Research ArticleDrug Discovery and Translational Medicine
Synthetic Farnesoid X Receptor Agonists Induce High-Density Lipoprotein-Mediated Transhepatic Cholesterol Efflux in Mice and Monkeys and Prevent Atherosclerosis in Cholesteryl Ester Transfer Protein Transgenic Low-Density Lipoprotein Receptor (−/−) Mice
Eva Hambruch, Shinobu Miyazaki-Anzai, Ulrike Hahn, Silke Matysik, Alfred Boettcher, Sanja Perović-Ottstadt, Thomas Schlüter, Olaf Kinzel, Helen Desiree Krol, Ulrich Deuschle, Michael Burnet, Moshe Levi, Gerd Schmitz, Makoto Miyazaki and Claus Kremoser
Journal of Pharmacology and Experimental Therapeutics December 2012, 343 (3) 556-567; DOI: https://doi.org/10.1124/jpet.112.196519
Eva Hambruch
Phenex Pharmaceuticals AG, Heidelberg, Germany (E.H., S.P.-O., T.S., O.K., H.D.K., U.D., C.K.); Division of Renal Diseases and Hypertension, University of Colorado, Denver, Colorado (S.M.-A., M.L., M.M.); Synovo GmbH, Tübingen, Germany (U.H., M.B.); and Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, Regensburg, Germany (S.M., A.B., G.S.)
Shinobu Miyazaki-Anzai
Phenex Pharmaceuticals AG, Heidelberg, Germany (E.H., S.P.-O., T.S., O.K., H.D.K., U.D., C.K.); Division of Renal Diseases and Hypertension, University of Colorado, Denver, Colorado (S.M.-A., M.L., M.M.); Synovo GmbH, Tübingen, Germany (U.H., M.B.); and Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, Regensburg, Germany (S.M., A.B., G.S.)
Ulrike Hahn
Phenex Pharmaceuticals AG, Heidelberg, Germany (E.H., S.P.-O., T.S., O.K., H.D.K., U.D., C.K.); Division of Renal Diseases and Hypertension, University of Colorado, Denver, Colorado (S.M.-A., M.L., M.M.); Synovo GmbH, Tübingen, Germany (U.H., M.B.); and Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, Regensburg, Germany (S.M., A.B., G.S.)
Silke Matysik
Phenex Pharmaceuticals AG, Heidelberg, Germany (E.H., S.P.-O., T.S., O.K., H.D.K., U.D., C.K.); Division of Renal Diseases and Hypertension, University of Colorado, Denver, Colorado (S.M.-A., M.L., M.M.); Synovo GmbH, Tübingen, Germany (U.H., M.B.); and Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, Regensburg, Germany (S.M., A.B., G.S.)
Alfred Boettcher
Phenex Pharmaceuticals AG, Heidelberg, Germany (E.H., S.P.-O., T.S., O.K., H.D.K., U.D., C.K.); Division of Renal Diseases and Hypertension, University of Colorado, Denver, Colorado (S.M.-A., M.L., M.M.); Synovo GmbH, Tübingen, Germany (U.H., M.B.); and Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, Regensburg, Germany (S.M., A.B., G.S.)
Sanja Perović-Ottstadt
Phenex Pharmaceuticals AG, Heidelberg, Germany (E.H., S.P.-O., T.S., O.K., H.D.K., U.D., C.K.); Division of Renal Diseases and Hypertension, University of Colorado, Denver, Colorado (S.M.-A., M.L., M.M.); Synovo GmbH, Tübingen, Germany (U.H., M.B.); and Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, Regensburg, Germany (S.M., A.B., G.S.)
Thomas Schlüter
Phenex Pharmaceuticals AG, Heidelberg, Germany (E.H., S.P.-O., T.S., O.K., H.D.K., U.D., C.K.); Division of Renal Diseases and Hypertension, University of Colorado, Denver, Colorado (S.M.-A., M.L., M.M.); Synovo GmbH, Tübingen, Germany (U.H., M.B.); and Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, Regensburg, Germany (S.M., A.B., G.S.)
Olaf Kinzel
Phenex Pharmaceuticals AG, Heidelberg, Germany (E.H., S.P.-O., T.S., O.K., H.D.K., U.D., C.K.); Division of Renal Diseases and Hypertension, University of Colorado, Denver, Colorado (S.M.-A., M.L., M.M.); Synovo GmbH, Tübingen, Germany (U.H., M.B.); and Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, Regensburg, Germany (S.M., A.B., G.S.)
Helen Desiree Krol
Phenex Pharmaceuticals AG, Heidelberg, Germany (E.H., S.P.-O., T.S., O.K., H.D.K., U.D., C.K.); Division of Renal Diseases and Hypertension, University of Colorado, Denver, Colorado (S.M.-A., M.L., M.M.); Synovo GmbH, Tübingen, Germany (U.H., M.B.); and Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, Regensburg, Germany (S.M., A.B., G.S.)
Ulrich Deuschle
Phenex Pharmaceuticals AG, Heidelberg, Germany (E.H., S.P.-O., T.S., O.K., H.D.K., U.D., C.K.); Division of Renal Diseases and Hypertension, University of Colorado, Denver, Colorado (S.M.-A., M.L., M.M.); Synovo GmbH, Tübingen, Germany (U.H., M.B.); and Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, Regensburg, Germany (S.M., A.B., G.S.)
Michael Burnet
Phenex Pharmaceuticals AG, Heidelberg, Germany (E.H., S.P.-O., T.S., O.K., H.D.K., U.D., C.K.); Division of Renal Diseases and Hypertension, University of Colorado, Denver, Colorado (S.M.-A., M.L., M.M.); Synovo GmbH, Tübingen, Germany (U.H., M.B.); and Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, Regensburg, Germany (S.M., A.B., G.S.)
Moshe Levi
Phenex Pharmaceuticals AG, Heidelberg, Germany (E.H., S.P.-O., T.S., O.K., H.D.K., U.D., C.K.); Division of Renal Diseases and Hypertension, University of Colorado, Denver, Colorado (S.M.-A., M.L., M.M.); Synovo GmbH, Tübingen, Germany (U.H., M.B.); and Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, Regensburg, Germany (S.M., A.B., G.S.)
Gerd Schmitz
Phenex Pharmaceuticals AG, Heidelberg, Germany (E.H., S.P.-O., T.S., O.K., H.D.K., U.D., C.K.); Division of Renal Diseases and Hypertension, University of Colorado, Denver, Colorado (S.M.-A., M.L., M.M.); Synovo GmbH, Tübingen, Germany (U.H., M.B.); and Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, Regensburg, Germany (S.M., A.B., G.S.)
Makoto Miyazaki
Phenex Pharmaceuticals AG, Heidelberg, Germany (E.H., S.P.-O., T.S., O.K., H.D.K., U.D., C.K.); Division of Renal Diseases and Hypertension, University of Colorado, Denver, Colorado (S.M.-A., M.L., M.M.); Synovo GmbH, Tübingen, Germany (U.H., M.B.); and Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, Regensburg, Germany (S.M., A.B., G.S.)
Claus Kremoser
Phenex Pharmaceuticals AG, Heidelberg, Germany (E.H., S.P.-O., T.S., O.K., H.D.K., U.D., C.K.); Division of Renal Diseases and Hypertension, University of Colorado, Denver, Colorado (S.M.-A., M.L., M.M.); Synovo GmbH, Tübingen, Germany (U.H., M.B.); and Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, Regensburg, Germany (S.M., A.B., G.S.)

JPET articles become freely available 12 months after publication, and remain freely available for 5 years.Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page.
|
Log in using your username and password
Purchase access
You may purchase access to this article. This will require you to create an account if you don't already have one.
In this issue
Research ArticleDrug Discovery and Translational Medicine
FXR Agonists Induce Transhepatic Cholesterol Flux
Eva Hambruch, Shinobu Miyazaki-Anzai, Ulrike Hahn, Silke Matysik, Alfred Boettcher, Sanja Perović-Ottstadt, Thomas Schlüter, Olaf Kinzel, Helen Desiree Krol, Ulrich Deuschle, Michael Burnet, Moshe Levi, Gerd Schmitz, Makoto Miyazaki and Claus Kremoser
Journal of Pharmacology and Experimental Therapeutics December 1, 2012, 343 (3) 556-567; DOI: https://doi.org/10.1124/jpet.112.196519
Research ArticleDrug Discovery and Translational Medicine
FXR Agonists Induce Transhepatic Cholesterol Flux
Eva Hambruch, Shinobu Miyazaki-Anzai, Ulrike Hahn, Silke Matysik, Alfred Boettcher, Sanja Perović-Ottstadt, Thomas Schlüter, Olaf Kinzel, Helen Desiree Krol, Ulrich Deuschle, Michael Burnet, Moshe Levi, Gerd Schmitz, Makoto Miyazaki and Claus Kremoser
Journal of Pharmacology and Experimental Therapeutics December 1, 2012, 343 (3) 556-567; DOI: https://doi.org/10.1124/jpet.112.196519