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Research ArticleInflammation, Immunopharmacology, and Asthma

Pharmacologic Profile of OC000459, a Potent, Selective, and Orally Active D Prostanoid Receptor 2 Antagonist That Inhibits Mast Cell-Dependent Activation of T Helper 2 Lymphocytes and Eosinophils

Roy Pettipher, Shân L. Vinall, Luzheng Xue, Graham Speight, Elizabeth R. Townsend, Lucien Gazi, Cliff J. Whelan, Richard E. Armer, Mark A. Payton and Michael G. Hunter
Journal of Pharmacology and Experimental Therapeutics February 2012, 340 (2) 473-482; DOI: https://doi.org/10.1124/jpet.111.187203

Article Information

vol. 340 no. 2 473-482
DOI 
https://doi.org/10.1124/jpet.111.187203
PubMed 
22106101
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received August 25, 2011
  • Accepted November 16, 2011
  • Published online January 19, 2012.

Article Versions

Copyright & Usage 
Copyright © 2012 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Roy Pettipher,
  2. Shân L. Vinall,
  3. Luzheng Xue,
  4. Graham Speight,
  5. Elizabeth R. Townsend,
  6. Lucien Gazi,
  7. Cliff J. Whelan,
  8. Richard E. Armer,
  9. Mark A. Payton and
  10. Michael G. Hunter
  1. Oxagen Ltd, Abingdon, Oxon, United Kingdom (R.P., S.L.V., L.X., G.S., E.R.T., L.G., R.E.A, M.A.P., M.G.H.); and Department of Life Sciences, University of Hertfordshire, Hatfield, Herts, United Kingdom (C.J.W.)
  1. Address correspondence to:
    Roy Pettipher, Oxagen Ltd, 91 Milton Park, Abingdon, Oxon, OX14 4RY, United Kingdom. E-mail: r.pettipher{at}oxagen.co.uk
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Research ArticleInflammation, Immunopharmacology, and Asthma

Pharmacological Profile of the Novel DP2 Antagonist OC000459

Roy Pettipher, Shân L. Vinall, Luzheng Xue, Graham Speight, Elizabeth R. Townsend, Lucien Gazi, Cliff J. Whelan, Richard E. Armer, Mark A. Payton and Michael G. Hunter
Journal of Pharmacology and Experimental Therapeutics February 1, 2012, 340 (2) 473-482; DOI: https://doi.org/10.1124/jpet.111.187203
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