Journal of Pharmacology and Experimental Therapeutics: 342 (2)

August 01, 2012; Volume 342,Issue 2

Highlighted Papers

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Compartmentalized Regulation of Adenylyl Cyclases Provides Opportunity for Selective Bronchodilatory Modalities
Journal of Pharmacology and Experimental Therapeutics August 2012, 342 (2) 235;
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Regulating Hypoxia-Inducible Factor-1α with Apolipoprotein A-I Mimetic Peptides
Journal of Pharmacology and Experimental Therapeutics August 2012, 342 (2) 235;
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Treating Parkinson's Disease with Selective Dopamine D4 Antagonists
Journal of Pharmacology and Experimental Therapeutics August 2012, 342 (2) 235;
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Modulating Stress through β-Adrenergic Receptors as Pharmacotherapy for Relapse Prevention
Journal of Pharmacology and Experimental Therapeutics August 2012, 342 (2) 235;

Perspectives in Pharmacology

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Role of TRPML and Two-Pore Channels in Endolysosomal Cation Homeostasis
Christian Grimm, Sami Hassan, Christian Wahl-Schott and Martin Biel

Journal of Pharmacology and Experimental Therapeutics August 2012, 342 (2) 236-244; DOI: https://doi.org/10.1124/jpet.112.192880

Behavioral Pharmacology

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L-745,870 Reduces l-DOPA-Induced Dyskinesia in the 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Lesioned Macaque Model of Parkinson's Disease
Philippe Huot, Tom H. Johnston, James B. Koprich, Ahmed Aman, Susan H. Fox and Jonathan M. Brotchie

Journal of Pharmacology and Experimental Therapeutics August 2012, 342 (2) 576-585; DOI: https://doi.org/10.1124/jpet.112.195693

Cardiovascular

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Structure-Guided Topographic Mapping and Mutagenesis to Elucidate Binding Sites for the Human Ether-a-Go-Go-Related Gene 1 Potassium Channel (KCNH2) Activator NS1643
Serdar Durdagi, Jiqing Guo, James P. Lees-Miller, Sergei Y. Noskov and Henry J. Duff

Journal of Pharmacology and Experimental Therapeutics August 2012, 342 (2) 441-452; DOI: https://doi.org/10.1124/jpet.111.189159
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Penitrem A as a Tool for Understanding the Role of Large Conductance Ca²⁺/Voltage-Sensitive K⁺ Channels in Vascular Function
Shinichi Asano, Ian N. Bratz, Zachary C. Berwick, Ibra S. Fancher, Johnathan D. Tune and Gregory M. Dick

Journal of Pharmacology and Experimental Therapeutics August 2012, 342 (2) 453-460; DOI: https://doi.org/10.1124/jpet.111.191072
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Enhanced Vascular Neuronal Nitric-Oxide Synthase-Derived Nitric-Oxide Production Underlies the Pressor Response Caused by Peripheral N-Methyl-d-Aspartate Receptor Activation in Conscious Rats
Marie A. McGee and Abdel A. Abdel-Rahman

Journal of Pharmacology and Experimental Therapeutics August 2012, 342 (2) 461-471; DOI: https://doi.org/10.1124/jpet.112.194464
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Involvement of Inositol 1,4,5-Trisphosphate Formation in the Voltage-Dependent Regulation of the Ca²⁺ Concentration in Porcine Coronary Arterial Smooth Muscle Cells
Hisao Yamamura, Susumu Ohya, Katsuhiko Muraki and Yuji Imaizumi

Journal of Pharmacology and Experimental Therapeutics August 2012, 342 (2) 486-496; DOI: https://doi.org/10.1124/jpet.112.194233
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Estrogen Provokes the Depressant Effect of Chronic Nicotine on Vagally Mediated Reflex Chronotropism in Female Rats
Mahmoud M. El-Mas, Hanan M. El-Gowelli, Sahar M. El-Gowilly, Mohamed A. Fouda and Mai M. Helmy

Journal of Pharmacology and Experimental Therapeutics August 2012, 342 (2) 568-575; DOI: https://doi.org/10.1124/jpet.112.191940

Cellular and Molecular

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Naltrindole Inhibits Human Multiple Myeloma Cell Proliferation In Vitro and in a Murine Xenograft Model In Vivo
Jyoti Joshi Mundra, Alexandra Terskiy and Richard D. Howells

Journal of Pharmacology and Experimental Therapeutics August 2012, 342 (2) 273-287; DOI: https://doi.org/10.1124/jpet.112.194159
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Selected Melanocortin 1 Receptor Single-Nucleotide Polymorphisms Differentially Alter Multiple Signaling Pathways
J. R. Doyle, J. P. Fortin, M. Beinborn and A. S. Kopin

Journal of Pharmacology and Experimental Therapeutics August 2012, 342 (2) 318-326; DOI: https://doi.org/10.1124/jpet.112.194548
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Selective Aryl Hydrocarbon Receptor Modulator-Mediated Repression of CD55 Expression Induced by Cytokine Exposure
Gitanjali A. Narayanan, Iain A. Murray, Gowdahalli Krishnegowda, Shantu Amin and Gary H. Perdew

Journal of Pharmacology and Experimental Therapeutics August 2012, 342 (2) 345-355; DOI: https://doi.org/10.1124/jpet.112.193482
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Pharmacology of Modality-Specific Transient Receptor Potential Vanilloid-1 Antagonists That Do Not Alter Body Temperature
Regina M. Reilly, Heath A. McDonald, Pamela S. Puttfarcken, Shailen K. Joshi, LaGeisha Lewis, Madhavi Pai, Pamela H. Franklin, Jason A. Segreti, Torben R. Neelands, Ping Han, Jun Chen, Patrick W. Mantyh, Joseph R. Ghilardi, Teresa M. Turner, Eric A. Voight, Jerome F. Daanen, Robert G. Schmidt, Arthur Gomtsyan, Michael E. Kort, Connie R. Faltynek and Philip R. Kym

Journal of Pharmacology and Experimental Therapeutics August 2012, 342 (2) 416-428; DOI: https://doi.org/10.1124/jpet.111.190314
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Ring Substituents on Substituted Benzamide Ligands Indirectly Mediate Interactions with Position 7.39 of Transmembrane Helix 7 of the D4 Dopamine Receptor
Spencer S. Ericksen, David F. Cummings, Michael E. Teer, Shahnawaz Amdani and John A. Schetz

Journal of Pharmacology and Experimental Therapeutics August 2012, 342 (2) 472-485; DOI: https://doi.org/10.1124/jpet.112.193979
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Copper Is Required for Cobalt-Induced Transcriptional Activity of Hypoxia-Inducible Factor-1
Liying Qiu, Xueqin Ding, Zhen Zhang and Y. James Kang

Journal of Pharmacology and Experimental Therapeutics August 2012, 342 (2) 561-567; DOI: https://doi.org/10.1124/jpet.112.194662
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Adenylyl Cyclase 2 Selectively Couples to E Prostanoid Type 2 Receptors, Whereas Adenylyl Cyclase 3 Is Not Receptor-Regulated in Airway Smooth Muscle
Amy S. Bogard, Piyatilake Adris and Rennolds S. Ostrom

Journal of Pharmacology and Experimental Therapeutics August 2012, 342 (2) 586-595; DOI: https://doi.org/10.1124/jpet.112.193425

Drug Discovery and Translational Medicine

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Apolipoprotein A-I Mimetic Peptides Inhibit Expression and Activity of Hypoxia-Inducible Factor-1α in Human Ovarian Cancer Cell Lines and a Mouse Ovarian Cancer Model
Feng Gao, Arnab Chattopadhyay, Mohamad Navab, Victor Grijalva, Feng Su, Alan M. Fogelman, Srinivasa T. Reddy and Robin Farias-Eisner

Journal of Pharmacology and Experimental Therapeutics August 2012, 342 (2) 255-262; DOI: https://doi.org/10.1124/jpet.112.191544
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Cerebrospinal Fluid Amyloid-β (Aβ) as an Effect Biomarker for Brain Aβ Lowering Verified by Quantitative Preclinical Analyses
Yasong Lu, David Riddell, Eva Hajos-Korcsok, Kelly Bales, Kathleen M. Wood, Charles E. Nolan, Ashley E. Robshaw, Liming Zhang, Louis Leung, Stacey L. Becker, Elaine Tseng, Jason Barricklow, Emily H. Miller, Sarah Osgood, Brian T. O'Neill, Michael A. Brodney, Douglas S. Johnson and Martin Pettersson

Journal of Pharmacology and Experimental Therapeutics August 2012, 342 (2) 366-375; DOI: https://doi.org/10.1124/jpet.112.192625
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Translational Evaluation of JNJ-18038683, a 5-Hydroxytryptamine Type 7 Receptor Antagonist, on Rapid Eye Movement Sleep and in Major Depressive Disorder
Pascal Bonaventure, Christine Dugovic, Michelle Kramer, Peter De Boer, Jaskaran Singh, Sue Wilson, Kirk Bertelsen, Jianing Di, Jonathan Shelton, Leah Aluisio, Lisa Dvorak, Ian Fraser, Brian Lord, Diane Nepomuceno, Abdellah Ahnaou, Wilhelmus Drinkenburg, Wenying Chai, Curt Dvorak, Steve Sands, Nicholas Carruthers and Timothy W. Lovenberg

Journal of Pharmacology and Experimental Therapeutics August 2012, 342 (2) 429-440; DOI: https://doi.org/10.1124/jpet.112.193995
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Pharmacological Characterization of Abediterol, a Novel Inhaled β₂-Adrenoceptor Agonist with Long Duration of Action and a Favorable Safety Profile in Preclinical Models
Mònica Aparici, Mireia Gómez-Angelats, Dolors Vilella, Raquel Otal, Carla Carcasona, Marisa Viñals, Israel Ramos, Amadeu Gavaldà, Jorge De Alba, Jordi Gras, Julio Cortijo, Esteban Morcillo, Carlos Puig, Hamish Ryder, Jorge Beleta and Montserrat Miralpeix

Journal of Pharmacology and Experimental Therapeutics August 2012, 342 (2) 497-509; DOI: https://doi.org/10.1124/jpet.112.193284

Endocrine and Diabetes

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KGA-2727, a Novel Selective Inhibitor of a High-Affinity Sodium Glucose Cotransporter (SGLT1), Exhibits Antidiabetic Efficacy in Rodent Models
Toshihide Shibazaki, Masaki Tomae, Yukiko Ishikawa-Takemura, Nobuhiko Fushimi, Fumiaki Itoh, Mitsuhiko Yamada and Masayuki Isaji

Journal of Pharmacology and Experimental Therapeutics August 2012, 342 (2) 288-296; DOI: https://doi.org/10.1124/jpet.112.193045
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Cerebral Myogenic Reactivity and Blood Flow in Type 2 Diabetic Rats: Role of Peroxynitrite in Hypoxia-Mediated Loss of Myogenic Tone
Aisha I. Kelly-Cobbs, Roshini Prakash, Maha Coucha, Robert A. Knight, Weiguo Li, Safia N. Ogbi, Maribeth Johnson and Adviye Ergul

Journal of Pharmacology and Experimental Therapeutics August 2012, 342 (2) 407-415; DOI: https://doi.org/10.1124/jpet.111.191296

Gastrointestinal, Hepatic, Pulmonary, and Renal

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Modulation of Purinergic Neuromuscular Transmission by Phorbol Dibutyrate is Independent of Protein Kinase C in Murine Urinary Bladder
T. J. Searl and E. M. Silinsky

Journal of Pharmacology and Experimental Therapeutics August 2012, 342 (2) 312-317; DOI: https://doi.org/10.1124/jpet.112.194704
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Carboxyamidotriazole Ameliorates Experimental Colitis by Inhibition of Cytokine Production, Nuclear Factor-κB Activation, and Colonic Fibrosis
Lei Guo, Caiying Ye, Xiaojian Hao, Ru Zheng, Rui Ju, Danwei Wu, Lifeng Luo, Conghui Wang, Juan Li, Xiaoli Yu, Lei Zhu and Dechang Zhang

Journal of Pharmacology and Experimental Therapeutics August 2012, 342 (2) 356-365; DOI: https://doi.org/10.1124/jpet.112.192849
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Levosimendan Protection against Kidney Ischemia/Reperfusion Injuries in Anesthetized Pigs
Elena Grossini, Claudio Molinari, Piero Pollesello, Giorgio Bellomo, Guido Valente, David Mary, Giovanni Vacca and Philippe Caimmi

Journal of Pharmacology and Experimental Therapeutics August 2012, 342 (2) 376-388; DOI: https://doi.org/10.1124/jpet.112.193961

Inflammation, Immunopharmacology, and Asthma

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Targeting Phosphoinositide 3-Kinase γ in Airway Smooth Muscle Cells to Suppress Interleukin-13-Induced Mouse Airway Hyperresponsiveness
Haihong Jiang, Yan Xie, Peter W. Abel, Myron L. Toews, Robert G. Townley, Thomas B. Casale and Yaping Tu

Journal of Pharmacology and Experimental Therapeutics August 2012, 342 (2) 305-311; DOI: https://doi.org/10.1124/jpet.111.189704
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Sphingosine-1-Phosphate-Induced Airway Hyper-Reactivity in Rodents Is Mediated by the Sphingosine-1-Phosphate Type 3 Receptor
Alexandre Trifilieff and John R. Fozard

Journal of Pharmacology and Experimental Therapeutics August 2012, 342 (2) 399-406; DOI: https://doi.org/10.1124/jpet.112.191585

Metabolism, Transport, and Pharmacogenomics

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3-Monoglucuronyl-Glycyrrhretinic Acid Is a Substrate of Organic Anion Transporters Expressed in Tubular Epithelial Cells and Plays Important Roles in Licorice-Induced Pseudoaldosteronism by Inhibiting 11β-Hydroxysteroid Dehydrogenase 2
Toshiaki Makino, Kyoko Okajima, Rie Uebayashi, Nobuhiro Ohtake, Katsuhisa Inoue and Hajime Mizukami

Journal of Pharmacology and Experimental Therapeutics August 2012, 342 (2) 297-304; DOI: https://doi.org/10.1124/jpet.111.190009
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Differential Role of Organic Anion-Transporting Polypeptides in Estrone-3-Sulphate Uptake by Breast Epithelial Cells and Breast Cancer Cells
Nilasha Banerjee, Christine Allen and Reina Bendayan

Journal of Pharmacology and Experimental Therapeutics August 2012, 342 (2) 510-519; DOI: https://doi.org/10.1124/jpet.112.192344

Neuropharmacology

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Regulation of the Distribution and Function of [¹²⁵I]Epibatidine Binding Sites by Chronic Nicotine in Mouse Embryonic Neuronal Cultures
Cristian A. Zambrano, Rakel M. Salamander, Allan C. Collins, Sharon R. Grady and Michael J. Marks

Journal of Pharmacology and Experimental Therapeutics August 2012, 342 (2) 245-254; DOI: https://doi.org/10.1124/jpet.112.192542
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Selectivity of Action of Pregabalin on Ca²⁺ Channels but Not on Fusion Pore, Exocytotic Machinery, or Mitochondria in Chromaffin Cells of the Adrenal Gland
Alicia Hernández-Vivanco, Alberto Pérez-Alvarez, José Carlos Caba-González, María Teresa Alonso, Ana José Moreno-Ortega, María Cano-Abad, Ana Ruiz-Nuño, Beatriz Carmona-Hidalgo and Almudena Albillos

Journal of Pharmacology and Experimental Therapeutics August 2012, 342 (2) 263-272; DOI: https://doi.org/10.1124/jpet.111.190652
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Varenicline Is a Potent Partial Agonist at α6β2* Nicotinic Acetylcholine Receptors in Rat and Monkey Striatum
Tanuja Bordia, Maya Hrachova, Matthew Chin, J. Michael McIntosh and Maryka Quik

Journal of Pharmacology and Experimental Therapeutics August 2012, 342 (2) 327-334; DOI: https://doi.org/10.1124/jpet.112.194852
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Long-Term Nicotine Exposure Depresses Dopamine Release in Nonhuman Primate Nucleus Accumbens
Xiomara A. Perez, Jason Ly, J. Michael McIntosh and Maryka Quik

Journal of Pharmacology and Experimental Therapeutics August 2012, 342 (2) 335-344; DOI: https://doi.org/10.1124/jpet.112.194084
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7-tert-Butyl-6-(4-Chloro-Phenyl)-2-Thioxo-2,3-Dihydro-1H-Pyrido[2,3-d]Pyrimidin-4-One, a Classic Polymodal Inhibitor of Transient Receptor Potential Vanilloid Type 1 with a Reduced Liability for Hyperthermia, Is Analgesic and Ameliorates Visceral Hypersensitivity
Mark S. Nash, Peter McIntyre, Alex Groarke, Elliot Lilley, Andrew Culshaw, Allan Hallett, Moh Panesar, Alyson Fox and Stuart Bevan

Journal of Pharmacology and Experimental Therapeutics August 2012, 342 (2) 389-398; DOI: https://doi.org/10.1124/jpet.112.191932
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Pharmacological Characterization of (3S)-3-(Hydroxymethyl)-4-(5-Methylpyridin-2-yl)-N-[6-(2,2,2-Trifluoroethoxy)pyridin-3-yl]-3,4-Dihydro-2H-Benzo[b][1,4]Oxazine-8-Carboxamide (JTS-653), a Novel Transient Receptor Potential Vanilloid 1 Antagonist
Yoshihiro Kitagawa, Atsuko Miyai, Kenji Usui, Yuji Hamada, Katsuya Deai, Masashi Wada, Yoshihisa Koga, Masahiro Sakata, Mikio Hayashi, Makoto Tominaga and Mutsuyoshi Matsushita

Journal of Pharmacology and Experimental Therapeutics August 2012, 342 (2) 520-528; DOI: https://doi.org/10.1124/jpet.112.194027
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β-Adrenergic Receptor Mediation of Stress-Induced Reinstatement of Extinguished Cocaine-Induced Conditioned Place Preference in Mice: Roles for β₁ and β₂ Adrenergic Receptors
Oliver Vranjkovic, Shona Hang, David A. Baker and John R. Mantsch

Journal of Pharmacology and Experimental Therapeutics August 2012, 342 (2) 541-551; DOI: https://doi.org/10.1124/jpet.112.193615
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Enhancement of μ-Opioid Receptor Desensitization by Nitric Oxide in Rat Locus Coeruleus Neurons: Involvement of Reactive Oxygen Species
J. Llorente, M. T. Santamarta, G. Henderson and J. Pineda

Journal of Pharmacology and Experimental Therapeutics August 2012, 342 (2) 552-560; DOI: https://doi.org/10.1124/jpet.112.194225

Toxicology

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An Analysis of N-Acetylcysteine Treatment for Acetaminophen Overdose Using a Systems Model of Drug-Induced Liver Injury
Jeffrey L. Woodhead, Brett A. Howell, Yuching Yang, Alison H. Harrill, Harvey J. Clewell, Melvin E. Andersen, Scott Q. Siler and Paul B. Watkins

Journal of Pharmacology and Experimental Therapeutics August 2012, 342 (2) 529-540; DOI: https://doi.org/10.1124/jpet.112.192930

Erratum

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Correction to “The Mitochondria-Targeted Antioxidant Mitoquinone Protects against Cold Storage Injury of Renal Tubular Cells and Rat Kidneys”
Journal of Pharmacology and Experimental Therapeutics August 2012, 342 (2) 596;

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Table of Contents

Highlighted Papers

Perspectives in Pharmacology

Behavioral Pharmacology

Cardiovascular

Cellular and Molecular

Drug Discovery and Translational Medicine

Endocrine and Diabetes

Gastrointestinal, Hepatic, Pulmonary, and Renal

Inflammation, Immunopharmacology, and Asthma

Metabolism, Transport, and Pharmacogenomics

Neuropharmacology

Toxicology

Erratum

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