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Research ArticleDrug Discovery and Translational Medicine

Pharmacological Characterization of Abediterol, a Novel Inhaled β2-Adrenoceptor Agonist with Long Duration of Action and a Favorable Safety Profile in Preclinical Models

Mònica Aparici, Mireia Gómez-Angelats, Dolors Vilella, Raquel Otal, Carla Carcasona, Marisa Viñals, Israel Ramos, Amadeu Gavaldà, Jorge De Alba, Jordi Gras, Julio Cortijo, Esteban Morcillo, Carlos Puig, Hamish Ryder, Jorge Beleta and Montserrat Miralpeix
Journal of Pharmacology and Experimental Therapeutics August 2012, 342 (2) 497-509; DOI: https://doi.org/10.1124/jpet.112.193284
Mònica Aparici
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Mireia Gómez-Angelats
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Dolors Vilella
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Raquel Otal
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Carla Carcasona
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Marisa Viñals
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Israel Ramos
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Amadeu Gavaldà
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Jorge De Alba
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Jordi Gras
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Julio Cortijo
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Esteban Morcillo
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Carlos Puig
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Hamish Ryder
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Jorge Beleta
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Montserrat Miralpeix
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Article Information

vol. 342 no. 2 497-509
DOI 
https://doi.org/10.1124/jpet.112.193284
PubMed 
22588259

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received March 1, 2012
  • Accepted May 14, 2012
  • Published online July 16, 2012.

Article Versions

  • Earlier version (May 15, 2012 - 12:05).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2012 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Mònica Aparici,
  2. Mireia Gómez-Angelats1,
  3. Dolors Vilella,
  4. Raquel Otal,
  5. Carla Carcasona,
  6. Marisa Viñals,
  7. Israel Ramos,
  8. Amadeu Gavaldà,
  9. Jorge De Alba,
  10. Jordi Gras,
  11. Julio Cortijo,
  12. Esteban Morcillo,
  13. Carlos Puig,
  14. Hamish Ryder2,
  15. Jorge Beleta and
  16. Montserrat Miralpeix
  1. Almirall R&D Center, Sant Feliu de Llobregat, Barcelona, Spain (M.A., M.G.-A., D.V., R.O., C.C., M.V., I.R., A.G., J.D.A., J.G., C.P., H.R., J.B., M.M.); Department of Pharmacology, Faculty of Medicine, University of Valencia, Valencia, Spain (J.C., E.M.); Ciber Respiratory Diseases, Valencia, Spain (J.C., E.M.); Research Foundation, University General Hospital, Valencia, Spain (J.C.); and Clinical Pharmacology Unit, Research Foundation, University Clinic Hospital, Valencia, Spain (E.M.)
  1. Address correspondence to:
    Dr. Mònica Aparici, Almirall S.A., Laureà Miró, 408-410, 08980 Sant Feliu de Llobregat, Barcelona, Spain. E-mail: monica.aparici{at}almirall.com
  1. This work was partially presented in abstract form: Aparici M, Gómez-Angelats M, Vilella D, Cortijo J, Morcillo E, Carcasona C, Gavaldà A, Beleta J, Puig C, Ryder H, et al. (2010) The in vitro pharmacological profile of LAS100977–a potent, selective and long-acting β2 receptor agonist, at the American Thoracic Society Meeting, 2010 May 14–19, New Orleans, LA, American Thoracic Society, New York, NY. Miralpeix M, Gómez-Angelats M, Aparici M, Viñals M, Beleta J, Gavaldà A, Puig C, Ryder H, Llenas J and Gras J (2010) LAS100977, a novel β2 receptor agonist, with a longer duration of action and more favorable safety margin than salmeterol in anesthetized dogs, at the American Thoracic Society Meeting, 2010 May 14–19, New Orleans, LA, American Thoracic Society, New York, NY. Aparici M, Gómez-Angelats M, Vilella D, Cortijo J, Morcillo E, Carcasona C, Gavaldà A, Beleta J, Puig C, Ryder H, et al. (2010) LAS100977 is a novel, potent β2-agonist with rapid onset and sustained duration of action in isolated human bronchi, at the European Respiratory Society Meeting, 2010 Sept 18–22, Barcelona, Spain, European Respiratory Society, Lausanne, Switzerland. Miralpeix M, Gómez-Angelats M, Aparici M, Viñals M, Beleta J, Gavaldà A, Puig C, Ryder H, Llenas J, and Gras J (2010) LAS100977, a novel β2-agonist, has a longer duration of action and a more favorable therapeutic index than salmeterol in anesthetized dog, at the European Respiratory Society Meeting, 2010 Sept 18–22, Barcelona, Spain, European Respiratory Society, Lausanne, Switzerland.

  • ↵1Current affiliation: Johnson & Johnson, San Diego, California.

  • ↵2Current affiliation: Cancer Research Technology Ltd, London, United Kingdom.

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Journal of Pharmacology and Experimental Therapeutics: 342 (2)
Journal of Pharmacology and Experimental Therapeutics
Vol. 342, Issue 2
1 Aug 2012
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Research ArticleDrug Discovery and Translational Medicine

In Vitro and In Vivo Characterization of Abediterol

Mònica Aparici, Mireia Gómez-Angelats, Dolors Vilella, Raquel Otal, Carla Carcasona, Marisa Viñals, Israel Ramos, Amadeu Gavaldà, Jorge De Alba, Jordi Gras, Julio Cortijo, Esteban Morcillo, Carlos Puig, Hamish Ryder, Jorge Beleta and Montserrat Miralpeix
Journal of Pharmacology and Experimental Therapeutics August 1, 2012, 342 (2) 497-509; DOI: https://doi.org/10.1124/jpet.112.193284

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Research ArticleDrug Discovery and Translational Medicine

In Vitro and In Vivo Characterization of Abediterol

Mònica Aparici, Mireia Gómez-Angelats, Dolors Vilella, Raquel Otal, Carla Carcasona, Marisa Viñals, Israel Ramos, Amadeu Gavaldà, Jorge De Alba, Jordi Gras, Julio Cortijo, Esteban Morcillo, Carlos Puig, Hamish Ryder, Jorge Beleta and Montserrat Miralpeix
Journal of Pharmacology and Experimental Therapeutics August 1, 2012, 342 (2) 497-509; DOI: https://doi.org/10.1124/jpet.112.193284
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