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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

March 01, 2012; Volume 340,Issue 3

Highlighted Papers

  • You have access
    α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Receptor Activation Induces Dystonia in Mice
    Journal of Pharmacology and Experimental Therapeutics March 2012, 340 (3) 491;
  • You have access
    Activated Endothelial Targeting of Nanocarriers with Fibrinogen-Derived Peptides
    Journal of Pharmacology and Experimental Therapeutics March 2012, 340 (3) 491;
  • You have access
    Regulating Hepatocyte Growth Factor/Met Signaling with Angiotensin IV Analogs
    Journal of Pharmacology and Experimental Therapeutics March 2012, 340 (3) 491;
  • You have access
    Neuropathic Pain through Epigenetic Augmentation of the Macrophage Inflammatory Protein 2/C-X-C Chemokine Receptor Type 2 Axis
    Journal of Pharmacology and Experimental Therapeutics March 2012, 340 (3) 491;

Behavioral Pharmacology

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    Effects of Peripherally Restricted κ Opioid Receptor Agonists on Pain-Related Stimulation and Depression of Behavior in Rats
    S. Stevens Negus, Robert O'Connell, Ember Morrissey, Kejun Cheng and Kenner C. Rice
    Journal of Pharmacology and Experimental Therapeutics March 2012, 340 (3) 501-509; DOI: https://doi.org/10.1124/jpet.111.186783
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    The Selective M1 Muscarinic Cholinergic Agonist CDD-0102A Enhances Working Memory and Cognitive Flexibility
    Michael E. Ragozzino, Sonja Artis, Amritha Singh, Trevor M. Twose, Joseph E. Beck and William S. Messer
    Journal of Pharmacology and Experimental Therapeutics March 2012, 340 (3) 588-594; DOI: https://doi.org/10.1124/jpet.111.187625
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    Nicotine Reduces Antipsychotic-Induced Orofacial Dyskinesia in Rats
    Tanuja Bordia, J. Michael McIntosh and Maryka Quik
    Journal of Pharmacology and Experimental Therapeutics March 2012, 340 (3) 612-619; DOI: https://doi.org/10.1124/jpet.111.189100
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    Selective and Sustained α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Receptor Activation in Cerebellum Induces Dystonia in Mice
    Xueliang Fan, Keryn E. Hughes, H. A. Jinnah and Ellen J. Hess
    Journal of Pharmacology and Experimental Therapeutics March 2012, 340 (3) 733-741; DOI: https://doi.org/10.1124/jpet.111.190082
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    Quantitative Analyses of Antagonism: Combinations of Midazolam and Either Flunitrazepam or Pregnanolone in Rhesus Monkeys Discriminating Midazolam
    Lisa R. Gerak and Charles P. France
    Journal of Pharmacology and Experimental Therapeutics March 2012, 340 (3) 742-749; DOI: https://doi.org/10.1124/jpet.111.188250
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    Sex Differences in Cannabinoid 1 vs. Cannabinoid 2 Receptor-Selective Antagonism of Antinociception Produced by Δ9-Tetrahydrocannabinol and CP55,940 in the Rat
    Rebecca M. Craft, Alexa A. Wakley, Kimberly T. Tsutsui and Jillian D. Laggart
    Journal of Pharmacology and Experimental Therapeutics March 2012, 340 (3) 787-800; DOI: https://doi.org/10.1124/jpet.111.188540
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    Orexin-1 Receptor Mediation of Cocaine Seeking in Male and Female Rats
    Luyi Zhou, Shannon M. Ghee, Clifford Chan, Li Lin, Michael D. Cameron, Paul J. Kenny and Ronald E. See
    Journal of Pharmacology and Experimental Therapeutics March 2012, 340 (3) 801-809; DOI: https://doi.org/10.1124/jpet.111.187567

Cardiovascular

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    A Fibrinogen-Derived Peptide Provides Intercellular Adhesion Molecule-1-Specific Targeting and Intraendothelial Transport of Polymer Nanocarriers in Human Cell Cultures and Mice
    Carmen Garnacho, Daniel Serrano and Silvia Muro
    Journal of Pharmacology and Experimental Therapeutics March 2012, 340 (3) 638-647; DOI: https://doi.org/10.1124/jpet.111.185579
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    Cobinamides Are Novel Coactivators of Nitric Oxide Receptor That Target Soluble Guanylyl Cyclase Catalytic Domain
    Iraida Sharina, Michael Sobolevsky, Marie-Francoise Doursout, Dorota Gryko and Emil Martin
    Journal of Pharmacology and Experimental Therapeutics March 2012, 340 (3) 723-732; DOI: https://doi.org/10.1124/jpet.111.186957

Drug Discovery and Translational Medicine

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    Mitigation of Off-Target Adrenergic Binding and Effects on Cardiovascular Function in the Discovery of Novel Ribosomal S6 Kinase 2 Inhibitors
    Ryan M. Fryer, Akalushi Muthukumarana, Rong Rhonda Chen, James D. Smith, Suzanne Nodop Mazurek, Kyle E. Harrington, Roger M. Dinallo, Jennifer Burke, Frank M. DiCapua, Xin Guo, Thomas M. Kirrane, Roger J. Snow, Yunlong Zhang, Fariba Soleymanzadeh, Jeffrey B. Madwed, Mohammed A. Kashem, Stanley Z. Kugler, Margaret M. O'Neill, Paul C. Harrison, Glenn A. Reinhart and Stephen J. Boyer
    Journal of Pharmacology and Experimental Therapeutics March 2012, 340 (3) 492-500; DOI: https://doi.org/10.1124/jpet.111.189365
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    LCB 03-0110, a Novel Pan-Discoidin Domain Receptor/c-Src Family Tyrosine Kinase Inhibitor, Suppresses Scar Formation by Inhibiting Fibroblast and Macrophage Activation
    Xiaoyan Sun, Trong Nhat Phan, Seung Hee Jung, Sun Young Kim, Jong Un Cho, Hyangsook Lee, Sung Ho Woo, Tae Kyo Park and Beom-Seok Yang
    Journal of Pharmacology and Experimental Therapeutics March 2012, 340 (3) 510-519; DOI: https://doi.org/10.1124/jpet.111.187328
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    Development of Angiotensin IV Analogs as Hepatocyte Growth Factor/Met Modifiers
    Leen H. Kawas, Alene T. McCoy, Brent J. Yamamoto, John W. Wright and Joseph W. Harding
    Journal of Pharmacology and Experimental Therapeutics March 2012, 340 (3) 539-548; DOI: https://doi.org/10.1124/jpet.111.188136
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    Pharmacokinetic/Pharmacodynamic Modeling of Crizotinib for Anaplastic Lymphoma Kinase Inhibition and Antitumor Efficacy in Human Tumor Xenograft Mouse Models
    Shinji Yamazaki, Paolo Vicini, Zhongzhou Shen, Helen Y. Zou, Joseph Lee, Qiuhua Li, James G. Christensen, Bill J. Smith and Bhasker Shetty
    Journal of Pharmacology and Experimental Therapeutics March 2012, 340 (3) 549-557; DOI: https://doi.org/10.1124/jpet.111.188870
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    Osteogenic Effects of a Potent Src-over-Abl-Selective Kinase Inhibitor in the Mouse
    Richard J. Murrills, Shoichi Fukayama, Frank Boschelli, Jeanne J. Matteo, Jane Owens, Jennifer M. Golas, Dharmesh Patel, Giovan Lane, Yao-Bin Liu, Laura Carter, Jason Jussif, Vikki Spaulding, Yanong D. Wang, Diane H. Boschelli, John C. McKew, X. Jian Li, Susan Lockhead, Colleen Milligan, Yogendra P. Kharode, Veronica Diesl, Yuchen Bai, Max Follettie, Frederick J. Bex, Barry Komm and Peter V. N. Bodine
    Journal of Pharmacology and Experimental Therapeutics March 2012, 340 (3) 676-687; DOI: https://doi.org/10.1124/jpet.111.185793

Gastrointestinal, Hepatic, Pulmonary, and Renal

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    Prostaglandin E2 Promotes Wound-Induced Migration of Intestinal Subepithelial Myofibroblasts via EP2, EP3, and EP4 Prostanoid Receptor Activation
    Koichi Iwanaga, Muneyoshi Okada, Takahisa Murata, Masatoshi Hori and Hiroshi Ozaki
    Journal of Pharmacology and Experimental Therapeutics March 2012, 340 (3) 604-611; DOI: https://doi.org/10.1124/jpet.111.189845
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    Antenatal Phosphodiesterase 4 Inhibition Restores Postnatal Growth and Pulmonary Development in a Model of Chorioamnionitis in Rabbits
    L. Homer, E. Launay, N. Joram, C. Jacqueline, P.-H. Jarreau, J. Caillon, T. Moyon, B. Branger, G. Potel, J. C. Roze, C. Méhats and C. Gras-LeGuen
    Journal of Pharmacology and Experimental Therapeutics March 2012, 340 (3) 620-628; DOI: https://doi.org/10.1124/jpet.111.179085
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    Prevention of Fibrosis Progression in CCl4-Treated Rats: Role of the Hepatic Endocannabinoid and Apelin Systems
    Vedrana Reichenbach, Josefa Ros, Guillermo Fernández-Varo, Gregori Casals, Pedro Melgar-Lesmes, Teresa Campos, Alexandros Makriyannis, Manuel Morales-Ruiz and Wladimiro Jiménez
    Journal of Pharmacology and Experimental Therapeutics March 2012, 340 (3) 629-637; DOI: https://doi.org/10.1124/jpet.111.188078
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    2,2,2-Tribromoethanol Phase-Shifts the Circadian Rhythm of the Liver Clock in Per2::Luciferase Knockin Mice: Lack of Dependence on Anesthetic Activity
    Yuji Kubo, Yu Tahara, Akiko Hirao and Shigenobu Shibata
    Journal of Pharmacology and Experimental Therapeutics March 2012, 340 (3) 698-705; DOI: https://doi.org/10.1124/jpet.111.188615
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    Characterization of New Stable Ghrelin Analogs with Prolonged Orexigenic Potency
    Lenka Maletínská, Miroslava Pýchová, Martina Holubová, Miroslava Blechová, Zuzana Demianová, Tomáš Elbert and Blanka Železná
    Journal of Pharmacology and Experimental Therapeutics March 2012, 340 (3) 781-786; DOI: https://doi.org/10.1124/jpet.111.185371

Inflammation, Immunopharmacology, and Asthma

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    Preclinical Evaluation of an Inhibitor of Cytosolic Phospholipase A2α for the Treatment of Asthma
    Christopher A. Hewson, Sheena Patel, Luigino Calzetta, Hinnah Campwala, Suzanne Havard, Emma Luscombe, Philip A. Clarke, Peter T. Peachell, Maria G. Matera, Mario Cazzola, Clive Page, William M. Abraham, Cara M. Williams, James D. Clark, Wai L. Liu, Nicholas P. Clarke and Michael Yeadon
    Journal of Pharmacology and Experimental Therapeutics March 2012, 340 (3) 656-665; DOI: https://doi.org/10.1124/jpet.111.186379
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    Apolipoprotein A-I (ApoA-I) Mimetic Peptide P2a by Restoring Cholesterol Esterification Unmasks ApoA-I Anti-Inflammatory Endogenous Activity In Vivo
    Mariarosaria Bucci, Luisa Cigliano, Valentina Vellecco, Luca Domenico D'Andrea, Barbara Ziaco, Antonietta Rossi, Lidia Sautebin, Alessandro Carlucci, Paolo Abrescia, Carlo Pedone, Angela Ianaro and Giuseppe Cirino
    Journal of Pharmacology and Experimental Therapeutics March 2012, 340 (3) 716-722; DOI: https://doi.org/10.1124/jpet.111.189308

Metabolism, Transport, and Pharmacogenomics

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    Regulation of Tissue-Specific Expression of Renal Organic Anion Transporters by Hepatocyte Nuclear Factor 1 α/β and DNA Methylation
    Li Jin, Ryota Kikuchi, Takami Saji, Hiroyuki Kusuhara and Yuichi Sugiyama
    Journal of Pharmacology and Experimental Therapeutics March 2012, 340 (3) 648-655; DOI: https://doi.org/10.1124/jpet.111.187161
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    An Insulin-Like Growth Factor 1 Receptor Inhibitor Induces CYP3A4 Expression through a Pregnane X Receptor-Independent, Noncanonical Constitutive Androstane Receptor-Related Mechanism
    Linhao Li, Michael W. Sinz, Kurt Zimmermann and Hongbing Wang
    Journal of Pharmacology and Experimental Therapeutics March 2012, 340 (3) 688-697; DOI: https://doi.org/10.1124/jpet.111.188854

Neuropharmacology

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    Dysfunction of Extrasynaptic GABAergic Transmission in Phospholipase C-Related, but Catalytically Inactive Protein 1 Knockout Mice Is Associated with an Epilepsy Phenotype
    Gang Zhu, Shukuko Yoshida, Keisuke Migita, Junko Yamada, Fumiaki Mori, Masahiko Tomiyama, Koichi Wakabayashi, Takashi Kanematsu, Masato Hirata, Sunao Kaneko, Shinya Ueno and Motohiro Okada
    Journal of Pharmacology and Experimental Therapeutics March 2012, 340 (3) 520-528; DOI: https://doi.org/10.1124/jpet.111.182386
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    Characterization of COR627 and COR628, Two Novel Positive Allosteric Modulators of the GABAB Receptor
    M. Paola Castelli, Angelo Casu, Paola Casti, Carla Lobina, Mauro A. M. Carai, Giancarlo Colombo, Maurizio Solinas, Daniela Giunta, Claudia Mugnaini, Serena Pasquini, Andrea Tafi, Simone Brogi, Gian Luigi Gessa and Federico Corelli
    Journal of Pharmacology and Experimental Therapeutics March 2012, 340 (3) 529-538; DOI: https://doi.org/10.1124/jpet.111.186460
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    The Role of β-Arrestin2 in the Mechanism of Morphine Tolerance in the Mouse and Guinea Pig Gastrointestinal Tract
    Minho Kang, Hercules T. Maguma, Tricia H. Smith, Gracious R. Ross, William L. Dewey and Hamid I. Akbarali
    Journal of Pharmacology and Experimental Therapeutics March 2012, 340 (3) 567-576; DOI: https://doi.org/10.1124/jpet.111.186320
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    Epigenetic Augmentation of the Macrophage Inflammatory Protein 2/C-X-C Chemokine Receptor Type 2 Axis through Histone H3 Acetylation in Injured Peripheral Nerves Elicits Neuropathic Pain
    Norikazu Kiguchi, Yuka Kobayashi, Takehiko Maeda, Yohji Fukazawa, Kazuo Tohya, Michio Kimura and Shiroh Kishioka
    Journal of Pharmacology and Experimental Therapeutics March 2012, 340 (3) 577-587; DOI: https://doi.org/10.1124/jpet.111.187724
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    Roles of the M1 Muscarinic Acetylcholine Receptor Subtype in the Regulation of Basal Ganglia Function and Implications for the Treatment of Parkinson's Disease
    Zixiu Xiang, Analisa D. Thompson, Carrie K. Jones, Craig W. Lindsley and P. Jeffrey Conn
    Journal of Pharmacology and Experimental Therapeutics March 2012, 340 (3) 595-603; DOI: https://doi.org/10.1124/jpet.111.187856
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    Pharmacological Effects of Lu AA21004: A Novel Multimodal Compound for the Treatment of Major Depressive Disorder
    A. Mørk, A. Pehrson, L. T. Brennum, S. Møller Nielsen, H. Zhong, A. B. Lassen, S. Miller, L. Westrich, N. J. Boyle, C. Sánchez, C. W. Fischer, N. Liebenberg, G. Wegener, C. Bundgaard, S. Hogg, B. Bang-Andersen and T. Bryan Stensbøl
    Journal of Pharmacology and Experimental Therapeutics March 2012, 340 (3) 666-675; DOI: https://doi.org/10.1124/jpet.111.189068
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    The Antipsychotic Drug Loxapine Is an Opener of the Sodium-Activated Potassium Channel Slack (Slo2.2)
    B. Biton, S. Sethuramanujam, Kelly E. Picchione, A. Bhattacharjee, N. Khessibi, F. Chesney, C. Lanneau, O. Curet and P. Avenet
    Journal of Pharmacology and Experimental Therapeutics March 2012, 340 (3) 706-715; DOI: https://doi.org/10.1124/jpet.111.184622
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    S32212, a Novel Serotonin Type 2C Receptor Inverse Agonist/α2-Adrenoceptor Antagonist and Potential Antidepressant: I. A Mechanistic Characterization
    Mark J. Millan, Clotilde Mannoury la Cour, Benjamin Chanrion, Delphine S. Dupuis, Benjamin Di Cara, Valérie Audinot, Didier Cussac, Adrian Newman-Tancredi, Maud Kamal, Jean A. Boutin, Ralf Jockers, Philippe Marin, Joël Bockaert, Olivier Muller, Anne Dekeyne and Gilbert Lavielle
    Journal of Pharmacology and Experimental Therapeutics March 2012, 340 (3) 750-764; DOI: https://doi.org/10.1124/jpet.111.187468
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    S32212, a Novel Serotonin Type 2C Receptor Inverse Agonist/α2-Adrenoceptor Antagonist and Potential Antidepressant: II. A Behavioral, Neurochemical, and Electrophysiological Characterization
    Anne Dekeyne, Mauricette Brocco, Florence Loiseau, Alain Gobert, Jean-Michel Rivet, Benjamin Di Cara, Thomas I. Cremers, Gunnar Flik, Kevin C. F. Fone, David J. G. Watson, Mariusz Papp, Trevor Sharp, Florence Serres, Raymond Cespuglio, Berend Olivier, Johnny S. W. Chan, Gilbert Lavielle and Mark J. Millan
    Journal of Pharmacology and Experimental Therapeutics March 2012, 340 (3) 765-780; DOI: https://doi.org/10.1124/jpet.111.187534

Toxicology

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    Effects of Neonatal Antiepileptic Drug Exposure on Cognitive, Emotional, and Motor Function in Adult Rats
    Patrick A. Forcelli, Ryan Kozlowski, Charles Snyder, Alexei Kondratyev and Karen Gale
    Journal of Pharmacology and Experimental Therapeutics March 2012, 340 (3) 558-566; DOI: https://doi.org/10.1124/jpet.111.188862

Erratum

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    Correction to “Pharmacologic Inhibition of Ghrelin Receptor Signaling Is Insulin Sparing and Promotes Insulin Sensitivity”
    Journal of Pharmacology and Experimental Therapeutics March 2012, 340 (3) 810;

Notices of Data Fabrication

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    Notice of Data Fabrication in “Resveratrol-Mediated Activation of cAMP Response Element-Binding Protein through Adenosine A3 Receptor by Akt-Dependent and -Independent Pathways”
    Journal of Pharmacology and Experimental Therapeutics March 2012, 340 (3) 811;
  • You have access
    Notice of Data Fabrication in “Potentiation of a Survival Signal in the Ischemic Heart by Resveratrol through p38 Mitogen-Activated Protein Kinase/Mitogen- and Stress-Activated Protein Kinase 1/cAMP Response Element-Binding Protein Signaling”
    Journal of Pharmacology and Experimental Therapeutics March 2012, 340 (3) 812;
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Journal of Pharmacology and Experimental Therapeutics: 340 (3)
Journal of Pharmacology and Experimental Therapeutics
Vol. 340, Issue 3
1 Mar 2012
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  • Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.
  • Functional Selectivity and Classical Concepts of Quantitative Pharmacology
  • Abl Protein-Tyrosine Kinase Inhibitor STI571 Inhibits In Vitro Signal Transduction Mediated by c-Kit and Platelet-Derived Growth Factor Receptors
  • The Prediction of Human Pharmacokinetic Parameters from Preclinical and In Vitro Metabolism Data
  • A METHOD FOR DETERMINING LOSS OF PAIN SENSATION
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