Candidate Optimization (H.S., Z.Y., Y.-H.H., C.C., P.B., M.J., W.Z., P.M., A.D.R.) and Genomic Technologies (G.M.), Bristol-Myers Squibb Research and Development, Princeton, New Jersey; Department of Molecular Biology, Bristol-Myers Squibb Biocon R&D Center, Bangalore, India (S.K., Sa.S., Su.S., P.K.); and Department of Bioanalytical Service, WuXi AppTec Co., Ltd, Shanghai, China (R.Z.)
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Prasad Krishnamurthy
Departments of Pharmaceutical Candidate Optimization (H.S., Z.Y., Y.-H.H., C.C., P.B., M.J., W.Z., P.M., A.D.R.) and Genomic Technologies (G.M.), Bristol-Myers Squibb Research and Development, Princeton, New Jersey; Department of Molecular Biology, Bristol-Myers Squibb Biocon R&D Center, Bangalore, India (S.K., Sa.S., Su.S., P.K.); and Department of Bioanalytical Service, WuXi AppTec Co., Ltd, Shanghai, China (R.Z.)
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Punit Marathe
Departments of Pharmaceutical Candidate Optimization (H.S., Z.Y., Y.-H.H., C.C., P.B., M.J., W.Z., P.M., A.D.R.) and Genomic Technologies (G.M.), Bristol-Myers Squibb Research and Development, Princeton, New Jersey; Department of Molecular Biology, Bristol-Myers Squibb Biocon R&D Center, Bangalore, India (S.K., Sa.S., Su.S., P.K.); and Department of Bioanalytical Service, WuXi AppTec Co., Ltd, Shanghai, China (R.Z.)
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A. David Rodrigues
Departments of Pharmaceutical Candidate Optimization (H.S., Z.Y., Y.-H.H., C.C., P.B., M.J., W.Z., P.M., A.D.R.) and Genomic Technologies (G.M.), Bristol-Myers Squibb Research and Development, Princeton, New Jersey; Department of Molecular Biology, Bristol-Myers Squibb Biocon R&D Center, Bangalore, India (S.K., Sa.S., Su.S., P.K.); and Department of Bioanalytical Service, WuXi AppTec Co., Ltd, Shanghai, China (R.Z.)
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Article Information

vol. 344 no. 3 673-685
DOI 
https://doi.org/10.1124/jpet.112.200691
PubMed 
23297161

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received September 27, 2012
  • Accepted January 4, 2013
  • Published online February 19, 2013.

Article Versions

  • Earlier version (January 7, 2013 - 07:47).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2013 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Hong Shen,
  2. Zheng Yang,
  3. Gabe Mintier,
  4. Yong-Hae Han,
  5. Cliff Chen,
  6. Praveen Balimane,
  7. Mohammed Jemal,
  8. Weiping Zhao,
  9. Renjie Zhang,
  10. Sanjith Kallipatti,
  11. Sabariya Selvam,
  12. Sunil Sukrutharaj,
  13. Prasad Krishnamurthy,
  14. Punit Marathe, and
  15. A. David Rodrigues
  1. Departments of Pharmaceutical Candidate Optimization (H.S., Z.Y., Y.-H.H., C.C., P.B., M.J., W.Z., P.M., A.D.R.) and Genomic Technologies (G.M.), Bristol-Myers Squibb Research and Development, Princeton, New Jersey; Department of Molecular Biology, Bristol-Myers Squibb Biocon R&D Center, Bangalore, India (S.K., Sa.S., Su.S., P.K.); and Department of Bioanalytical Service, WuXi AppTec Co., Ltd, Shanghai, China (R.Z.)
  1. Address correspondence to:
    Dr. Hong Shen, F1.3811, Route 206 and Province Line Road, Bristol-Myers Squibb Company, Princeton, NJ 08543-4000. E-mail: hong.shen1{at}bms.com
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Journal of Pharmacology and Experimental Therapeutics: 344 (3)
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Research ArticleMetabolism, Transport, and Pharmacogenomics

Use of Cynomolgus Monkey to Assess DDIs Involving OATPs

Hong Shen, Zheng Yang, Gabe Mintier, Yong-Hae Han, Cliff Chen, Praveen Balimane, Mohammed Jemal, Weiping Zhao, Renjie Zhang, Sanjith Kallipatti, Sabariya Selvam, Sunil Sukrutharaj, Prasad Krishnamurthy, Punit Marathe and A. David Rodrigues
Journal of Pharmacology and Experimental Therapeutics March 1, 2013, 344 (3) 673-685; DOI: https://doi.org/10.1124/jpet.112.200691

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Research ArticleMetabolism, Transport, and Pharmacogenomics

Use of Cynomolgus Monkey to Assess DDIs Involving OATPs

Hong Shen, Zheng Yang, Gabe Mintier, Yong-Hae Han, Cliff Chen, Praveen Balimane, Mohammed Jemal, Weiping Zhao, Renjie Zhang, Sanjith Kallipatti, Sabariya Selvam, Sunil Sukrutharaj, Prasad Krishnamurthy, Punit Marathe and A. David Rodrigues
Journal of Pharmacology and Experimental Therapeutics March 1, 2013, 344 (3) 673-685; DOI: https://doi.org/10.1124/jpet.112.200691
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