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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

April 01, 2012; Volume 341,Issue 1

Highlighted Papers

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    Humanized Glycoprotein VI Mouse to Study Anti-Glycoprotein VI Agents In Vivo
    Journal of Pharmacology and Experimental Therapeutics April 2012, 341 (1) 1;
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    Epigenectic Regulation of Angiomyogenesis to Preserve Myocardial Performance
    Journal of Pharmacology and Experimental Therapeutics April 2012, 341 (1) 1;
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    Treating Arthritis through Selective Bruton's Tryrosine Kinase Inhibition
    Journal of Pharmacology and Experimental Therapeutics April 2012, 341 (1) 1;
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    Cytoprotective Role of the Nuclear Factor (Erythroid-Derived 2)-Like 2 Pathway in the Central Nervous System
    Journal of Pharmacology and Experimental Therapeutics April 2012, 341 (1) 1;

Behavioral Pharmacology

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    Microinjection of Glycine into the Ventral Tegmental Area Selectively Decreases Ethanol Consumption
    Jing Li, Hong Nie, Weiliang Bian, Vaidehi Dave, Patricia H. Janak and Jiang-Hong Ye
    Journal of Pharmacology and Experimental Therapeutics April 2012, 341 (1) 196-204; DOI: https://doi.org/10.1124/jpet.111.190058

Cardiovascular

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    A Humanized Glycoprotein VI (GPVI) Mouse Model to Assess the Antithrombotic Efficacies of Anti-GPVI Agents
    Pierre Henri Mangin, ChaoJun Tang, Catherine Bourdon, Stéphane Loyau, Monique Freund, Béatrice Hechler, Christian Gachet and Martine Jandrot-Perrus
    Journal of Pharmacology and Experimental Therapeutics April 2012, 341 (1) 156-163; DOI: https://doi.org/10.1124/jpet.111.189050
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    Resveratrol Attenuates Doxorubicin-Induced Cardiomyocyte Death via Inhibition of p70 S6 Kinase 1-Mediated Autophagy
    Xianmin Xu, Kai Chen, Satoru Kobayashi, Derek Timm and Qiangrong Liang
    Journal of Pharmacology and Experimental Therapeutics April 2012, 341 (1) 183-195; DOI: https://doi.org/10.1124/jpet.111.189589
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    Inhibition of Histone Deacetylases Preserves Myocardial Performance and Prevents Cardiac Remodeling through Stimulation of Endogenous Angiomyogenesis
    Ling Zhang, Xin Qin, Yu Zhao, Loren Fast, Shougang Zhuang, Paul Liu, Guangmao Cheng and Ting C. Zhao
    Journal of Pharmacology and Experimental Therapeutics April 2012, 341 (1) 285-293; DOI: https://doi.org/10.1124/jpet.111.189910

Chemotherapy, Antibiotics, and Gene Therapy

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    Cellular Pharmacokinetic/Pharmacodynamic Relationship of Platinum Cytostatics in Head and Neck Squamous Cell Carcinoma Evaluated by Liquid Chromatography Coupled to Tandem Mass Spectrometry
    Dirk Theile, Jan-Christoph Detering, Christel Herold-Mende, Gerhard Dyckhoff, Walter E. Haefeli, Johanna Weiss and Jürgen Burhenne
    Journal of Pharmacology and Experimental Therapeutics April 2012, 341 (1) 51-58; DOI: https://doi.org/10.1124/jpet.111.189621

Drug Discovery and Translational Medicine

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    Blocking Epidermal Growth Factor Receptor Activation by 3,3′-Diindolylmethane Suppresses Ovarian Tumor Growth In Vitro and In Vivo
    Prabodh K. Kandala, Stephen E. Wright and Sanjay K. Srivastava
    Journal of Pharmacology and Experimental Therapeutics April 2012, 341 (1) 24-32; DOI: https://doi.org/10.1124/jpet.111.188706
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    Inactivating PSMB5 Mutations and P-Glycoprotein (Multidrug Resistance-Associated Protein/ATP-Binding Cassette B1) Mediate Resistance to Proteasome Inhibitors: Ex Vivo Efficacy of (Immuno)Proteasome Inhibitors in Mononuclear Blood Cells from Patients with Rheumatoid Arthritis
    Sue Ellen Verbrugge, Yehuda G. Assaraf, Ben A. C. Dijkmans, George L. Scheffer, Marjon Al, Debby den Uyl, Ruud Oerlemans, Elena T. Chan, Christopher J. Kirk, Godefridus J. Peters, Joost W. van der Heijden, Tanja D. de Gruijl, Rik J. Scheper and Gerrit Jansen
    Journal of Pharmacology and Experimental Therapeutics April 2012, 341 (1) 174-182; DOI: https://doi.org/10.1124/jpet.111.187542
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    An Oxycodone Conjugate Vaccine Elicits Drug-Specific Antibodies that Reduce Oxycodone Distribution to Brain and Hot-Plate Analgesia
    M. Pravetoni, M. Le Naour, T. M. Harmon, A. M. Tucker, P. S. Portoghese and P. R. Pentel
    Journal of Pharmacology and Experimental Therapeutics April 2012, 341 (1) 225-232; DOI: https://doi.org/10.1124/jpet.111.189506
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    Xanomeline Modulation of the Blood Oxygenation Level-Dependent Signal in Awake Rats: Development of Pharmacological Magnetic Resonance Imaging as a Translatable Pharmacodynamic Biomarker for Central Activity and Dose Selection
    Scott Baker, Chih-Liang Chin, Ana M. Basso, Gerard B. Fox, Gerard J. Marek and Mark Day
    Journal of Pharmacology and Experimental Therapeutics April 2012, 341 (1) 263-273; DOI: https://doi.org/10.1124/jpet.111.188797

Gastrointestinal, Hepatic, Pulmonary, and Renal

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    Selective Glucocorticoid Receptor Agonists for the Treatment of Inflammatory Bowel Disease: Studies in Mice with Acute Trinitrobenzene Sulfonic Acid Colitis
    Kerstin C. Reuter, Christian R. Grunwitz, Bettina M. Kaminski, Dieter Steinhilber, Heinfried H. Radeke and Jürgen Stein
    Journal of Pharmacology and Experimental Therapeutics April 2012, 341 (1) 68-80; DOI: https://doi.org/10.1124/jpet.111.183947
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    Interferon-γ Activates Transglutaminase 2 via a Phosphatidylinositol-3-Kinase-Dependent Pathway: Implications for Celiac Sprue Therapy
    Thomas R. DiRaimondo, Cornelius Klöck and Chaitan Khosla
    Journal of Pharmacology and Experimental Therapeutics April 2012, 341 (1) 104-114; DOI: https://doi.org/10.1124/jpet.111.187385
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    Role of Transient Receptor Potential Ankyrin 1 in Gastric Accommodation in Conscious Guinea Pigs
    Junichi Koseki, Tadayuki Oshima, Takashi Kondo, Toshihiko Tomita, Hirokazu Fukui, Jiro Watari, Tomohisa Hattori, Yoshio Kase and Hiroto Miwa
    Journal of Pharmacology and Experimental Therapeutics April 2012, 341 (1) 205-212; DOI: https://doi.org/10.1124/jpet.111.189027
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    Effects of Celecoxib on Prostanoid Biosynthesis and Circulating Angiogenesis Proteins in Familial Adenomatous Polyposis
    Melania Dovizio, Stefania Tacconelli, Emanuela Ricciotti, Annalisa Bruno, Thorsten Jürgen Maier, Paola Anzellotti, Luigia Di Francesco, Paola Sala, Stefano Signoroni, Lucio Bertario, Dan A. Dixon, John A. Lawson, Dieter Steinhilber, Garret A. FitzGerald and Paola Patrignani
    Journal of Pharmacology and Experimental Therapeutics April 2012, 341 (1) 242-250; DOI: https://doi.org/10.1124/jpet.111.190785

Inflammation, Immunopharmacology, and Asthma

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    RN486, a Selective Bruton's Tyrosine Kinase Inhibitor, Abrogates Immune Hypersensitivity Responses and Arthritis in Rodents
    Daigen Xu, Yong Kim, Jennifer Postelnek, Minh Diem Vu, Dong-Qing Hu, Cheng Liao, Mike Bradshaw, Jonathan Hsu, Jun Zhang, Achal Pashine, Dinesh Srinivasan, John Woods, Anita Levin, Alison O'Mahony, Timothy D. Owens, Yan Lou, Ronald J. Hill, Satwant Narula, Julie DeMartino and Jay S. Fine
    Journal of Pharmacology and Experimental Therapeutics April 2012, 341 (1) 90-103; DOI: https://doi.org/10.1124/jpet.111.187740
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    A Novel Small Molecule, (E)-5-(2,4-di-tert-butyl-6-((2,4-dioxothiazolidin-5-ylidene)methyl)phenyl)-5′-methyl-7,7′-dimethoxy-4,4′-bibenzo[d][1,3]dioxole-5,5′-dicarboxylate (7k), Alleviates the Development of d-Galactosamine/Lipopolysaccharide-Induced Acute Liver Failure by Inhibiting Macrophage Infiltration and Regulating Cytokine Expression
    Chongyang Deng, Juan Liu, Guangcheng Wang, Liang Ma, Caifeng Xie, Xuewei Wang, Xiuxia Li and Lijuan Chen
    Journal of Pharmacology and Experimental Therapeutics April 2012, 341 (1) 146-155; DOI: https://doi.org/10.1124/jpet.111.189498

Metabolism, Transport, and Pharmacogenomics

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    Simultaneous Assessment of Uptake and Metabolism in Rat Hepatocytes: A Comprehensive Mechanistic Model
    Karelle Ménochet, Kathryn E. Kenworthy, J. Brian Houston and Aleksandra Galetin
    Journal of Pharmacology and Experimental Therapeutics April 2012, 341 (1) 2-15; DOI: https://doi.org/10.1124/jpet.111.187112
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    Human Organic Cation Transporter 1 Is Expressed in Lymphoma Cells and Increases Susceptibility to Irinotecan and Paclitaxel
    Shivangi Gupta, Gerald Wulf, Maja Henjakovic, Hermann Koepsell, Gerhard Burckhardt and Yohannes Hagos
    Journal of Pharmacology and Experimental Therapeutics April 2012, 341 (1) 16-23; DOI: https://doi.org/10.1124/jpet.111.190561
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    P-Glycoprotein (ABCB1) and Breast Cancer Resistance Protein (ABCG2) Restrict Brain Accumulation of the Active Sunitinib Metabolite N-Desethyl Sunitinib
    Seng Chuan Tang, Nienke A. G. Lankheet, Birk Poller, Els Wagenaar, Jos H. Beijnen and Alfred H. Schinkel
    Journal of Pharmacology and Experimental Therapeutics April 2012, 341 (1) 164-173; DOI: https://doi.org/10.1124/jpet.111.186908
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    Estimation of Drug-Metabolizing Capacity by Cytochrome P450 Genotyping and Expression
    Manna Temesvári, László Kóbori, József Paulik, Enikő Sárváry, Ales Belic and Katalin Monostory
    Journal of Pharmacology and Experimental Therapeutics April 2012, 341 (1) 294-305; DOI: https://doi.org/10.1124/jpet.111.189597

Neuropharmacology

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    GABAergic Actions Mediate Opposite Ethanol Effects on Dopaminergic Neurons in the Anterior and Posterior Ventral Tegmental Area
    Yanzhong Guan, Cheng Xiao, Kresimir Krnjević, Guiqin Xie, Wanhong Zuo and Jiang-Hong Ye
    Journal of Pharmacology and Experimental Therapeutics April 2012, 341 (1) 33-42; DOI: https://doi.org/10.1124/jpet.111.187963
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    Salsolinol Stimulates Dopamine Neurons in Slices of Posterior Ventral Tegmental Area Indirectly by Activating μ-Opioid Receptors
    Guiqin Xie, Lucia Hipólito, Wanhong Zuo, Ana Polache, Luis Granero, Krešimir Krnjević and Jiang-Hong Ye
    Journal of Pharmacology and Experimental Therapeutics April 2012, 341 (1) 43-50; DOI: https://doi.org/10.1124/jpet.111.186833
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    Anti-Inflammatory Mechanism of Compound K in Activated Microglia and Its Neuroprotective Effect on Experimental Stroke in Mice
    Jin-Sun Park, Jin A. Shin, Ji-Sun Jung, Jin-Won Hyun, Thi Kim Van Le, Dong-Hyun Kim, Eun-Mi Park and Hee-Sun Kim
    Journal of Pharmacology and Experimental Therapeutics April 2012, 341 (1) 59-67; DOI: https://doi.org/10.1124/jpet.111.189035
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    Relationship between Dose, Drug Levels, and D2 Receptor Occupancy for the Atypical Antipsychotics Risperidone and Paliperidone
    E. C. Muly, J. R. Votaw, J. Ritchie and L. L. Howell
    Journal of Pharmacology and Experimental Therapeutics April 2012, 341 (1) 81-89; DOI: https://doi.org/10.1124/jpet.111.189076
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    Activation of Protein Kinase C (PKC)α or PKCε as an Approach to Increase Morphine Tolerance in Respiratory Depression and Lethal Overdose
    Hong-Yiou Lin, Ping-Yee Law and Horace H. Loh
    Journal of Pharmacology and Experimental Therapeutics April 2012, 341 (1) 115-125; DOI: https://doi.org/10.1124/jpet.111.188235
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    Prediction of Human Serotonin and Norepinephrine Transporter Occupancy of Duloxetine by Pharmacokinetic/Pharmacodynamic Modeling in the Rat
    David L. Bourdet, Pamela R. Tsuruda, Glenmar P. Obedencio and Jacqueline A. M. Smith
    Journal of Pharmacology and Experimental Therapeutics April 2012, 341 (1) 137-145; DOI: https://doi.org/10.1124/jpet.111.188417
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    Differential Cardiorespiratory and Sympathetic Reflex Responses to Microinjection of Neuromedin U in Rat Rostral Ventrolateral Medulla
    Ahmed A. Rahman, Israt Z. Shahid and Paul M. Pilowsky
    Journal of Pharmacology and Experimental Therapeutics April 2012, 341 (1) 213-224; DOI: https://doi.org/10.1124/jpet.111.191254
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    Studies of the Biogenic Amine Transporters. 14. Identification of Low-Efficacy “Partial” Substrates for the Biogenic Amine Transporters
    Richard B. Rothman, John S. Partilla, Michael H. Baumann, Catrissa Lightfoot-Siordia and Bruce E. Blough
    Journal of Pharmacology and Experimental Therapeutics April 2012, 341 (1) 251-262; DOI: https://doi.org/10.1124/jpet.111.188946
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    Fumarates Promote Cytoprotection of Central Nervous System Cells against Oxidative Stress via the Nuclear Factor (Erythroid-Derived 2)-Like 2 Pathway
    Robert H. Scannevin, Sowmya Chollate, Mi-young Jung, Melanie Shackett, Hiral Patel, Pradeep Bista, Weike Zeng, Sarah Ryan, Masayuki Yamamoto, Matvey Lukashev and Kenneth J. Rhodes
    Journal of Pharmacology and Experimental Therapeutics April 2012, 341 (1) 274-284; DOI: https://doi.org/10.1124/jpet.111.190132

Toxicology

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    Recovery from Glycerol-Induced Acute Kidney Injury Is Accelerated by Suramin
    Midhun C. Korrapati, Brooke E. Shaner and Rick G. Schnellmann
    Journal of Pharmacology and Experimental Therapeutics April 2012, 341 (1) 126-136; DOI: https://doi.org/10.1124/jpet.111.190249
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    Role of CYP2A5 in the Bioactivation of the Lung Carcinogen 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanone in Mice
    Xin Zhou, Jaime D'Agostino, Fang Xie and Xinxin Ding
    Journal of Pharmacology and Experimental Therapeutics April 2012, 341 (1) 233-241; DOI: https://doi.org/10.1124/jpet.111.190173
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Journal of Pharmacology and Experimental Therapeutics: 341 (1)
Journal of Pharmacology and Experimental Therapeutics
Vol. 341, Issue 1
1 Apr 2012
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