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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

September 01, 2012; Volume 342,Issue 3

Highlighted Papers

  • You have access
    Inverse Relationship between In Vitro Cannabinoid Efficacy and Decreased Sensitivity after Multiple Days of Dosing
    Journal of Pharmacology and Experimental Therapeutics September 2012, 342 (3) 597;
  • You have access
    Impact of Glucocorticosteroids and β2-Adrenoceptor Agonists on Airway Smooth Muscle
    Journal of Pharmacology and Experimental Therapeutics September 2012, 342 (3) 597;
  • You have access
    Vidofludimus Improves Colitis in Rats by a Dual Mode of Action
    Journal of Pharmacology and Experimental Therapeutics September 2012, 342 (3) 597;
  • You have access
    Antinociceptive Effects of Nicotinic Partial Agonists in Acute and Tonic Pain Models
    Journal of Pharmacology and Experimental Therapeutics September 2012, 342 (3) 597;

JPET Miniseries: Mitochondria

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    Mitochondrial Function and Dysfunction: An Update
    Robert E. Davis and Michael Williams
    Journal of Pharmacology and Experimental Therapeutics September 2012, 342 (3) 598-607; DOI: https://doi.org/10.1124/jpet.112.192104
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    Oxidative Shielding or Oxidative Stress?
    Robert K. Naviaux
    Journal of Pharmacology and Experimental Therapeutics September 2012, 342 (3) 608-618; DOI: https://doi.org/10.1124/jpet.112.192120
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    Mitochondrial Dysfunction in Neurodegenerative Diseases
    Ashu Johri and M. Flint Beal
    Journal of Pharmacology and Experimental Therapeutics September 2012, 342 (3) 619-630; DOI: https://doi.org/10.1124/jpet.112.192138
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    Transgenic Mouse Models Resistant to Diet-Induced Metabolic Disease: Is Energy Balance the Key?
    Laura A. A. Gilliam and P. Darrell Neufer
    Journal of Pharmacology and Experimental Therapeutics September 2012, 342 (3) 631-636; DOI: https://doi.org/10.1124/jpet.112.192146
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    Warburg Revisited: Regulation of Mitochondrial Metabolism by Voltage-Dependent Anion Channels in Cancer Cells
    Eduardo N. Maldonado and John J. Lemasters
    Journal of Pharmacology and Experimental Therapeutics September 2012, 342 (3) 637-641; DOI: https://doi.org/10.1124/jpet.112.192153

Behavioral Pharmacology

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    The Serotonin 2C Receptor Antagonist SB 242084 Exhibits Abuse-Related Effects Typical of Stimulants in Squirrel Monkeys
    Daniel F. Manvich, Heather L. Kimmel, Debra A. Cooper and Leonard L. Howell
    Journal of Pharmacology and Experimental Therapeutics September 2012, 342 (3) 761-769; DOI: https://doi.org/10.1124/jpet.112.195156
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    δ-Opioid Mechanisms for ADL5747 and ADL5859 Effects in Mice: Analgesia, Locomotion, and Receptor Internalization
    Chihiro Nozaki, Bertrand Le Bourdonnec, David Reiss, Rolf T. Windh, Patrick J. Little, Roland E. Dolle, Brigitte L. Kieffer and Claire Gavériaux-Ruff
    Journal of Pharmacology and Experimental Therapeutics September 2012, 342 (3) 799-807; DOI: https://doi.org/10.1124/jpet.111.188987
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    Apparent Inverse Relationship between Cannabinoid Agonist Efficacy and Tolerance/Cross-Tolerance Produced by Δ9-Tetrahydrocannabinol Treatment in Rhesus Monkeys
    Lenka Hruba, Brett C. Ginsburg and Lance R. McMahon
    Journal of Pharmacology and Experimental Therapeutics September 2012, 342 (3) 843-849; DOI: https://doi.org/10.1124/jpet.112.196444

Cardiovascular

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    Activation of AMP-Activated Protein Kinase Inhibits the Proliferation of Human Endothelial Cells
    Kelly J. Peyton, Xiao-ming Liu, Yajie Yu, Benjamin Yates and William Durante
    Journal of Pharmacology and Experimental Therapeutics September 2012, 342 (3) 827-834; DOI: https://doi.org/10.1124/jpet.112.194712

Cellular and Molecular

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    Morphine Withdrawal Activates Hypothalamic-Pituitary-Adrenal Axis and Heat Shock Protein 27 in the Left Ventricle: The Role of Extracellular Signal-Regulated Kinase
    E. Martínez-Laorden, M. A. Hurle, M. V. Milanés, M. L. Laorden and P. Almela
    Journal of Pharmacology and Experimental Therapeutics September 2012, 342 (3) 665-675; DOI: https://doi.org/10.1124/jpet.112.193581

Drug Discovery and Translational Medicine

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    Durable Pharmacological Responses from the Peptide ShK-186, a Specific Kv1.3 Channel Inhibitor That Suppresses T Cell Mediators of Autoimmune Disease
    Eric J. Tarcha, Victor Chi, Ernesto J. Muñoz-Elías, David Bailey, Luz M. Londono, Sanjeev K. Upadhyay, Kayla Norton, Amy Banks, Indra Tjong, Hai Nguyen, Xueyou Hu, Greg W. Ruppert, Scott E. Boley, Richard Slauter, James Sams, Brian Knapp, Dustin Kentala, Zachary Hansen, Michael W. Pennington, Christine Beeton, K. George Chandy and Shawn P. Iadonato
    Journal of Pharmacology and Experimental Therapeutics September 2012, 342 (3) 642-653; DOI: https://doi.org/10.1124/jpet.112.191890
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    An Ex Vivo Perfusion System Emulating In Vivo Conditions in Noncirrhotic and Cirrhotic Human Liver
    Thomas Schreiter, Guido Marquitan, Malin Darnell, Jan-Peter Sowa, Martina Bröcker-Preuss, Tommy B. Andersson, Hideo A. Baba, Marcus Furch, Gavin E. Arteel, Zoltan Mathé, Jürgen Treckmann, Guido Gerken, Robert K. Gieseler and Ali Canbay
    Journal of Pharmacology and Experimental Therapeutics September 2012, 342 (3) 730-741; DOI: https://doi.org/10.1124/jpet.112.194167
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    Pharmacokinetic/Pharmacodynamic Model of the Testosterone Effects of Triptorelin Administered in Sustained Release Formulations in Patients with Prostate Cancer
    Elba Romero, Nieves Vélez de Mendizabal, Josep-María Cendrós, Concepción Peraire, Emma Bascompta, Rosendo Obach and Iñaki F. Trocóniz
    Journal of Pharmacology and Experimental Therapeutics September 2012, 342 (3) 788-798; DOI: https://doi.org/10.1124/jpet.112.195560
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    Vaccination with Platelet-Derived Growth Factor B Kinoids Inhibits CCl4-Induced Hepatic Fibrosis in Mice
    Zhi-Ming Hao, Xiao-Bao Fan, Shuang Li, Yi-Fei Lv, Hou-Qiang Su, Hui-Ping Jiang and Hong-Hong Li
    Journal of Pharmacology and Experimental Therapeutics September 2012, 342 (3) 835-842; DOI: https://doi.org/10.1124/jpet.112.194357

Gastrointestinal, Hepatic, Pulmonary, and Renal

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    Production and Actions of the Anandamide Metabolite Prostamide E2 in the Renal Medulla
    Joseph K. Ritter, Cao Li, Min Xia, Justin L. Poklis, Aron H. Lichtman, Rehab A. Abdullah, William L. Dewey and Pin-Lan Li
    Journal of Pharmacology and Experimental Therapeutics September 2012, 342 (3) 770-779; DOI: https://doi.org/10.1124/jpet.112.196451

Inflammation, Immunopharmacology, and Asthma

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    Nodakenin Suppresses Lipopolysaccharide-Induced Inflammatory Responses in Macrophage Cells by Inhibiting Tumor Necrosis Factor Receptor-Associated Factor 6 and Nuclear Factor-κB Pathways and Protects Mice from Lethal Endotoxin Shock
    Hong-Kun Rim, Woong Cho, Sang Hyun Sung and Kyung-Tae Lee
    Journal of Pharmacology and Experimental Therapeutics September 2012, 342 (3) 654-664; DOI: https://doi.org/10.1124/jpet.112.194613
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    Glucocorticosteroids and β2-Adrenoceptor Agonists Synergize to Inhibit Airway Smooth Muscle Remodeling
    Bart G. J. Dekkers, Adnan Pehlić, Raissa Mariani, I. Sophie T. Bos, Herman Meurs and Johan Zaagsma
    Journal of Pharmacology and Experimental Therapeutics September 2012, 342 (3) 780-787; DOI: https://doi.org/10.1124/jpet.112.195867
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    Soluble Glucan Is Internalized and Trafficked to the Golgi Apparatus in Macrophages via a Clathrin-Mediated, Lipid Raft-Regulated Mechanism
    Tammy R. Ozment, Matthew P. Goldman, John H. Kalbfleisch and David L. Williams
    Journal of Pharmacology and Experimental Therapeutics September 2012, 342 (3) 808-815; DOI: https://doi.org/10.1124/jpet.112.196329
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    15-Deoxy-Δ12,14-Prostaglandin J2-Glycerol, a Putative Metabolite of 2-Arachidonyl Glycerol and a Peroxisome Proliferator-Activated Receptor γ Ligand, Modulates Nuclear Factor of Activated T Cells
    Priyadarshini Raman, Barbara L. F. Kaplan and Norbert E. Kaminski
    Journal of Pharmacology and Experimental Therapeutics September 2012, 342 (3) 816-826; DOI: https://doi.org/10.1124/jpet.112.193003
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    Vidofludimus Inhibits Colonic Interleukin-17 and Improves Hapten-Induced Colitis in Rats by a Unique Dual Mode of Action
    Leo R. Fitzpatrick, Jeffrey S. Small, Robert Doblhofer and Aldo Ammendola
    Journal of Pharmacology and Experimental Therapeutics September 2012, 342 (3) 850-860; DOI: https://doi.org/10.1124/jpet.112.192203

Metabolism, Transport, and Pharmacogenomics

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    Hormonal and Chemical Regulation of Paraoxonases in Mice
    Xingguo Cheng and Curtis D. Klaassen
    Journal of Pharmacology and Experimental Therapeutics September 2012, 342 (3) 688-695; DOI: https://doi.org/10.1124/jpet.112.194803
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    Intestinal Transport of Aminopterin Enantiomers in Dogs and Humans with Psoriasis Is Stereoselective: Evidence for a Mechanism Involving the Proton-Coupled Folate Transporter
    Alan Menter, Breck Thrash, Christina Cherian, Larry H. Matherly, Lei Wang, Aleem Gangjee, Joel R. Morgan, Dean Y. Maeda, Aaron D. Schuler, Stuart J. Kahn and John A. Zebala
    Journal of Pharmacology and Experimental Therapeutics September 2012, 342 (3) 696-708; DOI: https://doi.org/10.1124/jpet.112.195479
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    Bioenergetic Effects of Mitochondrial-Targeted Coenzyme Q Analogs in Endothelial Cells
    Brian D. Fink, Judith A. Herlein, Mark A. Yorek, Amanda M. Fenner, Robert J. Kerns and William I. Sivitz
    Journal of Pharmacology and Experimental Therapeutics September 2012, 342 (3) 709-719; DOI: https://doi.org/10.1124/jpet.112.195586
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    Quantification of Hepatic UDP Glucuronosyltransferase 1A Splice Variant Expression and Correlation of UDP Glucuronosyltransferase 1A1 Variant Expression with Glucuronidation Activity
    Nathan R. Jones, Dongxiao Sun, Willard M. Freeman and Philip Lazarus
    Journal of Pharmacology and Experimental Therapeutics September 2012, 342 (3) 720-729; DOI: https://doi.org/10.1124/jpet.112.192658
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    Phenanthrene Metabolism in Smokers: Use of a Two-Step Diagnostic Plot Approach to Identify Subjects with Extensive Metabolic Activation
    Jing Wang, Yan Zhong, Steven G. Carmella, J. Bradley Hochalter, Diane Rauch, Andrew Oliver, Joni Jensen, Dorothy K. Hatsukami, Pramod Upadhyaya, Stephen S. Hecht and Cheryl L. Zimmerman
    Journal of Pharmacology and Experimental Therapeutics September 2012, 342 (3) 750-760; DOI: https://doi.org/10.1124/jpet.112.194118

Neuropharmacology

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    The Antinociceptive Effects of Nicotinic Partial Agonists Varenicline and Sazetidine-A in Murine Acute and Tonic Pain Models
    Shakir D. AlSharari, F. Ivy Carroll, J. Michael McIntosh and M. Imad Damaj
    Journal of Pharmacology and Experimental Therapeutics September 2012, 342 (3) 742-749; DOI: https://doi.org/10.1124/jpet.112.194506

Toxicology

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    Differences in Early Acetaminophen Hepatotoxicity between Obese ob/ob and db/db Mice
    Jacinthe Aubert, Karima Begriche, Matthieu Delannoy, Isabelle Morel, Julie Pajaud, Catherine Ribault, Sylvie Lepage, Mitchell R. McGill, Catherine Lucas-Clerc, Bruno Turlin, Marie-Anne Robin, Hartmut Jaeschke and Bernard Fromenty
    Journal of Pharmacology and Experimental Therapeutics September 2012, 342 (3) 676-687; DOI: https://doi.org/10.1124/jpet.112.193813

Notice of Withdrawal

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    Notice of Withdrawal
    Journal of Pharmacology and Experimental Therapeutics September 2012, 342 (3) 861;
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In this issue

Journal of Pharmacology and Experimental Therapeutics: 342 (3)
Journal of Pharmacology and Experimental Therapeutics
Vol. 342, Issue 3
1 Sep 2012
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
  • Editorial Board (PDF)
  • Front Matter (PDF)
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Jump to

  • Highlighted Papers
  • JPET Miniseries: Mitochondria
  • Behavioral Pharmacology
  • Cardiovascular
  • Cellular and Molecular
  • Drug Discovery and Translational Medicine
  • Gastrointestinal, Hepatic, Pulmonary, and Renal
  • Inflammation, Immunopharmacology, and Asthma
  • Metabolism, Transport, and Pharmacogenomics
  • Neuropharmacology
  • Toxicology
  • Notice of Withdrawal
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  • Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.
  • Functional Selectivity and Classical Concepts of Quantitative Pharmacology
  • Abl Protein-Tyrosine Kinase Inhibitor STI571 Inhibits In Vitro Signal Transduction Mediated by c-Kit and Platelet-Derived Growth Factor Receptors
  • The Prediction of Human Pharmacokinetic Parameters from Preclinical and In Vitro Metabolism Data
  • A METHOD FOR DETERMINING LOSS OF PAIN SENSATION
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