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Research ArticleNeuropharmacology

CEP-26401 (Irdabisant), a Potent and Selective Histamine H3 Receptor Antagonist/Inverse Agonist with Cognition-Enhancing and Wake-Promoting Activities

Rita Raddatz, Robert L. Hudkins, Joanne R. Mathiasen, John A. Gruner, Dorothy G. Flood, Lisa D. Aimone, Siyuan Le, Hervé Schaffhauser, Emir Duzic, Maciej Gasior, Donna Bozyczko-Coyne, Michael J. Marino, Mark A. Ator, Edward R. Bacon, John P. Mallamo and Michael Williams
Journal of Pharmacology and Experimental Therapeutics January 2012, 340 (1) 124-133; DOI: https://doi.org/10.1124/jpet.111.186585

Article Information

vol. 340 no. 1 124-133
DOI 
https://doi.org/10.1124/jpet.111.186585
PubMed 
22001260
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received August 2, 2011
  • Accepted October 13, 2011
  • Published online December 14, 2011.

Article Versions

Copyright & Usage 
Copyright © 2012 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Rita Raddatz,
  2. Robert L. Hudkins,
  3. Joanne R. Mathiasen1,
  4. John A. Gruner2,
  5. Dorothy G. Flood3,
  6. Lisa D. Aimone,
  7. Siyuan Le4,
  8. Hervé Schaffhauser5,
  9. Emir Duzic6,
  10. Maciej Gasior7,
  11. Donna Bozyczko-Coyne,
  12. Michael J. Marino8,
  13. Mark A. Ator,
  14. Edward R. Bacon,
  15. John P. Mallamo and
  16. Michael Williams9
  1. Discovery Research, Cephalon, Inc., West Chester, Pennsylvania
  1. Address correspondence to:
    Rita Raddatz, Cephalon, Inc., 145 Brandywine Parkway, West Chester, PA 19380. E-mail: rraddatz{at}cephalon.com

  • ↵1Current affiliation: Taconic, Cranbury, New Jersey.

  • ↵2Current affiliation: Melior Discovery, Exton, Pennsylvania.

  • ↵3Current affiliation: EnVivo Pharmaceuticals, Inc., Watertown, Massachusetts.

  • ↵4Current affiliation: WuXi AppTec (Shanghai) Co., Ltd., Shanghai, China.

  • ↵5Current affiliation: CNS Research, Roche, Basel, Switzerland.

  • ↵6Current affiliation: ChanTest, Cleveland, Ohio.

  • ↵7Current affiliation: Discovery Medicine Neuroscience, Bristol-Myers Squibb, Princeton, New Jersey.

  • ↵8Current affiliation: CNS Research, Merck Research Laboratories, West Point, Pennsylvania.

  • ↵9Current affiliation: Northwestern University, Chicago, Illinois.

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Research ArticleNeuropharmacology

H3 Receptor Antagonist CEP-26401

Rita Raddatz, Robert L. Hudkins, Joanne R. Mathiasen, John A. Gruner, Dorothy G. Flood, Lisa D. Aimone, Siyuan Le, Hervé Schaffhauser, Emir Duzic, Maciej Gasior, Donna Bozyczko-Coyne, Michael J. Marino, Mark A. Ator, Edward R. Bacon, John P. Mallamo and Michael Williams
Journal of Pharmacology and Experimental Therapeutics January 1, 2012, 340 (1) 124-133; DOI: https://doi.org/10.1124/jpet.111.186585
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