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Research ArticleMetabolism, Transport, and Pharmacogenomics

Simultaneous Assessment of Uptake and Metabolism in Rat Hepatocytes: A Comprehensive Mechanistic Model

Karelle Ménochet, Kathryn E. Kenworthy, J. Brian Houston and Aleksandra Galetin
Journal of Pharmacology and Experimental Therapeutics April 2012, 341 (1) 2-15; DOI: https://doi.org/10.1124/jpet.111.187112
Karelle Ménochet
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Kathryn E. Kenworthy
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J. Brian Houston
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Aleksandra Galetin
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Article Information

vol. 341 no. 1 2-15
DOI 
https://doi.org/10.1124/jpet.111.187112
PubMed 
22190645

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received August 19, 2011
  • Accepted December 20, 2011
  • Published online March 14, 2012.

Article Versions

  • Earlier version (December 21, 2011 - 08:50).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2012 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Karelle Ménochet,
  2. Kathryn E. Kenworthy,
  3. J. Brian Houston and
  4. Aleksandra Galetin
  1. Centre for Applied Pharmacokinetic Research, School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester, United Kingdom (K.M., J.B.H., A.G.); and Department of Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Ware, United Kingdom (K.E.K.)
  1. Address correspondence to:
    Dr. Aleksandra Galetin, School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Stopford Building, Oxford Road, Manchester, M13 9PT, United Kingdom. E-mail: aleksandra.galetin{at}manchester.ac.uk
  1. Part of this work was presented previously: Ménochet K, Kenworthy KE, Houston JB, and Galetin A (2010) Contribution of active uptake to the hepatic clearance of seven OATP substrates in rat and human plated hepatocytes, at the 9th International Society for the Study of Xenobiotics Meeting; 2010 Sept 4–8; Istanbul, Turkey. International Society for the Study of Xenobiotics, Washington, DC.

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Journal of Pharmacology and Experimental Therapeutics: 341 (1)
Journal of Pharmacology and Experimental Therapeutics
Vol. 341, Issue 1
1 Apr 2012
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Research ArticleMetabolism, Transport, and Pharmacogenomics

Mechanistic Modeling of Uptake and Metabolism in Hepatocytes

Karelle Ménochet, Kathryn E. Kenworthy, J. Brian Houston and Aleksandra Galetin
Journal of Pharmacology and Experimental Therapeutics April 1, 2012, 341 (1) 2-15; DOI: https://doi.org/10.1124/jpet.111.187112

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Research ArticleMetabolism, Transport, and Pharmacogenomics

Mechanistic Modeling of Uptake and Metabolism in Hepatocytes

Karelle Ménochet, Kathryn E. Kenworthy, J. Brian Houston and Aleksandra Galetin
Journal of Pharmacology and Experimental Therapeutics April 1, 2012, 341 (1) 2-15; DOI: https://doi.org/10.1124/jpet.111.187112
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