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Research ArticleNeuropharmacology

The Orally Active Glutamate Carboxypeptidase II Inhibitor E2072 Exhibits Sustained Nerve Exposure and Attenuates Peripheral Neuropathy

Krystyna M. Wozniak, Ying Wu, James J. Vornov, Rena Lapidus, Rana Rais, Camilo Rojas, Takashi Tsukamoto and Barbara S. Slusher
Journal of Pharmacology and Experimental Therapeutics December 2012, 343 (3) 746-754; DOI: https://doi.org/10.1124/jpet.112.197665
Krystyna M. Wozniak
Brain Science Institute, NeuroTranslational Drug Discovery Program (K.M.W.,Y.W., C.R., T.T., B.S.S.), and Departments of Neurology (R.R., T.T., B.S.S.) and Psychiatry (B.S.S.), The Johns Hopkins School of Medicine, Baltimore, Maryland; Eisai Inc., Baltimore, Maryland (K.M.W., Y.W., R.L., C.R., T.T., B.S.S.); Parexel International, Waltham, Massachusetts (J.J.V.); and Greenbaum Cancer Center, University of Maryland, Baltimore, Maryland (R.L.)
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Ying Wu
Brain Science Institute, NeuroTranslational Drug Discovery Program (K.M.W.,Y.W., C.R., T.T., B.S.S.), and Departments of Neurology (R.R., T.T., B.S.S.) and Psychiatry (B.S.S.), The Johns Hopkins School of Medicine, Baltimore, Maryland; Eisai Inc., Baltimore, Maryland (K.M.W., Y.W., R.L., C.R., T.T., B.S.S.); Parexel International, Waltham, Massachusetts (J.J.V.); and Greenbaum Cancer Center, University of Maryland, Baltimore, Maryland (R.L.)
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James J. Vornov
Brain Science Institute, NeuroTranslational Drug Discovery Program (K.M.W.,Y.W., C.R., T.T., B.S.S.), and Departments of Neurology (R.R., T.T., B.S.S.) and Psychiatry (B.S.S.), The Johns Hopkins School of Medicine, Baltimore, Maryland; Eisai Inc., Baltimore, Maryland (K.M.W., Y.W., R.L., C.R., T.T., B.S.S.); Parexel International, Waltham, Massachusetts (J.J.V.); and Greenbaum Cancer Center, University of Maryland, Baltimore, Maryland (R.L.)
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Rena Lapidus
Brain Science Institute, NeuroTranslational Drug Discovery Program (K.M.W.,Y.W., C.R., T.T., B.S.S.), and Departments of Neurology (R.R., T.T., B.S.S.) and Psychiatry (B.S.S.), The Johns Hopkins School of Medicine, Baltimore, Maryland; Eisai Inc., Baltimore, Maryland (K.M.W., Y.W., R.L., C.R., T.T., B.S.S.); Parexel International, Waltham, Massachusetts (J.J.V.); and Greenbaum Cancer Center, University of Maryland, Baltimore, Maryland (R.L.)
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Rana Rais
Brain Science Institute, NeuroTranslational Drug Discovery Program (K.M.W.,Y.W., C.R., T.T., B.S.S.), and Departments of Neurology (R.R., T.T., B.S.S.) and Psychiatry (B.S.S.), The Johns Hopkins School of Medicine, Baltimore, Maryland; Eisai Inc., Baltimore, Maryland (K.M.W., Y.W., R.L., C.R., T.T., B.S.S.); Parexel International, Waltham, Massachusetts (J.J.V.); and Greenbaum Cancer Center, University of Maryland, Baltimore, Maryland (R.L.)
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Camilo Rojas
Brain Science Institute, NeuroTranslational Drug Discovery Program (K.M.W.,Y.W., C.R., T.T., B.S.S.), and Departments of Neurology (R.R., T.T., B.S.S.) and Psychiatry (B.S.S.), The Johns Hopkins School of Medicine, Baltimore, Maryland; Eisai Inc., Baltimore, Maryland (K.M.W., Y.W., R.L., C.R., T.T., B.S.S.); Parexel International, Waltham, Massachusetts (J.J.V.); and Greenbaum Cancer Center, University of Maryland, Baltimore, Maryland (R.L.)
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Takashi Tsukamoto
Brain Science Institute, NeuroTranslational Drug Discovery Program (K.M.W.,Y.W., C.R., T.T., B.S.S.), and Departments of Neurology (R.R., T.T., B.S.S.) and Psychiatry (B.S.S.), The Johns Hopkins School of Medicine, Baltimore, Maryland; Eisai Inc., Baltimore, Maryland (K.M.W., Y.W., R.L., C.R., T.T., B.S.S.); Parexel International, Waltham, Massachusetts (J.J.V.); and Greenbaum Cancer Center, University of Maryland, Baltimore, Maryland (R.L.)
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Barbara S. Slusher
Brain Science Institute, NeuroTranslational Drug Discovery Program (K.M.W.,Y.W., C.R., T.T., B.S.S.), and Departments of Neurology (R.R., T.T., B.S.S.) and Psychiatry (B.S.S.), The Johns Hopkins School of Medicine, Baltimore, Maryland; Eisai Inc., Baltimore, Maryland (K.M.W., Y.W., R.L., C.R., T.T., B.S.S.); Parexel International, Waltham, Massachusetts (J.J.V.); and Greenbaum Cancer Center, University of Maryland, Baltimore, Maryland (R.L.)
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Journal of Pharmacology and Experimental Therapeutics: 343 (3)
Journal of Pharmacology and Experimental Therapeutics
Vol. 343, Issue 3
1 Dec 2012
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Research ArticleNeuropharmacology

GCPII Inhibitor E2072 Attenuates Neuropathy

Krystyna M. Wozniak, Ying Wu, James J. Vornov, Rena Lapidus, Rana Rais, Camilo Rojas, Takashi Tsukamoto and Barbara S. Slusher
Journal of Pharmacology and Experimental Therapeutics December 1, 2012, 343 (3) 746-754; DOI: https://doi.org/10.1124/jpet.112.197665

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Research ArticleNeuropharmacology

GCPII Inhibitor E2072 Attenuates Neuropathy

Krystyna M. Wozniak, Ying Wu, James J. Vornov, Rena Lapidus, Rana Rais, Camilo Rojas, Takashi Tsukamoto and Barbara S. Slusher
Journal of Pharmacology and Experimental Therapeutics December 1, 2012, 343 (3) 746-754; DOI: https://doi.org/10.1124/jpet.112.197665
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