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Research ArticlePerspectives in Pharmacology

Sarcopenia: Pharmacology of Today and Tomorrow

Marco Brotto and Eduardo L. Abreu
Journal of Pharmacology and Experimental Therapeutics December 2012, 343 (3) 540-546; DOI: https://doi.org/10.1124/jpet.112.191759
Marco Brotto
Muscle Biology Research Group-MUBIG, Schools of Nursing and Medicine, University of Missouri-Kansas City, Kansas City, Missouri
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Eduardo L. Abreu
Muscle Biology Research Group-MUBIG, Schools of Nursing and Medicine, University of Missouri-Kansas City, Kansas City, Missouri
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Abstract

Sarcopenia remains largely undiagnosed and undertreated because of the lack of a universally accepted definition, effective ways to measure it, and identification of the outcomes that should guide treatment efficacy. An ever-growing number of clinicians and researchers along with funding and regulatory agencies have gradually recognized that sarcopenia is a human condition that requires both prevention and treatment. In this article, we review sarcopenia and its common and less known pharmacological treatments, attempt to define sarcopenia in its broader context, and present some new ideas for potential future treatment for this devastating condition.

Footnotes

  • This work was supported by the National Institutes of Health National Institute of Arthritis and Musculoskeletal and Skin Diseases [Grant RC2-AR058962]; the National Institutes of Health National Institute on Aging [Grant 1P01-AG039355-01A1]; and grants from Missouri Life Sciences Research Board and Department of Health Services-Clay County Senior Services (to MB).

  • Article, publication date, and citation information can be found at http://jpet.aspetjournals.org.

    http://dx.doi.org/10.1124/jpet.112.191759.

  • ABBREVIATIONS:

    GH
    growth hormone
    DHEA
    dehydroepiandrosterone
    EPA
    eicosapentaenoic acid
    DHA
    docosahexaenoic acid
    ALA
    α-linolenic acid
    ACE
    angiotensin-converting enzyme
    Myf-5
    myogenic factor 5
    AICAR
    5-amino-1-β-d-ribofuranosyl-imidazole-4-carboxamide.

  • Received June 26, 2012.
  • Accepted August 27, 2012.
  • Copyright © 2012 by The American Society for Pharmacology and Experimental Therapeutics
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Journal of Pharmacology and Experimental Therapeutics: 343 (3)
Journal of Pharmacology and Experimental Therapeutics
Vol. 343, Issue 3
1 Dec 2012
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Research ArticlePerspectives in Pharmacology

Sarcopenia: Today and Tomorrow

Marco Brotto and Eduardo L. Abreu
Journal of Pharmacology and Experimental Therapeutics December 1, 2012, 343 (3) 540-546; DOI: https://doi.org/10.1124/jpet.112.191759

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Research ArticlePerspectives in Pharmacology

Sarcopenia: Today and Tomorrow

Marco Brotto and Eduardo L. Abreu
Journal of Pharmacology and Experimental Therapeutics December 1, 2012, 343 (3) 540-546; DOI: https://doi.org/10.1124/jpet.112.191759
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  • Article
    • Abstract
    • Introduction
    • Sarcopenia: A Working Definition
    • Why Prevent and Treat Sarcopenia?
    • Can Resistance Exercise Prevent or Treat Sarcopenia?
    • How Is Sarcopenia Being Treated Pharmacologically?
    • New Perspectives and a Good “Dose” of Postulation
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