Journal of Pharmacology and Experimental Therapeutics: 340 (3)

March 01, 2012; Volume 340,Issue 3

Highlighted Papers

You have access
α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Receptor Activation Induces Dystonia in Mice
Journal of Pharmacology and Experimental Therapeutics March 2012, 340 (3) 491;
You have access
Activated Endothelial Targeting of Nanocarriers with Fibrinogen-Derived Peptides
Journal of Pharmacology and Experimental Therapeutics March 2012, 340 (3) 491;
You have access
Regulating Hepatocyte Growth Factor/Met Signaling with Angiotensin IV Analogs
Journal of Pharmacology and Experimental Therapeutics March 2012, 340 (3) 491;
You have access
Neuropathic Pain through Epigenetic Augmentation of the Macrophage Inflammatory Protein 2/C-X-C Chemokine Receptor Type 2 Axis
Journal of Pharmacology and Experimental Therapeutics March 2012, 340 (3) 491;

Behavioral Pharmacology

You have access
Effects of Peripherally Restricted κ Opioid Receptor Agonists on Pain-Related Stimulation and Depression of Behavior in Rats
S. Stevens Negus, Robert O'Connell, Ember Morrissey, Kejun Cheng and Kenner C. Rice

Journal of Pharmacology and Experimental Therapeutics March 2012, 340 (3) 501-509; DOI: https://doi.org/10.1124/jpet.111.186783
You have access
The Selective M₁ Muscarinic Cholinergic Agonist CDD-0102A Enhances Working Memory and Cognitive Flexibility
Michael E. Ragozzino, Sonja Artis, Amritha Singh, Trevor M. Twose, Joseph E. Beck and William S. Messer

Journal of Pharmacology and Experimental Therapeutics March 2012, 340 (3) 588-594; DOI: https://doi.org/10.1124/jpet.111.187625
You have access
Nicotine Reduces Antipsychotic-Induced Orofacial Dyskinesia in Rats
Tanuja Bordia, J. Michael McIntosh and Maryka Quik

Journal of Pharmacology and Experimental Therapeutics March 2012, 340 (3) 612-619; DOI: https://doi.org/10.1124/jpet.111.189100
You have access
Selective and Sustained α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Receptor Activation in Cerebellum Induces Dystonia in Mice
Xueliang Fan, Keryn E. Hughes, H. A. Jinnah and Ellen J. Hess

Journal of Pharmacology and Experimental Therapeutics March 2012, 340 (3) 733-741; DOI: https://doi.org/10.1124/jpet.111.190082
You have access
Quantitative Analyses of Antagonism: Combinations of Midazolam and Either Flunitrazepam or Pregnanolone in Rhesus Monkeys Discriminating Midazolam
Lisa R. Gerak and Charles P. France

Journal of Pharmacology and Experimental Therapeutics March 2012, 340 (3) 742-749; DOI: https://doi.org/10.1124/jpet.111.188250
You have access
Sex Differences in Cannabinoid 1 vs. Cannabinoid 2 Receptor-Selective Antagonism of Antinociception Produced by Δ⁹-Tetrahydrocannabinol and CP55,940 in the Rat
Rebecca M. Craft, Alexa A. Wakley, Kimberly T. Tsutsui and Jillian D. Laggart

Journal of Pharmacology and Experimental Therapeutics March 2012, 340 (3) 787-800; DOI: https://doi.org/10.1124/jpet.111.188540
You have access
Orexin-1 Receptor Mediation of Cocaine Seeking in Male and Female Rats
Luyi Zhou, Shannon M. Ghee, Clifford Chan, Li Lin, Michael D. Cameron, Paul J. Kenny and Ronald E. See

Journal of Pharmacology and Experimental Therapeutics March 2012, 340 (3) 801-809; DOI: https://doi.org/10.1124/jpet.111.187567

Cardiovascular

You have access
A Fibrinogen-Derived Peptide Provides Intercellular Adhesion Molecule-1-Specific Targeting and Intraendothelial Transport of Polymer Nanocarriers in Human Cell Cultures and Mice
Carmen Garnacho, Daniel Serrano and Silvia Muro

Journal of Pharmacology and Experimental Therapeutics March 2012, 340 (3) 638-647; DOI: https://doi.org/10.1124/jpet.111.185579
You have access
Cobinamides Are Novel Coactivators of Nitric Oxide Receptor That Target Soluble Guanylyl Cyclase Catalytic Domain
Iraida Sharina, Michael Sobolevsky, Marie-Francoise Doursout, Dorota Gryko and Emil Martin

Journal of Pharmacology and Experimental Therapeutics March 2012, 340 (3) 723-732; DOI: https://doi.org/10.1124/jpet.111.186957

Drug Discovery and Translational Medicine

You have access
Mitigation of Off-Target Adrenergic Binding and Effects on Cardiovascular Function in the Discovery of Novel Ribosomal S6 Kinase 2 Inhibitors
Ryan M. Fryer, Akalushi Muthukumarana, Rong Rhonda Chen, James D. Smith, Suzanne Nodop Mazurek, Kyle E. Harrington, Roger M. Dinallo, Jennifer Burke, Frank M. DiCapua, Xin Guo, Thomas M. Kirrane, Roger J. Snow, Yunlong Zhang, Fariba Soleymanzadeh, Jeffrey B. Madwed, Mohammed A. Kashem, Stanley Z. Kugler, Margaret M. O'Neill, Paul C. Harrison, Glenn A. Reinhart and Stephen J. Boyer

Journal of Pharmacology and Experimental Therapeutics March 2012, 340 (3) 492-500; DOI: https://doi.org/10.1124/jpet.111.189365
You have access
LCB 03-0110, a Novel Pan-Discoidin Domain Receptor/c-Src Family Tyrosine Kinase Inhibitor, Suppresses Scar Formation by Inhibiting Fibroblast and Macrophage Activation
Xiaoyan Sun, Trong Nhat Phan, Seung Hee Jung, Sun Young Kim, Jong Un Cho, Hyangsook Lee, Sung Ho Woo, Tae Kyo Park and Beom-Seok Yang

Journal of Pharmacology and Experimental Therapeutics March 2012, 340 (3) 510-519; DOI: https://doi.org/10.1124/jpet.111.187328
You have access
Development of Angiotensin IV Analogs as Hepatocyte Growth Factor/Met Modifiers
Leen H. Kawas, Alene T. McCoy, Brent J. Yamamoto, John W. Wright and Joseph W. Harding

Journal of Pharmacology and Experimental Therapeutics March 2012, 340 (3) 539-548; DOI: https://doi.org/10.1124/jpet.111.188136
You have access
Pharmacokinetic/Pharmacodynamic Modeling of Crizotinib for Anaplastic Lymphoma Kinase Inhibition and Antitumor Efficacy in Human Tumor Xenograft Mouse Models
Shinji Yamazaki, Paolo Vicini, Zhongzhou Shen, Helen Y. Zou, Joseph Lee, Qiuhua Li, James G. Christensen, Bill J. Smith and Bhasker Shetty

Journal of Pharmacology and Experimental Therapeutics March 2012, 340 (3) 549-557; DOI: https://doi.org/10.1124/jpet.111.188870
You have access
Osteogenic Effects of a Potent Src-over-Abl-Selective Kinase Inhibitor in the Mouse
Richard J. Murrills, Shoichi Fukayama, Frank Boschelli, Jeanne J. Matteo, Jane Owens, Jennifer M. Golas, Dharmesh Patel, Giovan Lane, Yao-Bin Liu, Laura Carter, Jason Jussif, Vikki Spaulding, Yanong D. Wang, Diane H. Boschelli, John C. McKew, X. Jian Li, Susan Lockhead, Colleen Milligan, Yogendra P. Kharode, Veronica Diesl, Yuchen Bai, Max Follettie, Frederick J. Bex, Barry Komm and Peter V. N. Bodine

Journal of Pharmacology and Experimental Therapeutics March 2012, 340 (3) 676-687; DOI: https://doi.org/10.1124/jpet.111.185793

Gastrointestinal, Hepatic, Pulmonary, and Renal

You have access
Prostaglandin E₂ Promotes Wound-Induced Migration of Intestinal Subepithelial Myofibroblasts via EP2, EP3, and EP4 Prostanoid Receptor Activation
Koichi Iwanaga, Muneyoshi Okada, Takahisa Murata, Masatoshi Hori and Hiroshi Ozaki

Journal of Pharmacology and Experimental Therapeutics March 2012, 340 (3) 604-611; DOI: https://doi.org/10.1124/jpet.111.189845
You have access
Antenatal Phosphodiesterase 4 Inhibition Restores Postnatal Growth and Pulmonary Development in a Model of Chorioamnionitis in Rabbits
L. Homer, E. Launay, N. Joram, C. Jacqueline, P.-H. Jarreau, J. Caillon, T. Moyon, B. Branger, G. Potel, J. C. Roze, C. Méhats and C. Gras-LeGuen

Journal of Pharmacology and Experimental Therapeutics March 2012, 340 (3) 620-628; DOI: https://doi.org/10.1124/jpet.111.179085
You have access
Prevention of Fibrosis Progression in CCl₄-Treated Rats: Role of the Hepatic Endocannabinoid and Apelin Systems
Vedrana Reichenbach, Josefa Ros, Guillermo Fernández-Varo, Gregori Casals, Pedro Melgar-Lesmes, Teresa Campos, Alexandros Makriyannis, Manuel Morales-Ruiz and Wladimiro Jiménez

Journal of Pharmacology and Experimental Therapeutics March 2012, 340 (3) 629-637; DOI: https://doi.org/10.1124/jpet.111.188078
You have access
2,2,2-Tribromoethanol Phase-Shifts the Circadian Rhythm of the Liver Clock in Per2::Luciferase Knockin Mice: Lack of Dependence on Anesthetic Activity
Yuji Kubo, Yu Tahara, Akiko Hirao and Shigenobu Shibata

Journal of Pharmacology and Experimental Therapeutics March 2012, 340 (3) 698-705; DOI: https://doi.org/10.1124/jpet.111.188615
You have access
Characterization of New Stable Ghrelin Analogs with Prolonged Orexigenic Potency
Lenka Maletínská, Miroslava Pýchová, Martina Holubová, Miroslava Blechová, Zuzana Demianová, Tomáš Elbert and Blanka Železná

Journal of Pharmacology and Experimental Therapeutics March 2012, 340 (3) 781-786; DOI: https://doi.org/10.1124/jpet.111.185371

Inflammation, Immunopharmacology, and Asthma

You have access
Preclinical Evaluation of an Inhibitor of Cytosolic Phospholipase A₂α for the Treatment of Asthma
Christopher A. Hewson, Sheena Patel, Luigino Calzetta, Hinnah Campwala, Suzanne Havard, Emma Luscombe, Philip A. Clarke, Peter T. Peachell, Maria G. Matera, Mario Cazzola, Clive Page, William M. Abraham, Cara M. Williams, James D. Clark, Wai L. Liu, Nicholas P. Clarke and Michael Yeadon

Journal of Pharmacology and Experimental Therapeutics March 2012, 340 (3) 656-665; DOI: https://doi.org/10.1124/jpet.111.186379
You have access
Apolipoprotein A-I (ApoA-I) Mimetic Peptide P2a by Restoring Cholesterol Esterification Unmasks ApoA-I Anti-Inflammatory Endogenous Activity In Vivo
Mariarosaria Bucci, Luisa Cigliano, Valentina Vellecco, Luca Domenico D'Andrea, Barbara Ziaco, Antonietta Rossi, Lidia Sautebin, Alessandro Carlucci, Paolo Abrescia, Carlo Pedone, Angela Ianaro and Giuseppe Cirino

Journal of Pharmacology and Experimental Therapeutics March 2012, 340 (3) 716-722; DOI: https://doi.org/10.1124/jpet.111.189308

Metabolism, Transport, and Pharmacogenomics

You have access
Regulation of Tissue-Specific Expression of Renal Organic Anion Transporters by Hepatocyte Nuclear Factor 1 α/β and DNA Methylation
Li Jin, Ryota Kikuchi, Takami Saji, Hiroyuki Kusuhara and Yuichi Sugiyama

Journal of Pharmacology and Experimental Therapeutics March 2012, 340 (3) 648-655; DOI: https://doi.org/10.1124/jpet.111.187161
You have access
An Insulin-Like Growth Factor 1 Receptor Inhibitor Induces CYP3A4 Expression through a Pregnane X Receptor-Independent, Noncanonical Constitutive Androstane Receptor-Related Mechanism
Linhao Li, Michael W. Sinz, Kurt Zimmermann and Hongbing Wang

Journal of Pharmacology and Experimental Therapeutics March 2012, 340 (3) 688-697; DOI: https://doi.org/10.1124/jpet.111.188854

Neuropharmacology

You have access
Dysfunction of Extrasynaptic GABAergic Transmission in Phospholipase C-Related, but Catalytically Inactive Protein 1 Knockout Mice Is Associated with an Epilepsy Phenotype
Gang Zhu, Shukuko Yoshida, Keisuke Migita, Junko Yamada, Fumiaki Mori, Masahiko Tomiyama, Koichi Wakabayashi, Takashi Kanematsu, Masato Hirata, Sunao Kaneko, Shinya Ueno and Motohiro Okada

Journal of Pharmacology and Experimental Therapeutics March 2012, 340 (3) 520-528; DOI: https://doi.org/10.1124/jpet.111.182386
You have access
Characterization of COR627 and COR628, Two Novel Positive Allosteric Modulators of the GABA_B Receptor
M. Paola Castelli, Angelo Casu, Paola Casti, Carla Lobina, Mauro A. M. Carai, Giancarlo Colombo, Maurizio Solinas, Daniela Giunta, Claudia Mugnaini, Serena Pasquini, Andrea Tafi, Simone Brogi, Gian Luigi Gessa and Federico Corelli

Journal of Pharmacology and Experimental Therapeutics March 2012, 340 (3) 529-538; DOI: https://doi.org/10.1124/jpet.111.186460
You have access
The Role of β-Arrestin2 in the Mechanism of Morphine Tolerance in the Mouse and Guinea Pig Gastrointestinal Tract
Minho Kang, Hercules T. Maguma, Tricia H. Smith, Gracious R. Ross, William L. Dewey and Hamid I. Akbarali

Journal of Pharmacology and Experimental Therapeutics March 2012, 340 (3) 567-576; DOI: https://doi.org/10.1124/jpet.111.186320
You have access
Epigenetic Augmentation of the Macrophage Inflammatory Protein 2/C-X-C Chemokine Receptor Type 2 Axis through Histone H3 Acetylation in Injured Peripheral Nerves Elicits Neuropathic Pain
Norikazu Kiguchi, Yuka Kobayashi, Takehiko Maeda, Yohji Fukazawa, Kazuo Tohya, Michio Kimura and Shiroh Kishioka

Journal of Pharmacology and Experimental Therapeutics March 2012, 340 (3) 577-587; DOI: https://doi.org/10.1124/jpet.111.187724
You have access
Roles of the M1 Muscarinic Acetylcholine Receptor Subtype in the Regulation of Basal Ganglia Function and Implications for the Treatment of Parkinson's Disease
Zixiu Xiang, Analisa D. Thompson, Carrie K. Jones, Craig W. Lindsley and P. Jeffrey Conn

Journal of Pharmacology and Experimental Therapeutics March 2012, 340 (3) 595-603; DOI: https://doi.org/10.1124/jpet.111.187856
You have access
Pharmacological Effects of Lu AA21004: A Novel Multimodal Compound for the Treatment of Major Depressive Disorder
A. Mørk, A. Pehrson, L. T. Brennum, S. Møller Nielsen, H. Zhong, A. B. Lassen, S. Miller, L. Westrich, N. J. Boyle, C. Sánchez, C. W. Fischer, N. Liebenberg, G. Wegener, C. Bundgaard, S. Hogg, B. Bang-Andersen and T. Bryan Stensbøl

Journal of Pharmacology and Experimental Therapeutics March 2012, 340 (3) 666-675; DOI: https://doi.org/10.1124/jpet.111.189068
You have access
The Antipsychotic Drug Loxapine Is an Opener of the Sodium-Activated Potassium Channel Slack (Slo2.2)
B. Biton, S. Sethuramanujam, Kelly E. Picchione, A. Bhattacharjee, N. Khessibi, F. Chesney, C. Lanneau, O. Curet and P. Avenet

Journal of Pharmacology and Experimental Therapeutics March 2012, 340 (3) 706-715; DOI: https://doi.org/10.1124/jpet.111.184622
You have access
S32212, a Novel Serotonin Type 2C Receptor Inverse Agonist/α₂-Adrenoceptor Antagonist and Potential Antidepressant: I. A Mechanistic Characterization
Mark J. Millan, Clotilde Mannoury la Cour, Benjamin Chanrion, Delphine S. Dupuis, Benjamin Di Cara, Valérie Audinot, Didier Cussac, Adrian Newman-Tancredi, Maud Kamal, Jean A. Boutin, Ralf Jockers, Philippe Marin, Joël Bockaert, Olivier Muller, Anne Dekeyne and Gilbert Lavielle

Journal of Pharmacology and Experimental Therapeutics March 2012, 340 (3) 750-764; DOI: https://doi.org/10.1124/jpet.111.187468
You have access
S32212, a Novel Serotonin Type 2C Receptor Inverse Agonist/α₂-Adrenoceptor Antagonist and Potential Antidepressant: II. A Behavioral, Neurochemical, and Electrophysiological Characterization
Anne Dekeyne, Mauricette Brocco, Florence Loiseau, Alain Gobert, Jean-Michel Rivet, Benjamin Di Cara, Thomas I. Cremers, Gunnar Flik, Kevin C. F. Fone, David J. G. Watson, Mariusz Papp, Trevor Sharp, Florence Serres, Raymond Cespuglio, Berend Olivier, Johnny S. W. Chan, Gilbert Lavielle and Mark J. Millan

Journal of Pharmacology and Experimental Therapeutics March 2012, 340 (3) 765-780; DOI: https://doi.org/10.1124/jpet.111.187534

Toxicology

You have access
Effects of Neonatal Antiepileptic Drug Exposure on Cognitive, Emotional, and Motor Function in Adult Rats
Patrick A. Forcelli, Ryan Kozlowski, Charles Snyder, Alexei Kondratyev and Karen Gale

Journal of Pharmacology and Experimental Therapeutics March 2012, 340 (3) 558-566; DOI: https://doi.org/10.1124/jpet.111.188862

Erratum

You have access
Correction to “Pharmacologic Inhibition of Ghrelin Receptor Signaling Is Insulin Sparing and Promotes Insulin Sensitivity”
Journal of Pharmacology and Experimental Therapeutics March 2012, 340 (3) 810;

Notices of Data Fabrication

You have access
Notice of Data Fabrication in “Resveratrol-Mediated Activation of cAMP Response Element-Binding Protein through Adenosine A₃ Receptor by Akt-Dependent and -Independent Pathways”
Journal of Pharmacology and Experimental Therapeutics March 2012, 340 (3) 811;
You have access
Notice of Data Fabrication in “Potentiation of a Survival Signal in the Ischemic Heart by Resveratrol through p38 Mitogen-Activated Protein Kinase/Mitogen- and Stress-Activated Protein Kinase 1/cAMP Response Element-Binding Protein Signaling”
Journal of Pharmacology and Experimental Therapeutics March 2012, 340 (3) 812;

Main menu

User menu

Search

Table of Contents

Highlighted Papers

Behavioral Pharmacology

Cardiovascular

Drug Discovery and Translational Medicine

Gastrointestinal, Hepatic, Pulmonary, and Renal

Inflammation, Immunopharmacology, and Asthma

Metabolism, Transport, and Pharmacogenomics

Neuropharmacology

Toxicology

Erratum

Notices of Data Fabrication

In this issue

Jump to

Navigate

More Information

ASPET's Other Journals