Journal of Pharmacology and Experimental Therapeutics: 344 (2)

February 01, 2013; Volume 344,Issue 2

Highlighted Papers

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Chimeric Mice with Humanized Livers Can Predict Human Drug Metabolism
Journal of Pharmacology and Experimental Therapeutics February 2013, 344 (2) 318; DOI: https://doi.org/10.1124/jpet.112.0213HI
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Kv2.x Channels Regulate Insulin and Somatostatin Release from Pancreatic Islets
Journal of Pharmacology and Experimental Therapeutics February 2013, 344 (2) 318; DOI: https://doi.org/10.1124/jpet.112.0213HIa
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Suramin Improves Regeneration of Ethanol-Induced Steatotic Partial Liver Grafts
Journal of Pharmacology and Experimental Therapeutics February 2013, 344 (2) 318; DOI: https://doi.org/10.1124/jpet.112.0213HIb
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Insight to Explain the Cardiac Safety of Pixantrone in Doxorubicin-Treated Patients
Journal of Pharmacology and Experimental Therapeutics February 2013, 344 (2) 318; DOI: https://doi.org/10.1124/jpet.112.0213HIc

Behavioral Pharmacology

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Analysis of Tolerance and Behavioral/Physical Dependence during Chronic CB₁ Agonist Treatment: Effects of CB₁ Agonists, Antagonists, and Noncannabinoid Drugs
Rajeev I. Desai, Ganesh A. Thakur, V. Kiran Vemuri, Shama Bajaj, Alexandros Makriyannis and Jack Bergman

Journal of Pharmacology and Experimental Therapeutics February 2013, 344 (2) 319-328; DOI: https://doi.org/10.1124/jpet.112.198374
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Effects of Dopamine D2/D3 Receptor Ligands on Food-Cocaine Choice in Socially Housed Male Cynomolgus Monkeys
Paul W. Czoty and Michael A. Nader

Journal of Pharmacology and Experimental Therapeutics February 2013, 344 (2) 329-338; DOI: https://doi.org/10.1124/jpet.112.201012

Cardiovascular

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Pharmacological Characterization of 1-Nitrosocyclohexyl Acetate, a Long-Acting Nitroxyl Donor That Shows Vasorelaxant and Antiaggregatory Effects
Sonia Donzelli, Gerry Fischer, Bruce S. King, Christin Niemann, Jenna F. DuMond, Jörg Heeren, Hartwig Wieboldt, Stephan Baldus, Christian Gerloff, Thomas Eschenhagen, Lucie Carrier, Rainer H. Böger and Michael Graham Espey

Journal of Pharmacology and Experimental Therapeutics February 2013, 344 (2) 339-347; DOI: https://doi.org/10.1124/jpet.112.199836
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AT1 Receptor Antagonism Is Proangiogenic in the Brain: BDNF a Novel Mediator
Ahmed Alhusban, Anna Kozak, Adviye Ergul and Susan C. Fagan

Journal of Pharmacology and Experimental Therapeutics February 2013, 344 (2) 348-359; DOI: https://doi.org/10.1124/jpet.112.197483

Cellular and Molecular

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Role of Prostaglandin Receptor EP2 in the Regulations of Cancer Cell Proliferation, Invasion, and Inflammation
Jianxiong Jiang and Ray Dingledine

Journal of Pharmacology and Experimental Therapeutics February 2013, 344 (2) 360-367; DOI: https://doi.org/10.1124/jpet.112.200444

Chemotherapy, Antibiotics, and Gene Therapy

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Impact of Tumor Blood Flow Modulation on Tumor Sensitivity to the Bioreductive Drug Banoxantrone
Eugene Manley and David J. Waxman

Journal of Pharmacology and Experimental Therapeutics February 2013, 344 (2) 368-377; DOI: https://doi.org/10.1124/jpet.112.200089
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The Selective Syk Inhibitor P505-15 (PRT062607) Inhibits B Cell Signaling and Function In Vitro and In Vivo and Augments the Activity of Fludarabine in Chronic Lymphocytic Leukemia
Stephen E. Spurgeon, Greg Coffey, Luke B. Fletcher, Russell Burke, Jeffrey W. Tyner, Brian J. Druker, Andreas Betz, Francis DeGuzman, Yvonne Pak, Dale Baker, Anjali Pandey, Stanley J. Hollenbach, Uma Sinha and Marc M. Loriaux

Journal of Pharmacology and Experimental Therapeutics February 2013, 344 (2) 378-387; DOI: https://doi.org/10.1124/jpet.112.200832

Drug Discovery and Translational Medicine

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Using Chimeric Mice with Humanized Livers to Predict Human Drug Metabolism and a Drug-Drug Interaction
Toshihiko Nishimura, Yajing Hu, Manhong Wu, Edward Pham, Hiroshi Suemizu, Menashe Elazar, Michael Liu, Ramazan Idilman, Cihan Yurdaydin, Peter Angus, Catherine Stedman, Brian Murphy, Jeffrey Glenn, Masato Nakamura, Tatsuji Nomura, Yuan Chen, Ming Zheng, William L. Fitch and Gary Peltz

Journal of Pharmacology and Experimental Therapeutics February 2013, 344 (2) 388-396; DOI: https://doi.org/10.1124/jpet.112.198697
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Selective Effects of a Morphine Conjugate Vaccine on Heroin and Metabolite Distribution and Heroin-Induced Behaviors in Rats
M.D. Raleigh, M. Pravetoni, A.C. Harris, A.K. Birnbaum and P.R. Pentel

Journal of Pharmacology and Experimental Therapeutics February 2013, 344 (2) 397-406; DOI: https://doi.org/10.1124/jpet.112.201194

Endocrine and Diabetes

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The Role of Voltage-Gated Potassium Channels Kv2.1 and Kv2.2 in the Regulation of Insulin and Somatostatin Release from Pancreatic Islets
Xiaoyan (Nina) Li, James Herrington, Aleksandr Petrov, Lan Ge, George Eiermann, Yusheng Xiong, Mette V. Jensen, Hans E. Hohmeier, Christopher B. Newgard, Maria L. Garcia, Michael Wagner, Bei B. Zhang, Nancy A. Thornberry, Andrew D. Howard, Gregory J. Kaczorowski and Yun-Ping Zhou

Journal of Pharmacology and Experimental Therapeutics February 2013, 344 (2) 407-416; DOI: https://doi.org/10.1124/jpet.112.199083

Gastrointestinal, Hepatic, Pulmonary, and Renal

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Suramin Decreases Injury and Improves Regeneration of Ethanol-Induced Steatotic Partial Liver Grafts
Songqing He, Hasibur Rehman, Yanjun Shi, Yasodha Krishnasamy, John J. Lemasters, Rick G. Schnellmann and Zhi Zhong

Journal of Pharmacology and Experimental Therapeutics February 2013, 344 (2) 417-425; DOI: https://doi.org/10.1124/jpet.112.199919

Inflammation, Immunopharmacology, and Asthma

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G_s-Coupled Adenosine Receptors Differentially Limit Antigen-Induced Mast Cell Activation
Xiaoyang Hua, Kelly D. Chason, Corey Jania, Tatiana Acosta, Catherine Ledent and Stephen L. Tilley

Journal of Pharmacology and Experimental Therapeutics February 2013, 344 (2) 426-435; DOI: https://doi.org/10.1124/jpet.112.198978
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Inhibition of Toll-Like Receptor-Mediated Inflammation In Vitro and In Vivo by a Novel Benzoxaborole
Chen Dong, Holly Sexton, Ana Gertrudes, Tsutomu Akama, Shamra Martin, Charlotte Virtucio, Chiao-Wen Chen, Xiaoqin Fan, Anne Wu, Wei Bu, Liang Liu, Lisa Feng, Kurt Jarnagin and Yvonne R. Freund

Journal of Pharmacology and Experimental Therapeutics February 2013, 344 (2) 436-446; DOI: https://doi.org/10.1124/jpet.112.200030
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Upregulation of Mer Receptor Tyrosine Kinase Signaling Attenuated Lipopolysaccharide-Induced Lung Inflammation
Ji-Yeon Choi, Hyun-Jung Park, Ye-Ji Lee, Jiyeon Byun, Young-So Youn, Ji Ha Choi, So-Youn Woo and Jihee Lee Kang

Journal of Pharmacology and Experimental Therapeutics February 2013, 344 (2) 447-458; DOI: https://doi.org/10.1124/jpet.112.199778
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Topical Surfactant-Induced Pruritus: Involvement of Histamine Released from Epidermal Keratinocytes
Yoshihiro Inami, Tsugunobu Andoh, Atsushi Sasaki and Yasushi Kuraishi

Journal of Pharmacology and Experimental Therapeutics February 2013, 344 (2) 459-466; DOI: https://doi.org/10.1124/jpet.112.200063

Metabolism, Transport, and Pharmacogenomics

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The Novel Anthracenedione, Pixantrone, Lacks Redox Activity and Inhibits Doxorubicinol Formation in Human Myocardium: Insight to Explain the Cardiac Safety of Pixantrone in Doxorubicin-Treated Patients
Emanuela Salvatorelli, Pierantonio Menna, Odalys Gonzalez Paz, Massimo Chello, Elvio Covino, Jack W. Singer and Giorgio Minotti

Journal of Pharmacology and Experimental Therapeutics February 2013, 344 (2) 467-478; DOI: https://doi.org/10.1124/jpet.112.200568
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Studies of (±)-3,4-Methylenedioxymethamphetamine (MDMA) Metabolism and Disposition in Rats and Mice: Relationship to Neuroprotection and Neurotoxicity Profile
Melanie Mueller, Concepcion Maldonado-Adrian, Jie Yuan, Una D. McCann and George A. Ricaurte

Journal of Pharmacology and Experimental Therapeutics February 2013, 344 (2) 479-488; DOI: https://doi.org/10.1124/jpet.112.201699

Neuropharmacology

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Mutation of a Zinc-Binding Residue in the Glycine Receptor α1 Subunit Changes Ethanol Sensitivity In Vitro and Alcohol Consumption In Vivo
Lindsay M. McCracken, Yuri A. Blednov, James R. Trudell, Jillian M. Benavidez, Heinrich Betz and R. Adron Harris

Journal of Pharmacology and Experimental Therapeutics February 2013, 344 (2) 489-500; DOI: https://doi.org/10.1124/jpet.112.197707
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In Vivo Occupancy of Dopamine D₃ Receptors by Antagonists Produces Neurochemical and Behavioral Effects of Potential Relevance to Attention-Deficit–Hyperactivity Disorder
V. Barth, A. B. Need, E. T. Tzavara, B. Giros, C. Overshiner, S. D. Gleason, M. Wade, A. M. Johansson, K. Perry, G. G. Nomikos and J. M. Witkin

Journal of Pharmacology and Experimental Therapeutics February 2013, 344 (2) 501-510; DOI: https://doi.org/10.1124/jpet.112.198895
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Expression and Activity of Nitric Oxide Synthase Isoforms in Methamphetamine-Induced Striatal Dopamine Toxicity
Danielle M. Friend, Jong H. Son, Kristen A. Keefe and Ashley N. Fricks-Gleason

Journal of Pharmacology and Experimental Therapeutics February 2013, 344 (2) 511-521; DOI: https://doi.org/10.1124/jpet.112.199745
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Sex, Pain, and Opioids: Interdependent Influences of Sex and Pain Modality on Dynorphin-Mediated Antinociception in Rats
Nai-Jiang Liu, Stephen Schnell, Martin W. Wessendorf and Alan R. Gintzler

Journal of Pharmacology and Experimental Therapeutics February 2013, 344 (2) 522-530; DOI: https://doi.org/10.1124/jpet.112.199851

Toxicology

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Immunodetection of Serum Albumin Adducts as Biomarkers for Organophosphorus Exposure
Sigeng Chen, Jun Zhang, Lucille Lumley and John R. Cashman

Journal of Pharmacology and Experimental Therapeutics February 2013, 344 (2) 531-541; DOI: https://doi.org/10.1124/jpet.112.201368

Erratum

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Correction to: “Morphine Withdrawal Activates Hypothalamic-Pituitary Adrenal Axis and Heat Shock Protein 27 in the Left Ventricle: The Role of Extracellular Signal-Regulated Kinase”
Journal of Pharmacology and Experimental Therapeutics February 2013, 344 (2) 542; DOI: https://doi.org/10.1124/jpet.112.02er13

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Table of Contents

Highlighted Papers

Behavioral Pharmacology

Cardiovascular

Cellular and Molecular

Chemotherapy, Antibiotics, and Gene Therapy

Drug Discovery and Translational Medicine

Endocrine and Diabetes

Gastrointestinal, Hepatic, Pulmonary, and Renal

Inflammation, Immunopharmacology, and Asthma

Metabolism, Transport, and Pharmacogenomics

Neuropharmacology

Toxicology

Erratum

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