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Research ArticleInflammation, Immunopharmacology, and Asthma

Topical Surfactant-Induced Pruritus: Involvement of Histamine Released from Epidermal Keratinocytes

Yoshihiro Inami, Tsugunobu Andoh, Atsushi Sasaki and Yasushi Kuraishi
Journal of Pharmacology and Experimental Therapeutics February 2013, 344 (2) 459-466; DOI: https://doi.org/10.1124/jpet.112.200063
Yoshihiro Inami
Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan (Y.I., T.A., A.S., Y.K.); and Fundamental Research Laboratory, Hoyu Co., Ltd., Nagakute, Japan (Y.I.)
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Tsugunobu Andoh
Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan (Y.I., T.A., A.S., Y.K.); and Fundamental Research Laboratory, Hoyu Co., Ltd., Nagakute, Japan (Y.I.)
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Atsushi Sasaki
Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan (Y.I., T.A., A.S., Y.K.); and Fundamental Research Laboratory, Hoyu Co., Ltd., Nagakute, Japan (Y.I.)
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Yasushi Kuraishi
Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan (Y.I., T.A., A.S., Y.K.); and Fundamental Research Laboratory, Hoyu Co., Ltd., Nagakute, Japan (Y.I.)
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Abstract

Surfactants, an important component of cleansers, often cause itch in humans. Topical application of sodium laurate and N-lauroylsarcosine sodium salt to the skin of mice immediately (for 1–1.5 hours) increased scratching, and the former increased scratching again between 2 and 3 hours after application. Thus, we examined the mechanisms of sodium laurate–induced delayed scratching. Sodium laurate (0.1%–10%) increased delayed scratching and skin surface pH in a concentration-dependent manner. N-lauroylsarcosine sodium salt had no effect on these parameters, and sodium hydroxide solution did not increase delayed scratching. Sodium laurate–induced delayed scratching was markedly inhibited by the H1 histamine receptor antagonist terfenadine, but it was not affected by mast cell deficiency. Sodium laurate application had no effect on the number of total and degranulated mast cells, and did not induce plasma extravasation or the infiltration of inflammatory cells in the skin. Sodium laurate application increased the histamine content of the epidermis, but not that of the dermis, in normal and mast cell–deficient mice. Sodium laurate application increased the ratio of 53-kDa l-histidine decarboxylase (HDC, a key enzyme for histamine production) to 74-kDa HDC in the mouse epidermis and in a human keratinocyte culture. Sodium laurate increased histamine in the human keratinocyte culture, without affecting cell viability. The present results suggest that sodium laurate induced delayed scratching at an alkaline pH through the increased production of histamine in keratinocytes, which may be due to enhanced processing of 74-kDa to 53-kDa HDC.

Footnotes

  • dx.doi.org/10.1124/jpet.112.200063.

  • Received September 12, 2012.
  • Accepted December 4, 2012.
  • Copyright © 2013 by The American Society for Pharmacology and Experimental Therapeutics
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Journal of Pharmacology and Experimental Therapeutics: 344 (2)
Journal of Pharmacology and Experimental Therapeutics
Vol. 344, Issue 2
1 Feb 2013
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Research ArticleInflammation, Immunopharmacology, and Asthma

Surfactant Itch and Keratinocyte Histamine

Yoshihiro Inami, Tsugunobu Andoh, Atsushi Sasaki and Yasushi Kuraishi
Journal of Pharmacology and Experimental Therapeutics February 1, 2013, 344 (2) 459-466; DOI: https://doi.org/10.1124/jpet.112.200063

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Research ArticleInflammation, Immunopharmacology, and Asthma

Surfactant Itch and Keratinocyte Histamine

Yoshihiro Inami, Tsugunobu Andoh, Atsushi Sasaki and Yasushi Kuraishi
Journal of Pharmacology and Experimental Therapeutics February 1, 2013, 344 (2) 459-466; DOI: https://doi.org/10.1124/jpet.112.200063
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