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Research ArticleMetabolism, Transport, and Pharmacogenomics

Impact of P-Glycoprotein (ABCB1) and Breast Cancer Resistance Protein (ABCG2) on the Brain Distribution of a Novel BRAF Inhibitor: Vemurafenib (PLX4032)

Rajendar K. Mittapalli, Shruthi Vaidhyanathan, Ramola Sane and William F. Elmquist
Journal of Pharmacology and Experimental Therapeutics July 2012, 342 (1) 33-40; DOI: https://doi.org/10.1124/jpet.112.192195

Article Information

vol. 342 no. 1 33-40
DOI 
https://doi.org/10.1124/jpet.112.192195
PubMed 
22454535
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received January 17, 2012
  • Accepted March 26, 2012
  • Published online June 15, 2012.

Article Versions

Copyright & Usage 
Copyright © 2012 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Rajendar K. Mittapalli,
  2. Shruthi Vaidhyanathan,
  3. Ramola Sane and
  4. William F. Elmquist
  1. Department of Pharmaceutics, Brain Barriers Research Center, University of Minnesota, Minneapolis, Minnesota
  1. Address correspondence to:
    William F. Elmquist, Department of Pharmaceutics, University of Minnesota, 9-177 Weaver Densford Hall, 308 Harvard Street SE, Minneapolis, MN 55455. E-mail: elmqu011{at}umn.edu

  1. R.K.M. and S.V. contributed equally to this work.

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Research ArticleMetabolism, Transport, and Pharmacogenomics

P-gp and Bcrp Restrict Brain Distribution of Vemurafenib

Rajendar K. Mittapalli, Shruthi Vaidhyanathan, Ramola Sane and William F. Elmquist
Journal of Pharmacology and Experimental Therapeutics July 1, 2012, 342 (1) 33-40; DOI: https://doi.org/10.1124/jpet.112.192195
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