Journal of Pharmacology and Experimental Therapeutics: 343 (3)

December 01, 2012; Volume 343,Issue 3

Highlighted Papers

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Natriuretic Peptide-Induced Catecholamine Release From Cardiac Sympathetic Neurons
Journal of Pharmacology and Experimental Therapeutics December 2012, 343 (3) 539;
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GPR35 Antagonists Display High Species Ortholog Selectivity
Journal of Pharmacology and Experimental Therapeutics December 2012, 343 (3) 539;
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Strontium Is a Biased Agonist of the Calcium-Sensing Receptor
Journal of Pharmacology and Experimental Therapeutics December 2012, 343 (3) 539;
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Differential Effects of Selexipag and Prostacyclin Analogs in Rat Pulmonary Artery
Journal of Pharmacology and Experimental Therapeutics December 2012, 343 (3) 539;

Perspectives in Pharmacology

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Sarcopenia: Pharmacology of Today and Tomorrow
Marco Brotto and Eduardo L. Abreu

Journal of Pharmacology and Experimental Therapeutics December 2012, 343 (3) 540-546; DOI: https://doi.org/10.1124/jpet.112.191759

Cardiovascular

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Natriuretic Peptide-Induced Catecholamine Release from Cardiac Sympathetic Neurons: Inhibition by Histamine H₃ and H₄ Receptor Activation
Noel Yan-Ki Chan, Pablo A. Robador and Roberto Levi

Journal of Pharmacology and Experimental Therapeutics December 2012, 343 (3) 568-577; DOI: https://doi.org/10.1124/jpet.112.198747
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GS-6201, a Selective Blocker of the A_2B Adenosine Receptor, Attenuates Cardiac Remodeling after Acute Myocardial Infarction in the Mouse
Stefano Toldo, Hongyan Zhong, Eleonora Mezzaroma, Benjamin W. Van Tassell, Harsha Kannan, Dewan Zeng, Luiz Belardinelli, Norbert F. Voelkel and Antonio Abbate

Journal of Pharmacology and Experimental Therapeutics December 2012, 343 (3) 587-595; DOI: https://doi.org/10.1124/jpet.111.191288
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Novel Antiplatelet Activity of Protocatechuic Acid through the Inhibition of High Shear Stress-Induced Platelet Aggregation
Keunyoung Kim, Ok-Nam Bae, Kyung-Min Lim, Ji-Yoon Noh, Seojin Kang, Ka Young Chung and Jin-Ho Chung

Journal of Pharmacology and Experimental Therapeutics December 2012, 343 (3) 704-711; DOI: https://doi.org/10.1124/jpet.112.198242
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Identification of Contractile P2Y₁, P2Y₆, and P2Y₁₂ Receptors in Rat Intrapulmonary Artery Using Selective Ligands
Callum Mitchell, Nawazish-i-Husain Syed, Asrin Tengah, Alison M. Gurney and Charles Kennedy

Journal of Pharmacology and Experimental Therapeutics December 2012, 343 (3) 755-762; DOI: https://doi.org/10.1124/jpet.112.198051

Cellular and Molecular

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Strontium Is a Biased Agonist of the Calcium-Sensing Receptor in Rat Medullary Thyroid Carcinoma 6-23 Cells
Alex Rojas Bie Thomsen, Jesper Worm, Stine Engesgaard Jacobsen, Martin Stahlhut, Markus Latta and Hans Bräuner-Osborne

Journal of Pharmacology and Experimental Therapeutics December 2012, 343 (3) 638-649; DOI: https://doi.org/10.1124/jpet.112.197210
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Antagonists of GPR35 Display High Species Ortholog Selectivity and Varying Modes of Action
Laura Jenkins, Nicholas Harries, Jennifer E. Lappin, Amanda E. MacKenzie, Zaynab Neetoo-Isseljee, Craig Southern, Edward G. McIver, Stuart A. Nicklin, Debra L. Taylor and Graeme Milligan

Journal of Pharmacology and Experimental Therapeutics December 2012, 343 (3) 683-695; DOI: https://doi.org/10.1124/jpet.112.198945
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The Autophagy-Senescence Connection in Chemotherapy: Must Tumor Cells (Self) Eat Before They Sleep?
Rachel W. Goehe, Xu Di, Khushboo Sharma, Molly L. Bristol, Scott C. Henderson, Kristoffer Valerie, Francis Rodier, Albert R. Davalos and David A. Gewirtz

Journal of Pharmacology and Experimental Therapeutics December 2012, 343 (3) 763-778; DOI: https://doi.org/10.1124/jpet.112.197590

Drug Discovery and Translational Medicine

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Differential Effects of Selexipag and Prostacyclin Analogs in Rat Pulmonary Artery
Keith Morrison, Rolf Studer, Roland Ernst, Franck Haag, Katalin Kauser and Martine Clozel

Journal of Pharmacology and Experimental Therapeutics December 2012, 343 (3) 547-555; DOI: https://doi.org/10.1124/jpet.112.197152
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Synthetic Farnesoid X Receptor Agonists Induce High-Density Lipoprotein-Mediated Transhepatic Cholesterol Efflux in Mice and Monkeys and Prevent Atherosclerosis in Cholesteryl Ester Transfer Protein Transgenic Low-Density Lipoprotein Receptor (−/−) Mice
Eva Hambruch, Shinobu Miyazaki-Anzai, Ulrike Hahn, Silke Matysik, Alfred Boettcher, Sanja Perović-Ottstadt, Thomas Schlüter, Olaf Kinzel, Helen Desiree Krol, Ulrich Deuschle, Michael Burnet, Moshe Levi, Gerd Schmitz, Makoto Miyazaki and Claus Kremoser

Journal of Pharmacology and Experimental Therapeutics December 2012, 343 (3) 556-567; DOI: https://doi.org/10.1124/jpet.112.196519
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Preclinical Characterization of ABT-348, a Kinase Inhibitor Targeting the Aurora, Vascular Endothelial Growth Factor Receptor/Platelet-Derived Growth Factor Receptor, and Src Kinase Families
Keith B. Glaser, Junling Li, Patrick A. Marcotte, Terrance J. Magoc, Jun Guo, David R. Reuter, Paul Tapang, Ru-Qi Wei, Lori J. Pease, Mai H. Bui, Zehan Chen, Robin R. Frey, Eric F. Johnson, Donald J. Osterling, Amanda M. Olson, Jennifer J. Bouska, Yanping Luo, Michael L. Curtin, Cherrie K. Donawho, Michael R. Michaelides, Chris Tse, Steven K. Davidsen and Daniel H. Albert

Journal of Pharmacology and Experimental Therapeutics December 2012, 343 (3) 617-627; DOI: https://doi.org/10.1124/jpet.112.197087
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Effects of the Novel α7 Nicotinic Acetylcholine Receptor Agonist ABT-107 on Sensory Gating in DBA/2 Mice: Pharmacodynamic Characterization
Richard J. Radek, Holly M. Robb, Karen E. Stevens, Murali Gopalakrishnan and Robert S. Bitner

Journal of Pharmacology and Experimental Therapeutics December 2012, 343 (3) 736-745; DOI: https://doi.org/10.1124/jpet.112.197970

Endocrine and Diabetes

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σ-1 Receptor at the Mitochondrial-Associated Endoplasmic Reticulum Membrane Is Responsible for Mitochondrial Metabolic Regulation
Karla-Sue C. Marriott, Manoj Prasad, Veena Thapliyal and Himangshu S. Bose

Journal of Pharmacology and Experimental Therapeutics December 2012, 343 (3) 578-586; DOI: https://doi.org/10.1124/jpet.112.198168

Inflammation, Immunopharmacology, and Asthma

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Inhibitory Influence of the Hexapeptidic Sequence SLIGRL on Influenza A Virus Infection in Mice
Richard J. Betts, Tracy S. Mann and Peter J. Henry

Journal of Pharmacology and Experimental Therapeutics December 2012, 343 (3) 725-735; DOI: https://doi.org/10.1124/jpet.112.196485

Metabolism, Transport, and Pharmacogenomics

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A Clearance System for Prostaglandin D₂, a Sleep-Promoting Factor, in Cerebrospinal Fluid: Role of the Blood-Cerebrospinal Barrier Transporters
Masanori Tachikawa, Kazuhiro Tsuji, Reiji Yokoyama, Takanori Higuchi, Go Ozeki, Ayane Yashiki, Shin-ichi Akanuma, Kazuyuki Hayashi, Akio Nishiura and Ken-ichi Hosoya

Journal of Pharmacology and Experimental Therapeutics December 2012, 343 (3) 608-616; DOI: https://doi.org/10.1124/jpet.112.197012
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Differential Effects of Nicotine Treatment and Ethanol Self-Administration on CYP2A6, CYP2B6 and Nicotine Pharmacokinetics in African Green Monkeys
C. S. Ferguson, S. Miksys, R. M. Palmour and R. F. Tyndale

Journal of Pharmacology and Experimental Therapeutics December 2012, 343 (3) 628-637; DOI: https://doi.org/10.1124/jpet.112.198564
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Inflammatory Regulation of ATP Binding Cassette Efflux Transporter Expression and Function in Microglia
Christopher J. Gibson, Muhammad M. Hossain, Jason R. Richardson and Lauren M. Aleksunes

Journal of Pharmacology and Experimental Therapeutics December 2012, 343 (3) 650-660; DOI: https://doi.org/10.1124/jpet.112.196543
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Identification and Functional Characterization of a Novel UDP-Glucuronosyltransferase 2A1 Splice Variant: Potential Importance in Tobacco-Related Cancer Susceptibility
Ryan T. Bushey and Philip Lazarus

Journal of Pharmacology and Experimental Therapeutics December 2012, 343 (3) 712-724; DOI: https://doi.org/10.1124/jpet.112.198770

Neuropharmacology

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Na⁺,K⁺-ATPase Functionally Interacts with the Plasma Membrane Na⁺,Ca²⁺ Exchanger to Prevent Ca²⁺ Overload and Neuronal Apoptosis in Excitotoxic Stress
Dmitry A. Sibarov, Artemiy E. Bolshakov, Polina A. Abushik, Igor I. Krivoi and Sergei M. Antonov

Journal of Pharmacology and Experimental Therapeutics December 2012, 343 (3) 596-607; DOI: https://doi.org/10.1124/jpet.112.198341
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Central Mechanisms of Menthol-Induced Analgesia
Rong Pan, Yuzhen Tian, Ruby Gao, Haitao Li, Xianguo Zhao, James E. Barrett and Huijuan Hu

Journal of Pharmacology and Experimental Therapeutics December 2012, 343 (3) 661-672; DOI: https://doi.org/10.1124/jpet.112.196717
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The Orally Active Glutamate Carboxypeptidase II Inhibitor E2072 Exhibits Sustained Nerve Exposure and Attenuates Peripheral Neuropathy
Krystyna M. Wozniak, Ying Wu, James J. Vornov, Rena Lapidus, Rana Rais, Camilo Rojas, Takashi Tsukamoto and Barbara S. Slusher

Journal of Pharmacology and Experimental Therapeutics December 2012, 343 (3) 746-754; DOI: https://doi.org/10.1124/jpet.112.197665

Toxicology

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Identification of Human Butyrylcholinesterase Organophosphate-Resistant Variants through a Novel Mammalian Enzyme Functional Screen
Jun Zhang, Sigeng Chen, Erik C. Ralph, Mary Dwyer and John R. Cashman

Journal of Pharmacology and Experimental Therapeutics December 2012, 343 (3) 673-682; DOI: https://doi.org/10.1124/jpet.112.198499
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Dendritic Spine Injury Induced by the 8-Hydroxy Metabolite of Efavirenz
Luis B. Tovar-y-Romo, Namandjé N. Bumpus, Daniel Pomerantz, Lindsay B. Avery, Ned Sacktor, Justin C. McArthur and Norman J. Haughey

Journal of Pharmacology and Experimental Therapeutics December 2012, 343 (3) 696-703; DOI: https://doi.org/10.1124/jpet.112.195701

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Table of Contents

Highlighted Papers

Perspectives in Pharmacology

Cardiovascular

Cellular and Molecular

Drug Discovery and Translational Medicine

Endocrine and Diabetes

Inflammation, Immunopharmacology, and Asthma

Metabolism, Transport, and Pharmacogenomics

Neuropharmacology

Toxicology

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