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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

January 01, 2013; Volume 344,Issue 1

Highlighted Papers

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    Phosphoinositide-Dependent Kinase-1 Can Contribute to Hypertension
    Journal of Pharmacology and Experimental Therapeutics January 2013, 344 (1) 1; DOI: https://doi.org/10.1124/jpet.112.0113HIa
  • You have access
    Screening for the Detection of G Protein-Coupled Receptor Heteromer Signaling
    Journal of Pharmacology and Experimental Therapeutics January 2013, 344 (1) 1; DOI: https://doi.org/10.1124/jpet.112.0113HIb
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    A Cationic Analog of Ceramide Induces Pancreatic Cancer Cell Death
    Journal of Pharmacology and Experimental Therapeutics January 2013, 344 (1) 1; DOI: https://doi.org/10.1124/jpet.112.0113HIc
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    Hydrophobic Amino Acids in the Hinge Region of the 5A Apolipoprotein Mimetic Peptide Are Essential for Promoting Cholesterol Efflux
    Journal of Pharmacology and Experimental Therapeutics January 2013, 344 (1) 1; DOI: https://doi.org/10.1124/jpet.112.0113HI

Perspectives in Pharmacology

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    Alkaline Phosphatase as a Treatment of Sepsis-Associated Acute Kidney Injury
    Esther Peters, Andrea van Elsas, Suzanne Heemskerk, Luigi Jonk, Johannes van der Hoeven, Jacques Arend, Rosalinde Masereeuw and Peter Pickkers
    Journal of Pharmacology and Experimental Therapeutics January 2013, 344 (1) 2-7; DOI: https://doi.org/10.1124/jpet.112.198226

Behavioral Pharmacology

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    Diuretic Effects of Cannabinoids
    Carol A. Paronis, Ganesh A. Thakur, Shama Bajaj, Spyros P. Nikas, V. Kiran Vemuri, Alexandros Makriyannis and Jack Bergman
    Journal of Pharmacology and Experimental Therapeutics January 2013, 344 (1) 8-14; DOI: https://doi.org/10.1124/jpet.112.199331

Cardiovascular

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    Endothelial Nitric Oxide Synthase-Independent Release of Nitric Oxide in the Aorta of the Spontaneously Hypertensive Rat
    Yingzi Zhao, Paul M. Vanhoutte and Susan W. S. Leung
    Journal of Pharmacology and Experimental Therapeutics January 2013, 344 (1) 15-22; DOI: https://doi.org/10.1124/jpet.112.198721
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    A Novel, Potent, and Selective Inhibitor of Cardiac Late Sodium Current Suppresses Experimental Arrhythmias
    Luiz Belardinelli, Gongxin Liu, Cathy Smith-Maxwell, Wei-Qun Wang, Nesrine El-Bizri, Ryoko Hirakawa, Serge Karpinski, Cindy Hong Li, Lufei Hu, Xiao-Jun Li, William Crumb, Lin Wu, Dmitry Koltun, Jeff Zablocki, Lina Yao, Arvinder K. Dhalla, Sridharan Rajamani and John C. Shryock
    Journal of Pharmacology and Experimental Therapeutics January 2013, 344 (1) 23-32; DOI: https://doi.org/10.1124/jpet.112.198887
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    A TRPC3 Blocker, Ethyl-1-(4-(2,3,3-Trichloroacrylamide)Phenyl)-5-(Trifluoromethyl)-1H-Pyrazole-4-Carboxylate (Pyr3), Prevents Stent-Induced Arterial Remodeling
    Sarah Koenig, Michaela Schernthaner, Heinrich Maechler, C. Oliver Kappe, Toma N. Glasnov, Gerald Hoefler, Marlen Braune, Eric Wittchow and Klaus Groschner
    Journal of Pharmacology and Experimental Therapeutics January 2013, 344 (1) 33-40; DOI: https://doi.org/10.1124/jpet.112.196832
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    Anti-Inflammatory Functions of Apolipoprotein A-I and High-Density Lipoprotein Are Preserved in Trimeric Apolipoprotein A-I
    Andrew J. Murphy, Anh Hoang, Andrea Aprico, Dmitri Sviridov and Jaye Chin-Dusting
    Journal of Pharmacology and Experimental Therapeutics January 2013, 344 (1) 41-49; DOI: https://doi.org/10.1124/jpet.112.199257
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    Hydrophobic Amino Acids in the Hinge Region of the 5A Apolipoprotein Mimetic Peptide are Essential for Promoting Cholesterol Efflux by the ABCA1 Transporter
    Denis O. Sviridov, Alexander M. Andrianov, Ivan V. Anishchenko, John A. Stonik, Marcelo J. A. Amar, Scott Turner and Alan T. Remaley
    Journal of Pharmacology and Experimental Therapeutics January 2013, 344 (1) 50-58; DOI: https://doi.org/10.1124/jpet.112.198143
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    INO-8875, a Highly Selective A1 Adenosine Receptor Agonist: Evaluation of Chronotropic, Dromotropic, and Hemodynamic Effects in Rats
    Michal Mor, Aryeh Shalev, Shani Dror, Oleg Pikovsky, Ofer Beharier, Arie Moran, Amos Katz and Yoram Etzion
    Journal of Pharmacology and Experimental Therapeutics January 2013, 344 (1) 59-67; DOI: https://doi.org/10.1124/jpet.112.200873
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    Phosphoinositide-Dependent Kinase-1 and Protein Kinase Cδ Contribute to Endothelin-1 Constriction and Elevated Blood Pressure in Intermittent Hypoxia
    Bradley R. Webster, Jessica M. Osmond, Daniel A. Paredes, Xavier A. DeLeon, Olan Jackson-Weaver, Benjimen R. Walker and Nancy L. Kanagy
    Journal of Pharmacology and Experimental Therapeutics January 2013, 344 (1) 68-76; DOI: https://doi.org/10.1124/jpet.112.195412
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    Cytosolic Ca2+–Induced Apoptosis in Rat Cardiomyocytes via Mitochondrial NO-cGMP-Protein Kinase G Pathway
    Kazuhiko Seya, Kyoichi Ono, Susumu Fujisawa, Ken Okumura, Shigeru Motomura and Ken-Ichi Furukawa
    Journal of Pharmacology and Experimental Therapeutics January 2013, 344 (1) 77-84; DOI: https://doi.org/10.1124/jpet.112.198176

Cellular and Molecular

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    Interruption of the Ionic Lock in the Bradykinin B2 Receptor Results in Constitutive Internalization and Turns Several Antagonists into Strong Agonists
    Jasmin Leschner, Goeran Wennerberg, Jens Feierler, Marcel Bermudez, Benjamin Welte, Irina Kalatskaya, Gerhard Wolber and Alexander Faussner
    Journal of Pharmacology and Experimental Therapeutics January 2013, 344 (1) 85-95; DOI: https://doi.org/10.1124/jpet.112.199190
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    C-Type Natriuretic Peptide Protects the Retinal Pigment Epithelium against Advanced Glycation End Product–Induced Barrier Dysfunction
    Mohammad Dahrouj, Oday Alsarraf, Yueying Liu, Craig E. Crosson and Zsolt Ablonczy
    Journal of Pharmacology and Experimental Therapeutics January 2013, 344 (1) 96-102; DOI: https://doi.org/10.1124/jpet.112.199307

Chemotherapy, Antibiotics, and Gene Therapy

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    Systems Pharmacological Analysis of Paclitaxel-Mediated Tumor Priming That Enhances Nanocarrier Deposition and Efficacy
    Sihem Ait-Oudhia, Robert M. Straubinger and Donald E. Mager
    Journal of Pharmacology and Experimental Therapeutics January 2013, 344 (1) 103-112; DOI: https://doi.org/10.1124/jpet.112.199109

Drug Discovery and Translational Medicine

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    Functional and Structural Interaction of (−)-Reboxetine with the Human α4β2 Nicotinic Acetylcholine Receptor
    Hugo R. Arias, Nikolai B. Fedorov, Lisa C. Benson, Patrick M. Lippiello, Greg J. Gatto, Dominik Feuerbach and Marcelo O. Ortells
    Journal of Pharmacology and Experimental Therapeutics January 2013, 344 (1) 113-123; DOI: https://doi.org/10.1124/jpet.112.197905
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    Differential Cell-Protective Function of Two Resveratrol (Trans-3,5,4′-trihydroxystilbene) Glucosides against Oxidative Stress
    Ryusuke Hosoda, Atsushi Kuno, Yusuke S. Hori, Katsuki Ohtani, Nobutaka Wakamiya, Azusa Oohiro, Hiroki Hamada and Yoshiyuki Horio
    Journal of Pharmacology and Experimental Therapeutics January 2013, 344 (1) 124-132; DOI: https://doi.org/10.1124/jpet.112.198937
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    Efficacy of the GluK1/AMPA Receptor Antagonist LY293558 against Seizures and Neuropathology in a Soman-Exposure Model without Pretreatment and its Pharmacokinetics after Intramuscular Administration
    James P. Apland, Vassiliki Aroniadou-Anderjaska, Taiza H. Figueiredo, Carol E. Green, Robert Swezey, Chun Yang, Felicia Qashu and Maria F. M. Braga
    Journal of Pharmacology and Experimental Therapeutics January 2013, 344 (1) 133-140; DOI: https://doi.org/10.1124/jpet.112.198689
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    Evaluation of Metabolically Stabilized Angiotensin IV Analogs as Procognitive/Antidementia Agents
    Alene T. McCoy, Caroline C. Benoist, John W. Wright, Leen H. Kawas, Jyote M. Bule-Ghogare, Mingyan Zhu, Suzanne M. Appleyard, Gary A. Wayman and Joseph W. Harding
    Journal of Pharmacology and Experimental Therapeutics January 2013, 344 (1) 141-154; DOI: https://doi.org/10.1124/jpet.112.199497
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    In Vitro Evaluation of Guanidine Analogs as Sigma Receptor Ligands for Potential Anti-Stroke Therapeutics
    Adam A. Behensky, Michelle Cortes-Salva, Michael J. Seminerio, Rae R. Matsumoto, Jon C. Antilla and Javier Cuevas
    Journal of Pharmacology and Experimental Therapeutics January 2013, 344 (1) 155-166; DOI: https://doi.org/10.1124/jpet.112.199513
  • You have access
    LCL124, a Cationic Analog of Ceramide, Selectively Induces Pancreatic Cancer Cell Death by Accumulating in Mitochondria
    Thomas H. Beckham, Ping Lu, Elizabeth E. Jones, Tucker Marrison, Clayton S. Lewis, Joseph C. Cheng, Venkat K. Ramshesh, Gyda Beeson, Craig C. Beeson, Richard R. Drake, Alicja Bielawska, Jacek Bielawski, Zdzislaw M. Szulc, Besim Ogretmen, James S. Norris and Xiang Liu
    Journal of Pharmacology and Experimental Therapeutics January 2013, 344 (1) 167-178; DOI: https://doi.org/10.1124/jpet.112.199216
  • You have access
    Novel Screening Assay for the Selective Detection of G-Protein-Coupled Receptor Heteromer Signaling
    Richard M. van Rijn, Jessica H. Harvey, Daniela I. Brissett, Julia N. DeFriel and Jennifer L. Whistler
    Journal of Pharmacology and Experimental Therapeutics January 2013, 344 (1) 179-188; DOI: https://doi.org/10.1124/jpet.112.198655

Gastrointestinal, Hepatic, Pulmonary, and Renal

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    Cyclooxygenase (COX)-1 and COX-2 Both Play an Important Role in the Protection of the Duodenal Mucosa in Cats
    Hiroshi Satoh, Kikuko Amagase, Satomi Ebara, Yasutada Akiba and Koji Takeuchi
    Journal of Pharmacology and Experimental Therapeutics January 2013, 344 (1) 189-195; DOI: https://doi.org/10.1124/jpet.112.199182
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    Pharmacologic Properties, Metabolism, and Disposition of Linaclotide, a Novel Therapeutic Peptide Approved for the Treatment of Irritable Bowel Syndrome with Constipation and Chronic Idiopathic Constipation
    Robert W. Busby, Marco M. Kessler, Wilmin P. Bartolini, Alexander P. Bryant, Gerhard Hannig, Carolyn S. Higgins, Robert M. Solinga, Jenny V. Tobin, James D. Wakefield, Caroline B. Kurtz and Mark G. Currie
    Journal of Pharmacology and Experimental Therapeutics January 2013, 344 (1) 196-206; DOI: https://doi.org/10.1124/jpet.112.199430
  • You have access
    Novel Insights on the Effect of Nicotine in a Murine Colitis Model
    Shakir D. AlSharari, Hamid I. Akbarali, Rehab A. Abdullah, Omer Shahab, Wimolnut Auttachoat, Gabriela A. Ferreira, Kimber L. White, Aron H. Lichtman, Guy A. Cabral and M. Imad Damaj
    Journal of Pharmacology and Experimental Therapeutics January 2013, 344 (1) 207-217; DOI: https://doi.org/10.1124/jpet.112.198796
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    In Vitro Pharmacological Characterization of Vilanterol, a Novel Long-Acting β2-Adrenoceptor Agonist with 24-Hour Duration of Action
    Robert J. Slack, Victoria J. Barrett, Valerie S. Morrison, Richard G. Sturton, Amanda J. Emmons, Alison J. Ford and Richard G. Knowles
    Journal of Pharmacology and Experimental Therapeutics January 2013, 344 (1) 218-230; DOI: https://doi.org/10.1124/jpet.112.198481

Inflammation, Immunopharmacology, and Asthma

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    Prasugrel Metabolites Inhibit Neutrophil Functions
    Elisabetta Liverani, Mario C. Rico, Analia E. Garcia, Laurie E. Kilpatrick and Satya P. Kunapuli
    Journal of Pharmacology and Experimental Therapeutics January 2013, 344 (1) 231-243; DOI: https://doi.org/10.1124/jpet.112.195883

Metabolism, Transport, and Pharmacogenomics

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    Regulation of Hepatic Phase II Metabolism in Pregnant Mice
    Xia Wen, Ajay C. Donepudi, Paul E. Thomas, Angela L. Slitt, Roberta S. King and Lauren M. Aleksunes
    Journal of Pharmacology and Experimental Therapeutics January 2013, 344 (1) 244-252; DOI: https://doi.org/10.1124/jpet.112.199034

Neuropharmacology

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    Reversal of Dopamine D2 Agonist-Induced Inhibition of Ventral Tegmental Area Neurons by Gq-Linked Neurotransmitters Is Dependent on Protein Kinase C, G Protein-Coupled Receptor Kinase, and Dynamin
    Sudarat Nimitvilai, Maureen A. McElvain and Mark S. Brodie
    Journal of Pharmacology and Experimental Therapeutics January 2013, 344 (1) 253-263; DOI: https://doi.org/10.1124/jpet.112.199844
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    The Antinociceptive Effects of Nicotinic Receptors α7-Positive Allosteric Modulators in Murine Acute and Tonic Pain Models
    Kelen Freitas, F. Ivy Carroll and M. Imad Damaj
    Journal of Pharmacology and Experimental Therapeutics January 2013, 344 (1) 264-275; DOI: https://doi.org/10.1124/jpet.112.197871
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    RETRACTION: Orexin-A Suppresses Postischemic Glucose Intolerance and Neuronal Damage through Hypothalamic Brain-Derived Neurotrophic Factor
    Shinichi Harada, Yui Yamazaki and Shogo Tokuyama
    Journal of Pharmacology and Experimental Therapeutics January 2013, 344 (1) 276-285; DOI: https://doi.org/10.1124/jpet.112.199604

Toxicology

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    Mouse Liver Protein Sulfhydryl Depletion after Acetaminophen Exposure
    Xi Yang, James Greenhaw, Qiang Shi, Dean W. Roberts, Jack A. Hinson, Levan Muskhelishvili, Kelly Davis and William F. Salminen
    Journal of Pharmacology and Experimental Therapeutics January 2013, 344 (1) 286-294; DOI: https://doi.org/10.1124/jpet.112.199067
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    Fetal Muscle-Type Nicotinic Acetylcholine Receptor Activation in TE-671 Cells and Inhibition of Fetal Movement in a Day 40 Pregnant Goat Model by Optical Isomers of the Piperidine Alkaloid Coniine
    Benedict T. Green, Stephen T. Lee, Kevin D. Welch, James A. Pfister and Kip E. Panter
    Journal of Pharmacology and Experimental Therapeutics January 2013, 344 (1) 295-307; DOI: https://doi.org/10.1124/jpet.112.199588
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    Postexposure Application of Fas Receptor Small-Interfering RNA to Suppress Sulfur Mustard–Induced Apoptosis in Human Airway Epithelial Cells: Implication for a Therapeutic Approach
    Brian M. Keyser, Devon K. Andres, Eric Nealley, Wesley W. Holmes, Betty Benton, Danielle Paradiso, Ashley Appell, Chris Carpin, Dana R. Anderson, William J. Smith and Radharaman Ray
    Journal of Pharmacology and Experimental Therapeutics January 2013, 344 (1) 308-316; DOI: https://doi.org/10.1124/jpet.112.199935

Erratum

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    Correction to Highlights: “Differential Effects of Selesipag and Prostacyclin Analogs in Rat Pulmonary Artery”
    Journal of Pharmacology and Experimental Therapeutics January 2013, 344 (1) 317; DOI: https://doi.org/10.1124/jpet.112.01er13
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Journal of Pharmacology and Experimental Therapeutics: 344 (1)
Journal of Pharmacology and Experimental Therapeutics
Vol. 344, Issue 1
1 Jan 2013
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