Journal of Pharmacology and Experimental Therapeutics: 340 (2)

February 01, 2012; Volume 340,Issue 2

Highlighted Papers

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Spleen Tyrosine Kinase Selective Inhibitor and Treatment of Rheumatoid Arthritis
Journal of Pharmacology and Experimental Therapeutics February 2012, 340 (2) 227;
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Treating Asthma with Prostaglandin D₂ Receptor Antagonists
Journal of Pharmacology and Experimental Therapeutics February 2012, 340 (2) 227;
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Mutations of the α1 Glycine Receptor Subunit Regulate Sensitivity to Alcohols
Journal of Pharmacology and Experimental Therapeutics February 2012, 340 (2) 227;
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Knockin of Mutated α1 Glycine Receptor Subunits Alters Sensitivity to GABAergic Drugs
Journal of Pharmacology and Experimental Therapeutics February 2012, 340 (2) 227;

Behavioral Pharmacology

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Effects of the α₂-Adrenergic Agonist Clonidine on the Pharmacodynamics and Pharmacokinetics of 3,4-Methylenedioxymethamphetamine in Healthy Volunteers
Cédric M. Hysek, Robin Brugger, Linda D. Simmler, Marcel Bruggisser, Massimiliano Donzelli, Eric Grouzmann, Marius C. Hoener and Matthias E. Liechti

Journal of Pharmacology and Experimental Therapeutics February 2012, 340 (2) 286-294; DOI: https://doi.org/10.1124/jpet.111.188425
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Methamphetamine Self-Administration Causes Persistent Striatal Dopaminergic Alterations and Mitigates the Deficits Caused by a Subsequent Methamphetamine Exposure
Lisa M. McFadden, Greg C. Hadlock, Scott C. Allen, Paula L. Vieira-Brock, Kristen A. Stout, Jonathan D. Ellis, Amanda J. Hoonakker, David M. Andrenyak, Shannon M. Nielsen, Diana G. Wilkins, Glen R. Hanson and Annette E. Fleckenstein

Journal of Pharmacology and Experimental Therapeutics February 2012, 340 (2) 295-303; DOI: https://doi.org/10.1124/jpet.111.188433
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Chronic Methadone Treatment Shows a Better Cost/Benefit Ratio than Chronic Morphine in Mice
Johan Enquist, Madeline Ferwerda, Laura Milan-Lobo and Jennifer L. Whistler

Journal of Pharmacology and Experimental Therapeutics February 2012, 340 (2) 386-392; DOI: https://doi.org/10.1124/jpet.111.187583

Cardiovascular

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Antiserotonergic Properties of Terguride in Blood Vessels, Platelets, and Valvular Interstitial Cells
Alexandra Kekewska, Tilo Görnemann, Florian Jantschak, Erika Glusa and Heinz H. Pertz

Journal of Pharmacology and Experimental Therapeutics February 2012, 340 (2) 369-376; DOI: https://doi.org/10.1124/jpet.111.187906

Cellular and Molecular

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Structural Nucleotide Analogs Are Potent Activators/Inhibitors of Pancreatic β Cell KATP Channels: An Emerging Mechanism Supporting Their Use as Antidiabetic Drugs
Domenico Tricarico, Jean-François Rolland, Gianluigi Cannone, Antonietta Mele, Valentina Cippone, Antonio Laghezza, Giuseppe Carbonara, Giuseppe Fracchiolla, Paolo Tortorella, Fulvio Loiodice and Diana Conte Camerino

Journal of Pharmacology and Experimental Therapeutics February 2012, 340 (2) 266-276; DOI: https://doi.org/10.1124/jpet.111.185835
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Spleen Tyrosine Kinase Mediates BEAS-2B Cell Migration and Proliferation and Human Rhinovirus-Induced Expression of Vascular Endothelial Growth Factor and Interleukin-8
Xiaomin Wang, Mirek Mychajlowycz, Christine Lau, Carlos Gutierrez, Jeremy A. Scott and Chung-Wai Chow

Journal of Pharmacology and Experimental Therapeutics February 2012, 340 (2) 277-285; DOI: https://doi.org/10.1124/jpet.111.186429
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The Basic Property of Lys385 Is Important for Potentiation of the Human α1 Glycine Receptor by Ethanol
Patricio A. Castro, Maximiliano Figueroa, Gonzalo E. Yevenes, Loreto S. San Martin and Luis G. Aguayo

Journal of Pharmacology and Experimental Therapeutics February 2012, 340 (2) 339-349; DOI: https://doi.org/10.1124/jpet.111.185140
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Roscovitine Inhibits Ca_V3.1 (T-Type) Channels by Preferentially Affecting Closed-State Inactivation
Viktor Yarotskyy and Keith S. Elmslie

Journal of Pharmacology and Experimental Therapeutics February 2012, 340 (2) 463-472; DOI: https://doi.org/10.1124/jpet.111.187104

Drug Discovery and Translational Medicine

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Proprotein Convertase Substilisin/Kexin Type 9 Antagonism Reduces Low-Density Lipoprotein Cholesterol in Statin-Treated Hypercholesterolemic Nonhuman Primates
Hong Liang, Javier Chaparro-Riggers, Pavel Strop, Tao Geng, Janette E. Sutton, Daniel Tsai, Lanfang Bai, Yasmina Abdiche, Jeanette Dilley, Jessica Yu, Si Wu, S. Michael Chin, Nicole A. Lee, Andrea Rossi, John C. Lin, Arvind Rajpal, Jaume Pons and David L. Shelton

Journal of Pharmacology and Experimental Therapeutics February 2012, 340 (2) 228-236; DOI: https://doi.org/10.1124/jpet.111.187419
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Specific Inhibition of Spleen Tyrosine Kinase Suppresses Leukocyte Immune Function and Inflammation in Animal Models of Rheumatoid Arthritis
Greg Coffey, Francis DeGuzman, Mayuko Inagaki, Yvonne Pak, Suzanne M. Delaney, Dan Ives, Andreas Betz, Zhaozhong J. Jia, Anjali Pandey, Dale Baker, Stanley J. Hollenbach, David R. Phillips and Uma Sinha

Journal of Pharmacology and Experimental Therapeutics February 2012, 340 (2) 350-359; DOI: https://doi.org/10.1124/jpet.111.188441
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The Metabotropic Glutamate Receptor 4-Positive Allosteric Modulator VU0364770 Produces Efficacy Alone and in Combination with l-DOPA or an Adenosine 2A Antagonist in Preclinical Rodent Models of Parkinson's Disease
Carrie K. Jones, Michael Bubser, Analisa D. Thompson, Jonathan W. Dickerson, Nathalie Turle-Lorenzo, Marianne Amalric, Anna L. Blobaum, Thomas M. Bridges, Ryan D. Morrison, Satyawan Jadhav, Darren W. Engers, Kimberly Italiano, Jacob Bode, J. Scott Daniels, Craig W. Lindsley, Corey R. Hopkins, P. Jeffrey Conn and Colleen M. Niswender

Journal of Pharmacology and Experimental Therapeutics February 2012, 340 (2) 404-421; DOI: https://doi.org/10.1124/jpet.111.187443

Endocrine and Diabetes

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Dipeptidyl Peptidase IV Inhibitor Attenuates Kidney Injury in Streptozotocin-Induced Diabetic Rats
Wei Jing Liu, Shu Hua Xie, Yu Ning Liu, Won Kim, Heung Yong Jin, Sung Kwang Park, Yi Ming Shao and Tae Sun Park

Journal of Pharmacology and Experimental Therapeutics February 2012, 340 (2) 248-255; DOI: https://doi.org/10.1124/jpet.111.186866
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The Effects of TAK-875, a Selective G Protein-Coupled Receptor 40/Free Fatty Acid 1 Agonist, on Insulin and Glucagon Secretion in Isolated Rat and Human Islets
Hiroaki Yashiro, Yoshiyuki Tsujihata, Koji Takeuchi, Masatoshi Hazama, Paul R. V. Johnson and Patrik Rorsman

Journal of Pharmacology and Experimental Therapeutics February 2012, 340 (2) 483-489; DOI: https://doi.org/10.1124/jpet.111.187708

Gastrointestinal, Hepatic, Pulmonary, and Renal

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Antagonism of Protease-Activated Receptor 2 Protects against Experimental Colitis
Rink-Jan Lohman, Adam J. Cotterell, Jacky Suen, Ligong Liu, Anh T. Do, David A. Vesey and David P. Fairlie

Journal of Pharmacology and Experimental Therapeutics February 2012, 340 (2) 256-265; DOI: https://doi.org/10.1124/jpet.111.187062
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γ-Tocotrienol Protects against Mitochondrial Dysfunction and Renal Cell Death
Grażyna Nowak, Diana Bakajsova, Corey Hayes, Martin Hauer-Jensen and Cesar M. Compadre

Journal of Pharmacology and Experimental Therapeutics February 2012, 340 (2) 330-338; DOI: https://doi.org/10.1124/jpet.111.186882

Inflammation, Immunopharmacology, and Asthma

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Influence of Influenza A Infection on Capsaicin-Induced Responses in Murine Airways
Samuel J. Taylor, Tracy S. Mann and Peter J. Henry

Journal of Pharmacology and Experimental Therapeutics February 2012, 340 (2) 377-385; DOI: https://doi.org/10.1124/jpet.111.187872
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Pharmacologic Profile of OC000459, a Potent, Selective, and Orally Active D Prostanoid Receptor 2 Antagonist That Inhibits Mast Cell-Dependent Activation of T Helper 2 Lymphocytes and Eosinophils
Roy Pettipher, Shân L. Vinall, Luzheng Xue, Graham Speight, Elizabeth R. Townsend, Lucien Gazi, Cliff J. Whelan, Richard E. Armer, Mark A. Payton and Michael G. Hunter

Journal of Pharmacology and Experimental Therapeutics February 2012, 340 (2) 473-482; DOI: https://doi.org/10.1124/jpet.111.187203

Metabolism, Transport, and Pharmacogenomics

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Competitive Inhibition of the Luminal Efflux by Multidrug and Toxin Extrusions, but Not Basolateral Uptake by Organic Cation Transporter 2, Is the Likely Mechanism Underlying the Pharmacokinetic Drug-Drug Interactions Caused by Cimetidine in the Kidney
Sumito Ito, Hiroyuki Kusuhara, Miyu Yokochi, Junko Toyoshima, Katsuhisa Inoue, Hiroaki Yuasa and Yuichi Sugiyama

Journal of Pharmacology and Experimental Therapeutics February 2012, 340 (2) 393-403; DOI: https://doi.org/10.1124/jpet.111.184986
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Carboxylesterases 1 and 2 Hydrolyze Phospho-Nonsteroidal Anti-Inflammatory Drugs: Relevance to Their Pharmacological Activity
Chi C. Wong, Ka-Wing Cheng, Gang Xie, Dingying Zhou, Cai-Hua Zhu, Panayiotis P. Constantinides and Basil Rigas

Journal of Pharmacology and Experimental Therapeutics February 2012, 340 (2) 422-432; DOI: https://doi.org/10.1124/jpet.111.188508
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Involvement of Concentrative Nucleoside Transporter 1 in Intestinal Absorption of Trifluorothymidine, a Novel Antitumor Nucleoside, in Rats
Takashige Okayama, Kunihiro Yoshisue, Keizo Kuwata, Masahito Komuro, Shigeru Ohta and Sekio Nagayama

Journal of Pharmacology and Experimental Therapeutics February 2012, 340 (2) 457-462; DOI: https://doi.org/10.1124/jpet.111.186296

Neuropharmacology

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Characterization of Two Mutations, M287L and Q266I, in the α1 Glycine Receptor Subunit That Modify Sensitivity to Alcohols
Cecilia M. Borghese, Yuri A. Blednov, Yu Quan, Sangeetha V. Iyer, Wei Xiong, S. John Mihic, Li Zhang, David M. Lovinger, James R. Trudell, Gregg E. Homanics and R. Adron Harris

Journal of Pharmacology and Experimental Therapeutics February 2012, 340 (2) 304-316; DOI: https://doi.org/10.1124/jpet.111.185116
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Behavioral Characterization of Knockin Mice with Mutations M287L and Q266I in the Glycine Receptor α1 Subunit
Yuri A. Blednov, Jill M. Benavidez, Gregg E. Homanics and R. Adron Harris

Journal of Pharmacology and Experimental Therapeutics February 2012, 340 (2) 317-329; DOI: https://doi.org/10.1124/jpet.111.185124
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3-Substituted Pyrazole Analogs of the Cannabinoid Type 1 (CB₁) Receptor Antagonist Rimonabant: Cannabinoid Agonist-Like Effects in Mice via Non-CB₁, Non-CB₂ Mechanism
Jenny L. Wiley, Dana E. Selley, Pinglang Wang, Rudresha Kottani, Srinivas Gadthula and Anu Mahadeven

Journal of Pharmacology and Experimental Therapeutics February 2012, 340 (2) 433-444; DOI: https://doi.org/10.1124/jpet.111.187815
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The TM2 6′ Position of GABA_A Receptors Mediates Alcohol Inhibition
W. David Johnson, Rebecca J. Howard, James R. Trudell and R. Adron Harris

Journal of Pharmacology and Experimental Therapeutics February 2012, 340 (2) 445-456; DOI: https://doi.org/10.1124/jpet.111.188037

Toxicology

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Histone H3 Phosphorylation (Ser10, Ser28) and Phosphoacetylation (K9S10) Are Differentially Associated with Gene Expression in Liver of Rats Treated In Vivo with Acute Ethanol
Taryn T. James, Annayya R. Aroor, Robert W. Lim and Shivendra D. Shukla

Journal of Pharmacology and Experimental Therapeutics February 2012, 340 (2) 237-247; DOI: https://doi.org/10.1124/jpet.111.186775
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Changes in Mouse Liver Protein Glutathionylation after Acetaminophen Exposure
Xi Yang, James Greenhaw, Akhtar Ali, Qiang Shi, Dean W. Roberts, Jack A. Hinson, Levan Muskhelishvili, Richard Beger, Lisa M. Pence, Yosuke Ando, Jinchun Sun, Kelly Davis and William F. Salminen

Journal of Pharmacology and Experimental Therapeutics February 2012, 340 (2) 360-368; DOI: https://doi.org/10.1124/jpet.111.187948

Erratum

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Correction to “The Cytochrome P450 4A/F-20-Hydroxyeicosatetraenoic Acid System: A Regulator of Endothelial Precursor Cells Derived from Human Umbilical Cord Blood”
Journal of Pharmacology and Experimental Therapeutics February 2012, 340 (2) 490;

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Table of Contents

Highlighted Papers

Behavioral Pharmacology

Cardiovascular

Cellular and Molecular

Drug Discovery and Translational Medicine

Endocrine and Diabetes

Gastrointestinal, Hepatic, Pulmonary, and Renal

Inflammation, Immunopharmacology, and Asthma

Metabolism, Transport, and Pharmacogenomics

Neuropharmacology

Toxicology

Erratum

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