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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

December 01, 2012; Volume 343,Issue 3

Highlighted Papers

  • You have access
    Natriuretic Peptide-Induced Catecholamine Release From Cardiac Sympathetic Neurons
    Journal of Pharmacology and Experimental Therapeutics December 2012, 343 (3) 539;
  • You have access
    GPR35 Antagonists Display High Species Ortholog Selectivity
    Journal of Pharmacology and Experimental Therapeutics December 2012, 343 (3) 539;
  • You have access
    Strontium Is a Biased Agonist of the Calcium-Sensing Receptor
    Journal of Pharmacology and Experimental Therapeutics December 2012, 343 (3) 539;
  • You have access
    Differential Effects of Selexipag and Prostacyclin Analogs in Rat Pulmonary Artery
    Journal of Pharmacology and Experimental Therapeutics December 2012, 343 (3) 539;

Perspectives in Pharmacology

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    Sarcopenia: Pharmacology of Today and Tomorrow
    Marco Brotto and Eduardo L. Abreu
    Journal of Pharmacology and Experimental Therapeutics December 2012, 343 (3) 540-546; DOI: https://doi.org/10.1124/jpet.112.191759

Cardiovascular

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    Natriuretic Peptide-Induced Catecholamine Release from Cardiac Sympathetic Neurons: Inhibition by Histamine H3 and H4 Receptor Activation
    Noel Yan-Ki Chan, Pablo A. Robador and Roberto Levi
    Journal of Pharmacology and Experimental Therapeutics December 2012, 343 (3) 568-577; DOI: https://doi.org/10.1124/jpet.112.198747
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    GS-6201, a Selective Blocker of the A2B Adenosine Receptor, Attenuates Cardiac Remodeling after Acute Myocardial Infarction in the Mouse
    Stefano Toldo, Hongyan Zhong, Eleonora Mezzaroma, Benjamin W. Van Tassell, Harsha Kannan, Dewan Zeng, Luiz Belardinelli, Norbert F. Voelkel and Antonio Abbate
    Journal of Pharmacology and Experimental Therapeutics December 2012, 343 (3) 587-595; DOI: https://doi.org/10.1124/jpet.111.191288
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    Novel Antiplatelet Activity of Protocatechuic Acid through the Inhibition of High Shear Stress-Induced Platelet Aggregation
    Keunyoung Kim, Ok-Nam Bae, Kyung-Min Lim, Ji-Yoon Noh, Seojin Kang, Ka Young Chung and Jin-Ho Chung
    Journal of Pharmacology and Experimental Therapeutics December 2012, 343 (3) 704-711; DOI: https://doi.org/10.1124/jpet.112.198242
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    Identification of Contractile P2Y1, P2Y6, and P2Y12 Receptors in Rat Intrapulmonary Artery Using Selective Ligands
    Callum Mitchell, Nawazish-i-Husain Syed, Asrin Tengah, Alison M. Gurney and Charles Kennedy
    Journal of Pharmacology and Experimental Therapeutics December 2012, 343 (3) 755-762; DOI: https://doi.org/10.1124/jpet.112.198051

Cellular and Molecular

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    Strontium Is a Biased Agonist of the Calcium-Sensing Receptor in Rat Medullary Thyroid Carcinoma 6-23 Cells
    Alex Rojas Bie Thomsen, Jesper Worm, Stine Engesgaard Jacobsen, Martin Stahlhut, Markus Latta and Hans Bräuner-Osborne
    Journal of Pharmacology and Experimental Therapeutics December 2012, 343 (3) 638-649; DOI: https://doi.org/10.1124/jpet.112.197210
  • You have access
    Antagonists of GPR35 Display High Species Ortholog Selectivity and Varying Modes of Action
    Laura Jenkins, Nicholas Harries, Jennifer E. Lappin, Amanda E. MacKenzie, Zaynab Neetoo-Isseljee, Craig Southern, Edward G. McIver, Stuart A. Nicklin, Debra L. Taylor and Graeme Milligan
    Journal of Pharmacology and Experimental Therapeutics December 2012, 343 (3) 683-695; DOI: https://doi.org/10.1124/jpet.112.198945
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    The Autophagy-Senescence Connection in Chemotherapy: Must Tumor Cells (Self) Eat Before They Sleep?
    Rachel W. Goehe, Xu Di, Khushboo Sharma, Molly L. Bristol, Scott C. Henderson, Kristoffer Valerie, Francis Rodier, Albert R. Davalos and David A. Gewirtz
    Journal of Pharmacology and Experimental Therapeutics December 2012, 343 (3) 763-778; DOI: https://doi.org/10.1124/jpet.112.197590

Drug Discovery and Translational Medicine

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    Differential Effects of Selexipag and Prostacyclin Analogs in Rat Pulmonary Artery
    Keith Morrison, Rolf Studer, Roland Ernst, Franck Haag, Katalin Kauser and Martine Clozel
    Journal of Pharmacology and Experimental Therapeutics December 2012, 343 (3) 547-555; DOI: https://doi.org/10.1124/jpet.112.197152
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    Synthetic Farnesoid X Receptor Agonists Induce High-Density Lipoprotein-Mediated Transhepatic Cholesterol Efflux in Mice and Monkeys and Prevent Atherosclerosis in Cholesteryl Ester Transfer Protein Transgenic Low-Density Lipoprotein Receptor (−/−) Mice
    Eva Hambruch, Shinobu Miyazaki-Anzai, Ulrike Hahn, Silke Matysik, Alfred Boettcher, Sanja Perović-Ottstadt, Thomas Schlüter, Olaf Kinzel, Helen Desiree Krol, Ulrich Deuschle, Michael Burnet, Moshe Levi, Gerd Schmitz, Makoto Miyazaki and Claus Kremoser
    Journal of Pharmacology and Experimental Therapeutics December 2012, 343 (3) 556-567; DOI: https://doi.org/10.1124/jpet.112.196519
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    Preclinical Characterization of ABT-348, a Kinase Inhibitor Targeting the Aurora, Vascular Endothelial Growth Factor Receptor/Platelet-Derived Growth Factor Receptor, and Src Kinase Families
    Keith B. Glaser, Junling Li, Patrick A. Marcotte, Terrance J. Magoc, Jun Guo, David R. Reuter, Paul Tapang, Ru-Qi Wei, Lori J. Pease, Mai H. Bui, Zehan Chen, Robin R. Frey, Eric F. Johnson, Donald J. Osterling, Amanda M. Olson, Jennifer J. Bouska, Yanping Luo, Michael L. Curtin, Cherrie K. Donawho, Michael R. Michaelides, Chris Tse, Steven K. Davidsen and Daniel H. Albert
    Journal of Pharmacology and Experimental Therapeutics December 2012, 343 (3) 617-627; DOI: https://doi.org/10.1124/jpet.112.197087
  • You have access
    Effects of the Novel α7 Nicotinic Acetylcholine Receptor Agonist ABT-107 on Sensory Gating in DBA/2 Mice: Pharmacodynamic Characterization
    Richard J. Radek, Holly M. Robb, Karen E. Stevens, Murali Gopalakrishnan and Robert S. Bitner
    Journal of Pharmacology and Experimental Therapeutics December 2012, 343 (3) 736-745; DOI: https://doi.org/10.1124/jpet.112.197970

Endocrine and Diabetes

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    σ-1 Receptor at the Mitochondrial-Associated Endoplasmic Reticulum Membrane Is Responsible for Mitochondrial Metabolic Regulation
    Karla-Sue C. Marriott, Manoj Prasad, Veena Thapliyal and Himangshu S. Bose
    Journal of Pharmacology and Experimental Therapeutics December 2012, 343 (3) 578-586; DOI: https://doi.org/10.1124/jpet.112.198168

Inflammation, Immunopharmacology, and Asthma

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    Inhibitory Influence of the Hexapeptidic Sequence SLIGRL on Influenza A Virus Infection in Mice
    Richard J. Betts, Tracy S. Mann and Peter J. Henry
    Journal of Pharmacology and Experimental Therapeutics December 2012, 343 (3) 725-735; DOI: https://doi.org/10.1124/jpet.112.196485

Metabolism, Transport, and Pharmacogenomics

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    A Clearance System for Prostaglandin D2, a Sleep-Promoting Factor, in Cerebrospinal Fluid: Role of the Blood-Cerebrospinal Barrier Transporters
    Masanori Tachikawa, Kazuhiro Tsuji, Reiji Yokoyama, Takanori Higuchi, Go Ozeki, Ayane Yashiki, Shin-ichi Akanuma, Kazuyuki Hayashi, Akio Nishiura and Ken-ichi Hosoya
    Journal of Pharmacology and Experimental Therapeutics December 2012, 343 (3) 608-616; DOI: https://doi.org/10.1124/jpet.112.197012
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    Differential Effects of Nicotine Treatment and Ethanol Self-Administration on CYP2A6, CYP2B6 and Nicotine Pharmacokinetics in African Green Monkeys
    C. S. Ferguson, S. Miksys, R. M. Palmour and R. F. Tyndale
    Journal of Pharmacology and Experimental Therapeutics December 2012, 343 (3) 628-637; DOI: https://doi.org/10.1124/jpet.112.198564
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    Inflammatory Regulation of ATP Binding Cassette Efflux Transporter Expression and Function in Microglia
    Christopher J. Gibson, Muhammad M. Hossain, Jason R. Richardson and Lauren M. Aleksunes
    Journal of Pharmacology and Experimental Therapeutics December 2012, 343 (3) 650-660; DOI: https://doi.org/10.1124/jpet.112.196543
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    Identification and Functional Characterization of a Novel UDP-Glucuronosyltransferase 2A1 Splice Variant: Potential Importance in Tobacco-Related Cancer Susceptibility
    Ryan T. Bushey and Philip Lazarus
    Journal of Pharmacology and Experimental Therapeutics December 2012, 343 (3) 712-724; DOI: https://doi.org/10.1124/jpet.112.198770

Neuropharmacology

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    Na+,K+-ATPase Functionally Interacts with the Plasma Membrane Na+,Ca2+ Exchanger to Prevent Ca2+ Overload and Neuronal Apoptosis in Excitotoxic Stress
    Dmitry A. Sibarov, Artemiy E. Bolshakov, Polina A. Abushik, Igor I. Krivoi and Sergei M. Antonov
    Journal of Pharmacology and Experimental Therapeutics December 2012, 343 (3) 596-607; DOI: https://doi.org/10.1124/jpet.112.198341
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    Central Mechanisms of Menthol-Induced Analgesia
    Rong Pan, Yuzhen Tian, Ruby Gao, Haitao Li, Xianguo Zhao, James E. Barrett and Huijuan Hu
    Journal of Pharmacology and Experimental Therapeutics December 2012, 343 (3) 661-672; DOI: https://doi.org/10.1124/jpet.112.196717
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    The Orally Active Glutamate Carboxypeptidase II Inhibitor E2072 Exhibits Sustained Nerve Exposure and Attenuates Peripheral Neuropathy
    Krystyna M. Wozniak, Ying Wu, James J. Vornov, Rena Lapidus, Rana Rais, Camilo Rojas, Takashi Tsukamoto and Barbara S. Slusher
    Journal of Pharmacology and Experimental Therapeutics December 2012, 343 (3) 746-754; DOI: https://doi.org/10.1124/jpet.112.197665

Toxicology

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    Identification of Human Butyrylcholinesterase Organophosphate-Resistant Variants through a Novel Mammalian Enzyme Functional Screen
    Jun Zhang, Sigeng Chen, Erik C. Ralph, Mary Dwyer and John R. Cashman
    Journal of Pharmacology and Experimental Therapeutics December 2012, 343 (3) 673-682; DOI: https://doi.org/10.1124/jpet.112.198499
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    Dendritic Spine Injury Induced by the 8-Hydroxy Metabolite of Efavirenz
    Luis B. Tovar-y-Romo, Namandjé N. Bumpus, Daniel Pomerantz, Lindsay B. Avery, Ned Sacktor, Justin C. McArthur and Norman J. Haughey
    Journal of Pharmacology and Experimental Therapeutics December 2012, 343 (3) 696-703; DOI: https://doi.org/10.1124/jpet.112.195701
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Journal of Pharmacology and Experimental Therapeutics: 343 (3)
Journal of Pharmacology and Experimental Therapeutics
Vol. 343, Issue 3
1 Dec 2012
  • Table of Contents
  • Table of Contents (PDF)
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  • Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.
  • Functional Selectivity and Classical Concepts of Quantitative Pharmacology
  • Abl Protein-Tyrosine Kinase Inhibitor STI571 Inhibits In Vitro Signal Transduction Mediated by c-Kit and Platelet-Derived Growth Factor Receptors
  • The Prediction of Human Pharmacokinetic Parameters from Preclinical and In Vitro Metabolism Data
  • A METHOD FOR DETERMINING LOSS OF PAIN SENSATION
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