Research ArticleDrug Discovery and Translational Medicine
ADX71743, a Potent and Selective Negative Allosteric Modulator of Metabotropic Glutamate Receptor 7: In Vitro and In Vivo Characterization
Mikhail Kalinichev, Mélanie Rouillier, Francoise Girard, Isabelle Royer-Urios, Bruno Bournique, Terry Finn, Delphine Charvin, Brice Campo, Emmanuel Le Poul, Vincent Mutel, Sonia Poli, Stuart A. Neale, Thomas E. Salt and Robert Lütjens
Journal of Pharmacology and Experimental Therapeutics March 2013, 344 (3) 624-636; DOI: https://doi.org/10.1124/jpet.112.200915
Mikhail Kalinichev
Addex Therapeutics SA, Geneva, Switzerland (M.K., M.R., F.G., I.R.-U., B.B., T.F., D.C., B.C., E.L.P., V.M., S.P., R.L.); Neurexpert Ltd, London, United Kingdom (S.A.N.); and Department of Visual Neuroscience, UCL Institute of Ophthalmology, London, United Kingdom (T.E.S.)
Mélanie Rouillier
Addex Therapeutics SA, Geneva, Switzerland (M.K., M.R., F.G., I.R.-U., B.B., T.F., D.C., B.C., E.L.P., V.M., S.P., R.L.); Neurexpert Ltd, London, United Kingdom (S.A.N.); and Department of Visual Neuroscience, UCL Institute of Ophthalmology, London, United Kingdom (T.E.S.)
Francoise Girard
Addex Therapeutics SA, Geneva, Switzerland (M.K., M.R., F.G., I.R.-U., B.B., T.F., D.C., B.C., E.L.P., V.M., S.P., R.L.); Neurexpert Ltd, London, United Kingdom (S.A.N.); and Department of Visual Neuroscience, UCL Institute of Ophthalmology, London, United Kingdom (T.E.S.)
Isabelle Royer-Urios
Addex Therapeutics SA, Geneva, Switzerland (M.K., M.R., F.G., I.R.-U., B.B., T.F., D.C., B.C., E.L.P., V.M., S.P., R.L.); Neurexpert Ltd, London, United Kingdom (S.A.N.); and Department of Visual Neuroscience, UCL Institute of Ophthalmology, London, United Kingdom (T.E.S.)
Bruno Bournique
Addex Therapeutics SA, Geneva, Switzerland (M.K., M.R., F.G., I.R.-U., B.B., T.F., D.C., B.C., E.L.P., V.M., S.P., R.L.); Neurexpert Ltd, London, United Kingdom (S.A.N.); and Department of Visual Neuroscience, UCL Institute of Ophthalmology, London, United Kingdom (T.E.S.)
Terry Finn
Addex Therapeutics SA, Geneva, Switzerland (M.K., M.R., F.G., I.R.-U., B.B., T.F., D.C., B.C., E.L.P., V.M., S.P., R.L.); Neurexpert Ltd, London, United Kingdom (S.A.N.); and Department of Visual Neuroscience, UCL Institute of Ophthalmology, London, United Kingdom (T.E.S.)
Delphine Charvin
Addex Therapeutics SA, Geneva, Switzerland (M.K., M.R., F.G., I.R.-U., B.B., T.F., D.C., B.C., E.L.P., V.M., S.P., R.L.); Neurexpert Ltd, London, United Kingdom (S.A.N.); and Department of Visual Neuroscience, UCL Institute of Ophthalmology, London, United Kingdom (T.E.S.)
Brice Campo
Addex Therapeutics SA, Geneva, Switzerland (M.K., M.R., F.G., I.R.-U., B.B., T.F., D.C., B.C., E.L.P., V.M., S.P., R.L.); Neurexpert Ltd, London, United Kingdom (S.A.N.); and Department of Visual Neuroscience, UCL Institute of Ophthalmology, London, United Kingdom (T.E.S.)
Emmanuel Le Poul
Addex Therapeutics SA, Geneva, Switzerland (M.K., M.R., F.G., I.R.-U., B.B., T.F., D.C., B.C., E.L.P., V.M., S.P., R.L.); Neurexpert Ltd, London, United Kingdom (S.A.N.); and Department of Visual Neuroscience, UCL Institute of Ophthalmology, London, United Kingdom (T.E.S.)
Vincent Mutel
Addex Therapeutics SA, Geneva, Switzerland (M.K., M.R., F.G., I.R.-U., B.B., T.F., D.C., B.C., E.L.P., V.M., S.P., R.L.); Neurexpert Ltd, London, United Kingdom (S.A.N.); and Department of Visual Neuroscience, UCL Institute of Ophthalmology, London, United Kingdom (T.E.S.)
Sonia Poli
Addex Therapeutics SA, Geneva, Switzerland (M.K., M.R., F.G., I.R.-U., B.B., T.F., D.C., B.C., E.L.P., V.M., S.P., R.L.); Neurexpert Ltd, London, United Kingdom (S.A.N.); and Department of Visual Neuroscience, UCL Institute of Ophthalmology, London, United Kingdom (T.E.S.)
Stuart A. Neale
Addex Therapeutics SA, Geneva, Switzerland (M.K., M.R., F.G., I.R.-U., B.B., T.F., D.C., B.C., E.L.P., V.M., S.P., R.L.); Neurexpert Ltd, London, United Kingdom (S.A.N.); and Department of Visual Neuroscience, UCL Institute of Ophthalmology, London, United Kingdom (T.E.S.)
Thomas E. Salt
Addex Therapeutics SA, Geneva, Switzerland (M.K., M.R., F.G., I.R.-U., B.B., T.F., D.C., B.C., E.L.P., V.M., S.P., R.L.); Neurexpert Ltd, London, United Kingdom (S.A.N.); and Department of Visual Neuroscience, UCL Institute of Ophthalmology, London, United Kingdom (T.E.S.)
Robert Lütjens
Addex Therapeutics SA, Geneva, Switzerland (M.K., M.R., F.G., I.R.-U., B.B., T.F., D.C., B.C., E.L.P., V.M., S.P., R.L.); Neurexpert Ltd, London, United Kingdom (S.A.N.); and Department of Visual Neuroscience, UCL Institute of Ophthalmology, London, United Kingdom (T.E.S.)

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In this issue
Research ArticleDrug Discovery and Translational Medicine
Characterization of an mGlu7 Negative Modulator ADX71743
Mikhail Kalinichev, Mélanie Rouillier, Francoise Girard, Isabelle Royer-Urios, Bruno Bournique, Terry Finn, Delphine Charvin, Brice Campo, Emmanuel Le Poul, Vincent Mutel, Sonia Poli, Stuart A. Neale, Thomas E. Salt and Robert Lütjens
Journal of Pharmacology and Experimental Therapeutics March 1, 2013, 344 (3) 624-636; DOI: https://doi.org/10.1124/jpet.112.200915
Research ArticleDrug Discovery and Translational Medicine
Characterization of an mGlu7 Negative Modulator ADX71743
Mikhail Kalinichev, Mélanie Rouillier, Francoise Girard, Isabelle Royer-Urios, Bruno Bournique, Terry Finn, Delphine Charvin, Brice Campo, Emmanuel Le Poul, Vincent Mutel, Sonia Poli, Stuart A. Neale, Thomas E. Salt and Robert Lütjens
Journal of Pharmacology and Experimental Therapeutics March 1, 2013, 344 (3) 624-636; DOI: https://doi.org/10.1124/jpet.112.200915
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