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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

May 01, 2012; Volume 341,Issue 2

Highlighted Papers

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    Phosphodiesterase 9A Regulates Multiple Cyclic Nucleotide Signaling Cascades
    Journal of Pharmacology and Experimental Therapeutics May 2012, 341 (2) 306;
  • You have access
    Ca2+ Channel Activation Pharmacology Is Different in Stem-Cell Derived Cardiomyoctyes
    Journal of Pharmacology and Experimental Therapeutics May 2012, 341 (2) 306;
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    Preventing Intestinal Damage of Nonsteroidal Anti-inflammatory Drugs
    Journal of Pharmacology and Experimental Therapeutics May 2012, 341 (2) 306;
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    Targeting Signal Transducer and Activator of Transcription 3 in Cancer Stem Cells with Cucurbitacin I
    Journal of Pharmacology and Experimental Therapeutics May 2012, 341 (2) 306;

Behavioral Pharmacology

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    Effects of the GABAB Receptor-Positive Modulators CGP7930 and rac-BHFF in Baclofen- and γ-Hydroxybutyrate-Discriminating Pigeons
    Wouter Koek, Charles P. France, Kejun Cheng and Kenner C. Rice
    Journal of Pharmacology and Experimental Therapeutics May 2012, 341 (2) 369-376; DOI: https://doi.org/10.1124/jpet.111.190975
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    Effects of Serotonin 2C Receptor Agonists on the Behavioral and Neurochemical Effects of Cocaine in Squirrel Monkeys
    Daniel F. Manvich, Heather L. Kimmel and Leonard L. Howell
    Journal of Pharmacology and Experimental Therapeutics May 2012, 341 (2) 424-434; DOI: https://doi.org/10.1124/jpet.111.186981
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    Role of Corticotropin-Releasing Factor and Corticosterone in Behavioral Sensitization to Ethanol
    Raúl Pastor, Cheryl Reed, Paul J. Meyer, Carrie McKinnon, Andrey E. Ryabinin and Tamara J. Phillips
    Journal of Pharmacology and Experimental Therapeutics May 2012, 341 (2) 455-463; DOI: https://doi.org/10.1124/jpet.111.190595
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    Activation of Adenosine1 Receptors Induces Antidepressant-Like, Anti-Impulsive Effects on Differential Reinforcement of Low-Rate 72-s Behavior in Rats
    Gerard J. Marek
    Journal of Pharmacology and Experimental Therapeutics May 2012, 341 (2) 564-570; DOI: https://doi.org/10.1124/jpet.112.191718

Cardiovascular

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    Ca2+ Channel Activators Reveal Differential L-Type Ca2+ Channel Pharmacology between Native and Stem Cell-Derived Cardiomyocytes
    Jiesheng Kang, Xiao-Liang Chen, Junzhi Ji, Qiubo Lei and David Rampe
    Journal of Pharmacology and Experimental Therapeutics May 2012, 341 (2) 510-517; DOI: https://doi.org/10.1124/jpet.112.192609

Cellular and Molecular

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    Targeting Signal Transducer and Activator of Transcription 3 Pathway by Cucurbitacin I Diminishes Self-Renewing and Radiochemoresistant Abilities in Thyroid Cancer-Derived CD133+ Cells
    Ling-Ming Tseng, Pin-I Huang, Yu-Rung Chen, Yu-Chih Chen, Yueh-Ching Chou, Yi-Wei Chen, Yuh-Lih Chang, Han-Shui Hsu, Yuan-Tzu Lan, Kuan-Hsuan Chen, Chin-Wen Chi, Shih-Hwa Chiou, De-Ming Yang and Chen-Hsen Lee
    Journal of Pharmacology and Experimental Therapeutics May 2012, 341 (2) 410-423; DOI: https://doi.org/10.1124/jpet.111.188730
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    Regulation of GABAergic Inputs to CA1 Pyramidal Neurons by Nicotinic Receptors and Kynurenic Acid
    Jyotirmoy Banerjee, Manickavasagom Alkondon, Edna F. R. Pereira and Edson X. Albuquerque
    Journal of Pharmacology and Experimental Therapeutics May 2012, 341 (2) 500-509; DOI: https://doi.org/10.1124/jpet.111.189860

Drug Discovery and Translational Medicine

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    Binding Kinetics Redefine the Antagonist Pharmacology of the Corticotropin-Releasing Factor Type 1 Receptor
    Beth A. Fleck, Sam R. J. Hoare, Rebecca R. Pick, Margaret J. Bradbury and Dimitri E. Grigoriadis
    Journal of Pharmacology and Experimental Therapeutics May 2012, 341 (2) 518-531; DOI: https://doi.org/10.1124/jpet.111.188714

Gastrointestinal, Hepatic, Pulmonary, and Renal

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    Hypoxia-Inducible Factor Activation in Myeloid Cells Contributes to the Development of Liver Fibrosis in Cholestatic Mice
    Bryan L. Copple, Sophia Kaska and Callie Wentling
    Journal of Pharmacology and Experimental Therapeutics May 2012, 341 (2) 307-316; DOI: https://doi.org/10.1124/jpet.111.189340
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    Complement Activation in Acetaminophen-Induced Liver Injury in Mice
    Rohit Singhal, Patricia E. Ganey and Robert A. Roth
    Journal of Pharmacology and Experimental Therapeutics May 2012, 341 (2) 377-385; DOI: https://doi.org/10.1124/jpet.111.189837
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    Pharmacologic Targeting of Bacterial β-Glucuronidase Alleviates Nonsteroidal Anti-Inflammatory Drug-Induced Enteropathy in Mice
    Amanda LoGuidice, Bret D. Wallace, Lauren Bendel, Matthew R. Redinbo and Urs A. Boelsterli
    Journal of Pharmacology and Experimental Therapeutics May 2012, 341 (2) 447-454; DOI: https://doi.org/10.1124/jpet.111.191122
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    Prevention of Bleomycin-Induced Lung Fibrosis in Mice by a Novel Approach of Parallel Inhibition of Cyclooxygenase and Nitric-Oxide Donation Using NCX 466, a Prototype Cyclooxygenase Inhibitor and Nitric-Oxide Donor
    Alessandro Pini, Serena Viappiani, Manlio Bolla, Emanuela Masini and Daniele Bani
    Journal of Pharmacology and Experimental Therapeutics May 2012, 341 (2) 493-499; DOI: https://doi.org/10.1124/jpet.111.190660
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    The Prostaglandin E2 Type 4 Receptor Participates in the Response to Acute Oxidant Stress in Airway Epithelial Cells
    Christina L. Jones, Tiesong Li and Elizabeth A. Cowley
    Journal of Pharmacology and Experimental Therapeutics May 2012, 341 (2) 552-563; DOI: https://doi.org/10.1124/jpet.111.187138

Inflammation, Immunopharmacology, and Asthma

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    Prevention of Trinitrobenzene Sulfonic Acid-Induced Experimental Colitis by Oral Administration of a Poly(lactic-coglycolic Acid) Microsphere Containing Prostaglandin E2 Receptor Subtype 4 Agonist
    Tatsuya Okamoto, Shinji Uemoto and Yasuhiko Tabata
    Journal of Pharmacology and Experimental Therapeutics May 2012, 341 (2) 340-349; DOI: https://doi.org/10.1124/jpet.111.190447

Metabolism, Transport, and Pharmacogenomics

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    Brain Distribution of Cediranib Is Limited by Active Efflux at the Blood-Brain Barrier
    Tianli Wang, Sagar Agarwal and William F. Elmquist
    Journal of Pharmacology and Experimental Therapeutics May 2012, 341 (2) 386-395; DOI: https://doi.org/10.1124/jpet.111.190488
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    Pharmacokinetic Characterization of Amrubicin Cardiac Safety in an Ex Vivo Human Myocardial Strip Model. I. Amrubicin Accumulates to a Lower Level than Doxorubicin or Epirubicin
    Emanuela Salvatorelli, Pierantonio Menna, Sekhar Surapaneni, Sharon L. Aukerman, Massimo Chello, Elvio Covino, Victoria Sung and Giorgio Minotti
    Journal of Pharmacology and Experimental Therapeutics May 2012, 341 (2) 464-473; DOI: https://doi.org/10.1124/jpet.111.190256
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    Pharmacokinetic Characterization of Amrubicin Cardiac Safety in an Ex Vivo Human Myocardial Strip Model. II. Amrubicin Shows Metabolic Advantages over Doxorubicin and Epirubicin
    Emanuela Salvatorelli, Pierantonio Menna, Odalys Gonzalez Paz, Sekhar Surapaneni, Sharon L. Aukerman, Massimo Chello, Elvio Covino, Victoria Sung and Giorgio Minotti
    Journal of Pharmacology and Experimental Therapeutics May 2012, 341 (2) 474-483; DOI: https://doi.org/10.1124/jpet.111.190264

Neuropharmacology

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    Comparison of ΔFosB Immunoreactivity Induced by Vagal Nerve Stimulation with That Caused by Pharmacologically Diverse Antidepressants
    Havan Furmaga, Mohona Sadhu and Alan Frazer
    Journal of Pharmacology and Experimental Therapeutics May 2012, 341 (2) 317-325; DOI: https://doi.org/10.1124/jpet.111.188953
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    Transmembrane Potential Polarization, Calcium Influx, and Receptor Conformational State Modulate the Sensitivity of the Imidacloprid-Insensitive Neuronal Insect Nicotinic Acetylcholine Receptor to Neonicotinoid Insecticides
    Béatrice Bodereau-Dubois, Olivier List, Delphine Calas-List, Olivier Marques, Pierre-Yves Communal, Steeve H. Thany and Bruno Lapied
    Journal of Pharmacology and Experimental Therapeutics May 2012, 341 (2) 326-339; DOI: https://doi.org/10.1124/jpet.111.188060
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    VUF10166, a Novel Compound with Differing Activities at 5-HT3A and 5-HT3AB Receptors
    A. J. Thompson, M. H. P. Verheij, I. J. P. de Esch and S. C. R. Lummis
    Journal of Pharmacology and Experimental Therapeutics May 2012, 341 (2) 350-359; DOI: https://doi.org/10.1124/jpet.111.190769
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    Species Comparison and Pharmacological Characterization of Human, Monkey, Rat, and Mouse TRPA1 Channels
    Bruce R. Bianchi, Xu-Feng Zhang, Regina M. Reilly, Philip R. Kym, Betty B. Yao and Jun Chen
    Journal of Pharmacology and Experimental Therapeutics May 2012, 341 (2) 360-368; DOI: https://doi.org/10.1124/jpet.111.189902
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    Phosphodiesterase 9A Regulates Central cGMP and Modulates Responses to Cholinergic and Monoaminergic Perturbation In Vivo
    Robin J. Kleiman, Douglas S. Chapin, Curt Christoffersen, Jody Freeman, Kari R. Fonseca, Kieran F. Geoghegan, Sarah Grimwood, Victor Guanowsky, Mihály Hajós, John F. Harms, Christopher J. Helal, William E. Hoffmann, Geralyn P. Kocan, Mark J. Majchrzak, Dina McGinnis, Stafford McLean, Frank S. Menniti, Fredrick Nelson, Robin Roof, Anne W. Schmidt, Patricia A. Seymour, Diane T. Stephenson, Francis David Tingley, Michelle Vanase-Frawley, Patrick R. Verhoest and Christopher J. Schmidt
    Journal of Pharmacology and Experimental Therapeutics May 2012, 341 (2) 396-409; DOI: https://doi.org/10.1124/jpet.111.191353
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    Characterization of Seizures Induced by Acute and Repeated Exposure to Tetramethylenedisulfotetramine
    Dorota Zolkowska, Christopher N. Banks, Ashish Dhir, Bora Inceoglu, James R. Sanborn, Mark R. McCoy, Donald A. Bruun, Bruce D. Hammock, Pamela J. Lein and Michael A. Rogawski
    Journal of Pharmacology and Experimental Therapeutics May 2012, 341 (2) 435-446; DOI: https://doi.org/10.1124/jpet.111.190579
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    Methylphenidate Modifies Overflow and Presynaptic Compartmentalization of Dopamine via an α-Synuclein-Dependent Mechanism
    Heramb Chadchankar, Jouni Ihalainen, Heikki Tanila and Leonid Yavich
    Journal of Pharmacology and Experimental Therapeutics May 2012, 341 (2) 484-492; DOI: https://doi.org/10.1124/jpet.111.189225
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    σ-1 Receptor Agonist SKF10047 Inhibits Glutamate Release in Rat Cerebral Cortex Nerve Endings
    Cheng-Wei Lu, Tzu-Yu Lin, Chia-Chuan Wang and Su-Jane Wang
    Journal of Pharmacology and Experimental Therapeutics May 2012, 341 (2) 532-542; DOI: https://doi.org/10.1124/jpet.111.191189
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    Charge and Geometry of Residues in the Loop 2 β Hairpin Differentially Affect Agonist and Ethanol Sensitivity in Glycine Receptors
    Daya I. Perkins, James R. Trudell, Liana Asatryan, Daryl L. Davies and Ronald L. Alkana
    Journal of Pharmacology and Experimental Therapeutics May 2012, 341 (2) 543-551; DOI: https://doi.org/10.1124/jpet.111.190942
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Journal of Pharmacology and Experimental Therapeutics: 341 (2)
Journal of Pharmacology and Experimental Therapeutics
Vol. 341, Issue 2
1 May 2012
  • Table of Contents
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