Journal of Pharmacology and Experimental Therapeutics: 341 (1)

April 01, 2012; Volume 341,Issue 1

Highlighted Papers

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Humanized Glycoprotein VI Mouse to Study Anti-Glycoprotein VI Agents In Vivo
Journal of Pharmacology and Experimental Therapeutics April 2012, 341 (1) 1;
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Epigenectic Regulation of Angiomyogenesis to Preserve Myocardial Performance
Journal of Pharmacology and Experimental Therapeutics April 2012, 341 (1) 1;
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Treating Arthritis through Selective Bruton's Tryrosine Kinase Inhibition
Journal of Pharmacology and Experimental Therapeutics April 2012, 341 (1) 1;
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Cytoprotective Role of the Nuclear Factor (Erythroid-Derived 2)-Like 2 Pathway in the Central Nervous System
Journal of Pharmacology and Experimental Therapeutics April 2012, 341 (1) 1;

Behavioral Pharmacology

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Microinjection of Glycine into the Ventral Tegmental Area Selectively Decreases Ethanol Consumption
Jing Li, Hong Nie, Weiliang Bian, Vaidehi Dave, Patricia H. Janak and Jiang-Hong Ye

Journal of Pharmacology and Experimental Therapeutics April 2012, 341 (1) 196-204; DOI: https://doi.org/10.1124/jpet.111.190058

Cardiovascular

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A Humanized Glycoprotein VI (GPVI) Mouse Model to Assess the Antithrombotic Efficacies of Anti-GPVI Agents
Pierre Henri Mangin, ChaoJun Tang, Catherine Bourdon, Stéphane Loyau, Monique Freund, Béatrice Hechler, Christian Gachet and Martine Jandrot-Perrus

Journal of Pharmacology and Experimental Therapeutics April 2012, 341 (1) 156-163; DOI: https://doi.org/10.1124/jpet.111.189050
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Resveratrol Attenuates Doxorubicin-Induced Cardiomyocyte Death via Inhibition of p70 S6 Kinase 1-Mediated Autophagy
Xianmin Xu, Kai Chen, Satoru Kobayashi, Derek Timm and Qiangrong Liang

Journal of Pharmacology and Experimental Therapeutics April 2012, 341 (1) 183-195; DOI: https://doi.org/10.1124/jpet.111.189589
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Inhibition of Histone Deacetylases Preserves Myocardial Performance and Prevents Cardiac Remodeling through Stimulation of Endogenous Angiomyogenesis
Ling Zhang, Xin Qin, Yu Zhao, Loren Fast, Shougang Zhuang, Paul Liu, Guangmao Cheng and Ting C. Zhao

Journal of Pharmacology and Experimental Therapeutics April 2012, 341 (1) 285-293; DOI: https://doi.org/10.1124/jpet.111.189910

Chemotherapy, Antibiotics, and Gene Therapy

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Cellular Pharmacokinetic/Pharmacodynamic Relationship of Platinum Cytostatics in Head and Neck Squamous Cell Carcinoma Evaluated by Liquid Chromatography Coupled to Tandem Mass Spectrometry
Dirk Theile, Jan-Christoph Detering, Christel Herold-Mende, Gerhard Dyckhoff, Walter E. Haefeli, Johanna Weiss and Jürgen Burhenne

Journal of Pharmacology and Experimental Therapeutics April 2012, 341 (1) 51-58; DOI: https://doi.org/10.1124/jpet.111.189621

Drug Discovery and Translational Medicine

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Blocking Epidermal Growth Factor Receptor Activation by 3,3′-Diindolylmethane Suppresses Ovarian Tumor Growth In Vitro and In Vivo
Prabodh K. Kandala, Stephen E. Wright and Sanjay K. Srivastava

Journal of Pharmacology and Experimental Therapeutics April 2012, 341 (1) 24-32; DOI: https://doi.org/10.1124/jpet.111.188706
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Inactivating PSMB5 Mutations and P-Glycoprotein (Multidrug Resistance-Associated Protein/ATP-Binding Cassette B1) Mediate Resistance to Proteasome Inhibitors: Ex Vivo Efficacy of (Immuno)Proteasome Inhibitors in Mononuclear Blood Cells from Patients with Rheumatoid Arthritis
Sue Ellen Verbrugge, Yehuda G. Assaraf, Ben A. C. Dijkmans, George L. Scheffer, Marjon Al, Debby den Uyl, Ruud Oerlemans, Elena T. Chan, Christopher J. Kirk, Godefridus J. Peters, Joost W. van der Heijden, Tanja D. de Gruijl, Rik J. Scheper and Gerrit Jansen

Journal of Pharmacology and Experimental Therapeutics April 2012, 341 (1) 174-182; DOI: https://doi.org/10.1124/jpet.111.187542
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An Oxycodone Conjugate Vaccine Elicits Drug-Specific Antibodies that Reduce Oxycodone Distribution to Brain and Hot-Plate Analgesia
M. Pravetoni, M. Le Naour, T. M. Harmon, A. M. Tucker, P. S. Portoghese and P. R. Pentel

Journal of Pharmacology and Experimental Therapeutics April 2012, 341 (1) 225-232; DOI: https://doi.org/10.1124/jpet.111.189506
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Xanomeline Modulation of the Blood Oxygenation Level-Dependent Signal in Awake Rats: Development of Pharmacological Magnetic Resonance Imaging as a Translatable Pharmacodynamic Biomarker for Central Activity and Dose Selection
Scott Baker, Chih-Liang Chin, Ana M. Basso, Gerard B. Fox, Gerard J. Marek and Mark Day

Journal of Pharmacology and Experimental Therapeutics April 2012, 341 (1) 263-273; DOI: https://doi.org/10.1124/jpet.111.188797

Gastrointestinal, Hepatic, Pulmonary, and Renal

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Selective Glucocorticoid Receptor Agonists for the Treatment of Inflammatory Bowel Disease: Studies in Mice with Acute Trinitrobenzene Sulfonic Acid Colitis
Kerstin C. Reuter, Christian R. Grunwitz, Bettina M. Kaminski, Dieter Steinhilber, Heinfried H. Radeke and Jürgen Stein

Journal of Pharmacology and Experimental Therapeutics April 2012, 341 (1) 68-80; DOI: https://doi.org/10.1124/jpet.111.183947
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Interferon-γ Activates Transglutaminase 2 via a Phosphatidylinositol-3-Kinase-Dependent Pathway: Implications for Celiac Sprue Therapy
Thomas R. DiRaimondo, Cornelius Klöck and Chaitan Khosla

Journal of Pharmacology and Experimental Therapeutics April 2012, 341 (1) 104-114; DOI: https://doi.org/10.1124/jpet.111.187385
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Role of Transient Receptor Potential Ankyrin 1 in Gastric Accommodation in Conscious Guinea Pigs
Junichi Koseki, Tadayuki Oshima, Takashi Kondo, Toshihiko Tomita, Hirokazu Fukui, Jiro Watari, Tomohisa Hattori, Yoshio Kase and Hiroto Miwa

Journal of Pharmacology and Experimental Therapeutics April 2012, 341 (1) 205-212; DOI: https://doi.org/10.1124/jpet.111.189027
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Effects of Celecoxib on Prostanoid Biosynthesis and Circulating Angiogenesis Proteins in Familial Adenomatous Polyposis
Melania Dovizio, Stefania Tacconelli, Emanuela Ricciotti, Annalisa Bruno, Thorsten Jürgen Maier, Paola Anzellotti, Luigia Di Francesco, Paola Sala, Stefano Signoroni, Lucio Bertario, Dan A. Dixon, John A. Lawson, Dieter Steinhilber, Garret A. FitzGerald and Paola Patrignani

Journal of Pharmacology and Experimental Therapeutics April 2012, 341 (1) 242-250; DOI: https://doi.org/10.1124/jpet.111.190785

Inflammation, Immunopharmacology, and Asthma

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RN486, a Selective Bruton's Tyrosine Kinase Inhibitor, Abrogates Immune Hypersensitivity Responses and Arthritis in Rodents
Daigen Xu, Yong Kim, Jennifer Postelnek, Minh Diem Vu, Dong-Qing Hu, Cheng Liao, Mike Bradshaw, Jonathan Hsu, Jun Zhang, Achal Pashine, Dinesh Srinivasan, John Woods, Anita Levin, Alison O'Mahony, Timothy D. Owens, Yan Lou, Ronald J. Hill, Satwant Narula, Julie DeMartino and Jay S. Fine

Journal of Pharmacology and Experimental Therapeutics April 2012, 341 (1) 90-103; DOI: https://doi.org/10.1124/jpet.111.187740
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A Novel Small Molecule, (E)-5-(2,4-di-tert-butyl-6-((2,4-dioxothiazolidin-5-ylidene)methyl)phenyl)-5′-methyl-7,7′-dimethoxy-4,4′-bibenzo[d][1,3]dioxole-5,5′-dicarboxylate (7k), Alleviates the Development of d-Galactosamine/Lipopolysaccharide-Induced Acute Liver Failure by Inhibiting Macrophage Infiltration and Regulating Cytokine Expression
Chongyang Deng, Juan Liu, Guangcheng Wang, Liang Ma, Caifeng Xie, Xuewei Wang, Xiuxia Li and Lijuan Chen

Journal of Pharmacology and Experimental Therapeutics April 2012, 341 (1) 146-155; DOI: https://doi.org/10.1124/jpet.111.189498

Metabolism, Transport, and Pharmacogenomics

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Simultaneous Assessment of Uptake and Metabolism in Rat Hepatocytes: A Comprehensive Mechanistic Model
Karelle Ménochet, Kathryn E. Kenworthy, J. Brian Houston and Aleksandra Galetin

Journal of Pharmacology and Experimental Therapeutics April 2012, 341 (1) 2-15; DOI: https://doi.org/10.1124/jpet.111.187112
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Human Organic Cation Transporter 1 Is Expressed in Lymphoma Cells and Increases Susceptibility to Irinotecan and Paclitaxel
Shivangi Gupta, Gerald Wulf, Maja Henjakovic, Hermann Koepsell, Gerhard Burckhardt and Yohannes Hagos

Journal of Pharmacology and Experimental Therapeutics April 2012, 341 (1) 16-23; DOI: https://doi.org/10.1124/jpet.111.190561
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P-Glycoprotein (ABCB1) and Breast Cancer Resistance Protein (ABCG2) Restrict Brain Accumulation of the Active Sunitinib Metabolite N-Desethyl Sunitinib
Seng Chuan Tang, Nienke A. G. Lankheet, Birk Poller, Els Wagenaar, Jos H. Beijnen and Alfred H. Schinkel

Journal of Pharmacology and Experimental Therapeutics April 2012, 341 (1) 164-173; DOI: https://doi.org/10.1124/jpet.111.186908
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Estimation of Drug-Metabolizing Capacity by Cytochrome P450 Genotyping and Expression
Manna Temesvári, László Kóbori, József Paulik, Enikő Sárváry, Ales Belic and Katalin Monostory

Journal of Pharmacology and Experimental Therapeutics April 2012, 341 (1) 294-305; DOI: https://doi.org/10.1124/jpet.111.189597

Neuropharmacology

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GABAergic Actions Mediate Opposite Ethanol Effects on Dopaminergic Neurons in the Anterior and Posterior Ventral Tegmental Area
Yanzhong Guan, Cheng Xiao, Kresimir Krnjević, Guiqin Xie, Wanhong Zuo and Jiang-Hong Ye

Journal of Pharmacology and Experimental Therapeutics April 2012, 341 (1) 33-42; DOI: https://doi.org/10.1124/jpet.111.187963
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Salsolinol Stimulates Dopamine Neurons in Slices of Posterior Ventral Tegmental Area Indirectly by Activating μ-Opioid Receptors
Guiqin Xie, Lucia Hipólito, Wanhong Zuo, Ana Polache, Luis Granero, Krešimir Krnjević and Jiang-Hong Ye

Journal of Pharmacology and Experimental Therapeutics April 2012, 341 (1) 43-50; DOI: https://doi.org/10.1124/jpet.111.186833
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Anti-Inflammatory Mechanism of Compound K in Activated Microglia and Its Neuroprotective Effect on Experimental Stroke in Mice
Jin-Sun Park, Jin A. Shin, Ji-Sun Jung, Jin-Won Hyun, Thi Kim Van Le, Dong-Hyun Kim, Eun-Mi Park and Hee-Sun Kim

Journal of Pharmacology and Experimental Therapeutics April 2012, 341 (1) 59-67; DOI: https://doi.org/10.1124/jpet.111.189035
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Relationship between Dose, Drug Levels, and D2 Receptor Occupancy for the Atypical Antipsychotics Risperidone and Paliperidone
E. C. Muly, J. R. Votaw, J. Ritchie and L. L. Howell

Journal of Pharmacology and Experimental Therapeutics April 2012, 341 (1) 81-89; DOI: https://doi.org/10.1124/jpet.111.189076
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Activation of Protein Kinase C (PKC)α or PKCε as an Approach to Increase Morphine Tolerance in Respiratory Depression and Lethal Overdose
Hong-Yiou Lin, Ping-Yee Law and Horace H. Loh

Journal of Pharmacology and Experimental Therapeutics April 2012, 341 (1) 115-125; DOI: https://doi.org/10.1124/jpet.111.188235
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Prediction of Human Serotonin and Norepinephrine Transporter Occupancy of Duloxetine by Pharmacokinetic/Pharmacodynamic Modeling in the Rat
David L. Bourdet, Pamela R. Tsuruda, Glenmar P. Obedencio and Jacqueline A. M. Smith

Journal of Pharmacology and Experimental Therapeutics April 2012, 341 (1) 137-145; DOI: https://doi.org/10.1124/jpet.111.188417
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Differential Cardiorespiratory and Sympathetic Reflex Responses to Microinjection of Neuromedin U in Rat Rostral Ventrolateral Medulla
Ahmed A. Rahman, Israt Z. Shahid and Paul M. Pilowsky

Journal of Pharmacology and Experimental Therapeutics April 2012, 341 (1) 213-224; DOI: https://doi.org/10.1124/jpet.111.191254
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Studies of the Biogenic Amine Transporters. 14. Identification of Low-Efficacy “Partial” Substrates for the Biogenic Amine Transporters
Richard B. Rothman, John S. Partilla, Michael H. Baumann, Catrissa Lightfoot-Siordia and Bruce E. Blough

Journal of Pharmacology and Experimental Therapeutics April 2012, 341 (1) 251-262; DOI: https://doi.org/10.1124/jpet.111.188946
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Fumarates Promote Cytoprotection of Central Nervous System Cells against Oxidative Stress via the Nuclear Factor (Erythroid-Derived 2)-Like 2 Pathway
Robert H. Scannevin, Sowmya Chollate, Mi-young Jung, Melanie Shackett, Hiral Patel, Pradeep Bista, Weike Zeng, Sarah Ryan, Masayuki Yamamoto, Matvey Lukashev and Kenneth J. Rhodes

Journal of Pharmacology and Experimental Therapeutics April 2012, 341 (1) 274-284; DOI: https://doi.org/10.1124/jpet.111.190132

Toxicology

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Recovery from Glycerol-Induced Acute Kidney Injury Is Accelerated by Suramin
Midhun C. Korrapati, Brooke E. Shaner and Rick G. Schnellmann

Journal of Pharmacology and Experimental Therapeutics April 2012, 341 (1) 126-136; DOI: https://doi.org/10.1124/jpet.111.190249
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Role of CYP2A5 in the Bioactivation of the Lung Carcinogen 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanone in Mice
Xin Zhou, Jaime D'Agostino, Fang Xie and Xinxin Ding

Journal of Pharmacology and Experimental Therapeutics April 2012, 341 (1) 233-241; DOI: https://doi.org/10.1124/jpet.111.190173

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Table of Contents

Highlighted Papers

Behavioral Pharmacology

Cardiovascular

Chemotherapy, Antibiotics, and Gene Therapy

Drug Discovery and Translational Medicine

Gastrointestinal, Hepatic, Pulmonary, and Renal

Inflammation, Immunopharmacology, and Asthma

Metabolism, Transport, and Pharmacogenomics

Neuropharmacology

Toxicology

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