Research ArticleMetabolism, Transport, and Pharmacogenomics
Mechanisms Limiting Distribution of the Threonine-Protein Kinase B-RaFV600E Inhibitor Dabrafenib to the Brain: Implications for the Treatment of Melanoma Brain Metastases
Rajendar K. Mittapalli, Shruthi Vaidhyanathan, Arkadiusz Z. Dudek and William F. Elmquist
Journal of Pharmacology and Experimental Therapeutics March 2013, 344 (3) 655-664; DOI: https://doi.org/10.1124/jpet.112.201475
Rajendar K. Mittapalli
Department of Pharmaceutics, Brain-Barriers Research Center (R.K.M., S.V., W.F.E.), and Divison of Hematology, Oncology and Transplantation, Department of Medicine (A.Z.D.), University of Minnesota, Minneapolis, Minnesota
Shruthi Vaidhyanathan
Department of Pharmaceutics, Brain-Barriers Research Center (R.K.M., S.V., W.F.E.), and Divison of Hematology, Oncology and Transplantation, Department of Medicine (A.Z.D.), University of Minnesota, Minneapolis, Minnesota
Arkadiusz Z. Dudek
Department of Pharmaceutics, Brain-Barriers Research Center (R.K.M., S.V., W.F.E.), and Divison of Hematology, Oncology and Transplantation, Department of Medicine (A.Z.D.), University of Minnesota, Minneapolis, Minnesota
William F. Elmquist
Department of Pharmaceutics, Brain-Barriers Research Center (R.K.M., S.V., W.F.E.), and Divison of Hematology, Oncology and Transplantation, Department of Medicine (A.Z.D.), University of Minnesota, Minneapolis, Minnesota
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Research ArticleMetabolism, Transport, and Pharmacogenomics
Brain Distribution of Dabrafenib in Mouse
Rajendar K. Mittapalli, Shruthi Vaidhyanathan, Arkadiusz Z. Dudek and William F. Elmquist
Journal of Pharmacology and Experimental Therapeutics March 1, 2013, 344 (3) 655-664; DOI: https://doi.org/10.1124/jpet.112.201475
Research ArticleMetabolism, Transport, and Pharmacogenomics
Brain Distribution of Dabrafenib in Mouse
Rajendar K. Mittapalli, Shruthi Vaidhyanathan, Arkadiusz Z. Dudek and William F. Elmquist
Journal of Pharmacology and Experimental Therapeutics March 1, 2013, 344 (3) 655-664; DOI: https://doi.org/10.1124/jpet.112.201475
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