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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

March 01, 2013; Volume 344,Issue 3

Highlighted Papers

  • You have access
    A µ-Opioid Receptor Ligand with Reduced Gastrointestinal and Respiratory Dysfunction
    Journal of Pharmacology and Experimental Therapeutics March 2013, 344 (3) 543; DOI: https://doi.org/10.1124/jpet.112.0313HI
  • You have access
    The PK and PD Relationships of an Engineered Human Follistatin Variant
    Journal of Pharmacology and Experimental Therapeutics March 2013, 344 (3) 543; DOI: https://doi.org/10.1124/jpet.112.0313HIa
  • You have access
    ADX71743, a Negative Allosteric Modulator of Metabotropic Glutamate Receptor 7
    Journal of Pharmacology and Experimental Therapeutics March 2013, 344 (3) 543; DOI: https://doi.org/10.1124/jpet.112.0313HIb
  • You have access
    Puerarin Ameliorates Experimental Alcoholic Liver Injury
    Journal of Pharmacology and Experimental Therapeutics March 2013, 344 (3) 543; DOI: https://doi.org/10.1124/jpet.112.0313HIc

Perspectives in Pharmacology

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    Autophagy Inhibition for Chemosensitization and Radiosensitization in Cancer: Do the Preclinical Data Support This Therapeutic Strategy?
    Molly L. Bristol, Sean M. Emery, Paola Maycotte, Andrew Thorburn, Shweta Chakradeo and David A. Gewirtz
    Journal of Pharmacology and Experimental Therapeutics March 2013, 344 (3) 544-552; DOI: https://doi.org/10.1124/jpet.112.199802

Behavioral Pharmacology

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    Discriminative Stimulus Effects of the GABAB Receptor-Positive Modulator rac-BHFF: Comparison with GABAB Receptor Agonists and Drugs of Abuse
    Wouter Koek, Kejun Cheng and Kenner C. Rice
    Journal of Pharmacology and Experimental Therapeutics March 2013, 344 (3) 553-560; DOI: https://doi.org/10.1124/jpet.112.202226
  • You have access
    Cannabinoid Discrimination and Antagonism by CB1 Neutral and Inverse Agonist Antagonists
    Brian D. Kangas, Marcus S. Delatte, V. Kiran Vemuri, Ganesh A. Thakur, Spyridon P. Nikas, Kumara V. Subramanian, Vidyanand G. Shukla, Alexandros Makriyannis and Jack Bergman
    Journal of Pharmacology and Experimental Therapeutics March 2013, 344 (3) 561-567; DOI: https://doi.org/10.1124/jpet.112.201962

Cellular and Molecular

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    High-Throughput Identification and Characterization of Novel, Species-selective GPR35 Agonists
    Zaynab Neetoo-Isseljee, Amanda E. MacKenzie, Craig Southern, Jeff Jerman, Edward G. McIver, Nicholas Harries, Debra L. Taylor and Graeme Milligan
    Journal of Pharmacology and Experimental Therapeutics March 2013, 344 (3) 568-578; DOI: https://doi.org/10.1124/jpet.112.201798
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    Identification of Stanniocalcin 2 as a Novel Aryl Hydrocarbon Receptor Target Gene
    Tod A. Harper, Aditya D. Joshi and Cornelis J. Elferink
    Journal of Pharmacology and Experimental Therapeutics March 2013, 344 (3) 579-588; DOI: https://doi.org/10.1124/jpet.112.201111

Drug Discovery and Translational Medicine

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    Structure-Based Optimization of Angiostatic Agent 6DBF7, an Allosteric Antagonist of Galectin-1
    Ruud P. M. Dings, Nigam Kumar, Michelle C. Miller, Melissa Loren, Huzaifa Rangwala, Thomas R. Hoye and Kevin H. Mayo
    Journal of Pharmacology and Experimental Therapeutics March 2013, 344 (3) 589-599; DOI: https://doi.org/10.1124/jpet.112.199646
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    5-Benzylglycinyl-Amiloride Kills Proliferating and Nonproliferating Malignant Glioma Cells through Caspase-Independent Necroptosis Mediated by Apoptosis-Inducing Factor
    Nagarekha Pasupuleti, Leonardo Leon, Kermit L. Carraway and Fredric Gorin
    Journal of Pharmacology and Experimental Therapeutics March 2013, 344 (3) 600-615; DOI: https://doi.org/10.1124/jpet.112.200519
  • You have access
    An Engineered Human Follistatin Variant: Insights into the Pharmacokinetic and Pharmocodynamic Relationships of a Novel Molecule with Broad Therapeutic Potential
    Amita Datta-Mannan, Benjamin Yaden, Venkatesh Krishnan, Bryan E. Jones and Johnny E. Croy
    Journal of Pharmacology and Experimental Therapeutics March 2013, 344 (3) 616-623; DOI: https://doi.org/10.1124/jpet.112.201491
  • You have access
    ADX71743, a Potent and Selective Negative Allosteric Modulator of Metabotropic Glutamate Receptor 7: In Vitro and In Vivo Characterization
    Mikhail Kalinichev, Mélanie Rouillier, Francoise Girard, Isabelle Royer-Urios, Bruno Bournique, Terry Finn, Delphine Charvin, Brice Campo, Emmanuel Le Poul, Vincent Mutel, Sonia Poli, Stuart A. Neale, Thomas E. Salt and Robert Lütjens
    Journal of Pharmacology and Experimental Therapeutics March 2013, 344 (3) 624-636; DOI: https://doi.org/10.1124/jpet.112.200915

Endocrine and Diabetes

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    Pharmacological Inhibition of Mitochondrial Carbonic Anhydrases Protects Mouse Cerebral Pericytes from High Glucose-Induced Oxidative Stress and Apoptosis
    Gul N. Shah, Tulin O. Price, William A. Banks, Yoichi Morofuji, Andrej Kovac, Nuran Ercal, Christine M. Sorenson, Eui S. Shin and Nader Sheibani
    Journal of Pharmacology and Experimental Therapeutics March 2013, 344 (3) 637-645; DOI: https://doi.org/10.1124/jpet.112.201400

Gastrointestinal, Hepatic, Pulmonary, and Renal

  • You have access
    Puerarin Ameliorates Experimental Alcoholic Liver Injury by Inhibition of Endotoxin Gut Leakage, Kupffer Cell Activation, and Endotoxin Receptors Expression
    Jing-Hua Peng, Tuan Cui, Fu Huang, Liang Chen, Yu Zhao, Lin Xu, Li-Li Xu, Qin Feng and Yi-Yang Hu
    Journal of Pharmacology and Experimental Therapeutics March 2013, 344 (3) 646-654; DOI: https://doi.org/10.1124/jpet.112.201137

Metabolism, Transport, and Pharmacogenomics

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    Mechanisms Limiting Distribution of the Threonine-Protein Kinase B-RaFV600E Inhibitor Dabrafenib to the Brain: Implications for the Treatment of Melanoma Brain Metastases
    Rajendar K. Mittapalli, Shruthi Vaidhyanathan, Arkadiusz Z. Dudek and William F. Elmquist
    Journal of Pharmacology and Experimental Therapeutics March 2013, 344 (3) 655-664; DOI: https://doi.org/10.1124/jpet.112.201475
  • You have access
    Carboxylesterase 1 as a Determinant of Clopidogrel Metabolism and Activation
    Hao-Jie Zhu, Xinwen Wang, Brian E. Gawronski, Bryan J. Brinda, Dominick J. Angiolillo and John S. Markowitz
    Journal of Pharmacology and Experimental Therapeutics March 2013, 344 (3) 665-672; DOI: https://doi.org/10.1124/jpet.112.201640
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    Cynomolgus Monkey as a Potential Model to Assess Drug Interactions Involving Hepatic Organic Anion Transporting Polypeptides: In Vitro, In Vivo, and In Vitro-to-In Vivo Extrapolation
    Hong Shen, Zheng Yang, Gabe Mintier, Yong-Hae Han, Cliff Chen, Praveen Balimane, Mohammed Jemal, Weiping Zhao, Renjie Zhang, Sanjith Kallipatti, Sabariya Selvam, Sunil Sukrutharaj, Prasad Krishnamurthy, Punit Marathe and A. David Rodrigues
    Journal of Pharmacology and Experimental Therapeutics March 2013, 344 (3) 673-685; DOI: https://doi.org/10.1124/jpet.112.200691

Neuropharmacology

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    Pharmacodynamics of Selective Inhibition of γ-Secretase by Avagacestat
    Charles F. Albright, Randy C. Dockens, Jere E. Meredith, Richard E. Olson, Randy Slemmon, Kimberley A. Lentz, Jun-Sheng Wang, R. Rex Denton, Gary Pilcher, Paul W. Rhyne, Joseph J. Raybon, Donna M. Barten, Catherine Burton, Jeremy H. Toyn, Sethu Sankaranarayanan, Craig Polson, Valerie Guss, Randy White, Frank Simutis, Thomas Sanderson, Kevin W. Gillman, John E. Starrett, Joanne Bronson, Oleksandr Sverdlov, Shu-Pang Huang, Lorna Castaneda, Howard Feldman, Vlad Coric, Robert Zaczek, John E. Macor, John Houston, Robert M. Berman and Gary Tong
    Journal of Pharmacology and Experimental Therapeutics March 2013, 344 (3) 686-695; DOI: https://doi.org/10.1124/jpet.112.199356
  • You have access
    The Antinociceptive Effect of Milnacipran in the Monosodium Iodoacetate Model of Osteoarthritis Pain and Its Relation to Changes in Descending Inhibition
    Liam J. Burnham and Anthony H. Dickenson
    Journal of Pharmacology and Experimental Therapeutics March 2013, 344 (3) 696-707; DOI: https://doi.org/10.1124/jpet.112.199489
  • You have access
    A G Protein-Biased Ligand at the μ-Opioid Receptor Is Potently Analgesic with Reduced Gastrointestinal and Respiratory Dysfunction Compared with Morphine
    Scott M. DeWire, Dennis S. Yamashita, David H. Rominger, Guodong Liu, Conrad L. Cowan, Thomas M. Graczyk, Xiao-Tao Chen, Philip M. Pitis, Dimitar Gotchev, Catherine Yuan, Michael Koblish, Michael W. Lark and Jonathan D. Violin
    Journal of Pharmacology and Experimental Therapeutics March 2013, 344 (3) 708-717; DOI: https://doi.org/10.1124/jpet.112.201616
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In this issue

Journal of Pharmacology and Experimental Therapeutics: 344 (3)
Journal of Pharmacology and Experimental Therapeutics
Vol. 344, Issue 3
1 Mar 2013
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
  • Editorial Board (PDF)
  • Front Matter (PDF)
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Jump to

  • Highlighted Papers
  • Perspectives in Pharmacology
  • Behavioral Pharmacology
  • Cellular and Molecular
  • Drug Discovery and Translational Medicine
  • Endocrine and Diabetes
  • Gastrointestinal, Hepatic, Pulmonary, and Renal
  • Metabolism, Transport, and Pharmacogenomics
  • Neuropharmacology
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  • Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.
  • Functional Selectivity and Classical Concepts of Quantitative Pharmacology
  • Abl Protein-Tyrosine Kinase Inhibitor STI571 Inhibits In Vitro Signal Transduction Mediated by c-Kit and Platelet-Derived Growth Factor Receptors
  • The Prediction of Human Pharmacokinetic Parameters from Preclinical and In Vitro Metabolism Data
  • A METHOD FOR DETERMINING LOSS OF PAIN SENSATION
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