Research ArticleCellular and Molecular
Antagonists of GPR35 Display High Species Ortholog Selectivity and Varying Modes of Action
Laura Jenkins, Nicholas Harries, Jennifer E. Lappin, Amanda E. MacKenzie, Zaynab Neetoo-Isseljee, Craig Southern, Edward G. McIver, Stuart A. Nicklin, Debra L. Taylor and Graeme Milligan
Journal of Pharmacology and Experimental Therapeutics December 2012, 343 (3) 683-695; DOI: https://doi.org/10.1124/jpet.112.198945
Laura Jenkins
Molecular Pharmacology Group, Institute of Molecular, Cell, and Systems Biology, (L.J., N.H., J.E.L., A.E.M., G.M.) and Institute of Cardiovascular and Medical Sciences (J.E.L., S.A.N.), College of Medical, Veterinary, and Life Sciences, University of Glasgow, Glasgow, United Kingdom; and Medical Research Council Technology, Centre for Therapeutics Discovery, London, United Kingdom (Z.N.-I., C.S., E.G.M., D.L.T.)
Nicholas Harries
Molecular Pharmacology Group, Institute of Molecular, Cell, and Systems Biology, (L.J., N.H., J.E.L., A.E.M., G.M.) and Institute of Cardiovascular and Medical Sciences (J.E.L., S.A.N.), College of Medical, Veterinary, and Life Sciences, University of Glasgow, Glasgow, United Kingdom; and Medical Research Council Technology, Centre for Therapeutics Discovery, London, United Kingdom (Z.N.-I., C.S., E.G.M., D.L.T.)
Jennifer E. Lappin
Molecular Pharmacology Group, Institute of Molecular, Cell, and Systems Biology, (L.J., N.H., J.E.L., A.E.M., G.M.) and Institute of Cardiovascular and Medical Sciences (J.E.L., S.A.N.), College of Medical, Veterinary, and Life Sciences, University of Glasgow, Glasgow, United Kingdom; and Medical Research Council Technology, Centre for Therapeutics Discovery, London, United Kingdom (Z.N.-I., C.S., E.G.M., D.L.T.)
Amanda E. MacKenzie
Molecular Pharmacology Group, Institute of Molecular, Cell, and Systems Biology, (L.J., N.H., J.E.L., A.E.M., G.M.) and Institute of Cardiovascular and Medical Sciences (J.E.L., S.A.N.), College of Medical, Veterinary, and Life Sciences, University of Glasgow, Glasgow, United Kingdom; and Medical Research Council Technology, Centre for Therapeutics Discovery, London, United Kingdom (Z.N.-I., C.S., E.G.M., D.L.T.)
Zaynab Neetoo-Isseljee
Molecular Pharmacology Group, Institute of Molecular, Cell, and Systems Biology, (L.J., N.H., J.E.L., A.E.M., G.M.) and Institute of Cardiovascular and Medical Sciences (J.E.L., S.A.N.), College of Medical, Veterinary, and Life Sciences, University of Glasgow, Glasgow, United Kingdom; and Medical Research Council Technology, Centre for Therapeutics Discovery, London, United Kingdom (Z.N.-I., C.S., E.G.M., D.L.T.)
Craig Southern
Molecular Pharmacology Group, Institute of Molecular, Cell, and Systems Biology, (L.J., N.H., J.E.L., A.E.M., G.M.) and Institute of Cardiovascular and Medical Sciences (J.E.L., S.A.N.), College of Medical, Veterinary, and Life Sciences, University of Glasgow, Glasgow, United Kingdom; and Medical Research Council Technology, Centre for Therapeutics Discovery, London, United Kingdom (Z.N.-I., C.S., E.G.M., D.L.T.)
Edward G. McIver
Molecular Pharmacology Group, Institute of Molecular, Cell, and Systems Biology, (L.J., N.H., J.E.L., A.E.M., G.M.) and Institute of Cardiovascular and Medical Sciences (J.E.L., S.A.N.), College of Medical, Veterinary, and Life Sciences, University of Glasgow, Glasgow, United Kingdom; and Medical Research Council Technology, Centre for Therapeutics Discovery, London, United Kingdom (Z.N.-I., C.S., E.G.M., D.L.T.)
Stuart A. Nicklin
Molecular Pharmacology Group, Institute of Molecular, Cell, and Systems Biology, (L.J., N.H., J.E.L., A.E.M., G.M.) and Institute of Cardiovascular and Medical Sciences (J.E.L., S.A.N.), College of Medical, Veterinary, and Life Sciences, University of Glasgow, Glasgow, United Kingdom; and Medical Research Council Technology, Centre for Therapeutics Discovery, London, United Kingdom (Z.N.-I., C.S., E.G.M., D.L.T.)
Debra L. Taylor
Molecular Pharmacology Group, Institute of Molecular, Cell, and Systems Biology, (L.J., N.H., J.E.L., A.E.M., G.M.) and Institute of Cardiovascular and Medical Sciences (J.E.L., S.A.N.), College of Medical, Veterinary, and Life Sciences, University of Glasgow, Glasgow, United Kingdom; and Medical Research Council Technology, Centre for Therapeutics Discovery, London, United Kingdom (Z.N.-I., C.S., E.G.M., D.L.T.)
Graeme Milligan
Molecular Pharmacology Group, Institute of Molecular, Cell, and Systems Biology, (L.J., N.H., J.E.L., A.E.M., G.M.) and Institute of Cardiovascular and Medical Sciences (J.E.L., S.A.N.), College of Medical, Veterinary, and Life Sciences, University of Glasgow, Glasgow, United Kingdom; and Medical Research Council Technology, Centre for Therapeutics Discovery, London, United Kingdom (Z.N.-I., C.S., E.G.M., D.L.T.)
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In this issue
Research ArticleCellular and Molecular
Species Selectivity of GPR35 Antagonists
Laura Jenkins, Nicholas Harries, Jennifer E. Lappin, Amanda E. MacKenzie, Zaynab Neetoo-Isseljee, Craig Southern, Edward G. McIver, Stuart A. Nicklin, Debra L. Taylor and Graeme Milligan
Journal of Pharmacology and Experimental Therapeutics December 1, 2012, 343 (3) 683-695; DOI: https://doi.org/10.1124/jpet.112.198945
Research ArticleCellular and Molecular
Species Selectivity of GPR35 Antagonists
Laura Jenkins, Nicholas Harries, Jennifer E. Lappin, Amanda E. MacKenzie, Zaynab Neetoo-Isseljee, Craig Southern, Edward G. McIver, Stuart A. Nicklin, Debra L. Taylor and Graeme Milligan
Journal of Pharmacology and Experimental Therapeutics December 1, 2012, 343 (3) 683-695; DOI: https://doi.org/10.1124/jpet.112.198945
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