Journal of Pharmacology and Experimental Therapeutics: 343 (2)

November 01, 2012; Volume 343,Issue 2

Highlighted Papers

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Vascular Disrupting Agent STA-9584 Targets Microvasculature at the Center and Periphery of Tumor
Journal of Pharmacology and Experimental Therapeutics November 2012, 343 (2) 252;
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The Relationship between In Vitro Potency, Pharmacokinetics, and Pharmacodynamics in a Series of β-Secretase Inhibitors
Journal of Pharmacology and Experimental Therapeutics November 2012, 343 (2) 252;
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Exacerbation of Nonsteroidal Anti-Inflammatory Drug-Induced Small Intestinal Lesions by Antisecretory Drugs
Journal of Pharmacology and Experimental Therapeutics November 2012, 343 (2) 252;
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Identification of the Plant Steroid α-Spinasterol as a Novel Transient Receptor Potential Vanilloid 1 Antagonist
Journal of Pharmacology and Experimental Therapeutics November 2012, 343 (2) 252;

Behavioral Pharmacology

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Dissociable Effects of the Cannabinoid Receptor Agonists Δ⁹-Tetrahydrocannabinol and CP55940 on Pain-Stimulated Versus Pain-Depressed Behavior in Rats
Andrew J. Kwilasz and S. Stevens Negus

Journal of Pharmacology and Experimental Therapeutics November 2012, 343 (2) 389-400; DOI: https://doi.org/10.1124/jpet.112.197780

Cardiovascular

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The Effects of Direct Thrombin Inhibition with Dabigatran on Plaque Formation and Endothelial Function in Apolipoprotein E-Deficient Mice
Illkyu-O. Lee, Mario T. Kratz, Stephan H. Schirmer, Magnus Baumhäkel and Michael Böhm

Journal of Pharmacology and Experimental Therapeutics November 2012, 343 (2) 253-257; DOI: https://doi.org/10.1124/jpet.112.194837
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Proatherogenic Macrophage Activities Are Targeted by the Flavonoid Quercetin
Oscar J. Lara-Guzman, Jorge H. Tabares-Guevara, Yudy M. Leon-Varela, Rafael M. Álvarez, Miguel Roldan, Jelver A. Sierra, Julian A. Londoño-Londoño and Jose R. Ramirez-Pineda

Journal of Pharmacology and Experimental Therapeutics November 2012, 343 (2) 296-306; DOI: https://doi.org/10.1124/jpet.112.196147
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Late Sodium Current Inhibition Alone with Ranolazine Is Sufficient to Reduce Ischemia- and Cardiac Glycoside-Induced Calcium Overload and Contractile Dysfunction Mediated by Reverse-Mode Sodium/Calcium Exchange
Daniel Soliman, Lianguo Wang, Kevin S. C. Hamming, Wei Yang, Mohammad Fatehi, Christian C. Carter, Alexander S. Clanachan and Peter E. Light

Journal of Pharmacology and Experimental Therapeutics November 2012, 343 (2) 325-332; DOI: https://doi.org/10.1124/jpet.112.196949
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Vinpocetine Suppresses Pathological Vascular Remodeling by Inhibiting Vascular Smooth Muscle Cell Proliferation and Migration
Yujun Cai, Walter E. Knight, Shujie Guo, Jian-Dong Li, Peter A. Knight and Chen Yan

Journal of Pharmacology and Experimental Therapeutics November 2012, 343 (2) 479-488; DOI: https://doi.org/10.1124/jpet.112.195446

Cellular and Molecular

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Aryl Hydrocarbon Receptor (AHR)-Active Pharmaceuticals Are Selective AHR Modulators in MDA-MB-468 and BT474 Breast Cancer Cells
Un-Ho Jin, Syng-ook Lee and Stephen Safe

Journal of Pharmacology and Experimental Therapeutics November 2012, 343 (2) 333-341; DOI: https://doi.org/10.1124/jpet.112.195339
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Target Binding Properties and Cellular Activity of Afatinib (BIBW 2992), an Irreversible ErbB Family Blocker
Flavio Solca, Goeran Dahl, Andreas Zoephel, Gerd Bader, Michael Sanderson, Christian Klein, Oliver Kraemer, Frank Himmelsbach, Eric Haaksma and Guenther R. Adolf

Journal of Pharmacology and Experimental Therapeutics November 2012, 343 (2) 342-350; DOI: https://doi.org/10.1124/jpet.112.197756
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Prenatal Exposure of Mice to Diethylstilbestrol Disrupts T-Cell Differentiation by Regulating Fas/Fas Ligand Expression through Estrogen Receptor Element and Nuclear Factor-κB Motifs
Narendra P. Singh, Udai P. Singh, Prakash S. Nagarkatti and Mitzi Nagarkatti

Journal of Pharmacology and Experimental Therapeutics November 2012, 343 (2) 351-361; DOI: https://doi.org/10.1124/jpet.112.196121
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The Influence of Receptor Kinetics on the Onset and Duration of Action and the Therapeutic Index of NVA237 and Tiotropium
David A. Sykes, Mark R. Dowling, Juliet Leighton-Davies, Toby C. Kent, Lindsay Fawcett, Emilie Renard, Alexandre Trifilieff and Steven J. Charlton

Journal of Pharmacology and Experimental Therapeutics November 2012, 343 (2) 520-528; DOI: https://doi.org/10.1124/jpet.112.194456

Chemotherapy, Antibiotics, and Gene Therapy

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Synthesis and Antifungal Activity of Derivatives of 2- and 3-Benzofurancarboxylic Acids
Elżbieta Hejchman, Kinga Ostrowska, Dorota Maciejewska, Jerzy Kossakowski and William E. Courchesne

Journal of Pharmacology and Experimental Therapeutics November 2012, 343 (2) 380-388; DOI: https://doi.org/10.1124/jpet.112.196980
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Up-Regulation of Human Prostaglandin Reductase 1 Improves the Efficacy of Hydroxymethylacylfulvene, an Antitumor Chemotherapeutic Agent
Xiang Yu, Melanie M. Erzinger, Kathryn E. Pietsch, Frances N. Cervoni-Curet, John Whang, John Niederhuber and Shana J. Sturla

Journal of Pharmacology and Experimental Therapeutics November 2012, 343 (2) 426-433; DOI: https://doi.org/10.1124/jpet.112.195768
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Activation of Alternate Prosurvival Pathways Accounts for Acquired Sunitinib Resistance in U87MG Glioma Xenografts
Qingyu Zhou, Hua Lv, Amin R. Mazloom, Huilei Xu, Avi Ma'ayan and James M. Gallo

Journal of Pharmacology and Experimental Therapeutics November 2012, 343 (2) 509-519; DOI: https://doi.org/10.1124/jpet.112.196097

Drug Discovery and Translational Medicine

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Novel C-1 Substituted Cocaine Analogs Unlike Cocaine or Benztropine
Maarten E. A. Reith, Solav Ali, Audrey Hashim, Imran S. Sheikh, Naresh Theddu, Narendra V. Gaddiraju, Suneet Mehrotra, Kyle C. Schmitt, Thomas F. Murray, Henry Sershen, Ellen M. Unterwald and Franklin A. Davis

Journal of Pharmacology and Experimental Therapeutics November 2012, 343 (2) 413-425; DOI: https://doi.org/10.1124/jpet.112.193771
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Identification of Granulocyte Colony-Stimulating Factor and Interleukin-6 as Candidate Biomarkers of CBLB502 Efficacy as a Medical Radiation Countermeasure
Vadim I. Krivokrysenko, Alexander N. Shakhov, Vijay K. Singh, Frederick Bone, Yevgeniy Kononov, Inna Shyshynova, Alec Cheney, Ratan K. Maitra, Andrei Purmal, Mark H. Whitnall, Andrei V. Gudkov and Elena Feinstein

Journal of Pharmacology and Experimental Therapeutics November 2012, 343 (2) 497-508; DOI: https://doi.org/10.1124/jpet.112.196071
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The Vascular Disrupting Agent STA-9584 Exhibits Potent Antitumor Activity by Selectively Targeting Microvasculature at Both the Center and Periphery of Tumors
Kevin P. Foley, Dan Zhou, Chris Borella, Yaming Wu, Mei Zhang, Jun Jiang, Hao Li, Jim Sang, Tim Korbut, Josephine Ye, Xuemei Zhang, James Barsoum and Andrew J. Sonderfan

Journal of Pharmacology and Experimental Therapeutics November 2012, 343 (2) 529-538; DOI: https://doi.org/10.1124/jpet.112.196873

Gastrointestinal, Hepatic, Pulmonary, and Renal

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Exacerbation of Nonsteroidal Anti-Inflammatory Drug-Induced Small Intestinal Lesions by Antisecretory Drugs in Rats: The Role of Intestinal Motility
Hiroshi Satoh, Kikuko Amagase and Koji Takeuchi

Journal of Pharmacology and Experimental Therapeutics November 2012, 343 (2) 270-277; DOI: https://doi.org/10.1124/jpet.112.197475
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Role of Intestinal Cytochrome P450 Enzymes in Diclofenac-Induced Toxicity in the Small Intestine
Yi Zhu and Qing-Yu Zhang

Journal of Pharmacology and Experimental Therapeutics November 2012, 343 (2) 362-370; DOI: https://doi.org/10.1124/jpet.112.198077

Inflammation, Immunopharmacology, and Asthma

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Angiopoietin-2 Enhances Survival in Experimental Sepsis Induced by Multidrug-Resistant Pseudomonas aeruginosa
Ira-Maria Tzepi, Evangelos J. Giamarellos-Bourboulis, Dionyssia-Pinelopi Carrer, Thomas Tsaganos, Ralf A. Claus, Ilia Vaki, Aimilia Pelekanou, Antigone Kotsaki, Vassiliki Tziortzioti, Stavros Topouzis, Michael Bauer and Andreas Papapetropoulos

Journal of Pharmacology and Experimental Therapeutics November 2012, 343 (2) 278-287; DOI: https://doi.org/10.1124/jpet.112.195180

Metabolism, Transport, and Pharmacogenomics

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CYP2A6- and CYP2A13-Catalyzed Metabolism of the Nicotine Δ^5′(1′)Iminium Ion
Linda B. von Weymarn, Cassandra Retzlaff and Sharon E. Murphy

Journal of Pharmacology and Experimental Therapeutics November 2012, 343 (2) 307-315; DOI: https://doi.org/10.1124/jpet.112.195255
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Deletion of Abcg2 Has Differential Effects on Excretion and Pharmacokinetics of Probe Substrates in Rats
Liyue Huang, Xuhai Be, Eskouhie H. Tchaparian, Adria E. Colletti, Jonathan Roberts, Meghan Langley, Yun Ling, Bradley K. Wong and Lixia Jin

Journal of Pharmacology and Experimental Therapeutics November 2012, 343 (2) 316-324; DOI: https://doi.org/10.1124/jpet.112.197046

Neuropharmacology

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Identification of the Plant Steroid α-Spinasterol as a Novel Transient Receptor Potential Vanilloid 1 Antagonist with Antinociceptive Properties
Gabriela Trevisan, Mateus Fortes Rossato, Cristiani Isabel Banderó Walker, Jonatas Zeni Klafke, Fernanda Rosa, Sara Marchesan Oliveira, Raquel Tonello, Gustavo Petri Guerra, Aline Augusti Boligon, Ricardo Basso Zanon, Margareth Linde Athayde and Juliano Ferreira

Journal of Pharmacology and Experimental Therapeutics November 2012, 343 (2) 258-269; DOI: https://doi.org/10.1124/jpet.112.195909
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Aberrant Dopamine D2-Like Receptor Function in a Rodent Model of Schizophrenia
Stephanie M. Perez and Daniel J. Lodge

Journal of Pharmacology and Experimental Therapeutics November 2012, 343 (2) 288-295; DOI: https://doi.org/10.1124/jpet.112.193201
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Subunit-Specific Inhibition of Glycine Receptors by Curcumol
Li Wang, Wei-Guang Li, Chen Huang, Michael X. Zhu, Tian-Le Xu, Da-Zheng Wu and Yong Li

Journal of Pharmacology and Experimental Therapeutics November 2012, 343 (2) 371-379; DOI: https://doi.org/10.1124/jpet.112.195669
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A New Radioligand Binding Assay to Measure the Concentration of Drugs in Rodent Brain Ex Vivo
G. Patrick Hussmann and Kenneth J. Kellar

Journal of Pharmacology and Experimental Therapeutics November 2012, 343 (2) 434-440; DOI: https://doi.org/10.1124/jpet.112.198069
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Chronic Sazetidine-A at Behaviorally Active Doses Does Not Increase Nicotinic Cholinergic Receptors in Rodent Brain
G. Patrick Hussmann, Jill R. Turner, Ermelinda Lomazzo, Rashmi Venkatesh, Vanessa Cousins, Yingxian Xiao, Robert P. Yasuda, Barry B. Wolfe, David C. Perry, Amir H. Rezvani, Edward D. Levin, Julie A. Blendy and Kenneth J. Kellar

Journal of Pharmacology and Experimental Therapeutics November 2012, 343 (2) 441-450; DOI: https://doi.org/10.1124/jpet.112.198085
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β1-Adrenoceptor Activation Is Required for Ethanol Enhancement of Lateral Paracapsular GABAergic Synapses in the Rat Basolateral Amygdala
Yuval Silberman, Olusegun J. Ariwodola and Jeff L. Weiner

Journal of Pharmacology and Experimental Therapeutics November 2012, 343 (2) 451-459; DOI: https://doi.org/10.1124/jpet.112.196022
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Establishing the Relationship between In Vitro Potency, Pharmacokinetic, and Pharmacodynamic Parameters in a Series of Orally Available, Hydroxyethylamine-Derived β-Secretase Inhibitors
Stephen Wood, Paul H. Wen, Jianhua Zhang, Li Zhu, Yi Luo, Safura Babu-Khan, Kui Chen, Roger Pham, Joel Esmay, Thomas A. Dineen, Matthew R. Kaller, Matthew M. Weiss, Stephen A. Hitchcock, Martin Citron, Wenge Zhong, Dean Hickman and Toni Williamson

Journal of Pharmacology and Experimental Therapeutics November 2012, 343 (2) 460-467; DOI: https://doi.org/10.1124/jpet.112.197954

Toxicology

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Vitamin D Supplementation Protects against Bone Loss Associated with Chronic Alcohol Administration in Female Mice
Kelly E. Mercer, Rebecca A. Wynne, Oxana P. Lazarenko, Charles K. Lumpkin, William R. Hogue, Larry J. Suva, Jin-Ran Chen, Andrew Z. Mason, Thomas M. Badger and Martin J. J. Ronis

Journal of Pharmacology and Experimental Therapeutics November 2012, 343 (2) 401-412; DOI: https://doi.org/10.1124/jpet.112.197038
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Chronic Anthracycline Cardiotoxicity: Molecular and Functional Analysis with Focus on Nuclear Factor Erythroid 2-Related Factor 2 and Mitochondrial Biogenesis Pathways
Eduard Jirkovský, Olga Popelová, Pavla Křiváková-Staňková, Anna Vávrová, Miloš Hroch, Pavlína Hašková, Eva Brčáková-Doleželová, Stanislav Mičuda, Michaela Adamcová, Tomáš Šimůnek, Zuzana Červinková, Vladimír Geršl and Martin Štěrba

Journal of Pharmacology and Experimental Therapeutics November 2012, 343 (2) 468-478; DOI: https://doi.org/10.1124/jpet.112.198358
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Pharmacodynamics and Subchronic Toxicity in Mice and Monkeys of ISIS 388626, a Second-Generation Antisense Oligonucleotide That Targets Human Sodium Glucose Cotransporter 2
Thomas A. Zanardi, Su-Cheol Han, Eun Ju Jeong, Soyub Rime, Rosie Z. Yu, Kaushik Chakravarty and Scott P. Henry

Journal of Pharmacology and Experimental Therapeutics November 2012, 343 (2) 489-496; DOI: https://doi.org/10.1124/jpet.112.197426

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Table of Contents

Highlighted Papers

Behavioral Pharmacology

Cardiovascular

Cellular and Molecular

Chemotherapy, Antibiotics, and Gene Therapy

Drug Discovery and Translational Medicine

Gastrointestinal, Hepatic, Pulmonary, and Renal

Inflammation, Immunopharmacology, and Asthma

Metabolism, Transport, and Pharmacogenomics

Neuropharmacology

Toxicology

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