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Research ArticleDrug Discovery and Translational Medicine

Effects of the Novel α7 Nicotinic Acetylcholine Receptor Agonist ABT-107 on Sensory Gating in DBA/2 Mice: Pharmacodynamic Characterization

Richard J. Radek, Holly M. Robb, Karen E. Stevens, Murali Gopalakrishnan and Robert S. Bitner
Journal of Pharmacology and Experimental Therapeutics December 2012, 343 (3) 736-745; DOI: https://doi.org/10.1124/jpet.112.197970
Richard J. Radek
Department of Neuroscience Research, Abbott Laboratories, Abbott Park, Illinois (R.J.R., H.M.R., M.G., R.S.B.); Medical Research Service, Department of Veterans Affairs Medical Center, Denver, Colorado (K.E.S.); and Department of Psychiatry, University of Colorado School of Medicine, Aurora, Colorado (K.E.S.)
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Holly M. Robb
Department of Neuroscience Research, Abbott Laboratories, Abbott Park, Illinois (R.J.R., H.M.R., M.G., R.S.B.); Medical Research Service, Department of Veterans Affairs Medical Center, Denver, Colorado (K.E.S.); and Department of Psychiatry, University of Colorado School of Medicine, Aurora, Colorado (K.E.S.)
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Karen E. Stevens
Department of Neuroscience Research, Abbott Laboratories, Abbott Park, Illinois (R.J.R., H.M.R., M.G., R.S.B.); Medical Research Service, Department of Veterans Affairs Medical Center, Denver, Colorado (K.E.S.); and Department of Psychiatry, University of Colorado School of Medicine, Aurora, Colorado (K.E.S.)
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Murali Gopalakrishnan
Department of Neuroscience Research, Abbott Laboratories, Abbott Park, Illinois (R.J.R., H.M.R., M.G., R.S.B.); Medical Research Service, Department of Veterans Affairs Medical Center, Denver, Colorado (K.E.S.); and Department of Psychiatry, University of Colorado School of Medicine, Aurora, Colorado (K.E.S.)
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Robert S. Bitner
Department of Neuroscience Research, Abbott Laboratories, Abbott Park, Illinois (R.J.R., H.M.R., M.G., R.S.B.); Medical Research Service, Department of Veterans Affairs Medical Center, Denver, Colorado (K.E.S.); and Department of Psychiatry, University of Colorado School of Medicine, Aurora, Colorado (K.E.S.)
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Article Information

vol. 343 no. 3 736-745
DOI 
https://doi.org/10.1124/jpet.112.197970
PubMed 
22988063

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received June 29, 2012
  • Accepted September 13, 2012
  • Published online November 14, 2012.

Article Versions

  • Earlier version (September 17, 2012 - 12:59).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2012 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Richard J. Radek,
  2. Holly M. Robb,
  3. Karen E. Stevens,
  4. Murali Gopalakrishnan, and
  5. Robert S. Bitner
  1. Department of Neuroscience Research, Abbott Laboratories, Abbott Park, Illinois (R.J.R., H.M.R., M.G., R.S.B.); Medical Research Service, Department of Veterans Affairs Medical Center, Denver, Colorado (K.E.S.); and Department of Psychiatry, University of Colorado School of Medicine, Aurora, Colorado (K.E.S.)
  1. Address correspondence to:
    Richard J. Radek, Global Pharmaceutical Research and Development, Abbott Laboratories, Dept. R4N5, AP9A/LL, 100 Abbott Park Road, Abbott Park, IL 60064. E-mail: rich.j.radek{at}abbott.com
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Journal of Pharmacology and Experimental Therapeutics: 343 (3)
Journal of Pharmacology and Experimental Therapeutics
Vol. 343, Issue 3
1 Dec 2012
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Research ArticleDrug Discovery and Translational Medicine

α7 Agonist ABT-107 and Sensory Gating

Richard J. Radek, Holly M. Robb, Karen E. Stevens, Murali Gopalakrishnan and Robert S. Bitner
Journal of Pharmacology and Experimental Therapeutics December 1, 2012, 343 (3) 736-745; DOI: https://doi.org/10.1124/jpet.112.197970

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Research ArticleDrug Discovery and Translational Medicine

α7 Agonist ABT-107 and Sensory Gating

Richard J. Radek, Holly M. Robb, Karen E. Stevens, Murali Gopalakrishnan and Robert S. Bitner
Journal of Pharmacology and Experimental Therapeutics December 1, 2012, 343 (3) 736-745; DOI: https://doi.org/10.1124/jpet.112.197970
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