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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

June 01, 2012; Volume 341,Issue 3

Highlighted Papers

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    T-Cell Activation by Piperacillin in Cystic Fibrosis
    Journal of Pharmacology and Experimental Therapeutics June 2012, 341 (3) 571;
  • You have access
    Bcl-2 and Proteosome Inhibition Synergize in Malignant Gliomas
    Journal of Pharmacology and Experimental Therapeutics June 2012, 341 (3) 571;
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    Treatment of Dyslipidemia through Activation of Lactate Receptors on Adipocytes
    Journal of Pharmacology and Experimental Therapeutics June 2012, 341 (3) 571;
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    Regulation of β2-Adrenoceptor Agonist by the Extracellular cAMP-Adenosine Pathway
    Journal of Pharmacology and Experimental Therapeutics June 2012, 341 (3) 571;

Perspectives in Pharmacology

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    Preclinical Predictors of Anticancer Drug Efficacy: Critical Assessment with Emphasis on Whether Nanomolar Potency Should Be Required of Candidate Agents
    C. C. Wong, Ka-Wing Cheng and Basil Rigas
    Journal of Pharmacology and Experimental Therapeutics June 2012, 341 (3) 572-578; DOI: https://doi.org/10.1124/jpet.112.191957

Behavioral Pharmacology

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    Immunophyllin Ligands Show Differential Effects on Alcohol Self-Administration in C57BL Mice
    Thomas Beresford, Tina Fay, Natalie J. Serkova and Peter H. Wu
    Journal of Pharmacology and Experimental Therapeutics June 2012, 341 (3) 611-616; DOI: https://doi.org/10.1124/jpet.111.188169
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    Behavioral Effects and Central Nervous System Levels of the Broadly Available κ-Agonist Hallucinogen Salvinorin A Are Affected by P-Glycoprotein Modulation In Vivo
    Eduardo R. Butelman, Michael Caspers, Kimberly M. Lovell, Mary Jeanne Kreek and Thomas E. Prisinzano
    Journal of Pharmacology and Experimental Therapeutics June 2012, 341 (3) 802-808; DOI: https://doi.org/10.1124/jpet.112.193227
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    Pharmacologic Characterization of a Nicotine-Discriminative Stimulus in Rhesus Monkeys
    Colin S. Cunningham, Martin A. Javors and Lance R. McMahon
    Journal of Pharmacology and Experimental Therapeutics June 2012, 341 (3) 840-849; DOI: https://doi.org/10.1124/jpet.112.193078

Cardiovascular

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    Enhancement of Rostral Ventrolateral Medulla Neuronal Nitric-Oxide Synthase–Nitric-Oxide Signaling Mediates the Central Cannabinoid Receptor 1-Evoked Pressor Response in Conscious Rats
    Badr Mostafa Ibrahim and Abdel A. Abdel-Rahman
    Journal of Pharmacology and Experimental Therapeutics June 2012, 341 (3) 579-586; DOI: https://doi.org/10.1124/jpet.112.192369
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    Activation of Nicotinic Receptors Can Contribute to Endothelium-Dependent Relaxations to Acetylcholine in the Rat Aorta
    Qian Zou, Susan W. S. Leung and Paul M. Vanhoutte
    Journal of Pharmacology and Experimental Therapeutics June 2012, 341 (3) 756-763; DOI: https://doi.org/10.1124/jpet.112.192229
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    Role of A2B Adenosine Receptors in Regulation of Paracrine Functions of Stem Cell Antigen 1-Positive Cardiac Stromal Cells
    Sergey Ryzhov, Anna E. Goldstein, Sergey V. Novitskiy, Michael R. Blackburn, Italo Biaggioni and Igor Feoktistov
    Journal of Pharmacology and Experimental Therapeutics June 2012, 341 (3) 764-774; DOI: https://doi.org/10.1124/jpet.111.190835
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    Heat Shock Protein 25-Enriched Plasma Transfusion Preconditions the Heart against Doxorubicin-Induced Dilated Cardiomyopathy in Mice
    Karthikeyan Krishnamurthy, Ragu Kanagasabai, Lawrence J. Druhan and Govindasamy Ilangovan
    Journal of Pharmacology and Experimental Therapeutics June 2012, 341 (3) 829-839; DOI: https://doi.org/10.1124/jpet.112.192245
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    Salvianolic Acid B Exerts Vasoprotective Effects through the Modulation of Heme Oxygenase-1 and Arginase Activities
    Yeonsoo Joe, Min Zheng, Hyo Jeong Kim, Sena Kim, Md. Jamal Uddin, Chul Park, Do Gon Ryu, Shin Sung Kang, Sungwoo Ryoo, Stefan W. Ryter, Ki Churl Chang and Hun Taeg Chung
    Journal of Pharmacology and Experimental Therapeutics June 2012, 341 (3) 850-858; DOI: https://doi.org/10.1124/jpet.111.190736

Cellular and Molecular

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    Smooth Muscle Pharmacology in the Isolated Virgin and Pregnant Rat Uterus and Cervix
    Emma S. Darios, Bridget Seitz and Stephanie W. Watts
    Journal of Pharmacology and Experimental Therapeutics June 2012, 341 (3) 587-596; DOI: https://doi.org/10.1124/jpet.111.191031
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    Contribution of the Extracellular cAMP-Adenosine Pathway to Dual Coupling of β2-Adrenoceptors to Gs and Gi Proteins in Mouse Skeletal Muscle
    Thiago Duarte, Francisco Sandro Menezes-Rodrigues and Rosely Oliveira Godinho
    Journal of Pharmacology and Experimental Therapeutics June 2012, 341 (3) 820-828; DOI: https://doi.org/10.1124/jpet.112.192997
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    ABT-737 Synergizes with Bortezomib to Induce Apoptosis, Mediated by Bid Cleavage, Bax Activation, and Mitochondrial Dysfunction in an Akt-Dependent Context in Malignant Human Glioma Cell Lines
    Daniel R. Premkumar, Esther P. Jane, Joseph D. DiDomenico, Natalie A. Vukmer, Naomi R. Agostino and Ian F. Pollack
    Journal of Pharmacology and Experimental Therapeutics June 2012, 341 (3) 859-872; DOI: https://doi.org/10.1124/jpet.112.191536
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    Pituitary Adenylate Cyclase-Activating Polypeptide Causes Tyrosine Phosphorylation of the Epidermal Growth Factor Receptor in Lung Cancer Cells
    Terry W. Moody, Nauramy Osefo, Bernardo Nuche-Berenguer, Lisa Ridnour, David Wink and Robert T. Jensen
    Journal of Pharmacology and Experimental Therapeutics June 2012, 341 (3) 873-881; DOI: https://doi.org/10.1124/jpet.111.190033

Chemotherapy, Antibiotics, and Gene Therapy

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    Diltiazem Enhances the Apoptotic Effects of Proteasome Inhibitors to Induce Prostate Cancer Cell Death
    Ismail Kaddour-Djebbar, Vivek Choudhary, Vijayabaskar Lakshmikanthan, Robert Shirley, Manal El Gaish, Mohamed Al-Shabrawey, Belal Al-Husein, Roger Zhong, Michael Davis, Zheng Dong, Wendy B. Bollag and M. Vijay Kumar
    Journal of Pharmacology and Experimental Therapeutics June 2012, 341 (3) 646-655; DOI: https://doi.org/10.1124/jpet.111.188151
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    p38 Mitogen-Activated Protein Kinase Is Required for the Antitumor Activity of the Vascular Disrupting Agent 5,6-Dimethylxanthenone-4-acetic Acid
    Qiong Wu, Haitian Quan, Yongping Xu, Yun Li, Youhong Hu and Liguang Lou
    Journal of Pharmacology and Experimental Therapeutics June 2012, 341 (3) 709-717; DOI: https://doi.org/10.1124/jpet.112.191635
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    Diaminothiazoles Inhibit Angiogenesis Efficiently by Suppressing Akt Phosphorylation
    Sannu A. Thomas, Reshma Thamkachy, Bindu Ashokan, Reena J. Komalam, Keerthi V. Sreerekha, Asha Bharathan, Thankayyan R. Santhoshkumar, Kallikat N. Rajasekharan and Suparna Sengupta
    Journal of Pharmacology and Experimental Therapeutics June 2012, 341 (3) 718-724; DOI: https://doi.org/10.1124/jpet.112.192559

Drug Discovery and Translational Medicine

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    An Inhibitor of Neuronal Exocytosis (DD04107) Displays Long-Lasting In Vivo Activity against Chronic Inflammatory and Neuropathic Pain
    Berta Ponsati, Cristina Carreño, Verdad Curto-Reyes, Belen Valenzuela, María José Duart, Wim Van Den Nest, Omar Cauli, Beatriz Beltran, Jimena Fernandez, Franco Borsini, Antonio Caprioli, Stefano Di Serio, Mario Veretchy, Ana Baamonde, Luis Menendez, Francisco Barros, Pilar de la Pena, Ricardo Borges, Vicente Felipo, Rosa Planells-Cases and Antonio Ferrer-Montiel
    Journal of Pharmacology and Experimental Therapeutics June 2012, 341 (3) 634-645; DOI: https://doi.org/10.1124/jpet.111.190678
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    Effects of Corticotropin-Releasing Factor 1 Receptor Antagonism on the Hypothalamic-Pituitary-Adrenal Axis of Rodents
    Donald R. Gehlert, Jeffrey Cramer and S. Michelle Morin
    Journal of Pharmacology and Experimental Therapeutics June 2012, 341 (3) 672-680; DOI: https://doi.org/10.1124/jpet.111.189753
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    A Model-Based Approach to Predicting the Human Pharmacokinetics of a Monoclonal Antibody Exhibiting Target-Mediated Drug Disposition
    Kenneth T. Luu, Simon Bergqvist, Enhong Chen, Dana Hu-Lowe and Eugenia Kraynov
    Journal of Pharmacology and Experimental Therapeutics June 2012, 341 (3) 702-708; DOI: https://doi.org/10.1124/jpet.112.191999
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    Pharmacologic Properties of Polyethylene Glycol-Modified Bacillus thiaminolyticus Thiaminase I Enzyme
    Shuqian Liu, Younsoo Bae, Markos Leggas, Abigail Daily, Saloni Bhatnagar, Sumitra Miriyala, Daret K. St. Clair and Jeffrey A. Moscow
    Journal of Pharmacology and Experimental Therapeutics June 2012, 341 (3) 775-783; DOI: https://doi.org/10.1124/jpet.112.191817
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    3,5-Dihydroxybenzoic Acid, a Specific Agonist for Hydroxycarboxylic Acid 1, Inhibits Lipolysis in Adipocytes
    Changlu Liu, Chester Kuei, Jessica Zhu, Jingxue Yu, Li Zhang, Amy Shih, Taraneh Mirzadegan, Jonathan Shelton, Steven Sutton, Margery A. Connelly, Grace Lee, Nicholas Carruthers, Jiejun Wu and Timothy W. Lovenberg
    Journal of Pharmacology and Experimental Therapeutics June 2012, 341 (3) 794-801; DOI: https://doi.org/10.1124/jpet.112.192799

Endocrine and Diabetes

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    Modeling Disease Progression and Rosiglitazone Intervention in Type 2 Diabetic Goto-Kakizaki Rats
    Wei Gao and William J. Jusko
    Journal of Pharmacology and Experimental Therapeutics June 2012, 341 (3) 617-625; DOI: https://doi.org/10.1124/jpet.112.192419
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    Tofogliflozin, a Potent and Highly Specific Sodium/Glucose Cotransporter 2 Inhibitor, Improves Glycemic Control in Diabetic Rats and Mice
    Masayuki Suzuki, Kiyofumi Honda, Masanori Fukazawa, Kazuharu Ozawa, Hitoshi Hagita, Takahiro Kawai, Minako Takeda, Tatsuo Yata, Mio Kawai, Taku Fukuzawa, Takamitsu Kobayashi, Tsutomu Sato, Yoshiki Kawabe and Sachiya Ikeda
    Journal of Pharmacology and Experimental Therapeutics June 2012, 341 (3) 692-701; DOI: https://doi.org/10.1124/jpet.112.191593

Gastrointestinal, Hepatic, Pulmonary, and Renal

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    Molecular Determinants of Ligand Selectivity for the Human Multidrug and Toxin Extruder Proteins MATE1 and MATE2-K
    Bethzaida Astorga, Sean Ekins, Mark Morales and Stephen H. Wright
    Journal of Pharmacology and Experimental Therapeutics June 2012, 341 (3) 743-755; DOI: https://doi.org/10.1124/jpet.112.191577

Metabolism, Transport, and Pharmacogenomics

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    In Vivo Kinetics of Indoxyl Sulfate in Humans and Its Renal Interaction with Angiotensin-Converting Enzyme Inhibitor Quinapril in Rats
    Tomoe Fujita, Kazuhiko Ishihara, Shuichi Yasuda, Tomomi Nakamura, Mika Maeda, Mami Kobayashi, Kunihiko Sahashi, Yasuhiko Ikeda, Yuji Kumagai and Masataka Majima
    Journal of Pharmacology and Experimental Therapeutics June 2012, 341 (3) 626-633; DOI: https://doi.org/10.1124/jpet.111.187732

Neuropharmacology

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    Compromising σ-1 Receptors at the Endoplasmic Reticulum Render Cytotoxicity to Physiologically Relevant Concentrations of Dopamine in a Nuclear Factor-κB/Bcl-2-Dependent Mechanism: Potential Relevance to Parkinson's Disease
    Tomohisa Mori, Teruo Hayashi and Tsung-Ping Su
    Journal of Pharmacology and Experimental Therapeutics June 2012, 341 (3) 663-671; DOI: https://doi.org/10.1124/jpet.111.190868
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    The 5-Hydroxytryptamine4 Receptor Agonists Prucalopride and PRX-03140 Increase Acetylcholine and Histamine Levels in the Rat Prefrontal Cortex and the Power of Stimulated Hippocampal θ Oscillations
    David E. Johnson, Elena Drummond, Sarah Grimwood, Aarti Sawant-Basak, Emily Miller, Elaine Tseng, Laura L. McDowell, Michelle A. Vanase-Frawley, Katherine E. Fisher, David M. Rubitski, Kim J. Stutzman-Engwall, Robin T. Nelson, Weldon E. Horner, Roxanne R. Gorczyca, Mihaly Hajos and Chester J. Siok
    Journal of Pharmacology and Experimental Therapeutics June 2012, 341 (3) 681-691; DOI: https://doi.org/10.1124/jpet.112.192351
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    Is Hydrogen Sulfide-Induced Suspended Animation General Anesthesia?
    Rosie Q. Li, Andrew R. McKinstry, Jason T. Moore, Breanna M. Caltagarone, Maryellen F. Eckenhoff, Roderic G. Eckenhoff and Max B. Kelz
    Journal of Pharmacology and Experimental Therapeutics June 2012, 341 (3) 735-742; DOI: https://doi.org/10.1124/jpet.111.187237
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    A Mouse Kindling Model of Perimenstrual Catamenial Epilepsy
    Doodipala Samba Reddy, Jordan Gould and O. Gangisetty
    Journal of Pharmacology and Experimental Therapeutics June 2012, 341 (3) 784-793; DOI: https://doi.org/10.1124/jpet.112.192377
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    Effects of Ethanol on GABAA Receptors in GABAergic and Glutamatergic Presynaptic Nerve Terminals
    Masahito Wakita, Min-Chul Shin, Satomi Iwata, Kiku Nonaka and Norio Akaike
    Journal of Pharmacology and Experimental Therapeutics June 2012, 341 (3) 809-819; DOI: https://doi.org/10.1124/jpet.111.189126

Toxicology

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    Characterization of the Antigen Specificity of T-Cell Clones from Piperacillin-Hypersensitive Patients with Cystic Fibrosis
    Sabah El-Ghaiesh, Manal M. Monshi, Paul Whitaker, Rosalind Jenkins, Xiaoli Meng, John Farrell, Ayman Elsheikh, Daniel Peckham, Neil French, Munir Pirmohamed, B. Kevin Park and Dean J. Naisbitt
    Journal of Pharmacology and Experimental Therapeutics June 2012, 341 (3) 597-610; DOI: https://doi.org/10.1124/jpet.111.190900
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    Urinary Vanin-1 As a Novel Biomarker for Early Detection of Drug-Induced Acute Kidney Injury
    Keiko Hosohata, Hitoshi Ando and Akio Fujimura
    Journal of Pharmacology and Experimental Therapeutics June 2012, 341 (3) 656-662; DOI: https://doi.org/10.1124/jpet.112.192807
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    Attenuation of Cisplatin-Induced Renal Injury by Inhibition of Soluble Epoxide Hydrolase Involves Nuclear Factor κB Signaling
    Yingmei Liu, Heather K. Webb, Hisayo Fukushima, Janine Micheli, Svetlana Markova, Jean L. Olson and Deanna L. Kroetz
    Journal of Pharmacology and Experimental Therapeutics June 2012, 341 (3) 725-734; DOI: https://doi.org/10.1124/jpet.111.191247
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Journal of Pharmacology and Experimental Therapeutics: 341 (3)
Journal of Pharmacology and Experimental Therapeutics
Vol. 341, Issue 3
1 Jun 2012
  • Table of Contents
  • Table of Contents (PDF)
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  • Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.
  • Functional Selectivity and Classical Concepts of Quantitative Pharmacology
  • Abl Protein-Tyrosine Kinase Inhibitor STI571 Inhibits In Vitro Signal Transduction Mediated by c-Kit and Platelet-Derived Growth Factor Receptors
  • The Prediction of Human Pharmacokinetic Parameters from Preclinical and In Vitro Metabolism Data
  • A METHOD FOR DETERMINING LOSS OF PAIN SENSATION
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