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Research ArticleToxicology

Differences in Early Acetaminophen Hepatotoxicity between Obese ob/ob and db/db Mice

Jacinthe Aubert, Karima Begriche, Matthieu Delannoy, Isabelle Morel, Julie Pajaud, Catherine Ribault, Sylvie Lepage, Mitchell R. McGill, Catherine Lucas-Clerc, Bruno Turlin, Marie-Anne Robin, Hartmut Jaeschke and Bernard Fromenty
Journal of Pharmacology and Experimental Therapeutics September 2012, 342 (3) 676-687; DOI: https://doi.org/10.1124/jpet.112.193813
Jacinthe Aubert
Institut National de la Santé et de la Recherche Médicale, U991(J.A., K.B., M.D., I.M., J.P., C.R., M.-A.R., B.F.) and Plate-forme d'Histopathologie H2P2 (B.T.), Université de Rennes 1, Rennes, France; Laboratoire de Toxicologie Biologique et Médico-Légale (I.M., S.L.), Laboratoire de Biochimie Générale, (C.L.-C.), and Département d'Anatomie et Cytologie Pathologiques (B.T.), Hôpital Pontchaillou, Rennes, France; and Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas (M.R.M., H.J.)
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Karima Begriche
Institut National de la Santé et de la Recherche Médicale, U991(J.A., K.B., M.D., I.M., J.P., C.R., M.-A.R., B.F.) and Plate-forme d'Histopathologie H2P2 (B.T.), Université de Rennes 1, Rennes, France; Laboratoire de Toxicologie Biologique et Médico-Légale (I.M., S.L.), Laboratoire de Biochimie Générale, (C.L.-C.), and Département d'Anatomie et Cytologie Pathologiques (B.T.), Hôpital Pontchaillou, Rennes, France; and Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas (M.R.M., H.J.)
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Matthieu Delannoy
Institut National de la Santé et de la Recherche Médicale, U991(J.A., K.B., M.D., I.M., J.P., C.R., M.-A.R., B.F.) and Plate-forme d'Histopathologie H2P2 (B.T.), Université de Rennes 1, Rennes, France; Laboratoire de Toxicologie Biologique et Médico-Légale (I.M., S.L.), Laboratoire de Biochimie Générale, (C.L.-C.), and Département d'Anatomie et Cytologie Pathologiques (B.T.), Hôpital Pontchaillou, Rennes, France; and Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas (M.R.M., H.J.)
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Isabelle Morel
Institut National de la Santé et de la Recherche Médicale, U991(J.A., K.B., M.D., I.M., J.P., C.R., M.-A.R., B.F.) and Plate-forme d'Histopathologie H2P2 (B.T.), Université de Rennes 1, Rennes, France; Laboratoire de Toxicologie Biologique et Médico-Légale (I.M., S.L.), Laboratoire de Biochimie Générale, (C.L.-C.), and Département d'Anatomie et Cytologie Pathologiques (B.T.), Hôpital Pontchaillou, Rennes, France; and Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas (M.R.M., H.J.)
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Julie Pajaud
Institut National de la Santé et de la Recherche Médicale, U991(J.A., K.B., M.D., I.M., J.P., C.R., M.-A.R., B.F.) and Plate-forme d'Histopathologie H2P2 (B.T.), Université de Rennes 1, Rennes, France; Laboratoire de Toxicologie Biologique et Médico-Légale (I.M., S.L.), Laboratoire de Biochimie Générale, (C.L.-C.), and Département d'Anatomie et Cytologie Pathologiques (B.T.), Hôpital Pontchaillou, Rennes, France; and Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas (M.R.M., H.J.)
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Catherine Ribault
Institut National de la Santé et de la Recherche Médicale, U991(J.A., K.B., M.D., I.M., J.P., C.R., M.-A.R., B.F.) and Plate-forme d'Histopathologie H2P2 (B.T.), Université de Rennes 1, Rennes, France; Laboratoire de Toxicologie Biologique et Médico-Légale (I.M., S.L.), Laboratoire de Biochimie Générale, (C.L.-C.), and Département d'Anatomie et Cytologie Pathologiques (B.T.), Hôpital Pontchaillou, Rennes, France; and Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas (M.R.M., H.J.)
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Sylvie Lepage
Institut National de la Santé et de la Recherche Médicale, U991(J.A., K.B., M.D., I.M., J.P., C.R., M.-A.R., B.F.) and Plate-forme d'Histopathologie H2P2 (B.T.), Université de Rennes 1, Rennes, France; Laboratoire de Toxicologie Biologique et Médico-Légale (I.M., S.L.), Laboratoire de Biochimie Générale, (C.L.-C.), and Département d'Anatomie et Cytologie Pathologiques (B.T.), Hôpital Pontchaillou, Rennes, France; and Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas (M.R.M., H.J.)
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Mitchell R. McGill
Institut National de la Santé et de la Recherche Médicale, U991(J.A., K.B., M.D., I.M., J.P., C.R., M.-A.R., B.F.) and Plate-forme d'Histopathologie H2P2 (B.T.), Université de Rennes 1, Rennes, France; Laboratoire de Toxicologie Biologique et Médico-Légale (I.M., S.L.), Laboratoire de Biochimie Générale, (C.L.-C.), and Département d'Anatomie et Cytologie Pathologiques (B.T.), Hôpital Pontchaillou, Rennes, France; and Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas (M.R.M., H.J.)
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Catherine Lucas-Clerc
Institut National de la Santé et de la Recherche Médicale, U991(J.A., K.B., M.D., I.M., J.P., C.R., M.-A.R., B.F.) and Plate-forme d'Histopathologie H2P2 (B.T.), Université de Rennes 1, Rennes, France; Laboratoire de Toxicologie Biologique et Médico-Légale (I.M., S.L.), Laboratoire de Biochimie Générale, (C.L.-C.), and Département d'Anatomie et Cytologie Pathologiques (B.T.), Hôpital Pontchaillou, Rennes, France; and Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas (M.R.M., H.J.)
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Bruno Turlin
Institut National de la Santé et de la Recherche Médicale, U991(J.A., K.B., M.D., I.M., J.P., C.R., M.-A.R., B.F.) and Plate-forme d'Histopathologie H2P2 (B.T.), Université de Rennes 1, Rennes, France; Laboratoire de Toxicologie Biologique et Médico-Légale (I.M., S.L.), Laboratoire de Biochimie Générale, (C.L.-C.), and Département d'Anatomie et Cytologie Pathologiques (B.T.), Hôpital Pontchaillou, Rennes, France; and Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas (M.R.M., H.J.)
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Marie-Anne Robin
Institut National de la Santé et de la Recherche Médicale, U991(J.A., K.B., M.D., I.M., J.P., C.R., M.-A.R., B.F.) and Plate-forme d'Histopathologie H2P2 (B.T.), Université de Rennes 1, Rennes, France; Laboratoire de Toxicologie Biologique et Médico-Légale (I.M., S.L.), Laboratoire de Biochimie Générale, (C.L.-C.), and Département d'Anatomie et Cytologie Pathologiques (B.T.), Hôpital Pontchaillou, Rennes, France; and Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas (M.R.M., H.J.)
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Hartmut Jaeschke
Institut National de la Santé et de la Recherche Médicale, U991(J.A., K.B., M.D., I.M., J.P., C.R., M.-A.R., B.F.) and Plate-forme d'Histopathologie H2P2 (B.T.), Université de Rennes 1, Rennes, France; Laboratoire de Toxicologie Biologique et Médico-Légale (I.M., S.L.), Laboratoire de Biochimie Générale, (C.L.-C.), and Département d'Anatomie et Cytologie Pathologiques (B.T.), Hôpital Pontchaillou, Rennes, France; and Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas (M.R.M., H.J.)
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Bernard Fromenty
Institut National de la Santé et de la Recherche Médicale, U991(J.A., K.B., M.D., I.M., J.P., C.R., M.-A.R., B.F.) and Plate-forme d'Histopathologie H2P2 (B.T.), Université de Rennes 1, Rennes, France; Laboratoire de Toxicologie Biologique et Médico-Légale (I.M., S.L.), Laboratoire de Biochimie Générale, (C.L.-C.), and Département d'Anatomie et Cytologie Pathologiques (B.T.), Hôpital Pontchaillou, Rennes, France; and Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas (M.R.M., H.J.)
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Journal of Pharmacology and Experimental Therapeutics: 342 (3)
Journal of Pharmacology and Experimental Therapeutics
Vol. 342, Issue 3
1 Sep 2012
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Research ArticleToxicology

Acetaminophen-Induced Liver Injury in Obese Mice

Jacinthe Aubert, Karima Begriche, Matthieu Delannoy, Isabelle Morel, Julie Pajaud, Catherine Ribault, Sylvie Lepage, Mitchell R. McGill, Catherine Lucas-Clerc, Bruno Turlin, Marie-Anne Robin, Hartmut Jaeschke and Bernard Fromenty
Journal of Pharmacology and Experimental Therapeutics September 1, 2012, 342 (3) 676-687; DOI: https://doi.org/10.1124/jpet.112.193813

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Research ArticleToxicology

Acetaminophen-Induced Liver Injury in Obese Mice

Jacinthe Aubert, Karima Begriche, Matthieu Delannoy, Isabelle Morel, Julie Pajaud, Catherine Ribault, Sylvie Lepage, Mitchell R. McGill, Catherine Lucas-Clerc, Bruno Turlin, Marie-Anne Robin, Hartmut Jaeschke and Bernard Fromenty
Journal of Pharmacology and Experimental Therapeutics September 1, 2012, 342 (3) 676-687; DOI: https://doi.org/10.1124/jpet.112.193813
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