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Research ArticleDrug Discovery and Translational Medicine

An Ex Vivo Perfusion System Emulating In Vivo Conditions in Noncirrhotic and Cirrhotic Human Liver

Thomas Schreiter, Guido Marquitan, Malin Darnell, Jan-Peter Sowa, Martina Bröcker-Preuss, Tommy B. Andersson, Hideo A. Baba, Marcus Furch, Gavin E. Arteel, Zoltan Mathé, Jürgen Treckmann, Guido Gerken, Robert K. Gieseler and Ali Canbay
Journal of Pharmacology and Experimental Therapeutics September 2012, 342 (3) 730-741; DOI: https://doi.org/10.1124/jpet.112.194167
Thomas Schreiter
Clinic for Gastroenterology and Hepatology, Center for Internal Medicine (T.S., G.M., J.-P.S., G.G., R.K.G., A.C.), Departments of Endocrinology and Clinical Chemistry and Laboratory Medicine (M.B.-P.), Institute for Pathology and Neuropathology (H.A.B.), and Clinic for General, Visceral, and Transplantation Surgery (Z.M., J.T.), University Hospital Essen, Essen, Germany; Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden (M.D., T.B.A.); Rodos BioTarget GmbH, Medical Park Hannover, Hannover, Germany (M.F., R.K.G.); and Department of Pharmacology and Toxicology, University of Louisville Health Sciences Center, Louisville, Kentucky (G.E.A.)
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Guido Marquitan
Clinic for Gastroenterology and Hepatology, Center for Internal Medicine (T.S., G.M., J.-P.S., G.G., R.K.G., A.C.), Departments of Endocrinology and Clinical Chemistry and Laboratory Medicine (M.B.-P.), Institute for Pathology and Neuropathology (H.A.B.), and Clinic for General, Visceral, and Transplantation Surgery (Z.M., J.T.), University Hospital Essen, Essen, Germany; Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden (M.D., T.B.A.); Rodos BioTarget GmbH, Medical Park Hannover, Hannover, Germany (M.F., R.K.G.); and Department of Pharmacology and Toxicology, University of Louisville Health Sciences Center, Louisville, Kentucky (G.E.A.)
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Malin Darnell
Clinic for Gastroenterology and Hepatology, Center for Internal Medicine (T.S., G.M., J.-P.S., G.G., R.K.G., A.C.), Departments of Endocrinology and Clinical Chemistry and Laboratory Medicine (M.B.-P.), Institute for Pathology and Neuropathology (H.A.B.), and Clinic for General, Visceral, and Transplantation Surgery (Z.M., J.T.), University Hospital Essen, Essen, Germany; Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden (M.D., T.B.A.); Rodos BioTarget GmbH, Medical Park Hannover, Hannover, Germany (M.F., R.K.G.); and Department of Pharmacology and Toxicology, University of Louisville Health Sciences Center, Louisville, Kentucky (G.E.A.)
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Jan-Peter Sowa
Clinic for Gastroenterology and Hepatology, Center for Internal Medicine (T.S., G.M., J.-P.S., G.G., R.K.G., A.C.), Departments of Endocrinology and Clinical Chemistry and Laboratory Medicine (M.B.-P.), Institute for Pathology and Neuropathology (H.A.B.), and Clinic for General, Visceral, and Transplantation Surgery (Z.M., J.T.), University Hospital Essen, Essen, Germany; Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden (M.D., T.B.A.); Rodos BioTarget GmbH, Medical Park Hannover, Hannover, Germany (M.F., R.K.G.); and Department of Pharmacology and Toxicology, University of Louisville Health Sciences Center, Louisville, Kentucky (G.E.A.)
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Martina Bröcker-Preuss
Clinic for Gastroenterology and Hepatology, Center for Internal Medicine (T.S., G.M., J.-P.S., G.G., R.K.G., A.C.), Departments of Endocrinology and Clinical Chemistry and Laboratory Medicine (M.B.-P.), Institute for Pathology and Neuropathology (H.A.B.), and Clinic for General, Visceral, and Transplantation Surgery (Z.M., J.T.), University Hospital Essen, Essen, Germany; Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden (M.D., T.B.A.); Rodos BioTarget GmbH, Medical Park Hannover, Hannover, Germany (M.F., R.K.G.); and Department of Pharmacology and Toxicology, University of Louisville Health Sciences Center, Louisville, Kentucky (G.E.A.)
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Tommy B. Andersson
Clinic for Gastroenterology and Hepatology, Center for Internal Medicine (T.S., G.M., J.-P.S., G.G., R.K.G., A.C.), Departments of Endocrinology and Clinical Chemistry and Laboratory Medicine (M.B.-P.), Institute for Pathology and Neuropathology (H.A.B.), and Clinic for General, Visceral, and Transplantation Surgery (Z.M., J.T.), University Hospital Essen, Essen, Germany; Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden (M.D., T.B.A.); Rodos BioTarget GmbH, Medical Park Hannover, Hannover, Germany (M.F., R.K.G.); and Department of Pharmacology and Toxicology, University of Louisville Health Sciences Center, Louisville, Kentucky (G.E.A.)
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Hideo A. Baba
Clinic for Gastroenterology and Hepatology, Center for Internal Medicine (T.S., G.M., J.-P.S., G.G., R.K.G., A.C.), Departments of Endocrinology and Clinical Chemistry and Laboratory Medicine (M.B.-P.), Institute for Pathology and Neuropathology (H.A.B.), and Clinic for General, Visceral, and Transplantation Surgery (Z.M., J.T.), University Hospital Essen, Essen, Germany; Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden (M.D., T.B.A.); Rodos BioTarget GmbH, Medical Park Hannover, Hannover, Germany (M.F., R.K.G.); and Department of Pharmacology and Toxicology, University of Louisville Health Sciences Center, Louisville, Kentucky (G.E.A.)
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Marcus Furch
Clinic for Gastroenterology and Hepatology, Center for Internal Medicine (T.S., G.M., J.-P.S., G.G., R.K.G., A.C.), Departments of Endocrinology and Clinical Chemistry and Laboratory Medicine (M.B.-P.), Institute for Pathology and Neuropathology (H.A.B.), and Clinic for General, Visceral, and Transplantation Surgery (Z.M., J.T.), University Hospital Essen, Essen, Germany; Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden (M.D., T.B.A.); Rodos BioTarget GmbH, Medical Park Hannover, Hannover, Germany (M.F., R.K.G.); and Department of Pharmacology and Toxicology, University of Louisville Health Sciences Center, Louisville, Kentucky (G.E.A.)
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Gavin E. Arteel
Clinic for Gastroenterology and Hepatology, Center for Internal Medicine (T.S., G.M., J.-P.S., G.G., R.K.G., A.C.), Departments of Endocrinology and Clinical Chemistry and Laboratory Medicine (M.B.-P.), Institute for Pathology and Neuropathology (H.A.B.), and Clinic for General, Visceral, and Transplantation Surgery (Z.M., J.T.), University Hospital Essen, Essen, Germany; Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden (M.D., T.B.A.); Rodos BioTarget GmbH, Medical Park Hannover, Hannover, Germany (M.F., R.K.G.); and Department of Pharmacology and Toxicology, University of Louisville Health Sciences Center, Louisville, Kentucky (G.E.A.)
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Zoltan Mathé
Clinic for Gastroenterology and Hepatology, Center for Internal Medicine (T.S., G.M., J.-P.S., G.G., R.K.G., A.C.), Departments of Endocrinology and Clinical Chemistry and Laboratory Medicine (M.B.-P.), Institute for Pathology and Neuropathology (H.A.B.), and Clinic for General, Visceral, and Transplantation Surgery (Z.M., J.T.), University Hospital Essen, Essen, Germany; Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden (M.D., T.B.A.); Rodos BioTarget GmbH, Medical Park Hannover, Hannover, Germany (M.F., R.K.G.); and Department of Pharmacology and Toxicology, University of Louisville Health Sciences Center, Louisville, Kentucky (G.E.A.)
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Jürgen Treckmann
Clinic for Gastroenterology and Hepatology, Center for Internal Medicine (T.S., G.M., J.-P.S., G.G., R.K.G., A.C.), Departments of Endocrinology and Clinical Chemistry and Laboratory Medicine (M.B.-P.), Institute for Pathology and Neuropathology (H.A.B.), and Clinic for General, Visceral, and Transplantation Surgery (Z.M., J.T.), University Hospital Essen, Essen, Germany; Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden (M.D., T.B.A.); Rodos BioTarget GmbH, Medical Park Hannover, Hannover, Germany (M.F., R.K.G.); and Department of Pharmacology and Toxicology, University of Louisville Health Sciences Center, Louisville, Kentucky (G.E.A.)
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Guido Gerken
Clinic for Gastroenterology and Hepatology, Center for Internal Medicine (T.S., G.M., J.-P.S., G.G., R.K.G., A.C.), Departments of Endocrinology and Clinical Chemistry and Laboratory Medicine (M.B.-P.), Institute for Pathology and Neuropathology (H.A.B.), and Clinic for General, Visceral, and Transplantation Surgery (Z.M., J.T.), University Hospital Essen, Essen, Germany; Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden (M.D., T.B.A.); Rodos BioTarget GmbH, Medical Park Hannover, Hannover, Germany (M.F., R.K.G.); and Department of Pharmacology and Toxicology, University of Louisville Health Sciences Center, Louisville, Kentucky (G.E.A.)
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Robert K. Gieseler
Clinic for Gastroenterology and Hepatology, Center for Internal Medicine (T.S., G.M., J.-P.S., G.G., R.K.G., A.C.), Departments of Endocrinology and Clinical Chemistry and Laboratory Medicine (M.B.-P.), Institute for Pathology and Neuropathology (H.A.B.), and Clinic for General, Visceral, and Transplantation Surgery (Z.M., J.T.), University Hospital Essen, Essen, Germany; Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden (M.D., T.B.A.); Rodos BioTarget GmbH, Medical Park Hannover, Hannover, Germany (M.F., R.K.G.); and Department of Pharmacology and Toxicology, University of Louisville Health Sciences Center, Louisville, Kentucky (G.E.A.)
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Ali Canbay
Clinic for Gastroenterology and Hepatology, Center for Internal Medicine (T.S., G.M., J.-P.S., G.G., R.K.G., A.C.), Departments of Endocrinology and Clinical Chemistry and Laboratory Medicine (M.B.-P.), Institute for Pathology and Neuropathology (H.A.B.), and Clinic for General, Visceral, and Transplantation Surgery (Z.M., J.T.), University Hospital Essen, Essen, Germany; Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden (M.D., T.B.A.); Rodos BioTarget GmbH, Medical Park Hannover, Hannover, Germany (M.F., R.K.G.); and Department of Pharmacology and Toxicology, University of Louisville Health Sciences Center, Louisville, Kentucky (G.E.A.)
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Article Information

vol. 342 no. 3 730-741
DOI 
https://doi.org/10.1124/jpet.112.194167
PubMed 
22674469

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received March 9, 2012
  • Accepted June 1, 2012
  • Published online August 14, 2012.

Article Versions

  • Earlier version (June 6, 2012 - 08:24).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2012 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Thomas Schreiter,
  2. Guido Marquitan,
  3. Malin Darnell,
  4. Jan-Peter Sowa,
  5. Martina Bröcker-Preuss,
  6. Tommy B. Andersson,
  7. Hideo A. Baba,
  8. Marcus Furch,
  9. Gavin E. Arteel,
  10. Zoltan Mathé,
  11. Jürgen Treckmann,
  12. Guido Gerken,
  13. Robert K. Gieseler and
  14. Ali Canbay
  1. Clinic for Gastroenterology and Hepatology, Center for Internal Medicine (T.S., G.M., J.-P.S., G.G., R.K.G., A.C.), Departments of Endocrinology and Clinical Chemistry and Laboratory Medicine (M.B.-P.), Institute for Pathology and Neuropathology (H.A.B.), and Clinic for General, Visceral, and Transplantation Surgery (Z.M., J.T.), University Hospital Essen, Essen, Germany; Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden (M.D., T.B.A.); Rodos BioTarget GmbH, Medical Park Hannover, Hannover, Germany (M.F., R.K.G.); and Department of Pharmacology and Toxicology, University of Louisville Health Sciences Center, Louisville, Kentucky (G.E.A.)
  1. Address correspondence to:
    Prof. Ali Canbay, Clinic for Gastroenterology and Hepatology, University Hospital Essen, Hufelandstr. 55, 45122 Essen, Germany. E-mail: ali.canbay{at}uni-due.de
  1. Portions of this work were presented previously: Schreiter T, Marquitan G, Darnell M, Sowa J-P, Bröcker-Preuss M, Andersson TB, Baba HA, Furch M, Rauen U, Mathé Z, et al. (2012) Characteristics of human noncirrhotic and cirrhotic liver, sections in a novel ex vivo perfusion system, at the 28th Annual Convention of the German Association for the Study of the Liver; 2012 Jan 27–28; Hamburg, Germany. German Association for the Study of the Liver, Hannover, Germany.

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Journal of Pharmacology and Experimental Therapeutics: 342 (3)
Journal of Pharmacology and Experimental Therapeutics
Vol. 342, Issue 3
1 Sep 2012
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Research ArticleDrug Discovery and Translational Medicine

Perfusion of Human Liver Sections

Thomas Schreiter, Guido Marquitan, Malin Darnell, Jan-Peter Sowa, Martina Bröcker-Preuss, Tommy B. Andersson, Hideo A. Baba, Marcus Furch, Gavin E. Arteel, Zoltan Mathé, Jürgen Treckmann, Guido Gerken, Robert K. Gieseler and Ali Canbay
Journal of Pharmacology and Experimental Therapeutics September 1, 2012, 342 (3) 730-741; DOI: https://doi.org/10.1124/jpet.112.194167

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Research ArticleDrug Discovery and Translational Medicine

Perfusion of Human Liver Sections

Thomas Schreiter, Guido Marquitan, Malin Darnell, Jan-Peter Sowa, Martina Bröcker-Preuss, Tommy B. Andersson, Hideo A. Baba, Marcus Furch, Gavin E. Arteel, Zoltan Mathé, Jürgen Treckmann, Guido Gerken, Robert K. Gieseler and Ali Canbay
Journal of Pharmacology and Experimental Therapeutics September 1, 2012, 342 (3) 730-741; DOI: https://doi.org/10.1124/jpet.112.194167
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