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Research ArticleNeuropharmacology

7-tert-Butyl-6-(4-Chloro-Phenyl)-2-Thioxo-2,3-Dihydro-1H-Pyrido[2,3-d]Pyrimidin-4-One, a Classic Polymodal Inhibitor of Transient Receptor Potential Vanilloid Type 1 with a Reduced Liability for Hyperthermia, Is Analgesic and Ameliorates Visceral Hypersensitivity

Mark S. Nash, Peter McIntyre, Alex Groarke, Elliot Lilley, Andrew Culshaw, Allan Hallett, Moh Panesar, Alyson Fox and Stuart Bevan
Journal of Pharmacology and Experimental Therapeutics August 2012, 342 (2) 389-398; DOI: https://doi.org/10.1124/jpet.112.191932

Article Information

vol. 342 no. 2 389-398
DOI 
https://doi.org/10.1124/jpet.112.191932
PubMed 
22566669
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received January 14, 2012
  • Accepted May 4, 2012
  • Published online July 16, 2012.

Article Versions

Copyright & Usage 
Copyright © 2012 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Mark S. Nash,
  2. Peter McIntyre,
  3. Alex Groarke,
  4. Elliot Lilley,
  5. Andrew Culshaw,
  6. Allan Hallett,
  7. Moh Panesar,
  8. Alyson Fox and
  9. Stuart Bevan
  1. Novartis Institutes for BioMedical Research, Horsham, United Kingdom (M.S.N., A.G., E.L., A.C., A.H., M.P., A.F.); Department of Pharmacology, University of Melbourne, Victoria, Australia (P.M.); and Wolfson Centre for Age-Related Diseases, King's College, London, United Kingdom (S.B.)
  1. Address correspondence to:
    Stuart Bevan, Wolfson Centre for Age Related Diseases, King's College London, London SE1 1UL, United Kingdom. E-mail: stuart.bevan{at}kcl.ac.uk
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Research ArticleNeuropharmacology

BCTP, a TRPV1 Inhibitor with Reduced Hyperthermia

Mark S. Nash, Peter McIntyre, Alex Groarke, Elliot Lilley, Andrew Culshaw, Allan Hallett, Moh Panesar, Alyson Fox and Stuart Bevan
Journal of Pharmacology and Experimental Therapeutics August 1, 2012, 342 (2) 389-398; DOI: https://doi.org/10.1124/jpet.112.191932
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