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Review ArticlePerspectives in Pharmacology

Autophagy Inhibition for Chemosensitization and Radiosensitization in Cancer: Do the Preclinical Data Support This Therapeutic Strategy?

Molly L. Bristol, Sean M. Emery, Paola Maycotte, Andrew Thorburn, Shweta Chakradeo and David A. Gewirtz
Journal of Pharmacology and Experimental Therapeutics March 2013, 344 (3) 544-552; DOI: https://doi.org/10.1124/jpet.112.199802
Molly L. Bristol
Departments of Pathology (M.L.B.), Pharmacology, and Toxicology (S.M.E., S.C., D.A.G.) and Massey Cancer Center (D.A.G.), Virginia Commonwealth University, Richmond, Virginia; and Department of Pharmacology, University of Colorado School of Medicine, Aurora, Colorado (P.M., A.T.)
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Sean M. Emery
Departments of Pathology (M.L.B.), Pharmacology, and Toxicology (S.M.E., S.C., D.A.G.) and Massey Cancer Center (D.A.G.), Virginia Commonwealth University, Richmond, Virginia; and Department of Pharmacology, University of Colorado School of Medicine, Aurora, Colorado (P.M., A.T.)
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Paola Maycotte
Departments of Pathology (M.L.B.), Pharmacology, and Toxicology (S.M.E., S.C., D.A.G.) and Massey Cancer Center (D.A.G.), Virginia Commonwealth University, Richmond, Virginia; and Department of Pharmacology, University of Colorado School of Medicine, Aurora, Colorado (P.M., A.T.)
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Andrew Thorburn
Departments of Pathology (M.L.B.), Pharmacology, and Toxicology (S.M.E., S.C., D.A.G.) and Massey Cancer Center (D.A.G.), Virginia Commonwealth University, Richmond, Virginia; and Department of Pharmacology, University of Colorado School of Medicine, Aurora, Colorado (P.M., A.T.)
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Shweta Chakradeo
Departments of Pathology (M.L.B.), Pharmacology, and Toxicology (S.M.E., S.C., D.A.G.) and Massey Cancer Center (D.A.G.), Virginia Commonwealth University, Richmond, Virginia; and Department of Pharmacology, University of Colorado School of Medicine, Aurora, Colorado (P.M., A.T.)
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David A. Gewirtz
Departments of Pathology (M.L.B.), Pharmacology, and Toxicology (S.M.E., S.C., D.A.G.) and Massey Cancer Center (D.A.G.), Virginia Commonwealth University, Richmond, Virginia; and Department of Pharmacology, University of Colorado School of Medicine, Aurora, Colorado (P.M., A.T.)
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Article Information

vol. 344 no. 3 544-552
DOI 
https://doi.org/10.1124/jpet.112.199802
PubMed 
23291713

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received September 25, 2012
  • Accepted January 3, 2013
  • Published online February 19, 2013.

Article Versions

  • Earlier version (January 4, 2013 - 06:57).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2013 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Molly L. Bristol,
  2. Sean M. Emery,
  3. Paola Maycotte,
  4. Andrew Thorburn,
  5. Shweta Chakradeo, and
  6. David A. Gewirtz
  1. Departments of Pathology (M.L.B.), Pharmacology, and Toxicology (S.M.E., S.C., D.A.G.) and Massey Cancer Center (D.A.G.), Virginia Commonwealth University, Richmond, Virginia; and Department of Pharmacology, University of Colorado School of Medicine, Aurora, Colorado (P.M., A.T.)
  1. Address correspondence to:
    Dr. David A. Gewirtz, Massey Cancer Center, 401 College St., Virginia Commonwealth University, Richmond, VA 23298. E-mail: gewirtz{at}vcu.edu
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Journal of Pharmacology and Experimental Therapeutics: 344 (3)
Journal of Pharmacology and Experimental Therapeutics
Vol. 344, Issue 3
1 Mar 2013
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Review ArticlePerspectives in Pharmacology

Autophagy Inhibition, Chemosensitization, and Radiosensitization

Molly L. Bristol, Sean M. Emery, Paola Maycotte, Andrew Thorburn, Shweta Chakradeo and David A. Gewirtz
Journal of Pharmacology and Experimental Therapeutics March 1, 2013, 344 (3) 544-552; DOI: https://doi.org/10.1124/jpet.112.199802

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Review ArticlePerspectives in Pharmacology

Autophagy Inhibition, Chemosensitization, and Radiosensitization

Molly L. Bristol, Sean M. Emery, Paola Maycotte, Andrew Thorburn, Shweta Chakradeo and David A. Gewirtz
Journal of Pharmacology and Experimental Therapeutics March 1, 2013, 344 (3) 544-552; DOI: https://doi.org/10.1124/jpet.112.199802
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