Journal of Pharmacology and Experimental Therapeutics: 342 (1)

July 01, 2012; Volume 342,Issue 1

Highlighted Papers

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Lyn Activation and Restoring Glucose Tolerance
Journal of Pharmacology and Experimental Therapeutics July 2012, 342 (1) 1;
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Lyn Kinase Activator MLR-1023 Potentiates Insulin and Improves Glucose Homeostasis
Journal of Pharmacology and Experimental Therapeutics July 2012, 342 (1) 1;
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Regulation of Vemurafenib Exposure in the Brain by ABC Transporters
Journal of Pharmacology and Experimental Therapeutics July 2012, 342 (1) 1;
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Attenuation of Chemotherapy-Induced Peripheral Neuropathy by Etodolac
Journal of Pharmacology and Experimental Therapeutics July 2012, 342 (1) 1;

Perspectives in Pharmacology

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Revisiting the Isobole and Related Quantitative Methods for Assessing Drug Synergism
Ronald J. Tallarida

Journal of Pharmacology and Experimental Therapeutics July 2012, 342 (1) 2-8; DOI: https://doi.org/10.1124/jpet.112.193474
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Cigarette Smoking, Coffee Drinking, and Ingestion of Charcoal-Broiled Beef as Potential Modifiers of Drug Therapy and Confounders of Clinical Trials
A. H. Conney and M. M. Reidenberg

Journal of Pharmacology and Experimental Therapeutics July 2012, 342 (1) 9-14; DOI: https://doi.org/10.1124/jpet.112.193193

Behavioral Pharmacology

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Effects of Alterations in Cannabinoid Signaling, Alone and in Combination with Morphine, on Pain-Elicited and Pain-Suppressed Behavior in Mice
Laurence L. Miller, Mitchell J. Picker, Michael D. Umberger, Karl T. Schmidt and Linda A. Dykstra

Journal of Pharmacology and Experimental Therapeutics July 2012, 342 (1) 177-187; DOI: https://doi.org/10.1124/jpet.112.191478
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Cocaine Dose and Self-Administration History, but Not Initial Cocaine Locomotor Responsiveness, Affects Sensitization to the Motivational Effects of Cocaine in Rats
Bruce H. Mandt, Emily Gomez, Nickie L. Johnston, Nancy R. Zahniser and Richard M. Allen

Journal of Pharmacology and Experimental Therapeutics July 2012, 342 (1) 214-221; DOI: https://doi.org/10.1124/jpet.112.194092

Cardiovascular

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Polyethylene Glycol-Modified Pigment Epithelial-Derived Factor: New Prospects for Treatment of Retinal Neovascularization
Yu-Jing Bai, Lv-Zhen Huang, Xiao-Lei Xu, Wei Du, Ai-Yi Zhou, Wen-Zhen Yu and Xiao-Xin Li

Journal of Pharmacology and Experimental Therapeutics July 2012, 342 (1) 131-139; DOI: https://doi.org/10.1124/jpet.112.192575

Chemotherapy, Antibiotics, and Gene Therapy

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Combining Doublecortin-Like Kinase Silencing and Vinca Alkaloids Results in a Synergistic Apoptotic Effect in Neuroblastoma Cells
Carla S. Verissimo, Sou Cheng, Jordi C. Puigvert, Yu Qin, Anne Vroon, Judith van Deutekom, Leo S. Price, Erik H. J. Danen, Bob van de Water, Carlos P. Fitzsimons and Erno Vreugdenhil

Journal of Pharmacology and Experimental Therapeutics July 2012, 342 (1) 119-130; DOI: https://doi.org/10.1124/jpet.111.188813

Drug Discovery and Translational Medicine

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The β₂-Adrenoceptor Agonist Formoterol Stimulates Mitochondrial Biogenesis
Lauren P. Wills, Richard E. Trager, Gyda C. Beeson, Christopher C. Lindsey, Yuri K. Peterson, Craig C. Beeson and Rick G. Schnellmann

Journal of Pharmacology and Experimental Therapeutics July 2012, 342 (1) 106-118; DOI: https://doi.org/10.1124/jpet.112.191528
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The Novel Reversible Fatty Acid Amide Hydrolase Inhibitor ST4070 Increases Endocannabinoid Brain Levels and Counteracts Neuropathic Pain in Different Animal Models
Antonio Caprioli, Roberto Coccurello, Cinzia Rapino, Stefano Di Serio, Monia Di Tommaso, Mario Vertechy, Valentina Vacca, Natalia Battista, Flaminia Pavone, Mauro Maccarrone and Franco Borsini

Journal of Pharmacology and Experimental Therapeutics July 2012, 342 (1) 188-195; DOI: https://doi.org/10.1124/jpet.111.191403
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Arginine Attenuates Methylglyoxal- and High Glucose-Induced Endothelial Dysfunction and Oxidative Stress by an Endothelial Nitric-Oxide Synthase-Independent Mechanism
Indu Dhar, Arti Dhar, Lingyun Wu and Kaushik Desai

Journal of Pharmacology and Experimental Therapeutics July 2012, 342 (1) 196-204; DOI: https://doi.org/10.1124/jpet.112.192112
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Repeated Administration of a Mutant Cocaine Esterase: Effects on Plasma Cocaine Levels, Cocaine-Induced Cardiovascular Activity, and Immune Responses in Rhesus Monkeys
Gregory T. Collins, Remy L. Brim, Kathleen R. Noon, Diwahar Narasimhan, Nicholas W. Lukacs, Roger K. Sunahara, James H. Woods and Mei-Chuan Ko

Journal of Pharmacology and Experimental Therapeutics July 2012, 342 (1) 205-213; DOI: https://doi.org/10.1124/jpet.112.194639

Endocrine and Diabetes

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MLR-1023 Is a Potent and Selective Allosteric Activator of Lyn Kinase In Vitro That Improves Glucose Tolerance In Vivo
Michael S. Saporito, Alexander R. Ochman, Christopher A. Lipinski, Jeffrey A. Handler and Andrew G. Reaume

Journal of Pharmacology and Experimental Therapeutics July 2012, 342 (1) 15-22; DOI: https://doi.org/10.1124/jpet.112.192096
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The Lyn Kinase Activator MLR-1023 Is a Novel Insulin Receptor Potentiator that Elicits a Rapid-Onset and Durable Improvement in Glucose Homeostasis in Animal Models of Type 2 Diabetes
Alexander R. Ochman, Christopher A. Lipinski, Jeffrey A. Handler, Andrew G. Reaume and Michael S. Saporito

Journal of Pharmacology and Experimental Therapeutics July 2012, 342 (1) 23-32; DOI: https://doi.org/10.1124/jpet.112.192187
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The Dipeptidyl Peptidase-4 Inhibitor Linagliptin Attenuates Inflammation and Accelerates Epithelialization in Wounds of Diabetic ob/ob Mice
Christoph Schürmann, Andreas Linke, Kerstin Engelmann-Pilger, Cornelia Steinmetz, Michael Mark, Josef Pfeilschifter, Thomas Klein and Stefan Frank

Journal of Pharmacology and Experimental Therapeutics July 2012, 342 (1) 71-80; DOI: https://doi.org/10.1124/jpet.111.191098

Gastrointestinal, Hepatic, Pulmonary, and Renal

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Nonsteroidal Anti-Inflammatory Drug-Activated Gene-1 Plays a Role in the Impairing Effects of Cyclooxygenase Inhibitors on Gastric Ulcer Healing
Rocchina Colucci, Luca Antonioli, Nunzia Bernardini, Chiara Ippolito, Cristina Segnani, Oriana Awwad, Marco Tuccori, Corrado Blandizzi, Carmelo Scarpignato and Matteo Fornai

Journal of Pharmacology and Experimental Therapeutics July 2012, 342 (1) 140-149; DOI: https://doi.org/10.1124/jpet.111.190116
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Effects of Ritobegron (KUC-7483), a Novel Selective β₃-Adrenoceptor Agonist, on Bladder Function in Cynomolgus Monkey
Itaru Maruyama, Satoshi Tatemichi, Yoshiaki Goi, Kazuyasu Maruyama, Yuji Hoyano, Yoshinobu Yamazaki and Hiroshi Kusama

Journal of Pharmacology and Experimental Therapeutics July 2012, 342 (1) 163-168; DOI: https://doi.org/10.1124/jpet.112.191783

Inflammation, Immunopharmacology, and Asthma

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Carnosol and Carnosic Acids from Salvia officinalis Inhibit Microsomal Prostaglandin E₂ Synthase-1
Julia Bauer, Susanne Kuehnl, Judith M. Rollinger, Olga Scherer, Hinnak Northoff, Hermann Stuppner, Oliver Werz and Andreas Koeberle

Journal of Pharmacology and Experimental Therapeutics July 2012, 342 (1) 169-176; DOI: https://doi.org/10.1124/jpet.112.193847

Metabolism, Transport, and Pharmacogenomics

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Impact of P-Glycoprotein (ABCB1) and Breast Cancer Resistance Protein (ABCG2) on the Brain Distribution of a Novel BRAF Inhibitor: Vemurafenib (PLX4032)
Rajendar K. Mittapalli, Shruthi Vaidhyanathan, Ramola Sane and William F. Elmquist

Journal of Pharmacology and Experimental Therapeutics July 2012, 342 (1) 33-40; DOI: https://doi.org/10.1124/jpet.112.192195

Neuropharmacology

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Morphine Activates the E Twenty Six-Like Transcription Factor-1/Serum Response Factor Pathway via Extracellular Signal-Regulated Kinases 1/2 in F11 Cells Derived from Dorsal Root Ganglia Neurons
Kathrin Rothe, Hans Jürgen Solinski, Ingrid Boekhoff, Thomas Gudermann and Andreas Breit

Journal of Pharmacology and Experimental Therapeutics July 2012, 342 (1) 41-52; DOI: https://doi.org/10.1124/jpet.112.192757
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Etodolac, a Cyclooxygenase-2 Inhibitor, Attenuates Paclitaxel-Induced Peripheral Neuropathy in a Mouse Model of Mechanical Allodynia
Sunao Ito, Koyuki Tajima, Masaki Nogawa, Naoki Inoue, Takashi Kyoi, Yosuke Takahashi, Takahiro Sasagawa, Akio Nakamura, Takashi Kotera, Makoto Ueda, Yasuhiro Yamashita and Kouji Banno

Journal of Pharmacology and Experimental Therapeutics July 2012, 342 (1) 53-60; DOI: https://doi.org/10.1124/jpet.111.187401
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Positive Allosteric Modulators Differentially Affect Full versus Partial Agonist Activation of the Glycine Receptor
Dean Kirson, Jelena Todorovic and S. John Mihic

Journal of Pharmacology and Experimental Therapeutics July 2012, 342 (1) 61-70; DOI: https://doi.org/10.1124/jpet.112.191486
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Pharmacology of JNJ-37822681, a Specific and Fast-Dissociating D₂ Antagonist for the Treatment of Schizophrenia
Xavier Langlois, Anton Megens, Hilde Lavreysen, John Atack, Miroslav Cik, Paula te Riele, Luc Peeters, Ria Wouters, Jef Vermeire, Herman Hendrickx, Gregor Macdonald and Marcel De Bruyn

Journal of Pharmacology and Experimental Therapeutics July 2012, 342 (1) 91-105; DOI: https://doi.org/10.1124/jpet.111.190702
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Pyroglutamyl Peptidase II Inhibition Enhances the Analeptic Effect of Thyrotropin-Releasing Hormone in the Rat Medial Septum
Ivan Lazcano, Rosa Maria Uribe, Erick Martínez-Chávez, Miguel Angel Vargas, Magdalini Matziari, Patricia Joseph-Bravo and Jean-Louis Charli

Journal of Pharmacology and Experimental Therapeutics July 2012, 342 (1) 222-231; DOI: https://doi.org/10.1124/jpet.112.192278

Toxicology

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Resveratrol Inhibits Paraquat-Induced Oxidative Stress and Fibrogenic Response by Activating the Nuclear Factor Erythroid 2-Related Factor 2 Pathway
Xiaoqing He, Liping Wang, Grazyna Szklarz, Yongyi Bi and Qiang Ma

Journal of Pharmacology and Experimental Therapeutics July 2012, 342 (1) 81-90; DOI: https://doi.org/10.1124/jpet.112.194142
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Unique O-Methoxyethyl Ribose-DNA Chimeric Oligonucleotide Induces an Atypical Melanoma Differentiation-Associated Gene 5-Dependent Induction of Type I Interferon Response
Sebastien A. Burel, Todd Machemer, Frank L. Ragone, Hiroki Kato, Patrick Cauntay, Sarah Greenlee, Aneeza Salim, William A. Gaarde, Gene Hung, Raechel Peralta, Susan M. Freier and Scott P. Henry

Journal of Pharmacology and Experimental Therapeutics July 2012, 342 (1) 150-162; DOI: https://doi.org/10.1124/jpet.112.193789

Erratum

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Correction to “Synergistic Interaction between the Two Mechanisms of Action of Tapentadol in Analgesia”
Journal of Pharmacology and Experimental Therapeutics July 2012, 342 (1) 232;

Notice of Retraction

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Notice of Retraction
Journal of Pharmacology and Experimental Therapeutics July 2012, 342 (1) 233;

Notice of Withdrawal

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Notice of Withdrawal
Journal of Pharmacology and Experimental Therapeutics July 2012, 342 (1) 234;

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Table of Contents

Highlighted Papers

Perspectives in Pharmacology

Behavioral Pharmacology

Cardiovascular

Chemotherapy, Antibiotics, and Gene Therapy

Drug Discovery and Translational Medicine

Endocrine and Diabetes

Gastrointestinal, Hepatic, Pulmonary, and Renal

Inflammation, Immunopharmacology, and Asthma

Metabolism, Transport, and Pharmacogenomics

Neuropharmacology

Toxicology

Erratum

Notice of Retraction

Notice of Withdrawal

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