Research ArticleDrug Discovery and Translational Medicine
Durable Pharmacological Responses from the Peptide ShK-186, a Specific Kv1.3 Channel Inhibitor That Suppresses T Cell Mediators of Autoimmune Disease
Eric J. Tarcha, Victor Chi, Ernesto J. Muñoz-Elías, David Bailey, Luz M. Londono, Sanjeev K. Upadhyay, Kayla Norton, Amy Banks, Indra Tjong, Hai Nguyen, Xueyou Hu, Greg W. Ruppert, Scott E. Boley, Richard Slauter, James Sams, Brian Knapp, Dustin Kentala, Zachary Hansen, Michael W. Pennington, Christine Beeton, K. George Chandy and Shawn P. Iadonato
Journal of Pharmacology and Experimental Therapeutics September 2012, 342 (3) 642-653; DOI: https://doi.org/10.1124/jpet.112.191890
Eric J. Tarcha
Kineta Inc., Seattle, Washington (E.J.T., E.J.M.-E., L.M.L., K.N., A.B., S.P.I.); Departments of Physiology and Biophysics and Surgery, University of California, Irvine, California (V.C., S.K.U., I.T., H.N., K.G.C.); Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas (X.H., C.B.); MPI Research, Mattawan, Michigan (D.B., G.W.R., S.E.B., R.S., J.S., B.K., D.K., Z.H.); and Peptides International, Louisville, Kentucky (M.W.P.)
Victor Chi
Kineta Inc., Seattle, Washington (E.J.T., E.J.M.-E., L.M.L., K.N., A.B., S.P.I.); Departments of Physiology and Biophysics and Surgery, University of California, Irvine, California (V.C., S.K.U., I.T., H.N., K.G.C.); Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas (X.H., C.B.); MPI Research, Mattawan, Michigan (D.B., G.W.R., S.E.B., R.S., J.S., B.K., D.K., Z.H.); and Peptides International, Louisville, Kentucky (M.W.P.)
Ernesto J. Muñoz-Elías
Kineta Inc., Seattle, Washington (E.J.T., E.J.M.-E., L.M.L., K.N., A.B., S.P.I.); Departments of Physiology and Biophysics and Surgery, University of California, Irvine, California (V.C., S.K.U., I.T., H.N., K.G.C.); Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas (X.H., C.B.); MPI Research, Mattawan, Michigan (D.B., G.W.R., S.E.B., R.S., J.S., B.K., D.K., Z.H.); and Peptides International, Louisville, Kentucky (M.W.P.)
David Bailey
Kineta Inc., Seattle, Washington (E.J.T., E.J.M.-E., L.M.L., K.N., A.B., S.P.I.); Departments of Physiology and Biophysics and Surgery, University of California, Irvine, California (V.C., S.K.U., I.T., H.N., K.G.C.); Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas (X.H., C.B.); MPI Research, Mattawan, Michigan (D.B., G.W.R., S.E.B., R.S., J.S., B.K., D.K., Z.H.); and Peptides International, Louisville, Kentucky (M.W.P.)
Luz M. Londono
Kineta Inc., Seattle, Washington (E.J.T., E.J.M.-E., L.M.L., K.N., A.B., S.P.I.); Departments of Physiology and Biophysics and Surgery, University of California, Irvine, California (V.C., S.K.U., I.T., H.N., K.G.C.); Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas (X.H., C.B.); MPI Research, Mattawan, Michigan (D.B., G.W.R., S.E.B., R.S., J.S., B.K., D.K., Z.H.); and Peptides International, Louisville, Kentucky (M.W.P.)
Sanjeev K. Upadhyay
Kineta Inc., Seattle, Washington (E.J.T., E.J.M.-E., L.M.L., K.N., A.B., S.P.I.); Departments of Physiology and Biophysics and Surgery, University of California, Irvine, California (V.C., S.K.U., I.T., H.N., K.G.C.); Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas (X.H., C.B.); MPI Research, Mattawan, Michigan (D.B., G.W.R., S.E.B., R.S., J.S., B.K., D.K., Z.H.); and Peptides International, Louisville, Kentucky (M.W.P.)
Kayla Norton
Kineta Inc., Seattle, Washington (E.J.T., E.J.M.-E., L.M.L., K.N., A.B., S.P.I.); Departments of Physiology and Biophysics and Surgery, University of California, Irvine, California (V.C., S.K.U., I.T., H.N., K.G.C.); Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas (X.H., C.B.); MPI Research, Mattawan, Michigan (D.B., G.W.R., S.E.B., R.S., J.S., B.K., D.K., Z.H.); and Peptides International, Louisville, Kentucky (M.W.P.)
Amy Banks
Kineta Inc., Seattle, Washington (E.J.T., E.J.M.-E., L.M.L., K.N., A.B., S.P.I.); Departments of Physiology and Biophysics and Surgery, University of California, Irvine, California (V.C., S.K.U., I.T., H.N., K.G.C.); Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas (X.H., C.B.); MPI Research, Mattawan, Michigan (D.B., G.W.R., S.E.B., R.S., J.S., B.K., D.K., Z.H.); and Peptides International, Louisville, Kentucky (M.W.P.)
Indra Tjong
Kineta Inc., Seattle, Washington (E.J.T., E.J.M.-E., L.M.L., K.N., A.B., S.P.I.); Departments of Physiology and Biophysics and Surgery, University of California, Irvine, California (V.C., S.K.U., I.T., H.N., K.G.C.); Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas (X.H., C.B.); MPI Research, Mattawan, Michigan (D.B., G.W.R., S.E.B., R.S., J.S., B.K., D.K., Z.H.); and Peptides International, Louisville, Kentucky (M.W.P.)
Hai Nguyen
Kineta Inc., Seattle, Washington (E.J.T., E.J.M.-E., L.M.L., K.N., A.B., S.P.I.); Departments of Physiology and Biophysics and Surgery, University of California, Irvine, California (V.C., S.K.U., I.T., H.N., K.G.C.); Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas (X.H., C.B.); MPI Research, Mattawan, Michigan (D.B., G.W.R., S.E.B., R.S., J.S., B.K., D.K., Z.H.); and Peptides International, Louisville, Kentucky (M.W.P.)
Xueyou Hu
Kineta Inc., Seattle, Washington (E.J.T., E.J.M.-E., L.M.L., K.N., A.B., S.P.I.); Departments of Physiology and Biophysics and Surgery, University of California, Irvine, California (V.C., S.K.U., I.T., H.N., K.G.C.); Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas (X.H., C.B.); MPI Research, Mattawan, Michigan (D.B., G.W.R., S.E.B., R.S., J.S., B.K., D.K., Z.H.); and Peptides International, Louisville, Kentucky (M.W.P.)
Greg W. Ruppert
Kineta Inc., Seattle, Washington (E.J.T., E.J.M.-E., L.M.L., K.N., A.B., S.P.I.); Departments of Physiology and Biophysics and Surgery, University of California, Irvine, California (V.C., S.K.U., I.T., H.N., K.G.C.); Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas (X.H., C.B.); MPI Research, Mattawan, Michigan (D.B., G.W.R., S.E.B., R.S., J.S., B.K., D.K., Z.H.); and Peptides International, Louisville, Kentucky (M.W.P.)
Scott E. Boley
Kineta Inc., Seattle, Washington (E.J.T., E.J.M.-E., L.M.L., K.N., A.B., S.P.I.); Departments of Physiology and Biophysics and Surgery, University of California, Irvine, California (V.C., S.K.U., I.T., H.N., K.G.C.); Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas (X.H., C.B.); MPI Research, Mattawan, Michigan (D.B., G.W.R., S.E.B., R.S., J.S., B.K., D.K., Z.H.); and Peptides International, Louisville, Kentucky (M.W.P.)
Richard Slauter
Kineta Inc., Seattle, Washington (E.J.T., E.J.M.-E., L.M.L., K.N., A.B., S.P.I.); Departments of Physiology and Biophysics and Surgery, University of California, Irvine, California (V.C., S.K.U., I.T., H.N., K.G.C.); Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas (X.H., C.B.); MPI Research, Mattawan, Michigan (D.B., G.W.R., S.E.B., R.S., J.S., B.K., D.K., Z.H.); and Peptides International, Louisville, Kentucky (M.W.P.)
James Sams
Kineta Inc., Seattle, Washington (E.J.T., E.J.M.-E., L.M.L., K.N., A.B., S.P.I.); Departments of Physiology and Biophysics and Surgery, University of California, Irvine, California (V.C., S.K.U., I.T., H.N., K.G.C.); Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas (X.H., C.B.); MPI Research, Mattawan, Michigan (D.B., G.W.R., S.E.B., R.S., J.S., B.K., D.K., Z.H.); and Peptides International, Louisville, Kentucky (M.W.P.)
Brian Knapp
Kineta Inc., Seattle, Washington (E.J.T., E.J.M.-E., L.M.L., K.N., A.B., S.P.I.); Departments of Physiology and Biophysics and Surgery, University of California, Irvine, California (V.C., S.K.U., I.T., H.N., K.G.C.); Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas (X.H., C.B.); MPI Research, Mattawan, Michigan (D.B., G.W.R., S.E.B., R.S., J.S., B.K., D.K., Z.H.); and Peptides International, Louisville, Kentucky (M.W.P.)
Dustin Kentala
Kineta Inc., Seattle, Washington (E.J.T., E.J.M.-E., L.M.L., K.N., A.B., S.P.I.); Departments of Physiology and Biophysics and Surgery, University of California, Irvine, California (V.C., S.K.U., I.T., H.N., K.G.C.); Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas (X.H., C.B.); MPI Research, Mattawan, Michigan (D.B., G.W.R., S.E.B., R.S., J.S., B.K., D.K., Z.H.); and Peptides International, Louisville, Kentucky (M.W.P.)
Zachary Hansen
Kineta Inc., Seattle, Washington (E.J.T., E.J.M.-E., L.M.L., K.N., A.B., S.P.I.); Departments of Physiology and Biophysics and Surgery, University of California, Irvine, California (V.C., S.K.U., I.T., H.N., K.G.C.); Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas (X.H., C.B.); MPI Research, Mattawan, Michigan (D.B., G.W.R., S.E.B., R.S., J.S., B.K., D.K., Z.H.); and Peptides International, Louisville, Kentucky (M.W.P.)
Michael W. Pennington
Kineta Inc., Seattle, Washington (E.J.T., E.J.M.-E., L.M.L., K.N., A.B., S.P.I.); Departments of Physiology and Biophysics and Surgery, University of California, Irvine, California (V.C., S.K.U., I.T., H.N., K.G.C.); Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas (X.H., C.B.); MPI Research, Mattawan, Michigan (D.B., G.W.R., S.E.B., R.S., J.S., B.K., D.K., Z.H.); and Peptides International, Louisville, Kentucky (M.W.P.)
Christine Beeton
Kineta Inc., Seattle, Washington (E.J.T., E.J.M.-E., L.M.L., K.N., A.B., S.P.I.); Departments of Physiology and Biophysics and Surgery, University of California, Irvine, California (V.C., S.K.U., I.T., H.N., K.G.C.); Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas (X.H., C.B.); MPI Research, Mattawan, Michigan (D.B., G.W.R., S.E.B., R.S., J.S., B.K., D.K., Z.H.); and Peptides International, Louisville, Kentucky (M.W.P.)
K. George Chandy
Kineta Inc., Seattle, Washington (E.J.T., E.J.M.-E., L.M.L., K.N., A.B., S.P.I.); Departments of Physiology and Biophysics and Surgery, University of California, Irvine, California (V.C., S.K.U., I.T., H.N., K.G.C.); Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas (X.H., C.B.); MPI Research, Mattawan, Michigan (D.B., G.W.R., S.E.B., R.S., J.S., B.K., D.K., Z.H.); and Peptides International, Louisville, Kentucky (M.W.P.)
Shawn P. Iadonato
Kineta Inc., Seattle, Washington (E.J.T., E.J.M.-E., L.M.L., K.N., A.B., S.P.I.); Departments of Physiology and Biophysics and Surgery, University of California, Irvine, California (V.C., S.K.U., I.T., H.N., K.G.C.); Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas (X.H., C.B.); MPI Research, Mattawan, Michigan (D.B., G.W.R., S.E.B., R.S., J.S., B.K., D.K., Z.H.); and Peptides International, Louisville, Kentucky (M.W.P.)
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In this issue
Research ArticleDrug Discovery and Translational Medicine
Durable Pharmacological Responses from ShK-186
Eric J. Tarcha, Victor Chi, Ernesto J. Muñoz-Elías, David Bailey, Luz M. Londono, Sanjeev K. Upadhyay, Kayla Norton, Amy Banks, Indra Tjong, Hai Nguyen, Xueyou Hu, Greg W. Ruppert, Scott E. Boley, Richard Slauter, James Sams, Brian Knapp, Dustin Kentala, Zachary Hansen, Michael W. Pennington, Christine Beeton, K. George Chandy and Shawn P. Iadonato
Journal of Pharmacology and Experimental Therapeutics September 1, 2012, 342 (3) 642-653; DOI: https://doi.org/10.1124/jpet.112.191890
Research ArticleDrug Discovery and Translational Medicine
Durable Pharmacological Responses from ShK-186
Eric J. Tarcha, Victor Chi, Ernesto J. Muñoz-Elías, David Bailey, Luz M. Londono, Sanjeev K. Upadhyay, Kayla Norton, Amy Banks, Indra Tjong, Hai Nguyen, Xueyou Hu, Greg W. Ruppert, Scott E. Boley, Richard Slauter, James Sams, Brian Knapp, Dustin Kentala, Zachary Hansen, Michael W. Pennington, Christine Beeton, K. George Chandy and Shawn P. Iadonato
Journal of Pharmacology and Experimental Therapeutics September 1, 2012, 342 (3) 642-653; DOI: https://doi.org/10.1124/jpet.112.191890
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